MAPK
Las MAPK son una familia de quinasas de proteínas involucradas en una variedad de procesos celulares, incluyendo crecimiento, proliferación, diferenciación y respuestas al estrés. La vía de señalización MAPK consta de varios niveles, incluidos ERK, JNK y p38 MAPK, cada uno con roles distintos en la función celular. La desregulación de la señalización MAPK está vinculada al cáncer, las enfermedades inflamatorias y los trastornos metabólicos. En CymitQuimica, ofrecemos una amplia gama de inhibidores y activadores de MAPK para apoyar su investigación en biología celular, transducción de señales y mecanismos de enfermedades.
Se han encontrado 895 productos de "MAPK"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
JNK Inhibitor VIII
CAS:<p>JNK Inhibitor VIII (TCS JNK 6o) is an ATP-competitive selective inhibitor of c-Jun N-terminal kinase (JNK)(IC50 values of 45 nM and 160 nM for JNK-1 and -2,</p>Fórmula:C18H20N4O4Pureza:98.93%Forma y color:SolidPeso molecular:356.38Pyridoxal 5'-phosphate hydrate
CAS:Pyridoxal 5'-phosphate hydrate (PLP)(1:x), the active form of vitamin B6, is a cofactor for many different enzymes involved in transamination reactions,Fórmula:C8H10NO6PPureza:97.52%Forma y color:SolidPeso molecular:247.14ZT-12-037-01
CAS:Zt-12-037-01 is a ATP competitive STK19 inhibitor（IC50 values of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N),respectively).Fórmula:C21H31N5O2Pureza:99.56%Forma y color:SolidPeso molecular:385.5GSK-114
CAS:GSK-114, a TNNI3K inhibitor with a 25 nM IC50, is 40x more selective than B-Raf and good for in vivo studies.Fórmula:C19H23N5O4SPureza:99.51%Forma y color:SolidPeso molecular:417.48K-Ras(G12C) inhibitor 6
CAS:<p>Irreversible K-Ras(G12C) inhibitor 6 fully modifies the protein at 10 μM after 24h in vitro.</p>Fórmula:C17H22Cl2N2O3SPureza:89.07% - 97.09%Forma y color:SolidPeso molecular:405.34ASP2453
CAS:ASP2453 is a potent, selective and covalent inhibitor of KRAS G12C.Fórmula:C40H48F3N7O4Pureza:99.71%Forma y color:SolidPeso molecular:747.85RAF709
CAS:RAF709 is a novel Raf kinase inhibitor with IC50s of 0.5 and 1.8 nM for c-Raf and b-Raf, respectively.Fórmula:C28H29F3N4O4Pureza:99.28% - 99.8%Forma y color:SolidPeso molecular:542.55Cefotetan
CAS:Cefotetan, a cephamycin antibiotic, fights various bacteria by disrupting cell wall synthesis.Fórmula:C17H17N7O8S4Pureza:95.72% - 99.38%Forma y color:SolidPeso molecular:575.62ASK1-IN-1
CAS:ASK1-IN-1 inhibits apoptosis kinase 1, crucial in cell stress responses, with 21 nM IC50.Fórmula:C19H19N9O2Pureza:99.92%Forma y color:SolidPeso molecular:405.41(S)-AMG-510
CAS:(S)-AMG-510 is the S-type compound of AMG-510 (Sotorasib), which effectively and selectively inhibits KRASG12C.Cost-effective and quality-assured.Fórmula:C30H30F2N6O3Pureza:99.05% - 99.76%Forma y color:SolidPeso molecular:560.594L-779450
CAS:L-779450, an effective, ATP-competitive Raf kinase inhibitor (IC50: 10 nM) , displays >7, >30 and >70-fold selectivity over p38α, GSK3β and Lck respectively.Fórmula:C20H14ClN3OPureza:≥95%Forma y color:SolidPeso molecular:347.8BMS582949
CAS:BMS-582949 inhibits p38 MAPK with 13 nM IC50, blocking kinase activity and activation.Fórmula:C22H26N6O2Pureza:98.11%Forma y color:SolidPeso molecular:406.48PLX-4720
CAS:PLX-4720 is a potent and selective B-Raf (V600E) inhibitor designed to block the ATP-binding site of oncogenic B-Raf.Cost-effective and quality-assured.Fórmula:C17H14ClF2N3O3SPureza:97.78% - 99.83%Forma y color:SolidPeso molecular:413.83Locostatin
CAS:Locostatin is a potent and cell permeable inhibitor of Raf kinase inhibitor protein (RKIP)/Raf1 kinase interaction and an inhibitor of cell migration.Fórmula:C14H15NO3Pureza:97.13%Forma y color:SolidPeso molecular:245.27IACS-13909
CAS:IACS-13909 (BBP-398), a specific and potent allosteric inhibitor of SHP2, that suppresses signaling through the MAPK pathway.Fórmula:C17H18Cl2N6Pureza:98.8%Forma y color:SolidPeso molecular:377.27SGX-523
CAS:<p>SGX-523 is a selective Met inhibitor (IC50: 4 nM), no inhibitory to Abl, BRAFV599E, p38α, and c-Raf.</p>Fórmula:C18H13N7SPureza:99% - >99.99%Forma y color:SolidPeso molecular:359.41ERK-IN-3
CAS:ERK-IN-3 (ASN007 free base) is a potent and orally active inhibitor of ERK.Fórmula:C22H25ClFN7O2Pureza:99.55% - 99.76%Forma y color:SolidPeso molecular:473.93BAY-293
CAS:BAY-293 is a potent, cell-active SOS1 inhibitor that disrupts the KRAS-SOS1 interaction (IC50: 21 nM).Fórmula:C25H28N4O2SPureza:97.16%Forma y color:SolidPeso molecular:448.58XMD17-109
CAS:<p>XMD17-109 (ERK5-IN-1) is a new selective ERK-5 inhibitor (EC50: 4.2 uM, HEK293 cells).</p>Fórmula:C36H46N8O3Pureza:98.75% - 99.7%Forma y color:SolidPeso molecular:638.8BI-78D3
CAS:BI-78D3, a competitive JNK inhibitor. IC50 of BI-78D3 is 280 nM that displays > 100 fold selectivity over p38α, and have no activity at mTOR and PI-3K.Fórmula:C13H9N5O5S2Pureza:97.89% - >99.99%Forma y color:SolidPeso molecular:379.37
