MAPK
Las MAPK son una familia de quinasas de proteínas involucradas en una variedad de procesos celulares, incluyendo crecimiento, proliferación, diferenciación y respuestas al estrés. La vía de señalización MAPK consta de varios niveles, incluidos ERK, JNK y p38 MAPK, cada uno con roles distintos en la función celular. La desregulación de la señalización MAPK está vinculada al cáncer, las enfermedades inflamatorias y los trastornos metabólicos. En CymitQuimica, ofrecemos una amplia gama de inhibidores y activadores de MAPK para apoyar su investigación en biología celular, transducción de señales y mecanismos de enfermedades.
Se han encontrado 892 productos de "MAPK"
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6-T-GDP
CAS:6-T-GDP (6-Thioguanosine 5'-diphosphate) is a metabolite of thiopurine. It inhibits the activity of Rac1, thereby reducing the transcription of inflammatory factors and the expression of cell adhesion molecules, which ultimately suppresses leukocyte migration and the occurrence of tissue inflammation.Fórmula:C10H15N5O10P2SForma y color:SolidPeso molecular:459.278-CPT-2Me-cAMP, sodium salt
CAS:8-CPT-2Me-cAMP sodium activates Epac GEFS, targets Rap1/2, has 2.2 μM EC50 for Epac1, doesn't activate PKA, and prompts Ca2+ release in β-cells.Fórmula:C17H16ClN5NaO6PSForma y color:SolidPeso molecular:507.82CAY10561
CAS:CAY10561: potent, selective ERK2 inhibitor (Ki=2nM); blocks cell proliferation; IC50 in COLO 205 cells: 0.54μM.Fórmula:C22H17Cl2FN4O2Forma y color:SolidPeso molecular:459.3(S)-CCG-1423
(S)-CCG-1423, a stereoisomer, inhibits Rho to block myocardin-related transcription factor A & serum response signaling.Fórmula:C18H13ClF6N2O3Pureza:98%Forma y color:SolidPeso molecular:454.8PHT-7.3
CAS:PHT-7.3 is a selective connector enhancer of kinase suppressor of Ras 1 (Cnk1) pleckstrin homology (PH) domain inhibitorFórmula:C24H23N3O3SPureza:98%Forma y color:SolidPeso molecular:433.52SR 3576
CAS:JNK3 inhibitor, potent and selectiveFórmula:C27H27N5O5Pureza:98%Forma y color:SolidPeso molecular:501.53CK1-IN-2
CAS:CK1-IN-2 (compound Nr.4) is a potent CK1 inhibitor p38a, and is used in DUX4 overexpression-associated diseases, such as muscular dystrophy.Fórmula:C17H12FN3O2Pureza:99.31%Forma y color:SolidPeso molecular:309.29UC-857993
CAS:UC-857993 is a selective SOS1-Ras inhibitor with a Kd of 14.7 μM that inhibits ERK, Ras, and reduces MEF growth.Fórmula:C25H22ClNO2Forma y color:SolidPeso molecular:403.9CBS-3595
CAS:CBS-3595: potent p38α MAPK/PDE-4 dual inhibitor, strong anti-inflammatory, low toxicity.Fórmula:C18H17FN4O2SPureza:98%Forma y color:SolidPeso molecular:372.42KRAS G12C inhibitor 39
CAS:KRAS G12C inhibitor 39 effectively targets KRAS G12C, a key protein in cancer research.Fórmula:C37H43N9O2Forma y color:SolidPeso molecular:645.8JNK3 inhibitor-2
CAS:<p>JNK3 inhibitor-2: selectively inhibits JNK3 (IC50 = 0.25 μM); less effective on JNK1/JNK2 (>100 μM); targets DDR1 and EGFR mutations.</p>Fórmula:C20H14N2O2Forma y color:SolidPeso molecular:314.34GDC-0879
CAS:GDC-0879 (AR-00341677) is a novel, potent and selective B-Raf inhibitor with IC50 of 0.13 nM with activity against c-Raf as well.Fórmula:C19H18N4O2Pureza:99.62%Forma y color:SolidPeso molecular:334.37Cuspin-1
CAS:Cuspin-1, a small molecule, increases SMN levels by 50% in SMA by boosting ERK phosphorylation and Ras-Raf-MEK signaling.Fórmula:C13H10BrNOForma y color:SolidPeso molecular:276.13LCRF-0004
CAS:LCRF-0004 inhibits RON kinase, key in KRAS-driven pancreatic cancer, reducing cell migration and enhancing chemo sensitivity.Fórmula:C28H18F4N6O2SForma y color:SolidPeso molecular:578.54NSC-658497
CAS:NSC-658497 is a SOS1-Ras interaction inhibitor that acts by dose-dependently inhibiting SOS1 GEF activity.Fórmula:C20H10N2O6S2Pureza:98%Forma y color:SolidPeso molecular:438.433,4-Dephostatin
CAS:3,4-Dephostatin is an inhibitor of the interactions of CFTR-associated ligand (CAL) and PSD-95/Dlg1/ZO-1 (PDZ) domain.Fórmula:C7H8N2O3Forma y color:SolidPeso molecular:168.15p38-α MAPK-IN-4
CAS:p38-α MAPK-IN-4 (Compound 69) is a selective inhibitor of p38α MAPK, demonstrating potent inhibition with an IC50 of 1.5 μM.Fórmula:C17H13BrN2OForma y color:SolidPeso molecular:341.2BSJ-04-122
CAS:BSJ-04-122: MKK4/7 inhibitor with IC50s of 4 nM & 181 nM, used in cancer research.Fórmula:C15H12ClN5OPureza:98.09%Forma y color:SolidPeso molecular:313.74(R)-PD 0325901CL
CAS:<p>(R)-PD 0325901CL, a PD 0325901CL isomer, is a MEK inhibitor used in cancer research, effective against cancer cells in vitro and in vivo.</p>Fórmula:C16H14ClF2IN2O4Forma y color:SolidPeso molecular:498.65BRAF inhibitor
CAS:BRAF inhibitor is an inhibitor of B-Raf.Fórmula:C22H18F2N4O3SPureza:98.2% - 98.41%Forma y color:SolidPeso molecular:456.47
