MAPK
Las MAPK son una familia de quinasas de proteínas involucradas en una variedad de procesos celulares, incluyendo crecimiento, proliferación, diferenciación y respuestas al estrés. La vía de señalización MAPK consta de varios niveles, incluidos ERK, JNK y p38 MAPK, cada uno con roles distintos en la función celular. La desregulación de la señalización MAPK está vinculada al cáncer, las enfermedades inflamatorias y los trastornos metabólicos. En CymitQuimica, ofrecemos una amplia gama de inhibidores y activadores de MAPK para apoyar su investigación en biología celular, transducción de señales y mecanismos de enfermedades.
Se han encontrado 893 productos para "MAPK". Se muestran los primeros 500.
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p38 MAP Kinase Inhibitor IV
CAS:p38 MAPK inhibitor IV blocks p38α/β/γ/δ with IC50s 0.13-8.63 μM and stops TNF-α/IL-1β at 22/44 nM in human cells.Fórmula:C12H4Cl6O4SForma y color:SolidPeso molecular:456.94ARS-2102
CAS:ARS-2102 is a potent covalent KRAS G12C inhibitor for use in cancer research .Fórmula:C28H31ClF2N6O2Forma y color:SolidPeso molecular:557.03ERK5-IN-4
CAS:ERK5-IN-4 (34b) is a potent, specific ERK5 inhibitor; IC50: 77 nM full-length, 300 nM ΔTAD in HEK293 cells.Fórmula:C16H11Cl2FN4O2Forma y color:SolidPeso molecular:381.19KRAS inhibitor-15
CAS:KRAS inhibitor-15 blocks KRAS G12C and p-ERK in cancer cells; potent against pancreatic and lung cancers. IC50: 0.954 μM (KRAS), 2.03/>33.3 μM (p-ERK).Fórmula:C20H17Cl2FN4OSForma y color:SolidPeso molecular:451.34KRAS inhibitor-10
CAS:KRAS inhibitor-10: potent, selective KRAS protein blocker; effective in various cancers; oral; tetrahydroisoquinoline class.Fórmula:C30H37N3O5Forma y color:SolidPeso molecular:519.63ERK5-IN-3
CAS:ERK5-IN-3 inhibits ERK5 strongly (IC50: 6 nM) and hampers Hela cell growth (IC50: 31 nM).Fórmula:C24H23Cl2FN4O2Forma y color:SolidPeso molecular:489.37SR-3737
CAS:SR-3737 is potent both JNK3 and p38 inhibitor.Fórmula:C29H25FN4O4Pureza:98%Forma y color:SolidPeso molecular:512.53KRAS G12C inhibitor 45
CAS:KRAS G12C inhibitor 45 is a potent KRAS G12C inhibitor .Fórmula:C32H33F2N5O5SForma y color:SolidPeso molecular:637.7JNK3 inhibitor-4
CAS:JNK3 inhibitor-4: potent, selective JNK3 blocker (IC50=1.0nM), neuroprotective, BBB-permeable.Fórmula:C28H27N7OForma y color:SolidPeso molecular:477.56HPK1-IN-17
CAS:HPK1-IN-17 selectively inhibits HPK1, a MAP4Ks family kinase from blood progenitor cells; useful against HPK1-related diseases like cancer.Fórmula:C26H28N6OForma y color:SolidPeso molecular:440.54(R)-CE3F4
CAS:(R)-CE3F4 is a selective inhibitor of exchange protein directly activated by cAMP isoform 1 (Epac1)(IC50 of 4.2 μM),Fórmula:C11H10Br2FNOForma y color:SolidPeso molecular:351.01PHT-7.3
CAS:PHT-7.3 is a selective connector enhancer of kinase suppressor of Ras 1 (Cnk1) pleckstrin homology (PH) domain inhibitorFórmula:C24H23N3O3SPureza:98%Forma y color:SolidPeso molecular:433.52KRAS inhibitor-17
CAS:KRAS inhibitor-17 blocks G12C mutation (IC50: 3.37μM) and p-ERK in MIA PaCA-2 (IC50: 9.25μM). Could target pancreatic, colorectal, lung cancers.Fórmula:C21H18Cl2FN3O2SForma y color:SolidPeso molecular:466.36BRAF V600E/CRAF-IN-2
CAS:Potent BRAFV600E/CRAF inhibitor, IC50: 0.888/0.229 μM, induces G0/G1 arrest and apoptosis in HCT-116 cells, potential for cancer research.Fórmula:C30H30F3N5O2Forma y color:SolidPeso molecular:549.59JNK-1-IN-1
CAS:JNK-1-IN-1 is an inhibitor specifically targeting JNK-1, also exhibiting inhibition of MKK7 with an IC50 value of 7.8μM.Fórmula:C24H22N6SForma y color:SolidPeso molecular:426.54BAY-846
CAS:BAY-846: allosteric MEK inhibitor, long-lasting, highly bioavailable, low brain entry, effective in K-Ras A549 model.Fórmula:C19H13F4IN4O4SForma y color:SolidPeso molecular:596.29CK1-IN-2
CAS:CK1-IN-2 (compound Nr.4) is a potent CK1 inhibitor p38a, and is used in DUX4 overexpression-associated diseases, such as muscular dystrophy.Fórmula:C17H12FN3O2Pureza:99.31%Forma y color:SolidPeso molecular:309.296-T-GDP
CAS:6-T-GDP (6-Thioguanosine 5'-diphosphate) is a metabolite of thiopurine. It inhibits the activity of Rac1, thereby reducing the transcription of inflammatory factors and the expression of cell adhesion molecules, which ultimately suppresses leukocyte migration and the occurrence of tissue inflammation.Fórmula:C10H15N5O10P2SForma y color:SolidPeso molecular:459.27B-Raf IN 7
CAS:"B-Raf IN 7 inhibits B-Raf (IC50: 110.23 nM); fights colon, breast, liver, cervical, prostate cancers (IC50: 7.50-12.83 μM)."Fórmula:C15H16N6O3Forma y color:SolidPeso molecular:328.33BRAF inhibitor
CAS:BRAF inhibitor is an inhibitor of B-Raf.Fórmula:C22H18F2N4O3SPureza:98.2% - 98.41%Forma y color:SolidPeso molecular:456.47Ref: TM-T10599
1mg44,00€5mg87,00€1mL*10mM (DMSO)99,00€10mg137,00€25mg236,00€50mg371,00€100mg530,00€200mg770,00€
