
MAPK
Las MAPK son una familia de quinasas de proteínas involucradas en una variedad de procesos celulares, incluyendo crecimiento, proliferación, diferenciación y respuestas al estrés. La vía de señalización MAPK consta de varios niveles, incluidos ERK, JNK y p38 MAPK, cada uno con roles distintos en la función celular. La desregulación de la señalización MAPK está vinculada al cáncer, las enfermedades inflamatorias y los trastornos metabólicos. En CymitQuimica, ofrecemos una amplia gama de inhibidores y activadores de MAPK para apoyar su investigación en biología celular, transducción de señales y mecanismos de enfermedades.
Se han encontrado 925 productos para "MAPK".
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HPK1-IN-28
CAS:HPK1-IN-28 inhibits HPK1, boosts anti-tumor immunity, and shows promise in immune disease research per patent WO2021175270A1.Fórmula:C25H22F3N5O4Forma y color:SolidPeso molecular:513.47JTP-70902
CAS:JTP-70902 is a protein kinase inhibitor with antineoplastic activity.Fórmula:C24H21BrFN5O5SForma y color:SolidPeso molecular:590.42JNK3 inhibitor-2
CAS:JNK3 inhibitor-2: selectively inhibits JNK3 (IC50 = 0.25 μM); less effective on JNK1/JNK2 (>100 μM); targets DDR1 and EGFR mutations.Fórmula:C20H14N2O2Forma y color:SolidPeso molecular:314.34MEK-IN-4
CAS:MEK-IN-4 is a MEK inhibitor that can be used to study inflammatory diseases and cancer.Fórmula:C21H18N4OSPureza:98.35% - 98.38%Forma y color:White SolidPeso molecular:374.459p38α inhibitor 2
CAS:P38α Inhibitor 2, a potent and selective inhibitor of p38α MAPK, exhibits a pIC50 value of 9.6.Fórmula:C27H33N5O3Forma y color:SolidPeso molecular:475.5826PB1
CAS:PB1, a stable borane-protected TCEP analogue, effectively reduces disulfides intracellularly and aids retinal cell survival post-axotomy.Fórmula:C14H22BO4PForma y color:SolidPeso molecular:296.11Angiogenesis inhibitor BT2
CAS:BT2 inhibits angiogenesis, vascular permeability by targeting ERK, FosB, VCAM-1, and related genes, affecting MEK1 and suppressing retinal markers.Fórmula:C18H18N2O4Forma y color:SolidPeso molecular:326.3465K-Ras G12C-IN-3
CAS:K-Ras G12C-IN-3 covalently binds G12C mutant cysteine, locking K-Ras in an inactive GDP-bound state and blocking MAPK/ERK signaling.Fórmula:C21H19Cl3N2O3Forma y color:SolidPeso molecular:453.746Antifungal agent 46
CAS:Compound 2f (Antifungal Agent 46) is a potent antifungal that inhibits Ras signaling by targeting protein farnesyltransferase [1].Fórmula:C26H28BrF3N4O2Pureza:98%Forma y color:SolidPeso molecular:565.43EO 1428
CAS:p38α and p38β2 inhibitorFórmula:C20H16BrClN2OPureza:98%Forma y color:SolidPeso molecular:415.71VU0424465
CAS:VU0424465 is a mGlu5-selective allosteric agonist.Fórmula:C19H19FN2O2Forma y color:SolidPeso molecular:326.36UC-857993
CAS:UC-857993 is a selective SOS1-Ras inhibitor with a Kd of 14.7 μM that inhibits ERK, Ras, and reduces MEF growth.Fórmula:C25H22ClNO2Forma y color:SolidPeso molecular:403.9Nek2-IN-5
CAS:Nek2-IN-5 (NCL00017509) is a potent and selective inhibitor of NIMA-related kinase 2 (Nek2).Fórmula:C15H12N6OPureza:99.86%Forma y color:SolidPeso molecular:292.3CP-281384
CAS:CP-281384 is a potent, p38alpha-selective inhibitor.Fórmula:C18H14F2N4OPureza:98%Forma y color:SolidPeso molecular:340.33Spiclomazine HCl
CAS:Spiclomazine HCl induced apoptosis in pancreatic cancer cells, which was generally related to cell viability, migration, and invasion.Fórmula:C22H25Cl2N3OS2Forma y color:SolidPeso molecular:482.49TOPK-p38/JNK-IN-1
CAS:TOPK-p38/JNK-IN-1 (Compound B12) is an orally active inhibitor of the TOPK-p38/JNK signaling pathway, with an IC50 value of 2.14 μM for the inhibition of NOFórmula:C17H15F3N2O4Forma y color:SolidPeso molecular:368.31B-Raf IN 13
CAS:B-Raf IN 13 is a potent B-Raf inhibitor with anticancer activity.B-Raf IN 13 has an IC50 of 3.55 nM in the BRAF V600E enzyme assay.Fórmula:C19H19ClFN3O4SPureza:99.41% - >99.99%Forma y color:SolidPeso molecular:439.89Spiclomazine free base
CAS:Spiclomazine free base is an antipsychotic compound.Fórmula:C22H24ClN3OS2Peso molecular:446.03ERK1/2 inhibitor 1
CAS:ERK1/2 inhibitor 1 is a potent, orally bioavailable ERK1/2 inhibitor, showing 60% inhibition at 1 nM and an IC50 of 3.0 nM against ERK1 and ERK2, respectively.Fórmula:C29H32ClN5O4Pureza:98.81%Forma y color:SolidPeso molecular:550.048

