MAPK
Las MAPK son una familia de quinasas de proteínas involucradas en una variedad de procesos celulares, incluyendo crecimiento, proliferación, diferenciación y respuestas al estrés. La vía de señalización MAPK consta de varios niveles, incluidos ERK, JNK y p38 MAPK, cada uno con roles distintos en la función celular. La desregulación de la señalización MAPK está vinculada al cáncer, las enfermedades inflamatorias y los trastornos metabólicos. En CymitQuimica, ofrecemos una amplia gama de inhibidores y activadores de MAPK para apoyar su investigación en biología celular, transducción de señales y mecanismos de enfermedades.
Se han encontrado 914 productos para "MAPK".
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KRAS G12C inhibitor 43
CAS:KRAS G12C inhibitor 43 strongly blocks KRAS G12C, H358 cell growth (IC50: 0.001-1μM), less effective on A549, HCC cells (IC50>1μM).Fórmula:C33H35N7O3Forma y color:SolidPeso molecular:577.68GGTI-286 hydrochloride
CAS:GGTI-286 HCl strongly inhibits GGTase I (IC50: 2 μM) and K-Ras4B farnesylation (IC50: 1 μM).Fórmula:C23H32ClN3O3SForma y color:SolidPeso molecular:466.04SMAP-2
CAS:SMAP-2: oral PP2A activator, targets Aα subunit, halts KRAS-mutant lung cancer growth.Fórmula:C27H27F3N2O4SPureza:98%Forma y color:SolidPeso molecular:532.57HPK1-IN-26
CAS:HPK1-IN-26, from WO2021254118A1, is a potent dual HPK1/GLK inhibitor for studying animal infections.Fórmula:C19H21N5OSForma y color:SolidPeso molecular:367.47ZINC09659342
CAS:ZINC09659342 (compound 13) is an inhibitor of Lbc-RhoA interaction (IC50: 3.6 μM).Fórmula:C23H15F3N2O4Forma y color:SolidPeso molecular:440.37NSC-658497
CAS:NSC-658497 is a SOS1-Ras interaction inhibitor that acts by dose-dependently inhibiting SOS1 GEF activity.Fórmula:C20H10N2O6S2Pureza:98%Forma y color:SolidPeso molecular:438.43SR 3576
CAS:JNK3 inhibitor, potent and selectiveFórmula:C27H27N5O5Pureza:98%Forma y color:SolidPeso molecular:501.53CAY10561
CAS:CAY10561: potent, selective ERK2 inhibitor (Ki=2nM); blocks cell proliferation; IC50 in COLO 205 cells: 0.54μM.Fórmula:C22H17Cl2FN4O2Forma y color:SolidPeso molecular:459.3KRAS G12C inhibitor 22
CAS:KRAS G12C inhibitor 22 is a KRAS G12C inhibitor.Fórmula:C32H41N7O2Forma y color:SolidPeso molecular:555.71Quazinone
CAS:Quazinone: PDE3 inhibitor, enhances heart muscle contractility, lowers blood pressure, and inhibits DNA synthesis in muscle cells. IC50 = 4.2 μM.Fórmula:C11H10ClN3OForma y color:SolidPeso molecular:235.67SB-747651A
CAS:SB-747651A: ATP-competitive MSK1 inhibitor (IC50=11nM), affects N-terminal domain, also hinders MSK2, PKA, PKB, RSK, p70S6K.Fórmula:C16H22N8OPureza:98%Forma y color:SolidPeso molecular:342.4EO 1428
CAS:p38α and p38β2 inhibitorFórmula:C20H16BrClN2OPureza:98%Forma y color:SolidPeso molecular:415.71p38α inhibitor 2
CAS:P38α Inhibitor 2, a potent and selective inhibitor of p38α MAPK, exhibits a pIC50 value of 9.6.Fórmula:C27H33N5O3Forma y color:SolidPeso molecular:475.58pan-KRAS-IN-16
CAS:3344 is an inhibitor of KRAS-effector interactions，with an affnity of 126nm.Fórmula:C24H26N2O3Pureza:98%Forma y color:SolidPeso molecular:390.47B-Raf IN 6
CAS:B-Raf IN 6: potent B-Raf kinase inhibitor, IC50 of 1.7 nM, doesn't target PXR, metabolically stable, potential in cancer research.Fórmula:C24H21F3N6O2S2Forma y color:SolidPeso molecular:546.59(R)-CE3F4
CAS:(R)-CE3F4 is a selective inhibitor of exchange protein directly activated by cAMP isoform 1 (Epac1)(IC50 of 4.2 μM),Fórmula:C11H10Br2FNOForma y color:SolidPeso molecular:351.01SR-3737
CAS:SR-3737 is potent both JNK3 and p38 inhibitor.Fórmula:C29H25FN4O4Pureza:98%Forma y color:SolidPeso molecular:512.53TOPK-p38/JNK-IN-1
CAS:TOPK-p38/JNK-IN-1 (Compound B12) is an orally active inhibitor of the TOPK-p38/JNK signaling pathway, with an IC50 value of 2.14 μM for the inhibition of NOFórmula:C17H15F3N2O4Forma y color:SolidPeso molecular:368.31B-Raf IN 7
CAS:"B-Raf IN 7 inhibits B-Raf (IC50: 110.23 nM); fights colon, breast, liver, cervical, prostate cancers (IC50: 7.50-12.83 μM)."Fórmula:C15H16N6O3Forma y color:SolidPeso molecular:328.33
