MAPK
Las MAPK son una familia de quinasas de proteínas involucradas en una variedad de procesos celulares, incluyendo crecimiento, proliferación, diferenciación y respuestas al estrés. La vía de señalización MAPK consta de varios niveles, incluidos ERK, JNK y p38 MAPK, cada uno con roles distintos en la función celular. La desregulación de la señalización MAPK está vinculada al cáncer, las enfermedades inflamatorias y los trastornos metabólicos. En CymitQuimica, ofrecemos una amplia gama de inhibidores y activadores de MAPK para apoyar su investigación en biología celular, transducción de señales y mecanismos de enfermedades.
Se han encontrado 893 productos de "MAPK"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
AZD6703 free base
CAS:AZD6703 is a potent, selective and reversible orally bioavailable inhibitor of p38 mitogen-activated protein kinase 14 (MAPK14).Fórmula:C24H27N5O2Forma y color:SolidPeso molecular:417.5Kobe2601
CAS:Kobe2601 is a Kobe0065 and Kobe02602 water-soluble analog. It displays inhibitory activity towards Ras-Raf binding.Fórmula:C13H10FN5O4SPureza:98%Forma y color:SolidPeso molecular:351.31GSK329
CAS:GSK329 selectively inhibits TNNI3K, showing cardioprotection in ischemic heart models.Fórmula:C19H14Cl2F3N5O2Pureza:98%Forma y color:SolidPeso molecular:472.25HCI-2184
CAS:HCI-2184 is an inhibitor of AXL kinase and Nek2 that acts by successfully mitigating drug resistance in bortezomib-resistant multiple myeloma.Fórmula:C23H28ClN7O2SPureza:98%Forma y color:SolidPeso molecular:502.03GSK649A
CAS:GSK649A is a novel activator of Satellite Cell Proliferation, it could enhance repair of Damaged Muscle.Fórmula:C15H12ClFN6OSPureza:98%Forma y color:SolidPeso molecular:378.81CP-281384
CAS:CP-281384 is a potent, p38alpha-selective inhibitor.Fórmula:C18H14F2N4OPureza:98%Forma y color:SolidPeso molecular:340.33RBC6
CAS:RBC6 is an inhibitor of the binding of Ral to its effector RALBP1.Fórmula:C16H14Cl2N4O2Pureza:98%Forma y color:SolidPeso molecular:365.21CP-944629
CAS:CP-944629 is a novel, potent, and selective inhibitor of p38alpha.Fórmula:C19H15F3N4OPureza:98%Forma y color:SolidPeso molecular:372.34BNC-1
CAS:BNC-1 reduces amyloid in mice, enhances synapses by activating Elk-1.Fórmula:C16H14N2O3Pureza:98%Forma y color:SolidPeso molecular:282.29(2Z,3Z)-U0126
CAS:U0126 selectively inhibits MEK1/2, blocks MAPK/ERK signaling, and suppresses Ki-ras-induced cell growth, with IC50s of 72 nM and 58 nM for MEK1/2.Fórmula:C18H16N6S2Forma y color:SolidPeso molecular:380.49Migoprotafib
CAS:Migoprotafib (GDC-1971) is a potent and highly selective SHP2 (Src Homology-2 Domain-Containing Phosphatase 2) inhibitor for advanced solid tumours.Fórmula:C25H26N8OPureza:98.31%Forma y color:SolidPeso molecular:454.53PB1
CAS:PB1, a stable borane-protected TCEP analogue, effectively reduces disulfides intracellularly and aids retinal cell survival post-axotomy.Fórmula:C14H22BO4PForma y color:SolidPeso molecular:296.11D-87503
CAS:D-87503 is a dual extracellular signaling-related kinase (ERK)/PI3K inhibitor.Fórmula:C17H15N5OSForma y color:SolidPeso molecular:337.4SW-034538
CAS:SW-034538 is a TAO2 inhibitor (IC 50= 300 nM).Fórmula:C18H20N4O3S2Forma y color:SolidPeso molecular:404.51BSJ-04-122
CAS:BSJ-04-122: MKK4/7 inhibitor with IC50s of 4 nM & 181 nM, used in cancer research.Fórmula:C15H12ClN5OPureza:98.09%Forma y color:SolidPeso molecular:313.74Cuspin-1
CAS:Cuspin-1, a small molecule, increases SMN levels by 50% in SMA by boosting ERK phosphorylation and Ras-Raf-MEK signaling.Fórmula:C13H10BrNOForma y color:SolidPeso molecular:276.13CK1-IN-2
CAS:CK1-IN-2 (compound Nr.4) is a potent CK1 inhibitor p38a, and is used in DUX4 overexpression-associated diseases, such as muscular dystrophy.Fórmula:C17H12FN3O2Pureza:99.31%Forma y color:SolidPeso molecular:309.29BAY-846
CAS:BAY-846: allosteric MEK inhibitor, long-lasting, highly bioavailable, low brain entry, effective in K-Ras A549 model.Fórmula:C19H13F4IN4O4SForma y color:SolidPeso molecular:596.29SR-3306
CAS:SR-3306 is a brain-penetrant and selective pan-JNK (JNK1/2/3) inhibitor with IC50 values of 67 nM, 283 nM, 159 nM.Cost-effective and quality-assured.Fórmula:C28H26N8OPureza:99.38% - 99.71%Forma y color:SolidPeso molecular:490.56GNE-1858
CAS:GNE-1858 inhibits HPK1; IC50: 1.9 nM for wild-type, 1.9 nM (HPK1-TSEE), 4.5 nM (HPK1-SA).Fórmula:C21H26F2N8Pureza:99.36%Forma y color:SolidPeso molecular:428.48
