ERK

Mefloquine is a quinoline derivative used for the prevention and therapy of P. falciparum malaria.

TRPM4 inhibitor 8 is an inhibitor of Transient receptor potential melastatin 4(TRPM4) which contributes to …

Methylthiouracil is a thiourea antithyroid agent that inhibits the synthesis of thyroid hormone, and it …

AX-15836 is an inhibitor of ERK5 (IC50 : 8 nM).

Lidocaine Hydrochloride hydrate is an amide local anesthetic, has anti-inflammatory property.

Honokiol is the active principle of magnolia extract. It inhibits the activation of Akt and …

Urolithin B is one of the gut microbial metabolites of ellagitannins and is found in …

(-)-Hydroxycitric acid (HCA) can inhibit fat synthesis and reduces food intake, the primary mechanism of …

MRTX-1257 is a selective, irreversible, and covalent inhibitor of KRAS G12C. It has an IC50 …

(E/Z)-BCI attenuates LPS-induced inflammatory mediators and ROS production in macrophage cells via activating the Nrf2 …

CC-90003 is a selective inhibitor of ERK 1/2. It has antitumor activity.

MK2-IN-3 hydrate is an orally active, selective, and ATP-competitive inhibitor of MAPKAP-K2 (MK-2) (IC50 of …

Lidocaine is an amide local anesthetic with anti-inflammatory properties in vitro and in vivo. It …

Lidocaine hydrochloride is a local anesthetic and cardiac depressant used as an antiarrhythmic agent. Its …

Mefloquine, a quinoline antimalarial agent, is an anti-SARS-CoV-2 entry inhibitor. Mefloquine is also a K+ …

AY 77 is a potent PAR2 biased agonist. AY 77 exhibits bias for Ca2+over ERK1/2 …

4,10-Aromadendranediol exhibits neurite outgrowth-inducing activity in neurons via activation of the ERK signaling pathway, which …

Enniatins B decreases the activation of ERK (p44/p42). Enniatin B is a Fusarium mycotoxin. Enniatin …

Torilin is an inhibitor of testosterone 5 alpha-reductase, it (IC50 = 31.7 +/- 4.23 microM) …

Pseudoginsenoside Rh2 has cytotoxicity, it induces mitochondrial apoptosis in A549 cells and is responsible for …

Cimiside E has anti-inflammatory activity, it selectively inhibits TNF-α-induced expression of VCAM-1 at least by …

Lyoniresinol has antioxidant effect, it shows robust anti-melanogenic activity, decreases tyrosinase activity and melanin biosynthesis …

Omtriptolide, triptolide purified from the Chinese herb, is a water-soluble derivative prodrug.

Lupalbigenin sensitizes detachment-induced cell death in human lung cancer cell through down-regulation of pro-survival proteins.

6,4'-Dihydroxy-7-methoxyflavanone is a biologically active compound isolated from the heartwood of Dalbergia odorifera T. Chen …

(E)-4-(3,4-dimethoxyphenyl)but-3-en-1-ol may promote melanin synthesis via USF1 dependent fashion and could be used as a …

Ganoderic acid X is a potential Mdm2 inhibitor(K(i) = 16nM). It is a potential anticancer …

CHPG hydrochloride is a selective agonist of mGluR5.

Alpinumisoflavone has atheroprotective effects, may result from their ability to upregulate mechanisms promoting HDL-cholesterol and …

Kaerophyllin has anti-fibrotic effects, it can protect the rat liver from TAA-caused injury and fibrogenesis …

Broussonins A and B, new phytoalexins from diseased paper mulberry. Broussonin A shows estrogenic activity …

Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in …

7,8-Didehydrocimigenol can be used for the treatment of cardiovascular disorders such as atherosclerosis. It upregulates …

Bufarenogin is a bufadienolide isolated from parotoid gland secretions of the Cuban endemic toad Peltophryne …

PD 198306 is a selective inhibitor of MAPK/ERK-kinase (MEK) with antihyperalgesic effects. PD 198306 reduces …

Gardenin A shows neurotrophic effects via activating MAPK/ERK, PKC, and PKA. Gardenin A exhibits antidepressant, …

Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it …

Fustin is the phytogenic flavanol component of the plant Rhus verniciflua Stokes. Fustin shows protective …

Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value …

Lup-20(29)-en-28-oic acid exhibits anticancer activities in various cancer types, it Inhibits autophagic flux and synergistically …

Bakkenolide IIIa has antioxidant, and neuroprotective effects, it protects against cerebral damage by inhibiting AKT …

Cearoin has anti-inflammatory, and antiallergic activities, it can markedly inhibit inflammatory responses including LPS-induced NO …

(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values …

Manassantin B is a potent inhibitor of NF-κB activation by the suppression of transciptional activity …

Enniatin A1 possesses anticarcinogenic properties by induction of apoptosis and disruption of ERK signalling pathway. …

2-Hydroxy-3-methylanthraquinone enhances apoptosis of U937 cells,in part,through activation of p-p38MAPK and downregulation of p-ERK1/2; triggers …

Vincristine binds to tubulin and inhibits the formation of microtubules, thereby inhibiting mitosis of the …

Allicin exerts antioxidant, bactericidal, anti-cancer, anti-inflammatory activities, it exerts an inhibitory immunomodulatory effect on intestinal …

Enniatin B1 crosss the blood-brain barrier. Enniatin B1 decreases the activation of ERK (p44/p42). Enniatin …

Broussonin E could suppress inflammation by modulating macrophages activation state via inhibiting the ERK and …

Saponarin shows in vitro and in vivo hepatoprotective and antioxidant activity against CCl4-induced liver damage.

Haginin A is an effective inhibitor of hyperpigmentation caused by UV irradiation or by pigmented …

Astragaloside, one of the main active ingredients in Astragalus membranaceus.

Cajanin has potential hypolipidemic effects,possibly via up-regulating the ABCA1 protein expression,subsequently resulting in increased macrophage …

Griffipavixanthone inhibits the growth of human Non-small-cell lung cancer H520 cells in dose- and time-dependent …

Desoxo-narchinol A exhibits protective effects against LPS-induced endotoxin shock and inflammation through p38 deactivation, it …

Peonidin chloride has antioxidant activity. Peonidin has show potent inhibitory and apoptotic effects on cancer …

Isocryptotanshinone inhibits protein tyrosine phosphatase 1B (PTP1B) activity with 50% inhibitory concentration values of 56.1±6.3 …

Nothofagin has antioxidant, and antithrombotic activities, it possesses anti-inflammatory activity by inhibiting hyperpermeability, expression of …

Quercetin 3,4'-dimethyl ether shows anti-lipid peroxidation activity (IC 50 values of 0.3 uM), it also …

Taspine shows antitumor activity by modulating the EGFR signaling pathway of Erk1/2 and Akt in …

Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C …

15-Methoxypinusolidic acid has anti-inflammatory effects, it inhibits LPS-induced iNOS expression and NO production, independent on …

6-Acetonyldihydrochelerythrine exhibits significant antioxidant activities, it exhibits significant anti-HIV activity in H9 lymphocytes with EC50 …

Corylifol C and, to a lesser extent, xanthoangelol are potent protein kinase inhibitors (inhibitory concentration …

5alpha-Hydroxycostic acid possesses anti-angiogenic ability by interfering the VEGF- and Ang2-related pathways, and it may …

Rupestonic acid is a compound in Artemisia rupestris L., a well-known traditional Uighur medicine for …

Hirsutenone has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition …

Olomoucine is an ATP competitive inhibitor of Cdk2/cyclin A, Cdc2/CyclinB, CDK2/CyclinE, CDK5/p35, and ERK1/p44 MAP …

A-674563 is an orally available, ATP-competitive, and reversible inhibitor of Akt (Ki: 11 nM for …

Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced …

ERK1/2 inhibitor 1 is a potent, orally bioavailable ERK1/2 inhibitor, showing 60% inhibition at 1 …

4-P-PDOT is a potent, selective and affinity Melatonin receptor (MT2) antagonist.

Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 …