ERK
ERK es una proteína clave en la vía de señalización MAPK (Mitogen-Activated Protein Kinase), que está involucrada en la transmisión de señales desde los receptores de la superficie celular hasta el ADN en el núcleo celular. ERK juega un papel crucial en la regulación de varios procesos celulares, incluyendo la proliferación, diferenciación y supervivencia. La desregulación de la señalización ERK está asociada con el desarrollo de cáncer y otras enfermedades, lo que la convierte en un objetivo importante para la intervención terapéutica. En CymitQuimica, ofrecemos una selección de inhibidores y moduladores de ERK de alta calidad para apoyar su investigación en señalización celular, oncología y desarrollo terapéutico.
Se han encontrado 194 productos de "ERK"
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Mefloquine hydrochloride
CAS:Mefloquine hydrochloride (Mefloquin hydrochloride) is a quinoline derivative used for the prevention and therapy of P. falciparum malaria.Fórmula:C17H17ClF6N2OPureza:99% - 99.99%Forma y color:Off-White To Yellow SolidPeso molecular:414.77MRTX-1257
CAS:<p>MRTX-1257: selective, irreversible KRAS G12C inhibitor; IC50 of 900 pM; 31% bioavailable in mice; 77% target engagement.</p>Fórmula:C33H39N7O2Pureza:97.3% - 99.07%Forma y color:SolidPeso molecular:565.71LUT014
CAS:<p>LUT014 is a B-Raf inhibitor (IC50: 11.7 nM) and developed to decrease dose-limiting acneiform lesions associated with EGFR Inhibitors treatment.</p>Fórmula:C27H19F3N8OPureza:99.03%Forma y color:SolidPeso molecular:528.49Lidocaine
CAS:<p>Lidocaine, an amide local anesthetic, reduces pain and inflammation by dampening ICAM-1, cytokines, and neutrophil influx.</p>Fórmula:C14H22N2OPureza:99.95% - >99.99%Forma y color:Needles From Benzene Or Alcohol SolidPeso molecular:234.34Lidocaine hydrochloride
CAS:<p>Lidocaine HCl: local anesthetic, antiarrhythmic, stronger & longer-lasting than procaine but shorter than bupivacaine/prilocaine.</p>Fórmula:C14H23ClN2OPureza:99.81% - 99.92%Forma y color:White Crystal PowderPeso molecular:270.798(E/Z)-BCI
CAS:<p>(E/Z)-BCI (NSC-150117), a dual-specificity phosphatase 6 (DUSP6) inhibitor with anti-inflammatory properties, reduces LPS-induced inflammatory mediators and ROS</p>Fórmula:C22H23NOPureza:99.94%Forma y color:SolidPeso molecular:317.42Methylthiouracil
CAS:<p>Methylthiouracil (NSC-193526) is a thiourea antithyroid agent that inhibits the synthesis of thyroid hormone, and it is used to treat hyperthyroidism.</p>Fórmula:C5H6N2OSPureza:99.89% - >99.99%Forma y color:Crystals Saturated Aqueous Solution Is Neutral Or Slightly Acidic (Ntp 1992)Peso molecular:142.18CC-90003
CAS:<p>CC-90003 is a selective inhibitor of ERK 1/2. It has antitumor activity.</p>Fórmula:C22H21F3N6O2Pureza:99.42%Forma y color:SolidPeso molecular:458.44Mefloquine
CAS:<p>Mefloquine (Ro 215998), a quinoline antimalarial agent, is an anti-SARS-CoV-2 entry inhibitor.</p>Fórmula:C17H16F6N2OPureza:99.89%Forma y color:SolidPeso molecular:378.31ERK5-IN-6
CAS:<p>ERK5-IN-6 is an ERK5 kinase inhibitor with antiproliferative, anticonvulsant, and antitumor activity for the study of central nervous system related diseases.</p>Fórmula:C23H21N3Pureza:98.59%Forma y color:SoildPeso molecular:339.43MK2-IN-3 hydrate
CAS:<p>MK2-IN-3 hydrate (MK-2 Inhibitor III) is an orally active, selective, and ATP-competitive inhibitor of MAPKAP-K2 (MK-2) (IC50 of 0.85 nM)</p>Fórmula:C21H18N4O2Pureza:99.58%Forma y color:SolidPeso molecular:358.39AX-15836
CAS:AX-15836 is an inhibitor of ERK5 (IC50 : 8 nM).Fórmula:C32H40N8O5SPureza:98.96%Forma y color:SolidPeso molecular:648.78Honokiol
CAS:<p>Honokiol (NSC-293100) is the active principle of magnolia extract. It inhibits the activation of Akt and enhances the phosphorylation of ERK1/ERK2.</p>Fórmula:C18H18O2Pureza:99.65% - 99.94%Forma y color:Dark Brown To White Fine Powder With Pleasant Odor Spicy And Slightly Bitter TastePeso molecular:266.33Lidocaine Hydrochloride hydrate
CAS:<p>Lidocaine Hydrochloride hydrate is an amide local anesthetic, has anti-inflammatory property.</p>Fórmula:C14H22N2O·HCl·H2OPureza:99.95%Forma y color:SolidPeso molecular:288.82Urolithin B
CAS:Urolithin B is one of the gut microbial metabolites of ellagitannins and is found in diverse plant foods, including pomegranates, berries, walnuts, tropicalFórmula:C13H8O3Pureza:99.45%Forma y color:SolidPeso molecular:212.2ERK5-IN-5
CAS:ERK5-IN-5 is extracellular signal-regulated kinase 5 (ERK5) inhibitor with anticancer activity anticonvulsant activity inhibits A549 cell proliferation.Fórmula:C19H16ClN3OPureza:99.89%Forma y color:SoildPeso molecular:337.8Emodic acid
CAS:<p>Emodic acid is a useful organic compound for research related to life sciences. The catalog number is T124807 and the CAS number is 478-45-5.</p>Fórmula:C15H8O7Forma y color:SolidPeso molecular:300.222KRAS G12C inhibitor 69
<p>KRAS G12C inhibitor 69 (Compound K09) is an inhibitor of the mutant RAS protein KRAS G12C with an IC50 of 4.36 nM. In the cell lines NCI-H358 and MIA-PACA-2, it suppresses ERK phosphorylation with IC50 values of 12 nM and 7 nM, respectively. Additionally, KRAS G12C inhibitor 69 hinders the proliferation of NCI-H358 and MIA-PACA-2 cancer cells, with IC50 values of 3.15 nM and 2.33 nM, respectively.</p>Fórmula:C29H29ClF3N5O3Forma y color:SolidPeso molecular:588.02ROCK-IN-5
CAS:<p>ROCK-IN-5 (I-B-37) inhibits kinases like ROCK/ERK/GSK; may aid in cardiac and neuro disease studies.</p>Fórmula:C16H11ClFN3OSPureza:99.72% - 99.83%Forma y color:SolidPeso molecular:347.79ERK1/2 inhibitor 3
CAS:<p>ERK1/2 inhibitor 3, a strong ERK1/2 blocker, may aid in cancer and inflammation research.</p>Fórmula:C28H31ClFN5O6SForma y color:SolidPeso molecular:620.09TAT-DEF-Elk-1
CAS:<p>TAT-DEF-Elk-1 is a cell-penetrating peptide Elk-1 inhibitor.</p>Fórmula:C155H259N57O40Pureza:98%Forma y color:SolidPeso molecular:3561.136BTX6654
<p>BTX-6654 is a cereblon-based bifunctional SOS1 PROTAC degrader. This compound exhibits antiproliferative activity against cells with various KRAS mutations by reducing the expression of downstream signaling markers pERK and pS6.</p>Fórmula:C50H57F4N9O5Forma y color:SolidPeso molecular:940.04STE-MEK1(13)
CAS:<p>STE-MEK1(13), a cell-permeable ERK1/2 inhibitor with IC50 values ranging from 13 to 30 μM, impedes the phosphorylation of ERK1/2, as demonstrated in studies [1</p>Fórmula:C86H153N19O17SPureza:98%Forma y color:SolidPeso molecular:1757.32PROTAC MEK1 Degrader-1
CAS:<p>PROTAC MEK1 Degrader-1, a targeted protein degradation agent, combines a MEK1 inhibitor with a von Hippel-Lindau ligand to effectively inhibit ERK1/2</p>Fórmula:C53H66FIN8O11S2Pureza:98%Forma y color:SolidPeso molecular:1201.17Anti-inflammatory agent 35
CAS:<p>Anti-inflammatory agent 35 is a potent anti-inflammatory agent.</p>Fórmula:C27H29NO8Pureza:99.98%Forma y color:SoildPeso molecular:495.52Kinase Inhibitor Library
<p>A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;</p>Forma y color:Odour SolidMAPK Inhibitor Library
<p>A unique collection of 365 compounds targeting MAPK signaling for drug discovery in MAPK related diseases;</p>Forma y color:Odour Solid4-P-PDOT
CAS:<p>4-P-PDOT (4-phenyl-2- propionamidotetralin) is a potent, selective and affinity Melatonin receptor (MT2) antagonist.</p>Fórmula:C19H21NOPureza:99.91%Forma y color:SolidPeso molecular:279.38VSLRGDTRG
CAS:<p>VSLRGDTRG is a synthetic peptide derived from the RGD motif in cadherin17 (CDH17) that binds to the α2β1 integrin, activating its signaling pathways. By promoting high-affinity conformational changes in β1 integrins through the RGD motif, VSLRGDTRG enhances cell adhesion and the phosphorylation of FAK and ERK1/2, thereby driving tumor proliferation and metastasis. This peptide is useful for research on cancers expressing CDH17, such as colorectal and pancreatic cancer.</p>Fórmula:C38H69N15O14Forma y color:SolidPeso molecular:960.047Rineterkib hydrochloride
CAS:<p>Rineterkib hydrochloride (B) is an oral RAF/ERK1/2 inhibitor for MAPK-driven cancers, including KRAS/BRAF-mutant NSCLC and CRC.</p>Fórmula:C26H28BrClF3N5O2Forma y color:SolidPeso molecular:614.89LC-SF-14
<p>LC-SF-14 is a selective dual inhibitor of SHP2 and FGFR, with IC50 values of 71.6 nM and 8.9 nM, respectively. It blocks FGFR2-FRS2α-SHP2-MAPK signaling and ERK phosphorylation, and also inhibits the proliferation of KATOIII cancer cells (IC50: 9.2 nM). Furthermore, LC-SF-14 exhibits antitumor activity in SNU-16 xenograft mouse models, making it suitable for research on FGFR2-driven gastric cancer.</p>Fórmula:C44H50Cl3N13O5SForma y color:SolidPeso molecular:977.28442A-674563 HCl (552325-73-2(free base))
CAS:<p>A-674563: Oral Akt inhibitor (Ki: 11 nM for Akt1), also targets PKA/Cdk2, with 10-1800x selectivity over other kinases.</p>Fórmula:C22H23ClN4OPureza:≥98%Forma y color:SolidPeso molecular:394.9Fulipiftide
CAS:<p>Fulipiftide is a short peptide derived from pigment epithelium-derived factor (PEDF). It stimulates the amplification of nuclear stem cell factor+TSPC by activating the ERK2 and STAT3 signaling pathways. Fulipiftide also exhibits anti-inflammatory properties and is applicable in research on acute tendon injuries.</p>Fórmula:C144H227N41O47Forma y color:SolidPeso molecular:3284.59GSK143
CAS:<p>GSK143: Oral SYK inhibitor, pIC50=7.5, curbs pErk, anti-inflammatory, hinders immune cells in mice.</p>Fórmula:C17H22N6O2Forma y color:SolidPeso molecular:342.403Anti-inflammatory agent 31
Andrographolide derivative 31 is an anti-inflammatory that blocks NF-κB, PI3K/Akt, and ERK1/2 MAPK, and restores GSH levels to protect the liver.Fórmula:C19H30O3Forma y color:SolidPeso molecular:306.44Astragaloside
CAS:<p>Astragaloside, one of the main active ingredients in Astragalus membranaceus.</p>Fórmula:C28H32O17Pureza:99.9%Forma y color:Odour SolidPeso molecular:640.54Olomoucine
CAS:<p>Olomoucine hinders Cdk2, Cdc2, CDK5, ERK1, regulates the cell cycle, and fights melanoma; IC50s: 3-25 µM.</p>Fórmula:C15H18N6OPureza:99.77%Forma y color:White Crystalline PowderPeso molecular:298.344′-Demethylnobiletin
CAS:<p>4′-Demethylnobiletin, a bioactive metabolite, activates the PKA/ERK/CREB signaling pathway, enhances CRE-mediated transcription in hippocampal neurons, and</p>Fórmula:C20H20O8Forma y color:SolidPeso molecular:388.37Edaxeterkib
CAS:<p>Edaxeterkib is a potent extracellular signal- regulated kinase (ERK) inhibitor for the research of cancer.</p>Fórmula:C26H27N7O2Forma y color:SolidPeso molecular:469.549PD 198306
CAS:<p>PD 198306: a MEK inhibitor with antihyperalgesic properties, reduces Streptozocin-boosted active ERK1.</p>Fórmula:C18H16F3IN2O2Pureza:99.66%Forma y color:SolidPeso molecular:476.23MHJ-627
<p>MHJ-627, a potent inhibitor of ERK5 (MAPK7) with an IC50 value of 0.91 μM, enhances the mRNA expression of tumor suppressors and anti-metastatic genes, leading</p>Fórmula:C34H45BrN2O3Pureza:98%Forma y color:SolidPeso molecular:609.64Endothelin-1 (1-31) (Human) TFA
<p>Endothelin-1 (1-31) (Human) TFA, a potent vasoconstrictor and hypertensive agent, originates from the chymase-mediated selective hydrolysis of big ET-1 [1].</p>Fórmula:C164H237F3N38O49S5Pureza:98%Forma y color:SolidPeso molecular:3742.18Laxiflorin B-4
<p>Laxiflorin B-4, a derivative of Laxiflorin B, demonstrates increased affinity for ERK1/2 and enhanced tumor-suppressive effects [1].</p>Pureza:98%Forma y color:Odour SolidMK2-IN-5
CAS:<p>MK2-IN-5, a pseudosubstrate of Mk2 with an inhibition constant (K_i) of 8 μM, selectively targets the protein interaction domain of the MAPK pathway and</p>Fórmula:C61H113N21O16Pureza:98%Forma y color:SolidPeso molecular:1396.68VSLRGDTRG acetate
<p>VSLRGDTRG acetate is a synthetic peptide of the RGD motif from cadherin17 (CDH17), capable of binding to α2β1 integrin and activating its signaling pathways. It facilitates the high-affinity conformational change of β1 integrin via the RGD motif, enhancing cell adhesion and phosphorylation of FAK and ERK1/2, thereby promoting tumor proliferation and metastasis. VSLRGDTRG acetate is applicable in research on cancers expressing CDH17, such as colon and pancreatic cancers.</p>Forma y color:Odour SolidSOS1-IN-18
<p>SOS1-IN-18 (Compound 8) is an inhibitor of the Son of Sevenless 1 protein (SOS1) with a dissociation constant (KD) of 2.6 nM. It disrupts the SOS1-KRAS G12C interaction with an IC50 of 3.4 nM, inhibits ERK phosphorylation in H358 cells with an IC50 of 31 nM, and curtails the proliferation of H358 cells with an IC50 of 5 nM.</p>Fórmula:C26H29F3N4O2Forma y color:SolidPeso molecular:486.53PPM-3
<p>PPM-3, a selective PROTAC ERK5 degrader, exhibits a potent inhibitory concentration (IC 50) of 62.4 nM.</p>Fórmula:C54H69N11O6SPureza:98%Forma y color:SolidPeso molecular:1000.26SCH772984 HCl
<p>SCH772984 HCl selectively inhibits ERK1/2, acts like type I/II kinase inhibitors, and is potent at 4/1 nM IC50s in certain mutated tumor cells.</p>Fórmula:C33H34ClN9O2Pureza:98%Forma y color:SolidPeso molecular:624.14CHPG hydrochloride
<p>CHPG hydrochloride is a selective agonist of mGluR5.</p>Fórmula:C8H9Cl2NO3Pureza:98.1%Forma y color:SoildPeso molecular:238.07TRPM4 inhibitor 8
CAS:<p>TRPM4 inhibitor 8 is an inhibitor of Transient receptor potential melastatin 4(TRPM4) which contributes to viability, migration, cell cycle shift, and adhesion.</p>Fórmula:C11H17BrN2Pureza:97%Forma y color:SolidPeso molecular:257.17EphB2 Protein, Human, Recombinant (His)
EphB2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.Forma y color:Lyophilized PowderPeso molecular:59.2 kDa (predicted); 65-75 kDa (reducing condition, due to glycosylation)ERK2 Protein, Mouse, Recombinant (His & GST)
<p>ERK2 Protein, Mouse, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag.</p>Forma y color:Lyophilized PowderPeso molecular:69.1 kDa (predicted); 60 kDa (reducing conditions)EphB2 Protein, Mouse, Recombinant (hFc)
EphB2 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag.Forma y color:Lyophilized PowderPeso molecular:84.6 kDa (predicted); 96.6 kDa (reducing conditions)EphB2 Protein, Human, Recombinant (aa 570-987, His & GST)
<p>EphB2 Protein, Human, Recombinant (aa 570-987, His & GST) is expressed in Baculovirus insect cells with His and GST tag.</p>Forma y color:Lyophilized PowderPeso molecular:75.2 kDa (predicted); 65 kDa (reducing conditions)EPHB2 Protein, Cynomolgus, Recombinant (His)
<p>EphB2, a receptor tyrosine kinase for ephrin ligands, is overexpressed in various cancers and plays an important role in tumor progression.</p>Forma y color:Lyophilized PowderPeso molecular:59.09 kDa (predicted). Due to glycosylation, the protein migrates to 65-75 kDa based on Tris-Bis PAGE result.EM127
CAS:<p>EM127: covalent SMYD3 inhibitor, KD 13μM, impedes ERK1/2, hinders SMYD3 gene regulation, long-term methyltransferase reduction, potential in cancer study.</p>Fórmula:C14H18ClN3O3Pureza:97.61%Forma y color:SolidPeso molecular:311.76ERα degrader-2
CAS:ERα degrader-2 is an estrogen receptor (SERD) degrader with anticancer activity that inhibits ERα for the prevention and treatment of HER-positive breast cancFórmula:C29H27F3N2O2Pureza:99.71%Forma y color:SolidPeso molecular:492.53PERK-IN-2
CAS:<p>PERK-IN-2 is a potent inhibitor of PERK(IC50 of 0.2 nM).</p>Fórmula:C23H18F3N5OPureza:98%Forma y color:SolidPeso molecular:437.42EphB2 Protein, Mouse, Recombinant (His)
<p>EphB2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.</p>Forma y color:Lyophilized PowderPeso molecular:59.3 kDa (predicted); 65 kDa (reducing conditions)EphB2 Protein, Human, Recombinant (His & hFc)
<p>EphB2 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag.</p>Forma y color:Lyophilized PowderPeso molecular:86 kDa (predicted); 90-100 kDa (reducing condition, due to glycosylation)Pamoic acid disodium
CAS:Pamoic acid disodium is a GPR35 agonist.Fórmula:C23H16NaO6Pureza:99.73%Forma y color:Yellow PowderPeso molecular:411.36ERK2 Protein, Human, Recombinant (GST)
<p>ERK2 Protein, Human, Recombinant (GST) is expressed in Baculovirus insect cells with GST tag.</p>Forma y color:Lyophilized PowderPeso molecular:67 kDa (predicted); 67 kDa (reducing conditions)(E/Z)-BIX02188
CAS:<p>BIX02188 inhibits MEK5 (IC50: 4.3 nM) and ERK5 (810 nM) but not MEK1/2, JNK2, or ERK2.</p>Fórmula:C25H24N4O2Pureza:97.39% - 98.38%Forma y color:SolidPeso molecular:412.48Avicularin
CAS:<p>Avicularin reduces inflammation via ERK pathway in RAW 264.7 cells and hinders lipid buildup in adipocytes by limiting glucose uptake and fatty acid synthesis.</p>Fórmula:C20H18O11Pureza:97.02% - 99.94%Forma y color:White PowderPeso molecular:434.35Corynoxeine
CAS:<p>Corynoxeine inhibits ERK1/2, curbs VSMC growth induced by PDGF-BB, and may prevent vascular diseases and restenosis post-angioplasty.</p>Fórmula:C22H26N2O4Pureza:98.61% - 99.73%Forma y color:SolidPeso molecular:382.45Aurothiomalate sodium
CAS:<p>Sodium aurothiomalate (Miochrysin) inhibits PKC-ι, TrxR; used as an anti-rheumatic and has anti-tumor properties.</p>Fórmula:C4H3AuNa2O4SPureza:99.66%Forma y color:SoildPeso molecular:390.07VX-11e
CAS:VX-11e (TCS ERK 11e) is a potent, selective, and orally bioavailable ERK(Extracellular Signal-Regulated Kinase) inhibitor; antitumor agent.Fórmula:C24H20Cl2FN5O2Pureza:98.92% - ≥98%Forma y color:SolidPeso molecular:500.35HS-1793
CAS:<p>HS-1793, resveratrol-like, reduces HIF-1, VEGF in hypoxia, and curbs human breast cancer growth in mouse model.</p>Fórmula:C16H12O3Pureza:98.16% - 99.82%Forma y color:SolidPeso molecular:252.26ERK1/2 inhibitor 2
CAS:<p>ERK1/2 inhibitor 2 (ASTX029) is a selective and orally bioavailable ERK 1/2 inhibitor, with potential antineoplastic activity.</p>Fórmula:C29H31ClFN5O5Pureza:98.99%Forma y color:SolidPeso molecular:584.04Astragaloside IV
CAS:<p>Astragaloside IV suppresses ERK1/2, JNK, MMP-2/9 in breast cancer; inhibits adenovirus and protects cardiovascular, immune, digestive, nervous systems.</p>Fórmula:C41H68O14Pureza:99% - 99.84%Forma y color:Hydroscopic Brown Or Yellow PowderPeso molecular:784.97magnolin
CAS:<p>Magnolin reduces the renal oxidative stress, suppresses caspase-3 activity, and increases Bcl-2 expression in vivo and in vitro.</p>Fórmula:C23H28O7Pureza:98% - 99.77%Forma y color:SolidPeso molecular:416.46Gypenoside L
CAS:<p>Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release.</p>Fórmula:C42H72O14Pureza:99.42% - 99.65%Forma y color:SolidPeso molecular:801.01Longdaysin
CAS:Longdaysin is an inhibitor of CK1α and CK1δ (IC50s: 5.6/8.8 μM). It also can inhibit ERK2 (IC50: 52 μM).Fórmula:C16H16F3N5Pureza:99.97%Forma y color:SolidPeso molecular:335.33A-443654
CAS:<p>A-443654 is a pan-Akt inhibitor. A-443654 has equal potency against Akt1, Akt2, or Akt3 within cells (Ki=160 pM).</p>Fórmula:C24H23N5OPureza:98.04% - 99.51%Forma y color:SolidPeso molecular:397.47SEW2871
CAS:<p>SEW 2871 is an orally available, highly selective S1P1 agonist. It activates ERK, Akt and Rac signaling pathways and induces S1P1 internalization and recycling.</p>Fórmula:C20H10F6N2OSPureza:99.96%Forma y color:White SolidPeso molecular:440.36BIX02189
CAS:<p>BIX02189 is a potent and selective inhibitor of MEK5 and ERK5(IC50 : 1.5 nM and 59 nM).</p>Fórmula:C27H28N4O2Pureza:97.84%Forma y color:SolidPeso molecular:440.54PD98059
CAS:<p>PD98059 is an MEK inhibitor that inhibits MEK1 and MEK2 (IC50=2/50 μM) and is non-ATP-competitive.</p>Fórmula:C16H13NO3Pureza:98.63% - >99.99%Forma y color:Yellow SolidPeso molecular:267.28Piperlongumine
CAS:<p>Piperlongumine (Piplartine) is a natural alkaloid from Piper longum L.</p>Fórmula:C17H19NO5Pureza:97.03% - 99.90%Forma y color:SolidPeso molecular:317.34TBHQ
CAS:TBHQ (tert-Butylhydroquinone) is an antioxidant that induces an antioxidant response through the redox-sensitive transcription factor Nrf2.Fórmula:C10H14O2Pureza:99.17% - 99.53%Forma y color:White Solid PowderPeso molecular:166.22SCH772984
CAS:<p>SCH772984 is an ERK inhibitor and is highly selective and ATP-competitive. SCH772984 exhibits antitumor activity. Cost-effective and quality-assured.</p>Fórmula:C33H33N9O2Pureza:97.565% - 98.75%Forma y color:SolidPeso molecular:587.67Theliatinib
CAS:<p>Theliatinib: potent, selective EGFR inhibitor, anti-tumor; Ki=0.05 nM (EGFR), IC50=3 nM (EGFR), 22 nM (T790M/L858R).</p>Fórmula:C25H26N6O2Pureza:99.67%Forma y color:SolidPeso molecular:442.51Periplocin
CAS:<p>Periplocin fights lung cancer, induces apoptosis, stunts growth via beta-catenin/Tcf, and treats rheumatoid arthritis/traditional ailments.</p>Fórmula:C36H56O13Pureza:99.66% - 99.74%Forma y color:SolidPeso molecular:696.82SC99
CAS:SC99 inhibits JAK2-STAT3, reducing STAT3 genes, platelet activity, and has anti-myeloma, anti-thrombotic effects.Fórmula:C15H8Cl2FN3OPureza:99.56%Forma y color:SolidPeso molecular:336.15Yoda 1
CAS:<p>Yoda 1 is an agonist of the Piezo1 channel that agonizes human- and mouse-derived Piezo1. Yoda 1 is also an inhibitor of GlyT2. Cost-effective, quality assurance.</p>Fórmula:C13H8Cl2N4S2Pureza:98% - 99.98%Forma y color:SolidPeso molecular:355.27ERK5-IN-2
CAS:<p>ERK5-IN-2 is an orally active, sub-micromolar, selective ERK5 inhibitor with IC50s of 0.82 μM, 3 μM for ERK5 and ERK5 MEF2D, respectively.</p>Fórmula:C17H11BrFN3O2Pureza:99.01%Forma y color:SolidPeso molecular:388.19Asperulosidic acid
CAS:<p>Asperulosidic acid (ASPA) has anti-tumor, anti-oxidant, and anti-inflammatory activities. ASPA is related to the inhibition of inflammatory cytokines.</p>Fórmula:C18H24O12Pureza:99.47%Forma y color:SolidPeso molecular:432.38CAFESTOL
CAS:<p>Cafestol, an ERK inhibitor, suppresses PGE2 and COX-2 by blocking NF-kB in LPS-stimulated RAW264.7 cells.</p>Fórmula:C20H28O3Pureza:97.06% - 99.08%Forma y color:SolidPeso molecular:316.43Sulforaphene
CAS:<p>Sulforaphene, from radish seeds, aids cancer cell apoptosis and inhibits migration; has an ED50 for velvetleaf at ~2x10^-4 M.</p>Fórmula:C6H9NOS2Pureza:97.55% - 99.19%Forma y color:Slightly Yellowish LiquidPeso molecular:175.27Acalabrutinib
CAS:<p>Acalabrutinib (ACP-196), also known as ACP-196, is an orally available inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity.</p>Fórmula:C26H23N7O2Pureza:98.94% - 99.64%Forma y color:SolidPeso molecular:465.51XMD8-92
CAS:<p>XMD8-92 is an effective and specific BMK1/ERK5 inhibitor (Kd: 80 nM).</p>Fórmula:C26H30N6O3Pureza:98.21%Forma y color:SolidPeso molecular:474.55Triptonide
CAS:<p>Triptonide treats autoimmune diseases, has antileukemic/tumor effects, is anti-inflammatory, and boosts IL-37.</p>Fórmula:C20H22O6Pureza:99.11% - 99.64%Forma y color:White Crystalline PowderPeso molecular:358.39Peramivir Trihydrate
CAS:<p>Peramivir Trihydrate (RWJ-270201) is a neuraminidase inhibitor (IC50: 0.09 nM) which prevents normal processing of virus particles such that virus particles are</p>Fórmula:C15H28N4O4·3H2OPureza:99.52% - ≥95%Forma y color:SolidPeso molecular:382.45Ulixertinib
CAS:<p>Ulixertinib (VRT752271) (BVD-523, VRT752271) is an effective and reversible ERK1/ERK2 inhibitor. The IC50 of Ulixertinib is less than 0.3 nM for ERK2.</p>Fórmula:C21H22Cl2N4O2Pureza:99.31% - 99.95%Forma y color:SolidPeso molecular:433.33N-tert-butyl-α-Phenylnitrone
CAS:N-tert-butyl-α-Phenylnitrone ((Z)-N-benzylidene-2-Methylpropan-2-aMine oxide) inhibits COX2 catalytic activity.Fórmula:C11H15NOPureza:99.46% - 99.84%Forma y color:SolidPeso molecular:177.24(E/Z)-BIX 02189
CAS:<p>BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM.</p>Fórmula:C27H28N4O2Pureza:98% - 99.89%Forma y color:SolidPeso molecular:440.54Pluripotin
CAS:<p>Pluripotin (SC1) (SC1), which keep embryonic stem cell (ESC) self-renewal, is a dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and</p>Fórmula:C27H25F3N8O2Pureza:98.77% - 98.82%Forma y color:SolidPeso molecular:550.53Tenuifoliside A
CAS:<p>Tenuifoliside A has anti-apoptotic , neuroprotective activity.</p>Fórmula:C31H38O17Pureza:98.99% - 99.91%Forma y color:SolidPeso molecular:682.62BAY885
CAS:<p>BAY885 is a new ERK5 inhibitor.</p>Fórmula:C25H28F3N7O2Pureza:99.83%Forma y color:SolidPeso molecular:515.53Mogrol
CAS:<p>Mogrol, a biometabolite of mogrosides, functions by inhibiting the ERK1/2 and STAT3 pathways, diminishing CREB activation, and activating AMPK signaling.</p>Fórmula:C30H52O4Pureza:99.85% - 99.90%Forma y color:SolidPeso molecular:476.73Temuterkib
CAS:<p>LY3214996 (Temuterkib) is a potent oral ERK1/2 inhibitor with potential cancer-fighting properties.</p>Fórmula:C22H27N7O2SPureza:99.57% - >99.99%Forma y color:SolidPeso molecular:453.56ERK5-IN-1
CAS:<p>ERK5-IN-1 is a potent ERK5 inhibitor (IC50: 87 nM). It also inhibits LRRK2[G2019S] (IC50: 26 nM).</p>Fórmula:C25H29N7O2Pureza:97.70%Forma y color:SolidPeso molecular:459.54Tauroursodeoxycholate
CAS:<p>Tauroursodeoxycholate (UR 906), a hydrophilic bile acid, low in humans, may treat PBC, insulin resistance, and ALS.</p>Fórmula:C26H45NO6SPureza:98.77% - 99.93%Forma y color:White SolidPeso molecular:499.7Loureirin B
CAS:<p>Loureirin B suppresses fibrosis by modulating MMPs/TIMPs, hindering fibroblast growth, and targeting TGF-β1/Smad2/3 pathway.</p>Fórmula:C18H20O5Pureza:99.33% - 99.86%Forma y color:SolidPeso molecular:316.35UNC569
CAS:<p>UNC569 selectively inhibits kidney URAT1, regulating uric acid excretion and aiding gout patient's uric balance.</p>Fórmula:C22H29FN6Pureza:98.91% - 99.67%Forma y color:SolidPeso molecular:396.5DEL-22379
CAS:<p>DEL-22379 is a water-soluble ERK dimerization inhibitor with IC50 of ～0.5 μM.</p>Fórmula:C26H28N4O3Pureza:99.3% - 99.53%Forma y color:SolidPeso molecular:444.532,5-Dihydroxyacetophenone
CAS:<p>2,5-Dihydroxyacetophenone has anti-anxiety, neuroprotective, anti-inflammatory properties, and modulates cell signaling and melanogenesis.</p>Fórmula:C8H8O3Pureza:99.75%Forma y color:Yellow PowderPeso molecular:152.15Butein
CAS:Butein is a cAMP-specific PDE inhibitor, protein tyrosine kinase inhibitor, and SIRT1 activator.Cost-effective and quality-assured.Fórmula:C15H12O5Pureza:98.76% - >99.99%Forma y color:SolidPeso molecular:272.25Pachymic acid
CAS:<p>Pachymic acid (3-O-Acetyltumulosic acid) is a natural product, and inhibits Akt and ERK signaling pathways.</p>Fórmula:C33H52O5Pureza:99.43% - >99.99%Forma y color:White PowderPeso molecular:528.76β-Neoendorphin acetate(77739-21-0 free base)
CAS:<p>beta-Neoendorphin acetate is an agonist of κ-opioid receptor</p>Fórmula:C56H81N13O14Pureza:99.91%Forma y color:SolidPeso molecular:1160.34GRK5-IN-2
CAS:<p>GRK5-IN-2, a pyridine-based bicyclic compound, is a potent G-protein-coupled receptor kinase 5 (GRK5) inhibitor.</p>Fórmula:C20H20N4O4Pureza:99.92%Forma y color:SolidPeso molecular:380.46-OAU
CAS:<p>6-OAU is a GPR84 agonist, activates it in HEK293 cells with a 105 nM EC50.</p>Fórmula:C12H21N3O2Pureza:98.14% - 99.01%Forma y color:SolidPeso molecular:239.31Nitidine chloride
CAS:1.Fórmula:C21H18ClNO4Pureza:96.59% - 99.55%Forma y color:SolidPeso molecular:383.82XMD17-109
CAS:<p>XMD17-109 (ERK5-IN-1) is a new selective ERK-5 inhibitor (EC50: 4.2 uM, HEK293 cells).</p>Fórmula:C36H46N8O3Pureza:98.75% - 99.7%Forma y color:SolidPeso molecular:638.8A-674563 2HCl(552325-73-2(fb-2hcl))
<p>A-674563 2HCl is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC.</p>Fórmula:C22H24Cl2N4OPureza:94.66%Forma y color:SolidPeso molecular:431.36DCLK1-IN-1
CAS:<p>DCLK1-IN-1 is a selective, in vivo compatible chemical probe of the kinase domain of doublecortin-like kinase 1 (DCLK1).Cost-effective and quality-assured.</p>Fórmula:C26H28F3N7O2Pureza:98.55% - 99.28%Forma y color:SolidPeso molecular:527.54AG126
CAS:AG126 (Tyrphostin AG126) selectively inhibits the phosphorylation of ERK1 (p44) and ERK2 (p42). AG-126 weakly inhibits epidermal GFRK and platelet-derived GFRK.Fórmula:C10H5N3O3Pureza:97.35%Forma y color:SolidPeso molecular:215.16Epieriocalyxin A
CAS:<p>Epieriocalyxin A can suppress Caco-2 colon cancer cell growth. It could be a potential drug for colon cancer therapy in the future.</p>Fórmula:C20H24O5Pureza:97.00%Forma y color:SolidPeso molecular:344.4DMU-212
CAS:<p>DMU-212, a Resveratrol derivative, has antimitotic, antiproliferative, antioxidant properties; induces apoptosis via ERK1/2.</p>Fórmula:C18H20O4Pureza:99.86%Forma y color:SolidPeso molecular:300.35SUN11602
CAS:<p>SUN11602, an aniline compound, mimics the neuroprotective mechanisms of basic fibroblast growth factor.</p>Fórmula:C26H37N5O2Pureza:99.36%Forma y color:SolidPeso molecular:451.6RU-301
CAS:<p>RU-301 is a novel pan-tam inhibitor</p>Fórmula:C21H19F3N4O4SPureza:98.87%Forma y color:SolidPeso molecular:480.46ERK-IN-3
CAS:<p>ERK-IN-3 (ASN007 free base) is a potent and orally active inhibitor of ERK.</p>Fórmula:C22H25ClFN7O2Pureza:99.55% - 99.76%Forma y color:SolidPeso molecular:473.93Methylnissolin
CAS:<p>Methylnissolin (3-Hydroxy-9,10-dimethoxyptercarpan) is derived from Astragalus and has antibacterial and anti-cancer effects.</p>Fórmula:C17H16O5Pureza:99.68% - 99.98%Forma y color:SolidPeso molecular:300.31EF24
CAS:<p>EF24 treatment boosts caspase 3/9 activity, hinders MEK1/ERK phosphorylation, and exhibits strong anti-tumor effects in OSCC by deactivating MAPK/ERK.</p>Fórmula:C19H15F2NOPureza:99.71%Forma y color:SolidPeso molecular:311.33Deltonin
CAS:<p>Deltonin inhibits ERK1/2 & AKT; toxic to HepG2 (IC50: 7.66μM), C26 (IC50: 1.22μM), MDA-MB-231 cells (IC50: 1.58μM).</p>Fórmula:C45H72O17Pureza:98.77% - 99.79%Forma y color:SolidPeso molecular:885.04trans-Zeatin
CAS:<p>trans-Zeatin ((E)-Zeatin) is the member of the plant growth hormone family known as cytokinins, which regulate cell division, development, and nutrient</p>Fórmula:C10H13N5OPureza:97.13% - 98.96%Forma y color:White To Light Yellow Crystal PowderPeso molecular:219.24Ravoxertinib
CAS:<p>Ravoxertinib (GDC-0994) is an effective and orally available ERK1/2 inhibitor (IC50: 1.1/0.3 nM).</p>Fórmula:C21H18ClFN6O2Pureza:98% - 99.87%Forma y color:SolidPeso molecular:440.86Bohemine
CAS:<p>Bohemine is a cyclin-dependent kinase inhibitor.</p>Fórmula:C18H24N6OPureza:99.09% - 99.53%Forma y color:SolidPeso molecular:340.42Prosaptide TX14(A) acetate
<p>Prosaptide TX14(A) acetate is a potent GPR37L1 and GPR37 agonist. Prosaptide Tx14(A) TFA increases both ERK1 and ERK2 phosphorylation in Schwann cells.</p>Fórmula:C71H114N16O28Pureza:95.29%Forma y color:SolidPeso molecular:1639.76Tauroursodeoxycholate sodium
CAS:<p>Tauroursodeoxycholate sodium (TUDC) is an endoplasmic reticulum (ER) stress inhibitor, used for the treatment of gallstones and liver cirrhosis.</p>Fórmula:C26H44NNaO6SPureza:97.90%Forma y color:SolidPeso molecular:521.69FR 180204
CAS:<p>FR 180204 is a potent and selective ATP-competitive inhibitor of ERK1 and ERK2.</p>Fórmula:C18H13N7Pureza:98% - 99.74%Forma y color:SolidPeso molecular:327.34MRTX1133
CAS:<p>View and buy MRTX1133 from TargetMol.MRTX1133 is a potent, selective, and noncovalent inhibitor of KRAS G12D.</p>Fórmula:C33H31F3N6O2Pureza:97.39% - 99.6%Forma y color:SolidPeso molecular:600.63KO-947
CAS:<p>KO-947 is a potent and specific inhibitor of ERK1/2 kinases.</p>Fórmula:C21H17N5OPureza:97.84%Forma y color:SolidPeso molecular:355.39LM22B-10
CAS:<p>LM22B-10 is an activator of TrkB/TrkC neurotrophin receptor and can induce TrkB, TrkC, ERK and AKT activation in vitro and in vivo.</p>Fórmula:C27H33ClN2O4Pureza:98.18%Forma y color:SolidPeso molecular:485.01AZD8330
CAS:<p>AZD8330 (ARRY-704) is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1.</p>Fórmula:C16H17FIN3O4Pureza:98.72%Forma y color:SolidPeso molecular:461.23Tizaterkib
CAS:<p>Tizaterkib (AZD-0364) is a potent and selective ERK2 inhibitor.</p>Fórmula:C24H24F2N8O2Pureza:99.6% - 99.63%Forma y color:SolidPeso molecular:494.5ERK-IN-4
CAS:<p>ERK-IN-4 is a cell-permeable ERK inhibitor with potential antiproliferative effects for the study of diseases caused by immune dysfunction.</p>Fórmula:C14H17ClN2O3SPureza:98.92% - 99.84%Forma y color:SolidPeso molecular:328.814Ulixertinib hydrochloride
CAS:<p>Ulixertinib hydrochloride (Ulixertinib HCl) is an ERK1/2 inhibitor with anticancer and antitumor activity that inhibits the NB cell cycle and promotes apoptosis</p>Fórmula:C21H23Cl3N4O2Pureza:99.85%Forma y color:SolidPeso molecular:469.79CAY10561
CAS:<p>CAY10561: potent, selective ERK2 inhibitor (Ki=2nM); blocks cell proliferation; IC50 in COLO 205 cells: 0.54μM.</p>Fórmula:C22H17Cl2FN4O2Forma y color:SolidPeso molecular:459.3GP17
CAS:<p>GP17 is a type II kinase inhibitor of the IRE1α endoribonuclease that acts by targeting the ATP-binding pocket of IRE1α.</p>Fórmula:C26H21F3N4OForma y color:SolidPeso molecular:462.47UC-857993
CAS:<p>UC-857993 is a selective SOS1-Ras inhibitor with a Kd of 14.7 μM that inhibits ERK, Ras, and reduces MEF growth.</p>Fórmula:C25H22ClNO2Forma y color:SolidPeso molecular:403.9BNC-1
CAS:<p>BNC-1 reduces amyloid in mice, enhances synapses by activating Elk-1.</p>Fórmula:C16H14N2O3Pureza:98%Forma y color:SolidPeso molecular:282.29mSIRK
CAS:<p>mSIRK (G-Protein βγ Binding Peptide) is an ERK1 and ERK2 dual activator that promotes alpha-subunit dissociation.</p>Fórmula:C93H150N20O25Pureza:99.26%Forma y color:SolidPeso molecular:1948.31Dihydrolipoic acid
CAS:<p>Dihydrolipoic acid (USAF XR-12), a dithiol carboxylic acid, is a potent antioxidant active against various reactive oxygen species at 0.01-0.5 mM.</p>Fórmula:C8H16O2S2Pureza:97.51%Forma y color:Yellow To Orange LiquidPeso molecular:208.34ERK5-IN-4
CAS:<p>ERK5-IN-4 (34b) is a potent, specific ERK5 inhibitor; IC50: 77 nM full-length, 300 nM ΔTAD in HEK293 cells.</p>Fórmula:C16H11Cl2FN4O2Forma y color:SolidPeso molecular:381.19PERK-IN-3
CAS:<p>PERK-IN-3 is a potent inhibitor of PERK(IC50 of 7.4 nM).</p>Fórmula:C22H16F2N4O2Pureza:98%Forma y color:SolidPeso molecular:406.38ADTL-EI1712
CAS:<p>ADTL-EI1712: ERK1/2/5 inhibitor (ERK1 IC50=40.43nM, ERK5=64.5nM), blocks HL-60/MKN74 cell growth, not HeLa; effective in MKN74 mouse model.</p>Fórmula:C22H18Cl2N4O2S2Forma y color:SolidPeso molecular:505.44ERK1/2 inhibitor 1
CAS:<p>ERK1/2 inhibitor 1 is a potent, orally bioavailable ERK1/2 inhibitor, showing 60% inhibition at 1 nM and an IC50 of 3.0 nM against ERK1 and ERK2, respectively.</p>Fórmula:C29H32ClN5O4Pureza:98.81%Forma y color:SolidPeso molecular:550.052,5-Dihydroxybiphenyl
CAS:<p>2,5-Dihydroxybiphenyl: a small molecule that induces trichothiodystrophy A protein dimerization, modulating TFIIH activity.</p>Fórmula:C12H10O2Pureza:99.66%Forma y color:White To Grey-Brownish PowderPeso molecular:186.21ERK5-IN-3
CAS:<p>ERK5-IN-3 inhibits ERK5 strongly (IC50: 6 nM) and hampers Hela cell growth (IC50: 31 nM).</p>Fórmula:C24H23Cl2FN4O2Forma y color:SolidPeso molecular:489.37GABAB receptor antagonist 1
CAS:(E)-GABAB receptor antagonist 1 decreases GABA-induced IP3 (inositol trisphosphate) production with IC50 of 37.9 μM.GABAB receptor antagonist 1 is a selectiveFórmula:C18H24O4Pureza:98%Forma y color:SolidPeso molecular:304.38Migoprotafib
CAS:Migoprotafib (GDC-1971) is a potent and highly selective SHP2 (Src Homology-2 Domain-Containing Phosphatase 2) inhibitor for advanced solid tumours.Fórmula:C25H26N8OForma y color:SolidPeso molecular:454.53NMDAR/TRPM4-IN-2
CAS:<p>Potent NMDAR/TRPM4-IN-2 blocks NMDAR/TRPM4, protects brain and retinal neurons, and prevents mitochondrial dysfunction with an IC50 of 2.1 μM.</p>Fórmula:C11H19BrCl2N2Pureza:98.77%Forma y color:SolidPeso molecular:330.092(E)-GABAB receptor antagonist 1
CAS:<p>(E)-GABAB antagonist 1 inhibits GABA IP3 production, with an IC50 of 37.9 μM and acts as a selective negative modulator.</p>Fórmula:C18H24O4Pureza:98.09%Forma y color:SolidPeso molecular:304.38RLX-33
CAS:<p>RLX-33 blocks RXFP3 and relaxin 3 effects, controls food intake in rats, and may help study metabolic syndrome.</p>Fórmula:C24H19ClN4O4Pureza:99.89%Forma y color:SolidPeso molecular:462.89ZINC12409120
CAS:<p>ZINC12409120 (R-4584) is a selective ERK inhibitor.ZINC12409120 inhibits ERK with an IC50 of 5.0 μM.ZINC12409120 inhibits ERK activity by interfering with FGF23</p>Fórmula:C20H16N4O2Pureza:99.71% - 99.95%Forma y color:SolidPeso molecular:344.37ERK1/2 inhibitor 8
CAS:<p>ERK1/2 inhibitor 8 is a potent inhibitor of ERK that acts on ERK2 (IC50: 0.48 nM).</p>Fórmula:C23H20ClN7O2SForma y color:SolidPeso molecular:493.97ERK1/2 inhibitor 5
CAS:ERK1/2 inhibitor 5: potent against ERK1/2, may combat cancer and inflammation.Fórmula:C28H32ClFN6O5Forma y color:SolidPeso molecular:587.04ERK1/2 inhibitor 9
CAS:<p>ERK1/2 Inhibitor 9 (Probe 1), a covalent antagonist of ERK1/2, exhibits sub-micromolar efficacy in cellular assays (A375 GI50=0.47 μM) and facilitates the</p>Fórmula:C31H32ClN7O3Pureza:98%Forma y color:SolidPeso molecular:586.08ERK Inhibitor II (Negative control)
CAS:<p>ERK Inhibitor II, a control, blocks ERK and insulin receptor activation, aiding diabetes research.</p>Fórmula:C18H12N6OForma y color:SolidPeso molecular:328.33MRS2693 trisodium
CAS:<p>MRS2693 trisodium, a selective P2Y6 agonist with an EC50 of 0.015 μM, demonstrates cytoprotective effects in a mouse hindlimb skeletal muscle ischemia-reperfusion injury model by reducing NF-kappaB activation and stimulating the ERK1/2 pathway [1] [2].</p>Fórmula:C9H10IN2Na3O12P2Forma y color:SolidPeso molecular:596Laxiflorin B
CAS:<p>Laxiflorin B, a novel selective inhibitor of ERK 1/2 derived from herbal sources, exhibits antitumor activity [1].</p>Fórmula:C20H24O5Pureza:98%Forma y color:SolidPeso molecular:344.4MEK-IN-6
CAS:<p>MEK-IN-6 (Example 69), a potent MEK inhibitor, effectively inhibits ERK1/2 (Thr202/Tyr204) phosphorylation in A375 cells, with an IC50 of 2 nM, making it</p>Fórmula:C18H20FN3O4SPureza:98%Forma y color:SolidPeso molecular:393.43KRAS G12C inhibitor 61
CAS:<p>KRAS G12C inhibitor 61 (Example 3) demonstrates potent activity by inhibiting phospho-ERK 1/2 in MIA PaCa-2 cells, reflected in an IC50 value of 9 nM.</p>Fórmula:C31H33ClFN7O2Pureza:98%Forma y color:SolidPeso molecular:590.09K145 hydrochloride
CAS:<p>K145 hydrochloride is a selective sphk2 inhibitor with substrate competitiveness and oral activity, with IC50 of 4.3 µM and Ki of 6.4 µM.</p>Fórmula:C18H25ClN2O3SPureza:99.8%Forma y color:SolidPeso molecular:384.92(R)-VX-11e
CAS:<p>(R)-VX-11e is an isomer of VX-11e, a potent and selective ERK2 inhibitor with potential to inhibit tumor growth.</p>Fórmula:C24H20Cl2FN5O2Pureza:98.73%Forma y color:SolidPeso molecular:500.35DL-threo dihydrosphingosine
CAS:<p>DL-threo dihydrosphingosine blocks ERK, inhibits smooth muscle proliferation, and works against growth factor/G-protein ERK activation.</p>Fórmula:C18H39NO2Forma y color:SolidPeso molecular:301.51Inflachromene
CAS:Inflachromene (ICM) is an inhibitor of HMGB1 and HMGB expression with anti-inflammatory activity.Inflachromene is used in the study of epilepsy.Fórmula:C21H19N3O4Pureza:97.36% - 99.88%Forma y color:SolidPeso molecular:377.39CXJ-2
CAS:<p>CXJ-2, a cyclic peptide, binds EDPs, inhibits PI3K/ERK, and reduces hepatic cell growth/migration, offering antifibrotic effects.</p>Fórmula:C55H87N15O22Pureza:98%Forma y color:SolidPeso molecular:1310.37I-287
CAS:<p>I-287 is a selective, orally active PAR2 inhibitor that functions as a negative allosteric modulator of Gαq and Gα12/13 activity and their downstream effectors.</p>Fórmula:C30H30ClFN4O4Forma y color:SolidPeso molecular:565.04ERK1/2 inhibitor 7
CAS:<p>ERK1/2 inhibitor 7 is a potent inhibitor of ERK, acting on ERK2 (IC50: 0.94 nM).</p>Fórmula:C23H22FN7OSForma y color:SolidPeso molecular:463.53EVT801
CAS:<p>EVT801 is a highly selective and low-toxic VEGFR-3 inhibitor that inhibits VEGF-C-induced tumor lymphoid and angiogenesis and reduces CCL4, CCL5 and MDSC.</p>Fórmula:C19H21N5O3Pureza:97.4%Forma y color:SolidPeso molecular:367.4ERK-IN-2 free base
CAS:<p>ERK-IN-2 free base inhibits ERK2 (IC50: 1.8 nM); potential off-target effects at >10 μM.</p>Fórmula:C16H17N5O2Forma y color:SolidPeso molecular:311.34JWG-071
CAS:<p>JWG-071: First ERK5 kinase probe, BET inhibitor, 1 μM BRD4 IC, boosts ERK5 function and BRD4 selectivity.</p>Fórmula:C34H44N8O3Pureza:98.33%Forma y color:SolidPeso molecular:612.77MK-8353
CAS:<p>MK-8353 (SCH900353) is a potent, selective and orally available inhibitor of ERK1/2 (IC50s of 23.0 nM and 8.8 nM, respectively)</p>Fórmula:C37H41N9O3SPureza:96.15% - 97.19%Forma y color:SolidPeso molecular:691.84ERK1/2 inhibitor 6
CAS:<p>ERK1/2 inhibitor 6 - potent cancer/inflammation treatment from WO2021063335A1.</p>Fórmula:C27H29ClFN7O5Forma y color:SolidPeso molecular:586.01Coelogin
CAS:<p>Coelogin is an orally effective bone-protective agent that activates ER-Erk and Akt-dependent signaling pathways, thereby stimulating osteoblast differentiation. It is utilized in osteoporosis research.</p>Fórmula:C17H16O5Forma y color:SolidPeso molecular:300.31ERK2 IN-1
CAS:<p>ERK2 IN-1 is a selective ERK2 inhibitor with an IC50 of 7 nM.</p>Fórmula:C36H34FN7O2SPureza:98%Forma y color:SolidPeso molecular:647.76ATX inhibitor 26
CAS:<p>ATX inhibitor 26 is an Autotaxin (ATX) inhibitor with an IC50 of 57 nM in human plasma. It effectively inhibits cell migration and collagen gel contraction. Additionally, ATX inhibitor 26 demonstrates significant antifibrotic activity, reducing collagen deposition in a Bleomycin (BLM)-induced pulmonary fibrosis model.</p>Fórmula:C18H19Cl2N7O3Forma y color:SolidPeso molecular:452.30DOR agonist 2
CAS:<p>Compound 3 (DOR agonist 2) acts as a Delta Opioid Receptor agonist. It inhibits the expression of TNF-α, obstructs NF-κB transportation to the nucleus, and activates the G protein-mediated ERK1/2 pathway. This compound is useful for research into neurodegenerative diseases.</p>Fórmula:C29H26N2O3Forma y color:SolidPeso molecular:450.53AL 8810
CAS:<p>AL-8810 is an 11β-fluoro analog of PGF 2α with selective antagonist effects at the PGF 2α receptor (FP receptor) [1].</p>Fórmula:C24H31FO4Forma y color:SolidPeso molecular:402.5SOS1 activator 2
CAS:<p>SOS1 activator 2 (Compound 65) is a benzothiazole derivative and an activator of SOS1. It demonstrates a high binding affinity for SOS1, with a Kd of 9 nM. By modulating the Ras-ERK signaling pathway, SOS1 activator 2 is suitable for tumor research.</p>Fórmula:C26H28ClFN6Forma y color:SolidPeso molecular:478.992KRASG12C IN-15
CAS:<p>KRASG12C IN-15 (Compound 21) is an orally active KRASG12C inhibitor that effectively blocks SOS1-mediated GDP/GTP exchange with an IC50 of 19 nM. It inhibits ERK phosphorylation with an IC50 of 0.051 μM and reduces the viability of KRASG12C mutant MIA PaCa-2 cells with an IC50 of 0.023 μM. Additionally, KRASG12C IN-15 demonstrates antitumor activity in a MIA PaCa-2 xenograft mouse model.</p>Fórmula:C31H32FN3O2Forma y color:SolidPeso molecular:497.603(rel)-AR234960
CAS:(rel)-AR234960 is an active relative configuration of AR234960. AR234960 is a non-peptide agonist of MAS.Fórmula:C27H30FN5O5SForma y color:SolidPeso molecular:555.63ERK-IN-2
CAS:<p>ERK-IN-2, an ERK2 inhibitor, exhibits an IC50 value of 1.8 nM. At doses greater than 10 μM, it may induce off-target toxicity and/or activity [1].</p>Fórmula:C16H18ClN5O2Pureza:98%Forma y color:SolidPeso molecular:347.80Hypothemycin
CAS:<p>Hypothemycin, a fungal polyketide, inhibits multiple kinases (VEGFR, MEK, FLT-3, PDGFR, ERK) with Kis ranging from 10 nM to 2.4 μM.</p>Fórmula:C19H22O8Pureza:98%Forma y color:SolidPeso molecular:378.37MAP855
CAS:<p>MAP855: potent, selective, oral MEK1/2 inhibitor; IC50=3 nM, pERKEC50=5 nM; effective on wild-type/mutant MEK1/2.</p>Fórmula:C28H23ClF2N6O3Forma y color:SolidPeso molecular:564.97SHR2415
<p>SHR2415: Potent, selective ERK1/2 inhibitor, oral; ERK1 IC50: 2.8 nM, ERK2 IC50: 5.9 nM; effective in Colo205 (IC50: 44.6 nM), for cancer research.</p>Fórmula:C23H22ClN7O2Forma y color:SolidPeso molecular:463.92KU004
CAS:<p>KU004, a potent dual EGFR/HER2 inhibitor, exhibits anticancer properties. It inhibits the proliferation of human breast cancer SKBR3 cells by inducing G1 phase arrest. KU004 blocks the activation of HER2, EGFR, and the downstream Akt and Erk pathways, primarily inducing apoptosis (Apoptosis) through the extrinsic pathway. Additionally, KU004 is a novel quinazoline derivative.</p>Fórmula:C29H27ClFN4O2PForma y color:SolidPeso molecular:548.98KRAS inhibitor-27
CAS:<p>KRAS inhibitor-27 (Compound 15h) is a KRAS inhibitor that effectively targets KRAS G12D/G12V mutated cells (AsPC-1 and SW620) and wild-type KRAS cells (HT-29), with IC50 values of 378 nM, 0.6 nM, and 3230 nM, respectively. It reduces ERK phosphorylation, with IC50 values of 0.6 nM and 1 nM in AsPC-1 and SW620 cells, respectively, and decreases DUSP4 expression, thereby inhibiting the MAPK signaling pathway.</p>Fórmula:C31H28ClF3N6O3SForma y color:SolidPeso molecular:657.106Rineterkib
CAS:Rineterkib (ERK-IN-1) is an inhibitor of RAF and ERK1/2 activating mutations in the MAPK pathway.Fórmula:C26H27BrF3N5O2Pureza:99.73%Forma y color:SolidPeso molecular:578.42Omtriptolide
CAS:<p>Omtriptolide, triptolide purified from the Chinese herb, is a water-soluble derivative prodrug.</p>Fórmula:C24H28O9Pureza:98%Forma y color:SolidPeso molecular:460.479Ravoxertinib hydrochloride
CAS:<p>Ravoxertinib hydrochloride is an orally bioavailable and selective inhibitor for ERK kinase activity (IC50: 6.1 nM and 3.1 nM for ERK1 and ERK2, respectively).</p>Fórmula:C21H19Cl2FN6O2Pureza:98%Forma y color:SolidPeso molecular:477.32Pamoic acid
CAS:<p>Pamoic acid is the orphan G protein-coupled receptor GPR35 agonist. Pamoic acid activates ERK and beta-arrestin2 and causes antinociceptive activity.</p>Fórmula:C23H16O6Pureza:99.99%Forma y color:Fine Yellow PowderPeso molecular:388.37WQ-C-401
CAS:<p>WQ-C-401 is an orally active inhibitor of the platelet-derived growth factor receptor (PDGFR). It inhibits cell proliferation by blocking PDGFR auto-phosphorylation in a concentration-dependent manner, with EC50 values of 3.5 nM for PDGFRαY849 and 5.8 nM for PDGFRβY1021. Additionally, WQ-C-401 suppresses the proliferation and migration of PASMCs by inhibiting PDGF-BB-induced phosphorylation of ERK1/2, reduces collagen I synthesis, and increases α-SMA expression, thereby preventing pulmonary vascular remodeling. This compound shows promise for research in the field of pulmonary arterial hypertension.</p>Fórmula:C24H26N4O3Forma y color:SolidPeso molecular:418.49Ref: TM-T200766
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