ERK
ERK es una proteína clave en la vía de señalización MAPK (Mitogen-Activated Protein Kinase), que está involucrada en la transmisión de señales desde los receptores de la superficie celular hasta el ADN en el núcleo celular. ERK juega un papel crucial en la regulación de varios procesos celulares, incluyendo la proliferación, diferenciación y supervivencia. La desregulación de la señalización ERK está asociada con el desarrollo de cáncer y otras enfermedades, lo que la convierte en un objetivo importante para la intervención terapéutica. En CymitQuimica, ofrecemos una selección de inhibidores y moduladores de ERK de alta calidad para apoyar su investigación en señalización celular, oncología y desarrollo terapéutico.
Se han encontrado 194 productos de "ERK"
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EphB2 Protein, Human, Recombinant (His)
EphB2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.Forma y color:Lyophilized PowderPeso molecular:59.2 kDa (predicted); 65-75 kDa (reducing condition, due to glycosylation)ERK2 Protein, Mouse, Recombinant (His & GST)
<p>ERK2 Protein, Mouse, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag.</p>Forma y color:Lyophilized PowderPeso molecular:69.1 kDa (predicted); 60 kDa (reducing conditions)EphB2 Protein, Mouse, Recombinant (hFc)
EphB2 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag.Forma y color:Lyophilized PowderPeso molecular:84.6 kDa (predicted); 96.6 kDa (reducing conditions)EphB2 Protein, Human, Recombinant (aa 570-987, His & GST)
<p>EphB2 Protein, Human, Recombinant (aa 570-987, His & GST) is expressed in Baculovirus insect cells with His and GST tag.</p>Forma y color:Lyophilized PowderPeso molecular:75.2 kDa (predicted); 65 kDa (reducing conditions)EPHB2 Protein, Cynomolgus, Recombinant (His)
<p>EphB2, a receptor tyrosine kinase for ephrin ligands, is overexpressed in various cancers and plays an important role in tumor progression.</p>Forma y color:Lyophilized PowderPeso molecular:59.09 kDa (predicted). Due to glycosylation, the protein migrates to 65-75 kDa based on Tris-Bis PAGE result.EM127
CAS:<p>EM127: covalent SMYD3 inhibitor, KD 13μM, impedes ERK1/2, hinders SMYD3 gene regulation, long-term methyltransferase reduction, potential in cancer study.</p>Fórmula:C14H18ClN3O3Pureza:97.61%Forma y color:SolidPeso molecular:311.76ERα degrader-2
CAS:ERα degrader-2 is an estrogen receptor (SERD) degrader with anticancer activity that inhibits ERα for the prevention and treatment of HER-positive breast cancFórmula:C29H27F3N2O2Pureza:99.71%Forma y color:SolidPeso molecular:492.53PERK-IN-2
CAS:<p>PERK-IN-2 is a potent inhibitor of PERK(IC50 of 0.2 nM).</p>Fórmula:C23H18F3N5OPureza:98%Forma y color:SolidPeso molecular:437.42EphB2 Protein, Mouse, Recombinant (His)
<p>EphB2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.</p>Forma y color:Lyophilized PowderPeso molecular:59.3 kDa (predicted); 65 kDa (reducing conditions)EphB2 Protein, Human, Recombinant (His & hFc)
<p>EphB2 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag.</p>Forma y color:Lyophilized PowderPeso molecular:86 kDa (predicted); 90-100 kDa (reducing condition, due to glycosylation)Pamoic acid disodium
CAS:Pamoic acid disodium is a GPR35 agonist.Fórmula:C23H16NaO6Pureza:99.73%Forma y color:Yellow PowderPeso molecular:411.36ERK2 Protein, Human, Recombinant (GST)
<p>ERK2 Protein, Human, Recombinant (GST) is expressed in Baculovirus insect cells with GST tag.</p>Forma y color:Lyophilized PowderPeso molecular:67 kDa (predicted); 67 kDa (reducing conditions)(E/Z)-BIX02188
CAS:<p>BIX02188 inhibits MEK5 (IC50: 4.3 nM) and ERK5 (810 nM) but not MEK1/2, JNK2, or ERK2.</p>Fórmula:C25H24N4O2Pureza:97.39% - 98.38%Forma y color:SolidPeso molecular:412.48Avicularin
CAS:<p>Avicularin reduces inflammation via ERK pathway in RAW 264.7 cells and hinders lipid buildup in adipocytes by limiting glucose uptake and fatty acid synthesis.</p>Fórmula:C20H18O11Pureza:97.02% - 99.94%Forma y color:White PowderPeso molecular:434.35Corynoxeine
CAS:<p>Corynoxeine inhibits ERK1/2, curbs VSMC growth induced by PDGF-BB, and may prevent vascular diseases and restenosis post-angioplasty.</p>Fórmula:C22H26N2O4Pureza:98.61% - 99.73%Forma y color:SolidPeso molecular:382.45Aurothiomalate sodium
CAS:<p>Sodium aurothiomalate (Miochrysin) inhibits PKC-ι, TrxR; used as an anti-rheumatic and has anti-tumor properties.</p>Fórmula:C4H3AuNa2O4SPureza:99.66%Forma y color:SoildPeso molecular:390.07VX-11e
CAS:VX-11e (TCS ERK 11e) is a potent, selective, and orally bioavailable ERK(Extracellular Signal-Regulated Kinase) inhibitor; antitumor agent.Fórmula:C24H20Cl2FN5O2Pureza:98.92% - ≥98%Forma y color:SolidPeso molecular:500.35HS-1793
CAS:<p>HS-1793, resveratrol-like, reduces HIF-1, VEGF in hypoxia, and curbs human breast cancer growth in mouse model.</p>Fórmula:C16H12O3Pureza:98.16% - 99.82%Forma y color:SolidPeso molecular:252.26ERK1/2 inhibitor 2
CAS:<p>ERK1/2 inhibitor 2 (ASTX029) is a selective and orally bioavailable ERK 1/2 inhibitor, with potential antineoplastic activity.</p>Fórmula:C29H31ClFN5O5Pureza:98.99%Forma y color:SolidPeso molecular:584.04Astragaloside IV
CAS:<p>Astragaloside IV suppresses ERK1/2, JNK, MMP-2/9 in breast cancer; inhibits adenovirus and protects cardiovascular, immune, digestive, nervous systems.</p>Fórmula:C41H68O14Pureza:99% - 99.84%Forma y color:Hydroscopic Brown Or Yellow PowderPeso molecular:784.97magnolin
CAS:<p>Magnolin reduces the renal oxidative stress, suppresses caspase-3 activity, and increases Bcl-2 expression in vivo and in vitro.</p>Fórmula:C23H28O7Pureza:98% - 99.77%Forma y color:SolidPeso molecular:416.46Gypenoside L
CAS:<p>Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release.</p>Fórmula:C42H72O14Pureza:99.42% - 99.65%Forma y color:SolidPeso molecular:801.01Longdaysin
CAS:Longdaysin is an inhibitor of CK1α and CK1δ (IC50s: 5.6/8.8 μM). It also can inhibit ERK2 (IC50: 52 μM).Fórmula:C16H16F3N5Pureza:99.97%Forma y color:SolidPeso molecular:335.33A-443654
CAS:<p>A-443654 is a pan-Akt inhibitor. A-443654 has equal potency against Akt1, Akt2, or Akt3 within cells (Ki=160 pM).</p>Fórmula:C24H23N5OPureza:98.04% - 99.51%Forma y color:SolidPeso molecular:397.47SEW2871
CAS:<p>SEW 2871 is an orally available, highly selective S1P1 agonist. It activates ERK, Akt and Rac signaling pathways and induces S1P1 internalization and recycling.</p>Fórmula:C20H10F6N2OSPureza:99.96%Forma y color:White SolidPeso molecular:440.36BIX02189
CAS:<p>BIX02189 is a potent and selective inhibitor of MEK5 and ERK5(IC50 : 1.5 nM and 59 nM).</p>Fórmula:C27H28N4O2Pureza:97.84%Forma y color:SolidPeso molecular:440.54PD98059
CAS:<p>PD98059 is an MEK inhibitor that inhibits MEK1 and MEK2 (IC50=2/50 μM) and is non-ATP-competitive.</p>Fórmula:C16H13NO3Pureza:98.63% - >99.99%Forma y color:Yellow SolidPeso molecular:267.28Piperlongumine
CAS:<p>Piperlongumine (Piplartine) is a natural alkaloid from Piper longum L.</p>Fórmula:C17H19NO5Pureza:97.03% - 99.90%Forma y color:SolidPeso molecular:317.34TBHQ
CAS:TBHQ (tert-Butylhydroquinone) is an antioxidant that induces an antioxidant response through the redox-sensitive transcription factor Nrf2.Fórmula:C10H14O2Pureza:99.17% - 99.53%Forma y color:White Solid PowderPeso molecular:166.22SCH772984
CAS:<p>SCH772984 is an ERK inhibitor and is highly selective and ATP-competitive. SCH772984 exhibits antitumor activity. Cost-effective and quality-assured.</p>Fórmula:C33H33N9O2Pureza:97.565% - 98.75%Forma y color:SolidPeso molecular:587.67Theliatinib
CAS:<p>Theliatinib: potent, selective EGFR inhibitor, anti-tumor; Ki=0.05 nM (EGFR), IC50=3 nM (EGFR), 22 nM (T790M/L858R).</p>Fórmula:C25H26N6O2Pureza:99.67%Forma y color:SolidPeso molecular:442.51Periplocin
CAS:<p>Periplocin fights lung cancer, induces apoptosis, stunts growth via beta-catenin/Tcf, and treats rheumatoid arthritis/traditional ailments.</p>Fórmula:C36H56O13Pureza:99.66% - 99.74%Forma y color:SolidPeso molecular:696.82SC99
CAS:SC99 inhibits JAK2-STAT3, reducing STAT3 genes, platelet activity, and has anti-myeloma, anti-thrombotic effects.Fórmula:C15H8Cl2FN3OPureza:99.56%Forma y color:SolidPeso molecular:336.15Yoda 1
CAS:<p>Yoda 1 is an agonist of the Piezo1 channel that agonizes human- and mouse-derived Piezo1. Yoda 1 is also an inhibitor of GlyT2. Cost-effective, quality assurance.</p>Fórmula:C13H8Cl2N4S2Pureza:98% - 99.98%Forma y color:SolidPeso molecular:355.27ERK5-IN-2
CAS:<p>ERK5-IN-2 is an orally active, sub-micromolar, selective ERK5 inhibitor with IC50s of 0.82 μM, 3 μM for ERK5 and ERK5 MEF2D, respectively.</p>Fórmula:C17H11BrFN3O2Pureza:99.01%Forma y color:SolidPeso molecular:388.19Asperulosidic acid
CAS:<p>Asperulosidic acid (ASPA) has anti-tumor, anti-oxidant, and anti-inflammatory activities. ASPA is related to the inhibition of inflammatory cytokines.</p>Fórmula:C18H24O12Pureza:99.47%Forma y color:SolidPeso molecular:432.38CAFESTOL
CAS:<p>Cafestol, an ERK inhibitor, suppresses PGE2 and COX-2 by blocking NF-kB in LPS-stimulated RAW264.7 cells.</p>Fórmula:C20H28O3Pureza:97.06% - 99.08%Forma y color:SolidPeso molecular:316.43Sulforaphene
CAS:<p>Sulforaphene, from radish seeds, aids cancer cell apoptosis and inhibits migration; has an ED50 for velvetleaf at ~2x10^-4 M.</p>Fórmula:C6H9NOS2Pureza:97.55% - 99.19%Forma y color:Slightly Yellowish LiquidPeso molecular:175.27Acalabrutinib
CAS:<p>Acalabrutinib (ACP-196), also known as ACP-196, is an orally available inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity.</p>Fórmula:C26H23N7O2Pureza:98.94% - 99.64%Forma y color:SolidPeso molecular:465.51XMD8-92
CAS:<p>XMD8-92 is an effective and specific BMK1/ERK5 inhibitor (Kd: 80 nM).</p>Fórmula:C26H30N6O3Pureza:98.21%Forma y color:SolidPeso molecular:474.55Triptonide
CAS:<p>Triptonide treats autoimmune diseases, has antileukemic/tumor effects, is anti-inflammatory, and boosts IL-37.</p>Fórmula:C20H22O6Pureza:99.11% - 99.64%Forma y color:White Crystalline PowderPeso molecular:358.39Peramivir Trihydrate
CAS:<p>Peramivir Trihydrate (RWJ-270201) is a neuraminidase inhibitor (IC50: 0.09 nM) which prevents normal processing of virus particles such that virus particles are</p>Fórmula:C15H28N4O4·3H2OPureza:99.52% - ≥95%Forma y color:SolidPeso molecular:382.45Ulixertinib
CAS:<p>Ulixertinib (VRT752271) (BVD-523, VRT752271) is an effective and reversible ERK1/ERK2 inhibitor. The IC50 of Ulixertinib is less than 0.3 nM for ERK2.</p>Fórmula:C21H22Cl2N4O2Pureza:99.31% - 99.95%Forma y color:SolidPeso molecular:433.33N-tert-butyl-α-Phenylnitrone
CAS:N-tert-butyl-α-Phenylnitrone ((Z)-N-benzylidene-2-Methylpropan-2-aMine oxide) inhibits COX2 catalytic activity.Fórmula:C11H15NOPureza:99.46% - 99.84%Forma y color:SolidPeso molecular:177.24(E/Z)-BIX 02189
CAS:<p>BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM.</p>Fórmula:C27H28N4O2Pureza:98% - 99.89%Forma y color:SolidPeso molecular:440.54Pluripotin
CAS:<p>Pluripotin (SC1) (SC1), which keep embryonic stem cell (ESC) self-renewal, is a dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and</p>Fórmula:C27H25F3N8O2Pureza:98.77% - 98.82%Forma y color:SolidPeso molecular:550.53Tenuifoliside A
CAS:<p>Tenuifoliside A has anti-apoptotic , neuroprotective activity.</p>Fórmula:C31H38O17Pureza:98.99% - 99.91%Forma y color:SolidPeso molecular:682.62BAY885
CAS:<p>BAY885 is a new ERK5 inhibitor.</p>Fórmula:C25H28F3N7O2Pureza:99.83%Forma y color:SolidPeso molecular:515.53Mogrol
CAS:<p>Mogrol, a biometabolite of mogrosides, functions by inhibiting the ERK1/2 and STAT3 pathways, diminishing CREB activation, and activating AMPK signaling.</p>Fórmula:C30H52O4Pureza:99.85% - 99.90%Forma y color:SolidPeso molecular:476.73Temuterkib
CAS:<p>LY3214996 (Temuterkib) is a potent oral ERK1/2 inhibitor with potential cancer-fighting properties.</p>Fórmula:C22H27N7O2SPureza:99.57% - >99.99%Forma y color:SolidPeso molecular:453.56
