ERK
ERK es una proteína clave en la vía de señalización MAPK (Mitogen-Activated Protein Kinase), que está involucrada en la transmisión de señales desde los receptores de la superficie celular hasta el ADN en el núcleo celular. ERK juega un papel crucial en la regulación de varios procesos celulares, incluyendo la proliferación, diferenciación y supervivencia. La desregulación de la señalización ERK está asociada con el desarrollo de cáncer y otras enfermedades, lo que la convierte en un objetivo importante para la intervención terapéutica. En CymitQuimica, ofrecemos una selección de inhibidores y moduladores de ERK de alta calidad para apoyar su investigación en señalización celular, oncología y desarrollo terapéutico.
Se han encontrado 223 productos para "ERK".
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Ulixertinib hydrochloride
CAS:Ulixertinib hydrochloride (Ulixertinib HCl) is an ERK1/2 inhibitor with anticancer and antitumor activity that inhibits the NB cell cycle and promotes apoptosisFórmula:C21H23Cl3N4O2Pureza:99.85%Forma y color:SolidPeso molecular:469.79VSLRGDTRG acetate
VSLRGDTRG acetate is a synthetic peptide of the RGD motif from cadherin17 (CDH17), capable of binding to α2β1 integrin and activating its signaling pathways. It facilitates the high-affinity conformational change of β1 integrin via the RGD motif, enhancing cell adhesion and phosphorylation of FAK and ERK1/2, thereby promoting tumor proliferation and metastasis. VSLRGDTRG acetate is applicable in research on cancers expressing CDH17, such as colon and pancreatic cancers.Forma y color:Odour SolidmSIRK
CAS:mSIRK (G-Protein βγ Binding Peptide) is an ERK1 and ERK2 dual activator that promotes alpha-subunit dissociation.Fórmula:C93H150N20O25Pureza:99.26%Forma y color:SolidPeso molecular:1948.31ADTL-EI1712
CAS:ADTL-EI1712: ERK1/2/5 inhibitor (ERK1 IC50=40.43nM, ERK5=64.5nM), blocks HL-60/MKN74 cell growth, not HeLa; effective in MKN74 mouse model.Fórmula:C22H18Cl2N4O2S2Forma y color:SolidPeso molecular:505.44Dihydrolipoic acid
CAS:Dihydrolipoic acid (USAF XR-12), a dithiol carboxylic acid, is a potent antioxidant active against various reactive oxygen species at 0.01-0.5 mM.Fórmula:C8H16O2S2Pureza:97.51%Forma y color:Yellow To Orange LiquidPeso molecular:208.34Angiogenesis inhibitor BT2
CAS:BT2 inhibits angiogenesis, vascular permeability by targeting ERK, FosB, VCAM-1, and related genes, affecting MEK1 and suppressing retinal markers.Fórmula:C18H18N2O4Forma y color:SolidPeso molecular:326.35VU0424465
CAS:VU0424465 is a mGlu5-selective allosteric agonist.Fórmula:C19H19FN2O2Forma y color:SolidPeso molecular:326.36UC-857993
CAS:UC-857993 is a selective SOS1-Ras inhibitor with a Kd of 14.7 μM that inhibits ERK, Ras, and reduces MEF growth.Fórmula:C25H22ClNO2Forma y color:SolidPeso molecular:403.9GP17
CAS:GP17 is a type II kinase inhibitor of the IRE1α endoribonuclease that acts by targeting the ATP-binding pocket of IRE1α.Fórmula:C26H21F3N4OForma y color:SolidPeso molecular:462.47GABAB receptor antagonist 1
CAS:(E)-GABAB receptor antagonist 1 decreases GABA-induced IP3 (inositol trisphosphate) production with IC50 of 37.9 μM.GABAB receptor antagonist 1 is a selectiveFórmula:C18H24O4Pureza:98%Forma y color:SolidPeso molecular:304.38BNC-1
CAS:BNC-1 reduces amyloid in mice, enhances synapses by activating Elk-1.Fórmula:C16H14N2O3Pureza:98%Forma y color:SolidPeso molecular:282.29CAY10561
CAS:CAY10561: potent, selective ERK2 inhibitor (Ki=2nM); blocks cell proliferation; IC50 in COLO 205 cells: 0.54μM.Fórmula:C22H17Cl2FN4O2Forma y color:SolidPeso molecular:459.32,5-Dihydroxybiphenyl
CAS:2,5-Dihydroxybiphenyl: a small molecule that induces trichothiodystrophy A protein dimerization, modulating TFIIH activity.Fórmula:C12H10O2Pureza:99.66%Forma y color:Cyan SolidPeso molecular:186.21Tinlorafenib
CAS:Tinlorafenib (PF-07284890), a BRAFV600E/K inhibitor, is oral & CNS-permeable, used for BRAF-linked CNS tumors. IC50: 4.25/2.7 nM.Fórmula:C19H19ClF2N4O3SForma y color:SolidPeso molecular:456.89ERK1/2 inhibitor 1
CAS:ERK1/2 inhibitor 1 is a potent, orally bioavailable ERK1/2 inhibitor, showing 60% inhibition at 1 nM and an IC50 of 3.0 nM against ERK1 and ERK2, respectively.Fórmula:C29H32ClN5O4Pureza:98.81%Forma y color:SolidPeso molecular:550.05Ref: TM-T11226
1mg119,00€5mg289,00€1mL*10mM (DMSO)320,00€10mg419,00€25mg642,00€50mg858,00€100mg1.170,00€ERK2 IN-5
CAS:ERK2IN-5 (Compound 5g) is an inhibitor of ERK2 and demonstrates good affinity for both ERK2 and JNK3, with Ki values of 86 nM and 550 nM, respectively.Fórmula:C21H17ClN4OPeso molecular:376.84Cuspin-1
CAS:Cuspin-1, a small molecule, increases SMN levels by 50% in SMA by boosting ERK phosphorylation and Ras-Raf-MEK signaling.Fórmula:C13H10BrNOForma y color:SolidPeso molecular:276.13PB1
CAS:PB1, a stable borane-protected TCEP analogue, effectively reduces disulfides intracellularly and aids retinal cell survival post-axotomy.Fórmula:C14H22BO4PForma y color:SolidPeso molecular:296.11PERK-IN-3
CAS:PERK-IN-3 is a potent inhibitor of PERK(IC50 of 7.4 nM).Fórmula:C22H16F2N4O2Pureza:98%Forma y color:SolidPeso molecular:406.38D-87503
CAS:D-87503 is a dual extracellular signaling-related kinase (ERK)/PI3K inhibitor.Fórmula:C17H15N5OSForma y color:SolidPeso molecular:337.4
