ERK
ERK es una proteína clave en la vía de señalización MAPK (Mitogen-Activated Protein Kinase), que está involucrada en la transmisión de señales desde los receptores de la superficie celular hasta el ADN en el núcleo celular. ERK juega un papel crucial en la regulación de varios procesos celulares, incluyendo la proliferación, diferenciación y supervivencia. La desregulación de la señalización ERK está asociada con el desarrollo de cáncer y otras enfermedades, lo que la convierte en un objetivo importante para la intervención terapéutica. En CymitQuimica, ofrecemos una selección de inhibidores y moduladores de ERK de alta calidad para apoyar su investigación en señalización celular, oncología y desarrollo terapéutico.
Se han encontrado 205 productos de "ERK"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
Tizaterkib
CAS:Tizaterkib (AZD-0364) is a potent and selective ERK2 inhibitor.Fórmula:C24H24F2N8O2Pureza:99.6% - 99.63%Forma y color:SolidPeso molecular:494.5ERK-IN-4
CAS:ERK-IN-4 is a cell-permeable ERK inhibitor with potential antiproliferative effects for the study of diseases caused by immune dysfunction.Fórmula:C14H17ClN2O3SPureza:98.92% - 99.84%Forma y color:SolidPeso molecular:328.814Ref: TM-T36675
1mg48,00€2mg60,00€5mg87,00€10mg144,00€25mg230,00€50mg341,00€100mg510,00€1mL*10mM (DMSO)104,00€Ulixertinib hydrochloride
CAS:Ulixertinib hydrochloride (Ulixertinib HCl) is an ERK1/2 inhibitor with anticancer and antitumor activity that inhibits the NB cell cycle and promotes apoptosisFórmula:C21H23Cl3N4O2Pureza:99.85%Forma y color:SolidPeso molecular:469.79PERK-IN-3
CAS:PERK-IN-3 is a potent inhibitor of PERK(IC50 of 7.4 nM).Fórmula:C22H16F2N4O2Pureza:98%Forma y color:SolidPeso molecular:406.38CAY10561
CAS:CAY10561: potent, selective ERK2 inhibitor (Ki=2nM); blocks cell proliferation; IC50 in COLO 205 cells: 0.54μM.Fórmula:C22H17Cl2FN4O2Forma y color:SolidPeso molecular:459.3BNC-1
CAS:BNC-1 reduces amyloid in mice, enhances synapses by activating Elk-1.Fórmula:C16H14N2O3Pureza:98%Forma y color:SolidPeso molecular:282.29Migoprotafib
CAS:Migoprotafib (GDC-1971) is a potent and highly selective SHP2 (Src Homology-2 Domain-Containing Phosphatase 2) inhibitor for advanced solid tumours.Fórmula:C25H26N8OPureza:98.31%Forma y color:SolidPeso molecular:454.53Ref: TM-T62798
1mg130,00€5mg313,00€10mg497,00€25mg982,00€50mg1.603,00€100mg2.592,00€1mL*10mM (DMSO)341,00€PB1
CAS:PB1, a stable borane-protected TCEP analogue, effectively reduces disulfides intracellularly and aids retinal cell survival post-axotomy.Fórmula:C14H22BO4PForma y color:SolidPeso molecular:296.11ERK5-IN-3
CAS:ERK5-IN-3 inhibits ERK5 strongly (IC50: 6 nM) and hampers Hela cell growth (IC50: 31 nM).Fórmula:C24H23Cl2FN4O2Forma y color:SolidPeso molecular:489.37ADTL-EI1712
CAS:ADTL-EI1712: ERK1/2/5 inhibitor (ERK1 IC50=40.43nM, ERK5=64.5nM), blocks HL-60/MKN74 cell growth, not HeLa; effective in MKN74 mouse model.Fórmula:C22H18Cl2N4O2S2Forma y color:SolidPeso molecular:505.44GP17
CAS:GP17 is a type II kinase inhibitor of the IRE1α endoribonuclease that acts by targeting the ATP-binding pocket of IRE1α.Fórmula:C26H21F3N4OForma y color:SolidPeso molecular:462.47Angiogenesis inhibitor BT2
CAS:BT2 inhibits angiogenesis, vascular permeability by targeting ERK, FosB, VCAM-1, and related genes, affecting MEK1 and suppressing retinal markers.Fórmula:C18H18N2O4Forma y color:SolidPeso molecular:326.35Cuspin-1
CAS:Cuspin-1, a small molecule, increases SMN levels by 50% in SMA by boosting ERK phosphorylation and Ras-Raf-MEK signaling.Fórmula:C13H10BrNOForma y color:SolidPeso molecular:276.13mSIRK
CAS:mSIRK (G-Protein βγ Binding Peptide) is an ERK1 and ERK2 dual activator that promotes alpha-subunit dissociation.Fórmula:C93H150N20O25Pureza:99.26%Forma y color:SolidPeso molecular:1948.312,5-Dihydroxybiphenyl
CAS:2,5-Dihydroxybiphenyl: a small molecule that induces trichothiodystrophy A protein dimerization, modulating TFIIH activity.
Fórmula:C12H10O2Pureza:99.66%Forma y color:White To Grey-Brownish PowderPeso molecular:186.21Tinlorafenib
CAS:Tinlorafenib (PF-07284890), a BRAFV600E/K inhibitor, is oral & CNS-permeable, used for BRAF-linked CNS tumors. IC50: 4.25/2.7 nM.Fórmula:C19H19ClF2N4O3SForma y color:SolidPeso molecular:456.89D-87503
CAS:D-87503 is a dual extracellular signaling-related kinase (ERK)/PI3K inhibitor.Fórmula:C17H15N5OSForma y color:SolidPeso molecular:337.4ERK1/2 inhibitor 1
CAS:ERK1/2 inhibitor 1 is a potent, orally bioavailable ERK1/2 inhibitor, showing 60% inhibition at 1 nM and an IC50 of 3.0 nM against ERK1 and ERK2, respectively.
Fórmula:C29H32ClN5O4Pureza:98.81%Forma y color:SolidPeso molecular:550.05UC-857993
CAS:UC-857993 is a selective SOS1-Ras inhibitor with a Kd of 14.7 μM that inhibits ERK, Ras, and reduces MEF growth.Fórmula:C25H22ClNO2Forma y color:SolidPeso molecular:403.9ERK5-IN-4
CAS:ERK5-IN-4 (34b) is a potent, specific ERK5 inhibitor; IC50: 77 nM full-length, 300 nM ΔTAD in HEK293 cells.Fórmula:C16H11Cl2FN4O2Forma y color:SolidPeso molecular:381.19
