Raf
Las quinasas Raf son componentes clave de la vía de señalización MAPK/ERK, desempeñando un papel crítico en la transmisión de señales desde la membrana celular hasta el núcleo. La activación de Raf conduce a la fosforilación de MEK, que posteriormente activa ERK, influyendo en la división, diferenciación y supervivencia celular. Las mutaciones en Raf, particularmente en B-Raf, están asociadas con varios tipos de cáncer, lo que convierte a Raf en un objetivo crucial en la terapia contra el cáncer. En CymitQuimica, ofrecemos una variedad de inhibidores y moduladores de Raf para apoyar su investigación en oncología, transducción de señales y desarrollo terapéutico.
Se han encontrado 86 productos para "Raf".
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Sorafenib
CAS:Sorafenib (Bay 43-9006) is a multikinase inhibitor that inhibits Raf-1, B-Raf, VEGFR2, VEGFR3, VEGFR4, PDGFRβ, FLT3, c-Kit, and others (IC50=6/22/90/15/20/20/57Fórmula:C21H16ClF3N4O3Pureza:98% - 99.89%Forma y color:White SolidPeso molecular:464.82LXH254
CAS:LXH254 is a B/C RAF inhibitor with IC50 values of 0.2 nM and 0.07 nM for inhibiting BRAF and CRAF.Cost-effective and quality-assured.Fórmula:C25H25F3N4O4Pureza:98.30% - 99.92%Forma y color:White SolidPeso molecular:502.4856B-Raf IN 2
CAS:B-Raf IN 2, compound Ia, is a highly effective and specific inhibitor of BRAF. It exhibits significant potential for cancer research.Fórmula:C20H17F2N5O4SPureza:98.86%Forma y color:White SolidPeso molecular:461.442Pepinh-TRIF TFA
Pepinh-TRIF TFA is a 30 aa peptide associated with the immune system that blocks TRIF signaling by interfering with TLR-TRIF interaction (TLR-TRIF interactionFórmula:C180H279F3N58O40S2Pureza:98% - 99.98%Forma y color:SolidPeso molecular:4014.09741MRTX0902
CAS:MRTX0902 is an effective and high selective inhibitor of SOS1 with an IC50 of 46 nM and a Ki of 2 nM.Fórmula:C22H24N6OPureza:99.69%Forma y color:SolidPeso molecular:388.4656Xl-281
CAS:XL-281: potent oral RAF kinase inhibitor, effective on wild-type and mutants, reduces tumor growth and cell proliferation, increases apoptosis.Fórmula:C24H19ClN4O4Pureza:95.77% - 99.12%Forma y color:White SolidPeso molecular:462.89LUT014
CAS:LUT014 is a B-Raf inhibitor (IC50: 11.7 nM) and developed to decrease dose-limiting acneiform lesions associated with EGFR Inhibitors treatment.Fórmula:C27H19F3N8OPureza:99.03%Forma y color:Yellow SolidPeso molecular:528.488Sorafenib tosylate
CAS:Sorafenib tosylate (Bay 43-9006) is a potent multikinase inhibitor (IC50s: 6/20/22 nM for Raf-1/VEGFR-3/B-Raf).Fórmula:C21H16ClF3N4O3·C7H8O3SPureza:99.22% - 99.94%Forma y color:SolidPeso molecular:637.03Cyclorasin 9A5 TFA
Cyclorasin 9A5 TFA is a cell-penetrating cyclic peptide consisting of 11 residues that inhibits the interaction between Ras and Raf proteins, with an IC50 of 120 nM.Fórmula:C75H108FN25O13·xC2HF3O2Forma y color:SolidPeso molecular:1586.82 (free base)Encorafenib-13C,D3
Encorafenib-13C,D3 is a version of Encorafenib (T6487) labeled with 13C and deuterium. Encorafenib (T6487) (LGX818) is a potent BRAF inhibitor, exhibiting selective antiproliferative and pro-apoptotic activity against BRAFV600E cells, with an EC50 value of 4 nM.MAPK Inhibitor Library
A unique collection of xnum cancer cell differentiation inducing compounds for high throughput and high content screening;Forma y color:Odour SolidSOS1-IN-17
SOS1-IN-17 (Compound 8d) is an orally active inhibitor targeting the SOS1-KRASG12C interaction, with an IC50 of 5.1 nM. It suppresses ERK phosphorylation in DLD-1 cells with an IC50 of 18 nM and demonstrates antiproliferative activity in KRASG12C-mutant Mia-Paca-2 cells, with an IC50 of 0.11 μM. In mouse models, SOS1-IN-17 shows antitumor efficacy against pancreatic cancer.Fórmula:C29H34F3N5O2Forma y color:SolidPeso molecular:541.61VUBI1-octanoic acid
VUBI1-octanoic acid is a conjugate of both the SOS1 ligand and linker, and it is applied in the synthesis of (4S)-PROTAC SOS1 degrader-1.Forma y color:Odour SolidKG5
CAS:KG5 inhibits PDGFRβ, B-Raf, FLT3, KIT, c-Raf; has anticancer and antiangiogenic effects; Kd: 520 nM (PDGFRβ), 300 nM (PDGFRα).Fórmula:C20H16F3N7OSPureza:98.32%Forma y color:SolidPeso molecular:459.45SOS1-IN-24
SOS1-IN-24 (Compound 15) is an SOS1 inhibitor with an IC50 of 0.398 μM, effectively blocking the interaction of SOS1::KRAS12D. It is applicable in research on cancers such as pancreatic and colorectal cancer.SOS1-IN-11
CAS:SOS1-IN-11 is an effective inhibitor of SOS1 (IC50 = 30 nM).Fórmula:C22H24F3N5OPureza:99.4%Forma y color:SolidPeso molecular:431.4541Cyclorasin 9A5
CAS:Cyclorasin 9A5 is a cell-permeable, 11-residue cyclic peptide that orthosterically disrupts the Ras-Raf protein interaction, demonstrating an inhibitionFórmula:C75H108FN25O13Pureza:98%Forma y color:SolidPeso molecular:1586.82R18
CAS:14.3.3 protein antagonist, blocks binding to Raf-1/Bad/ASK1/exoenzyme S, competitive, no phosphorylation needed, KD ~80 nM.Fórmula:C101H157N27O29S3Pureza:98%Forma y color:SolidPeso molecular:2309.69Vem-L-Cy5
Vem-L-Cy5 (compound 3), a Vemurafenib-based BRAF inhibitor conjugated with the near-infrared (NIR) fluorophore cyanine-5 (Cy5), selectively targets the BRAFFórmula:C63H68F5N7O9SPureza:98%Forma y color:SolidPeso molecular:1194.31RAS GTPase inhibitor 1 TFA
CAS:RAS GTPase inhibitor 1 TFA is a RAS GTPase inhibitor with potential antitumor activity.Fórmula:C27H28ClF4N5O2Pureza:98.43%Forma y color:SolidPeso molecular:565.99
