CFTR
El CFTR es una proteína de canal de cloruro que regula el transporte de iones cloruro y bicarbonato a través de las membranas de las células epiteliales, desempeñando un papel crucial en el mantenimiento del equilibrio de fluidos en los tejidos. Las mutaciones en el gen CFTR conducen a la fibrosis quística, un trastorno genético caracterizado por la producción de moco espeso que puede obstruir las vías respiratorias y provocar graves problemas respiratorios y digestivos. En CymitQuimica, ofrecemos una selección de moduladores de CFTR para apoyar su investigación en fibrosis quística, transporte de iones y trastornos genéticos.
Se han encontrado 66 productos para "CFTR".
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GLPG2451
CAS:GLPG2451 is an effective CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) enhancer, potentiates cold-rescued F508del CFTR (EC50=11.1 nM).Fórmula:C16H16F3N3O5SPureza:99.13%Forma y color:White SolidPeso molecular:419.38Ref: TM-T13705
1mg98,00€5mg234,00€1mL*10mM (DMSO)258,00€10mg358,00€25mg737,00€50mg1.099,00€100mg1.468,00€(R)-Posenacaftor sodium
CAS:(R)-Posenacaftor sodium is a modulator for correcting cystic fibrosis protein folding.Fórmula:C27H27NNaO5Forma y color:SolidPeso molecular:468.505Posenacaftor
CAS:Posenacaftor (PTI-801) regulates CFTR protein for cystic fibrosis research.Fórmula:C27H27NO5Forma y color:SolidPeso molecular:445.51GLPG-3221
CAS:GLPG-3221, a potent oral CFTR corrector for cystic fibrosis treatment, has an EC50 of 105 nM.Fórmula:C30H37F3N2O6Pureza:98%Forma y color:SolidPeso molecular:578.62Bamocaftor
CAS:Bamocaftor corrects CFTR in CF, restoring F508del-CFTR function, used with tezacaftor and VX-561 for F508del/MF patients.Fórmula:C28H32F3N5O4SPureza:99.71%Forma y color:SolidPeso molecular:591.65Ref: TM-T30293
1mg334,00€5mg802,00€1mL*10mM (DMSO)1.035,00€10mg1.099,00€25mg1.611,00€50mg2.187,00€100mg2.952,00€PG01
CAS:PG01 is a potent CFTR Cl-channel potentiator, effective against ΔF508 (Ka 0.3 μM), and also against E193K, G970R and G551D (CFTR mutants), with Kd values of 0.Fórmula:C28H29N3O2Pureza:99.79%Forma y color:SolidPeso molecular:439.55Ref: TM-T16516
1mg55,00€1mL*10mM (DMSO)144,00€5mg148,00€10mg215,00€25mg344,00€50mg465,00€100mg630,00€200mg850,00€Crinecerfont
CAS:Crinecerfont (SSR-125543) is a CRF1 antagonist, useful in congenital adrenal hyperplasia research.Fórmula:C27H28ClFN2OSPureza:97.79% - 98.55%Forma y color:SolidPeso molecular:483.04VRT-325
CAS:VRT-325 aids in dimerizing NBDs and folding TMDs, speeding up CF cell monolayer repair.Fórmula:C27H34N4O4SPureza:99.15% - 99.58%Forma y color:SolidPeso molecular:510.65UCCF-853
CAS:UCCF-853 是一种小分子 CFTR 调节剂，可用于研究囊性纤维化。Fórmula:C14H8ClF3N2OPureza:99.82%Forma y color:SolidPeso molecular:312.67VRT-532
CAS:VRT-532 (CFpot-532) is an effective modulator of CFTR and is commonly used in studies of cystic fibrosis (CF) caused by CFTR defects.Fórmula:C16H14N2OPureza:99.88% - 99.93%Forma y color:SolidPeso molecular:250.3Ref: TM-T29114
1mg70,00€1mL*10mM (DMSO)138,00€5mg156,00€10mg225,00€25mg371,00€50mg504,00€100mg662,00€200mg875,00€CFTR corrector 8
CAS:CFTR corrector 8: potent for cystic fibrosis research, modulates CFTR protein.Fórmula:C29H27F2NO7Pureza:99.57%Forma y color:White SolidPeso molecular:539.52Ref: TM-T63806
1mg34,00€5mg78,00€1mL*10mM (DMSO)90,00€10mg109,00€25mg212,00€50mg334,00€100mg548,00€200mg737,00€Chromanol 293B
CAS:Chromanol 293B, Cardiac IK and CFTR chloride current inhibitor (IC50=1-19 μM), weak KATP channel blocker, for arrhythmia research.Fórmula:C15H20N2O4SPureza:99.78%Forma y color:White SolidPeso molecular:324.4(R)-Elexacaftor
CAS:(R)-Elexacaftor (compound 37) is the enantiomer of Elexacaftor (compound 1). (R)-Elexacaftor is a CFTR modulator with an EC50 of 0.29 μM for CFTR dF508.Fórmula:C26H34F3N7O4SPureza:98.99%Forma y color:SolidPeso molecular:597.65Ref: TM-T78240
1mg92,00€5mg230,00€1mL*10mM (DMSO)304,00€10mg371,00€25mg712,00€50mg1.009,00€100mg1.378,00€CRF1 receptor antagonist-1
CAS:CRF1 Receptor Antagonist-1 (Compound 2), a CRF1 receptor antagonist, is utilized in research pertaining to congenital adrenal hyperplasia (CAH) [1].Fórmula:C27H28ClFN2O2SPureza:98%Forma y color:SolidPeso molecular:499.04CFTR corrector 6
CAS:CFTR corrector 6, a potent CFTR potentiator, aids cystic fibrosis research and related disorders.Fórmula:C22H13F4N9Forma y color:SolidPeso molecular:479.39CFTR corrector 12
CAS:CFTR corrector 12 is a CFTR corrector that rescues all mutant proteins except M760R ABCA3 and can be used to study cystic fibrosis.Fórmula:C19H21ClN4O2S2Pureza:99.47%Forma y color:SolidPeso molecular:436.98DNDS
CAS:DNDS is a channel blocker of voltage-dependent cystic fibrosis transmembrane conductance regulator (CFTR).Fórmula:C14H8N2Na2O10S2Pureza:99.92%Forma y color:Yellow SolidPeso molecular:474.33BPO-27 racemate
CAS:BPO-27 racemate (BPO-27 (racemate)) is an effective CFTR inhibitor with IC50 of 8 nM.Fórmula:C26H18BrN3O6Pureza:97.67% - 98.86%Forma y color:SolidPeso molecular:548.34Ref: TM-T10591
1mg44,00€5mg111,00€1mL*10mM (DMSO)128,00€10mg166,00€25mg265,00€50mg388,00€100mg535,00€200mg718,00€(R)-Vanzacaftor
CAS:(R)-Vanzacaftor ((R)-VX-121) is a cystic fibrosis transmembrane conductance regulator (CFTR) modulator [1].Fórmula:C32H39N7O4SForma y color:SolidPeso molecular:617.76CFTR corrector 4
CAS:Potent, oral CFTR corrector 4 targets cystic fibrosis, increasing cell surface CFTR levels.Fórmula:C29H27F2NO7Pureza:99.32%Forma y color:White SolidPeso molecular:539.52Ref: TM-T10776
1mg46,00€5mg100,00€1mL*10mM (DMSO)119,00€10mg156,00€25mg304,00€50mg429,00€100mg610,00€
