Canal TRP / TRPV
Los canales TRP (Receptor Potencial Transitorio), incluida la subfamilia TRPV, son un grupo de canales iónicos involucrados en diversos procesos sensoriales, como la sensación de temperatura, la percepción del dolor y la osmorregulación. Los canales TRP están ampliamente expresados en diferentes tejidos y desempeñan un papel en las respuestas fisiológicas a estímulos ambientales. Los canales TRPV, en particular, están involucrados en la detección de cambios de temperatura y están implicados en condiciones como el dolor crónico, la inflamación y el cáncer. En CymitQuimica, ofrecemos una gama completa de moduladores de canales TRP/TRPV para apoyar su investigación en biología sensorial, manejo del dolor y transducción de señales.
Se han encontrado 96 productos de "Canal TRP / TRPV"
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ML204
CAS:ML204 is a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels.Fórmula:C15H18N2Pureza:98.1% - 99.72%Forma y color:SolidPeso molecular:226.32RN-1734
CAS:RN-1734 is selective TRPV4 channel antagonist(IC50 of 2.3 μM,5.9 μM,3.2 μM for hTRPV4, mTRPV4 and rTRPV4,respectively)Fórmula:C14H22Cl2N2O2SPureza:99.1% - 99.3%Forma y color:SolidPeso molecular:353.31AMG 333
CAS:AMG 333 is TRPM8 antagonist with an IC50 of 13 nM,a Clinical Candidate for the Treatment of Migraine.Fórmula:C20H12F5N3O4Pureza:99.95%Forma y color:SolidPeso molecular:453.32Chembridge-5861528
CAS:Chembridge-5861528 (TCS 5861528) is a TRPA1 channel blocker that antagonizes AITC- and 4-HNE-evoked calcium influx with IC50 values of 14.3 and 18.7 μM.Fórmula:C19H23N5O3Pureza:99.97%Forma y color:SolidPeso molecular:369.42RQ-00203078
CAS:RQ-00203078 is a highly selective, potent and orally available TRPM8 antagonist.Fórmula:C21H13ClF6N2O5SPureza:98% - 99.6%Forma y color:SolidPeso molecular:554.85A-967079
CAS:A 967079 is a potent, selective, and bioavailable inhibitor of the TRPA1 channel, with IC50 values of 67 and 289 nM for the human and rat isoforms, respectively
Fórmula:C12H14FNOPureza:98.34% - 99.75%Forma y color:SolidPeso molecular:207.24ICILIN
CAS:ICILIN (AG-3-5) is a synthetic TRPM8 ion channel super-agonist.Fórmula:C16H13N3O4Pureza:98.45% - ≥95%Forma y color:Light Yellow SolidPeso molecular:311.29ASP7663
CAS:ASP7663 is a TRPA1 Receptor Agonist and exhibiting an abdominal analgesic effect in vivo.Fórmula:C14H14FNO3Pureza:98.61%Forma y color:SolidPeso molecular:263.26AM-0902
CAS:AM-0902 is a potent and specific TRPA1 antagonist (IC50s: 71/131 nM for rTRPA1 and hTRPA1).Fórmula:C17H15ClN6O2Pureza:>99.99%Forma y color:SolidPeso molecular:370.79SB 452533
CAS:SB 452533 is an antagonist of the vanilloid receptor 1(pKb: 7.8).Fórmula:C18H22BrN3OPureza:99.87%Forma y color:SolidPeso molecular:376.29Ref: TM-T23322
2mg39,00€5mg60,00€1mL*10mM (DMSO)73,00€10mg92,00€25mg173,00€50mg269,00€100mg389,00€200mg555,00€PF-4840154
CAS:PF-4840154: potent TrpA1 agonist; EC50 of 97 nM (rat) & 23 nM (human); triggers nociception in mice.
Fórmula:C26H38N6O2Pureza:>99.99%Forma y color:SolidPeso molecular:466.62Pyr10
CAS:Pyr10, a pyrazole derivative, selectively inhibits TRPC3, not STIM1/Orai1, with IC50 of 0.72 μM in TRPC3-HEK293, and 13.08 μM in BRL-2H3 cells.Fórmula:C18H13F6N3O2SPureza:99.69% - 99.7%Forma y color:SolidPeso molecular:449.37SB-705498
CAS:SB705498 is a TRPV1 antagonist for hTRPV1. SB-705498 has been investigated for the treatment of Rhinitis, Chronic Cough, and Non-allergic Rhinitis.Fórmula:C17H16BrF3N4OPureza:99.57% - ≥95%Forma y color:SolidPeso molecular:429.23Vanilloid receptor antagonist 1
CAS:Vanilloid receptor antagonist 1 (4-(7-Hydroxy-2-isopropyl-4-oxoquinazolin-3(4H)-yl)benzonitrile) is a potent vanilloid receptor TRPV1 antagonist.Fórmula:C18H15N3O2Pureza:98.14%Forma y color:SolidPeso molecular:305.33AMG9810
CAS:AMG 9810 blocks capsaicin's action on TRPV1; human IC50=24.5 nM, rat IC50=85.6 nM.Fórmula:C21H23NO3Pureza:99.79% - 99.95%Forma y color:SolidPeso molecular:337.41Ref: TM-T7189
2mg34,00€5mg48,00€1mL*10mM (DMSO)50,00€10mg58,00€25mg110,00€50mg177,00€100mg286,00€200mg425,00€Optovin
CAS:Optovin is a TRPA1 activator, which is reversibly photoactivated.Fórmula:C15H13N3OS2Pureza:99.47% - 99.67%Forma y color:SolidPeso molecular:315.41Ref: TM-T6617
2mg37,00€5mg54,00€1mL*10mM (DMSO)60,00€10mg88,00€25mg152,00€50mg236,00€100mg385,00€200mg560,00€MDR-652
CAS:MDR-652 is a highly specific and efficacious agonist of nonpungent transient receptor potential vanilloid 1 (TRPV1) with Ki value of 11.4 nM and 23.8 nM forFórmula:C22H23ClFN3O2SPureza:99.96%Forma y color:SolidPeso molecular:447.95Ref: TM-T22360
1mg60,00€2mg87,00€5mg130,00€1mL*10mM (DMSO)142,00€10mg178,00€25mg331,00€50mg512,00€100mg707,00€200mg973,00€RN-1747
CAS:RN-1747: TRPV4 agonist (EC50: human 0.77 μM, mouse 4.0 μM, rat 4.1 μM), TRPM8 antagonist (IC50: 4 μM).Fórmula:C17H18ClN3O4SPureza:99.29%Forma y color:SolidPeso molecular:395.86AMTB hydrochloride
CAS:AMTB HCl: Novel TRPM8 blocker, relieves pain, treats urinary issues, moderates bladder reflexes in rats.Fórmula:C23H27ClN2O2SPureza:99.08%Forma y color:SolidPeso molecular:430.99Ref: TM-T19723
1mg34,00€5mg74,00€1mL*10mM (DMSO)87,00€10mg119,00€25mg250,00€50mg424,00€100mg627,00€200mg890,00€TRPM8 antagonist 2
CAS:TRPM8 antagonist 2 is a potent and selective TRPM8 antagonist with an IC50 of 0.2 nM. TRPM8 antagonist 2 is used in the research of neuropathic pain syndromes.Fórmula:C26H26N2O2Pureza:98.1%Forma y color:SolidPeso molecular:398.5Ref: TM-T5698
1mg34,00€5mg66,00€1mL*10mM (DMSO)73,00€10mg99,00€25mg167,00€50mg260,00€100mg416,00€200mg600,00€
