Receptor CGRP
Los receptores de CGRP están involucrados en la transmisión del dolor y la regulación del flujo sanguíneo. El CGRP es un neuropéptido que desempeña un papel crucial en la fisiopatología de la migraña al dilatar los vasos sanguíneos y modular las vías de señalización del dolor. Dirigirse a los receptores de CGRP se ha convertido en un enfoque prometedor en el desarrollo de terapias para la migraña. En CymitQuimica, ofrecemos una gama de moduladores de receptores de CGRP para apoyar su investigación en el manejo del dolor, neurobiología y salud vascular.
Se han encontrado 55 productos de "Receptor CGRP"
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β-CGRP, human acetate
β-CGRP, human acetate is one of calcitonin peptides and acts via the complex of receptor-activity-modifying protein (RAMP) and calcitonin-receptor-like receptorFórmula:C164H271N51O50S3Pureza:99.35%Forma y color:SolidPeso molecular:3853.46Rimegepant
CAS:View and buy Rimegepant from TargetMol.BMS-927711 is a highly potent, oral calcitonin gene-related peptide (CGRP) receptor antagonist with a Ki value of 0.027 nM.Cited in 1 publications.Fórmula:C28H28F2N6O3Pureza:99.1% - 99.99%Forma y color:SolidPeso molecular:534.56Atogepant
CAS:Atogepant (MK-8031) is an orally available, selective and potent calcitonin gene-related peptide receptor (CGRP) antagonist for the study of migraine.Fórmula:C29H23F6N5O3Pureza:99.66%Forma y color:SolidPeso molecular:603.52Ref: TM-T26682
1mg147,00€5mg250,00€10mg313,00€1mL*10mM (DMSO)334,00€25mg620,00€50mg1.108,00€100mg1.611,00€200mg2.178,00€Fremanezumab
CAS:Fremanezumab (TEV-48125) is a humanised monoclonal antibody targeting CGRP, capable of neutralising human, mouse and rat CGRP, migraine.Pureza:95% - 97.6% (SDS-PAGE); 95.9% (SEC-HPLC)Forma y color:LiquidPeso molecular:145.49 kDaEptinezumab
CAS:Eptinezumab is a humanised monoclonal antibody targeting CGRP (calcitonin gene-related peptide), which prevents CGRP binding to its receptor, migraine.
Pureza:95% - 95%Forma y color:LiquidCGRP antagonist 1
CAS:CGRP antagonist 1 is a potent CGRP receptor antagonist with Ki values of 35 nM and IC50 values of 57 nM, respectively.CGRP antagonist 1 can be used for theFórmula:C29H26N4O4Pureza:99.55%Forma y color:SolidPeso molecular:494.54Ubrogepant
CAS:Ubrogepant (MK-1602) is an antagonist of calcitonin gene-related peptide receptor that can be used in the acute treatment of migraine studies.Fórmula:C29H26F3N5O3Pureza:99.452% - 99.78%Forma y color:SolidPeso molecular:549.54Ref: TM-T17194
1mg144,00€5mg358,00€1mL*10mM (DMSO)432,00€10mg565,00€25mg880,00€50mg1.161,00€100mg1.594,00€MK-8825
CAS:MK-8825 is a CGRP receptor antagonist.Fórmula:C31H30F2N6O3Forma y color:SolidPeso molecular:572.61MK-3207
CAS:MK-3207 is a potent, oral CGRP receptor antagonist with high selectivity for human and monkey receptors, inhibiting blood flow in vivo.Fórmula:C31H29F2N5O3Forma y color:SolidPeso molecular:557.59CGRP antagonist 7
CAS:CGRP antagonist 7 is a potent calcitonin gene-related peptide receptor (CGRP) antagonist with a Ki value of 0.029 nM. It effectively inhibits CGRP receptor-mediated cyclic adenosine monophosphate (cAMP) production, with an IC50 value of 1.5 nM. This compound is useful in migraine research.Fórmula:C30H32FN5O3Forma y color:SolidPeso molecular:529.61DNA crosslinker 6
CAS:DNA crosslinker 6 (compound 1) is an anti-mitotic agent known for its strong binding affinity to AT-DNA and inhibition of AT-hook 1 binding to DNA (IC50=0.03 µM). Additionally, it exhibits anti-protozoal activity, effectively inhibiting T. brucei with an EC50 of 0.83 µM.Fórmula:C19H21N7OForma y color:SolidPeso molecular:363.42Rimegepant sulfate hydrate
CAS:Rimegepant (BMS-927711/BHV-3000): oral CGRP blocker for migraines, effective without vasoconstriction, beats placebo, well-tolerated.Fórmula:C56H64F4N12O13SForma y color:SolidPeso molecular:1221.2526MK-3207 Hydrochloride
CAS:MK-3207 Hydrochloride (MK-3207 HCl) is a potent CGRP receptor antagonist with IC50 and Kiof 0.12 nM and 0.022 nM, highly selective versus human AM1, AM2, CTR, and AMY3. Phase 2.Fórmula:C31H30ClF2N5O3Pureza:98.19%Forma y color:SolidPeso molecular:594.05BI-44370
CAS:BI-44370, a CGRP (calcitonin gene-related peptide) receptor antagonist, can be used to treat migraines and other chronic pain.Fórmula:C35H47N5O6Forma y color:SolidPeso molecular:633.78
