P-gp
La P-glicoproteína es una bomba de eflujo dependiente de ATP que transporta una amplia variedad de sustratos, incluidos medicamentos, toxinas y lípidos, fuera de las células. Desempeña un papel crucial en la resistencia a los medicamentos, particularmente en el cáncer, al reducir la concentración intracelular de agentes quimioterapéuticos. La P-gp también está involucrada en la barrera hematoencefálica, influyendo en la exposición del sistema nervioso central a varios compuestos. En CymitQuimica, ofrecemos una gama de moduladores de la P-gp para apoyar su investigación en resistencia a los medicamentos, farmacocinética y desarrollo terapéutico.
Se han encontrado 55 productos de "P-gp"
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Trifluoperazine
CAS:Trifluoperazine (trifluoroperazine) is a Dopamine D2 receptor inhibitor(IC50 : 1.2 nM), and Treatment of schizophrenia.Fórmula:C21H24F3N3SPureza:98.3% - 99.46%Forma y color:White To Yellowish Crystalline PowderPeso molecular:407.5γ-Tocotrienol
CAS:γ-Tocotrienol (Plastochromanol) is one of the four types of tocotrienol, a type of vitamin E.Fórmula:C28H42O2Pureza:97.27% - 98.13%Forma y color:SolidPeso molecular:410.63Ref: TM-T19768
1mg44,00€2mg58,00€5mg96,00€10mg137,00€25mg224,00€50mg333,00€100mg489,00€200mg705,00€1mL*10mM (DMSO)92,00€Sinapine thiocyanate
CAS:Sinapine Thiocyanate, is a derivative of Sinapine (S486605), an alkaloidal amine found in black mustard seeds.Fórmula:C16H24NO5·CNSPureza:99.79% - ≥95%Forma y color:SolidPeso molecular:368.45Talinolol
CAS:(±)-Talinolol is a selective β1 adrenoceptor antagonist well known for its cardioprotective and antihypertensive activity.Fórmula:C20H33N3O3Pureza:98.8%Forma y color:SolidPeso molecular:363.49Ref: TM-T21640
2mg34,00€5mg52,00€10mg92,00€25mg178,00€50mg313,00€100mg535,00€200mg775,00€1mL*10mM (DMSO)52,00€Elacridar
CAS:Elacridar (GG918) is a potent inhibitor of P-glycoprotein and BCRP.Cost-effective and quality-assured.Fórmula:C34H33N3O5Pureza:98.12% - >99.99%Forma y color:SolidPeso molecular:563.64Chrysosplenetin
CAS:Chrysosplenetin is a metabolic inhibitor of artemisinin.Fórmula:C19H18O8Pureza:97.43% - 98.4%Forma y color:SolidPeso molecular:374.34Ref: TM-TJS1159
1mg57,00€5mg120,00€10mg178,00€25mg329,00€50mg485,00€100mg692,00€500mg1.404,00€1mL*10mM (DMSO)215,00€HTT-D3
CAS:HTT-D3 is a Huntington splicing regulator that induces HTT mRNA degradation, leading to a reduction in HTT protein levels.
Fórmula:C23H25FN6Pureza:99.31%Forma y color:SolidPeso molecular:404.48Verapamil
CAS:Verapamil (CP-16533-1), an oral calcium channel blocker, inhibits P-gp and CYP3A4, used for hypertension, arrhythmias, and angina research.Fórmula:C27H38N2O4Pureza:99.61% - 99.93%Forma y color:OilPeso molecular:454.6Ref: TM-T20656
10mg34,00€25mg49,00€50mg70,00€100mg90,00€200mg136,00€500mg219,00€1mL*10mM (DMSO)52,00€P-gp inhibitor 1
CAS:P-gp inhibitor 1 inhibits reversing P-glycoprotein-mediated multidrug resistance with an EC50 of 57.9 nM (K562/A02 cells).Fórmula:C32H31N5O2Pureza:98.65%Forma y color:SolidPeso molecular:517.62Ref: TM-T12341
5mg50,00€10mg84,00€25mg150,00€50mg219,00€100mg304,00€200mg419,00€1mL*10mM (DMSO)58,00€P-gp inhibitor 17
CAS:P-gp Inhibitor 17 (compound 2g), a potent inhibitor, directly interacts with the transmembrane domain of P-gp. This compound is useful for studying P-gp-mediated multidrug resistance in tumor cells [1].Fórmula:C36H49N3O3Forma y color:SolidPeso molecular:571.79ONT-093
CAS:ONT-093 (OC-144-093) is an oral P-glycoprotein (P-gp) inhibitor with potential anti-cancer activity, used in the study of myelodysplastic syndromes.Fórmula:C32H38N4OPureza:98.86%Forma y color:SolidPeso molecular:494.67coniferyl ferulate
CAS:Coniferyl ferulate is a strong inhibitor of glutathione S-transferase (GST) isolated from Radix Angelicae sinensis.Fórmula:C20H20O6Pureza:99.39%Forma y color:SolidPeso molecular:356.37PGP-4008
CAS:PGP-4008 is a selective and potent P-glycoprotein (Pgp) inhibitor that inhibits tumor growth by co-administration with Doxorubicin.Fórmula:C26H23N3OPureza:97.41% - 97.99%Forma y color:SolidPeso molecular:393.488-Prenylchrysin
CAS:8-Prenylchrysin is a C8-isopentenyl flavonoid compound. It acts as an inhibitor of P-glycoprotein (P-gp) and can be utilized in cancer research.Fórmula:C20H18O4Forma y color:SolidPeso molecular:322.354NSC73306
CAS:NSC73306 is a thiosemicarbazone known for its role as a cell-permeable agent, exhibiting increased toxicity towards cells expressing p-glycoprotein.Fórmula:C16H14N4O2SForma y color:SolidPeso molecular:326.373
