P-gp
La P-glicoproteína es una bomba de eflujo dependiente de ATP que transporta una amplia variedad de sustratos, incluidos medicamentos, toxinas y lípidos, fuera de las células. Desempeña un papel crucial en la resistencia a los medicamentos, particularmente en el cáncer, al reducir la concentración intracelular de agentes quimioterapéuticos. La P-gp también está involucrada en la barrera hematoencefálica, influyendo en la exposición del sistema nervioso central a varios compuestos. En CymitQuimica, ofrecemos una gama de moduladores de la P-gp para apoyar su investigación en resistencia a los medicamentos, farmacocinética y desarrollo terapéutico.
Se han encontrado 53 productos de "P-gp"
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Piperine
CAS:<p>Piperine (Bioperine) , a alkaloid, has been used in trials studying the treatment of multiple myeloma and deglutition disorders.</p>Fórmula:C17H19NO3Pureza:98.41% - 98.51%Forma y color:SolidPeso molecular:285.34Dofequidar fumarate
CAS:<p>Dofequidar fumarate (MS-209)(MS-209 fumarate), a quinoline-based compound administered orally, is known for counteracting multidrug resistance (MDR) through the</p>Fórmula:C34H35N3O7Pureza:99.93%Forma y color:SolidPeso molecular:597.66Encequidar mesylate
CAS:<p>Encequidar mesylate (HM30181A mesylate) is a competitive P-glycoprotein inhibitor.</p>Fórmula:C39H40N6O10SPureza:99.84%Forma y color:SolidPeso molecular:784.83Risperidone
CAS:<p>Risperidone (R 64 766) is a selective blocker of dopamine D2 receptors and serotonin 5-HT2 receptors that act as an atypical antipsychotic agent.</p>Fórmula:C23H27FN4O2Pureza:99.73%Forma y color:Crystalline SolidPeso molecular:410.48Atazanavir sulfate
CAS:<p>Atazanavir sulfate, an azapeptide HIV-protease inhibitor, treats HIV/AIDS alongside other anti-HIV drugs.</p>Fórmula:C38H52N6O7·H2SO4Pureza:99.31% - 99.40%Forma y color:SolidPeso molecular:802.93(20S)-Protopanaxadiol
CAS:<p>(20S)-Protopanaxadiol (20-Epiprotopanaxadiol) (20-Epiprotopanaxadiol), an apoptosis inducer, is an aglycon metabolic derivative of the protopanaxadiol-type</p>Fórmula:C30H52O3Pureza:97.07% - 98.91%Forma y color:SolidPeso molecular:460.73Glibenclamide
CAS:<p>Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.</p>Fórmula:C23H28ClN3O5SPureza:99.05% - 99.75%Forma y color:SolidPeso molecular:494.00Trifluoperazine dihydrochloride
CAS:<p>Trifluoperazine dihydrochloride (SKF5019) is a potent dopamine D2 receptor inhibitor used as an antipsychotic and an antiemetic.</p>Fórmula:C21H26Cl2F3N3SPureza:99.57% - 99.96%Forma y color:Cream Fine PowderPeso molecular:480.43Norverapamil hydrochloride
CAS:<p>Norverapamil HCl, a Verapamil metabolite, blocks L-type calcium channels and inhibits P-gp function.</p>Fórmula:C26H37ClN2O4Pureza:99.47%Forma y color:SolidPeso molecular:477.04Verapamil hydrochloride
CAS:<p>Verapamil hydrochloride (Verapamil HCl) is a calcium channel blocker that is a class IV anti-arrhythmia agent.</p>Fórmula:C27H39ClN2O4Pureza:98.7% - 99.98%Forma y color:White To Off-White PowderPeso molecular:491.06Zamicastat
CAS:<p>Zamicastat (BIA 5-1058) inhibits DBH, P-gp (IC50=73.8μM), and BCRP (IC50=17.0μM).</p>Fórmula:C21H21F2N3OSPureza:99.58%Forma y color:SolidPeso molecular:401.47Atazanavir
CAS:<p>Atazanavir (BMS-232632)(BMS-232632) is an highly effective HIV-1 protease inhibitor.</p>Fórmula:C38H52N6O7Pureza:98% - 99.95%Forma y color:Crystalline SolidPeso molecular:704.86CPI1
<p>CPI1 is an effective and highly specific inhibitor of multidrug resistance protein 1 (MRP1). It exhibits inhibitory activity against MRP1 at the nanomolar level (Ki: 100 nM) and has minimal effect on P-glycoprotein (Pgp). CPI1 competes with LTC4 for binding to the same site on MRP1, inhibiting ATP hydrolysis and substrate transport. It is useful in research related to drug delivery and addressing cancer chemotherapy resistance.</p>Fórmula:C111H131N23O30SForma y color:SolidPeso molecular:2299.43Valspodar
CAS:<p>Valspodar (PSC 833) is a specific P-glycoprotein inhibitor and MDR regulator often used as a chemical sensitizer to study advanced epithelial ovarian cancer.</p>Fórmula:C63H111N11O12Pureza:95% - >99.99%Forma y color:SolidPeso molecular:1214.62YS-370
CAS:<p>YS-370 orally blocks P-gp, moderately inhibits CYP3A4, reverses drug resistance, and enhances paclitaxel's anticancer effects.</p>Fórmula:C37H35BrN4O3Pureza:98.055%Forma y color:SolidPeso molecular:663.6P-gb-IN-1
CAS:<p>P-gb-IN-1 is a potent P-glycoprotein (P-gp) inhibitor that exhibits reverse activity by inhibiting P-gp outflow.</p>Fórmula:C30H28N2O6Pureza:99.58%Forma y color:SoildPeso molecular:512.55Tariquidar methanesulfonate hydrate
CAS:<p>m-PEG8-Ms is a PROTAC linker belonging to the PEG class and can be used to synthesize PROTAC compounds.</p>Fórmula:C40H58N4O18S2Pureza:98.13%Forma y color:SolidPeso molecular:947.04Evodine
CAS:<p>1. Evodine has antinociceptive activity.</p>Fórmula:C18H19NO5Pureza:98%Forma y color:SolidPeso molecular:329.35Laniquidar TFA
<p>Laniquidar TFA (R101933), a non-competitive P-gp inhibitor, has an IC50 of 0.51 μM; used to study AML and MDS, but with limited bioavailability.</p>Fórmula:C39H37F3N4O5Pureza:99.85%Forma y color:SoildPeso molecular:698.73P-gp inhibitor 14
CAS:<p>Compound 8a, also known as P-gp inhibitor 14, demonstrates high affinity as a P-gp inhibitor and effectively reverses P-gp-mediated multidrug resistance (EC 50 = 48.74 nM). Additionally, this compound exhibits a weak inhibitory effect on CYP3A4 activity [1].</p>Fórmula:C37H38N2O8Forma y color:SolidPeso molecular:638.71FM04
CAS:<p>FM04 is a potent oral P-gp inhibitor (EC50: 83 nM), disrupting human P-gp NBD2 to enhance cancer treatment.</p>Fórmula:C26H25NO4Pureza:99.77%Forma y color:SolidPeso molecular:415.48Solamargine
CAS:<p>Solamargine, a steroidal alkaloid from Solanum nigrum, inhibits cancer cell growth and induces apoptosis.</p>Fórmula:C45H73NO15Pureza:99.17% - 99.96%Forma y color:SolidPeso molecular:868.06Ceefourin 1
CAS:<p>Ceefourin 1 is a highly selective multidrug resistance protein 4 (MRP4) inhibitor.</p>Fórmula:C11H10N4S3Pureza:99.15%Forma y color:SolidPeso molecular:294.42Paris saponin VII
CAS:<p>Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation.</p>Fórmula:C51H82O21Pureza:99.51% - 99.63%Forma y color:SolidPeso molecular:1031.18Polyoxyethylene stearate
CAS:<p>Polyoxyethylene stearate (POES) is an agent of non-ionic emulsifying.</p>Fórmula:C20H40O3Pureza:n~9-10Forma y color:Light Amber SemisolidPeso molecular:328.29775Isosinensetin
CAS:<p>1. Isosinensetin (6-Demethoxynobiletin) shows antioxidant and HIV-1 protease inhibiting activities.</p>Fórmula:C20H20O7Pureza:99.05% - ≥95%Forma y color:SolidPeso molecular:372.37Voacamine
CAS:<p>Voacamine: an indole alkaloid, CB1 antagonist, inhibits P-gp, may affect rhythm.</p>Fórmula:C43H52N4O5Pureza:98.54% - 99.82%Forma y color:SolidPeso molecular:704.9Tariquidar
CAS:<p>Tariquidar (XR9576)(Kd=5.1 nM) is a specific and effective non-competitive inhibitor of P-glycoprotein. It can reverse drug resistance in MDR cell Lines.</p>Fórmula:C38H38N4O6Pureza:98.07% - 99.45%Forma y color:SolidPeso molecular:646.73Selamectin
CAS:<p>Selamectin (UK-124114) is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in</p>Fórmula:C43H63NO11Pureza:99.84%Forma y color:SolidPeso molecular:769.96Phellamurin
CAS:<p>Phellamurin blocks intestinal P-glycoprotein dose-dependently and it seriously interacts with cyclosporin; coadministration should be avoided.</p>Fórmula:C26H30O11Pureza:97.91%Forma y color:SolidPeso molecular:518.51Sinapine
CAS:<p>Sinapine: an alkaloid with chemo-resistance, antioxidant, and radioprotective properties from cruciferous seeds.</p>Fórmula:C16H24NO5Pureza:98% - 99.68%Forma y color:White Or Light-Tan SolidPeso molecular:310.37Convallatoxin
CAS:<p>Convallatoxin is a natural product.</p>Fórmula:C29H42O10Pureza:99.27% - 99.53%Forma y color:Prisms From Methanol + Ether SolidPeso molecular:550.64Zosuquidar trihydrochloride
CAS:<p>Zosuquidar trihydrochloride (LY-335979 trihydrochloride) is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM. Phase 3.</p>Fórmula:C32H31F2N3O2·3HClPureza:99.49% - >99.99%Forma y color:SolidPeso molecular:636.99Hypophyllanthin
CAS:<p>Hypophyllanthin and phyllanthin have antitumour effects against Ehrlich Ascites Carcinoma in mice.</p>Fórmula:C24H30O7Pureza:98.39%Forma y color:SolidPeso molecular:430.49Zosuquidar
CAS:<p>Zosuquidar (RS 33295-198) is a potent P-glycoprotein inhibitor with antitumor activity that inhibits tumor growth.</p>Fórmula:C32H31F2N3O2Forma y color:SolidPeso molecular:527.6HM-30181 mesylate monohydrate
CAS:<p>HM-30181 mesylate monohydrate is an oral P-glycoprotein (P-gp) inhibitor, used to enhance the oral bioavailability of P-gp substrate drugs.</p>Fórmula:C39H42N6O11SPureza:99.37%Forma y color:SolidPeso molecular:802.85Encequidar
CAS:<p>Encequidar (HM30181A) is a potent and selective P-glycoprotein inhibitor.</p>Fórmula:C38H36N6O7Pureza:99.93%Forma y color:SolidPeso molecular:688.73Trifluoperazine
CAS:<p>Trifluoperazine (trifluoroperazine) is a Dopamine D2 receptor inhibitor(IC50 : 1.2 nM), and Treatment of schizophrenia.</p>Fórmula:C21H24F3N3SPureza:98.3% - 99.46%Forma y color:White To Yellowish Crystalline PowderPeso molecular:407.5γ-Tocotrienol
CAS:<p>γ-Tocotrienol (Plastochromanol) is one of the four types of tocotrienol, a type of vitamin E.</p>Fórmula:C28H42O2Pureza:97.27% - 98.13%Forma y color:SolidPeso molecular:410.63Sinapine thiocyanate
CAS:<p>Sinapine Thiocyanate, is a derivative of Sinapine (S486605), an alkaloidal amine found in black mustard seeds.</p>Fórmula:C16H24NO5·CNSPureza:99.79% - ≥95%Forma y color:SolidPeso molecular:368.45Talinolol
CAS:<p>(±)-Talinolol is a selective β1 adrenoceptor antagonist well known for its cardioprotective and antihypertensive activity.</p>Fórmula:C20H33N3O3Pureza:98.8%Forma y color:SolidPeso molecular:363.49Elacridar
CAS:<p>Elacridar (GG918) is a potent inhibitor of P-glycoprotein and BCRP.Cost-effective and quality-assured.</p>Fórmula:C34H33N3O5Pureza:98.12% - >99.99%Forma y color:SolidPeso molecular:563.64Chrysosplenetin
CAS:<p>Chrysosplenetin is a metabolic inhibitor of artemisinin.</p>Fórmula:C19H18O8Pureza:97.43% - 98.4%Forma y color:SolidPeso molecular:374.34HTT-D3
CAS:<p>HTT-D3 is a Huntington splicing regulator that induces HTT mRNA degradation, leading to a reduction in HTT protein levels.</p>Fórmula:C23H25FN6Pureza:99.31%Forma y color:SolidPeso molecular:404.48Verapamil
CAS:<p>Verapamil (CP-16533-1), an oral calcium channel blocker, inhibits P-gp and CYP3A4, used for hypertension, arrhythmias, and angina research.</p>Fórmula:C27H38N2O4Pureza:99.61% - 99.93%Forma y color:OilPeso molecular:454.6ONT-093
CAS:<p>ONT-093 (OC-144-093) is an oral P-glycoprotein (P-gp) inhibitor with potential anti-cancer activity, used in the study of myelodysplastic syndromes.</p>Fórmula:C32H38N4OPureza:98.86%Forma y color:SolidPeso molecular:494.67P-gp inhibitor 1
CAS:<p>P-gp inhibitor 1 inhibits reversing P-glycoprotein-mediated multidrug resistance with an EC50 of 57.9 nM (K562/A02 cells).</p>Fórmula:C32H31N5O2Pureza:98.65%Forma y color:SolidPeso molecular:517.62PGP-4008
CAS:<p>PGP-4008 is a selective and potent P-glycoprotein (Pgp) inhibitor that inhibits tumor growth by co-administration with Doxorubicin.</p>Fórmula:C26H23N3OPureza:98.07% - 98.95%Forma y color:SolidPeso molecular:393.48P-gp inhibitor 17
CAS:<p>P-gp Inhibitor 17 (compound 2g), a potent inhibitor, directly interacts with the transmembrane domain of P-gp. This compound is useful for studying P-gp-mediated multidrug resistance in tumor cells [1].</p>Fórmula:C36H49N3O3Forma y color:SolidPeso molecular:571.79coniferyl ferulate
CAS:<p>Coniferyl ferulate is a strong inhibitor of glutathione S-transferase (GST) isolated from Radix Angelicae sinensis.</p>Fórmula:C20H20O6Pureza:99.39%Forma y color:SolidPeso molecular:356.37MCI826
CAS:<p>MCI826 is a potent and selective antagonist of P-glycoprotein (P-gp) and peptide leukotrienes (p-LTs), showing anti-asthmatic activity in a guinea pig model of</p>Fórmula:C22H28N2O3SPureza:98.73%Forma y color:SolidPeso molecular:400.538-Prenylchrysin
CAS:<p>8-Prenylchrysin is a C8-isopentenyl flavonoid compound. It acts as an inhibitor of P-glycoprotein (P-gp) and can be utilized in cancer research.</p>Fórmula:C20H18O4Forma y color:SolidPeso molecular:322.354NSC73306
CAS:<p>NSC73306 is a thiosemicarbazone known for its role as a cell-permeable agent, exhibiting increased toxicity towards cells expressing p-glycoprotein.</p>Fórmula:C16H14N4O2SForma y color:SolidPeso molecular:326.373
