P-gp
La P-glicoproteína es una bomba de eflujo dependiente de ATP que transporta una amplia variedad de sustratos, incluidos medicamentos, toxinas y lípidos, fuera de las células. Desempeña un papel crucial en la resistencia a los medicamentos, particularmente en el cáncer, al reducir la concentración intracelular de agentes quimioterapéuticos. La P-gp también está involucrada en la barrera hematoencefálica, influyendo en la exposición del sistema nervioso central a varios compuestos. En CymitQuimica, ofrecemos una gama de moduladores de la P-gp para apoyar su investigación en resistencia a los medicamentos, farmacocinética y desarrollo terapéutico.
Se han encontrado 56 productos para "P-gp".
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ONT-093
CAS:ONT-093 (OC-144-093) is an oral P-glycoprotein (P-gp) inhibitor with potential anti-cancer activity, used in the study of myelodysplastic syndromes.Fórmula:C32H38N4OPureza:98.86%Forma y color:SolidPeso molecular:494.67coniferyl ferulate
CAS:Coniferyl ferulate is a strong inhibitor of glutathione S-transferase (GST) isolated from Radix Angelicae sinensis.Fórmula:C20H20O6Pureza:97.09% - 99.39%Forma y color:White SolidPeso molecular:356.37P-gp inhibitor 17
CAS:P-gp Inhibitor 17 (compound 2g), a potent inhibitor, directly interacts with the transmembrane domain of P-gp. This compound is useful for studying P-gp-mediated multidrug resistance in tumor cells [1].Fórmula:C36H49N3O3Forma y color:SolidPeso molecular:571.79NSC73306
CAS:NSC73306 is a thiosemicarbazone known for its role as a cell-permeable agent, exhibiting increased toxicity towards cells expressing p-glycoprotein.Fórmula:C16H14N4O2SForma y color:SolidPeso molecular:326.3738-Prenylchrysin
CAS:8-Prenylchrysin is a C8-isopentenyl flavonoid compound. It acts as an inhibitor of P-glycoprotein (P-gp) and can be utilized in cancer research.Fórmula:C20H18O4Forma y color:SolidPeso molecular:322.354P-gp-IN-30
CAS:P-gp-IN-30 (Compound 13) is an inhibitor of P-glycoprotein (P-gp) that targets YB-1. It reduces the expression of total YB-1 protein and nuclear YB-1 protein, thereby inhibiting the expression and function of downstream P-gp, which significantly enhances sensitivity to paclitaxel by inhibiting its efflux rate. When combined with paclitaxel, P-gp-IN-30 effectively suppresses tumor growth in A549/Taxol xenograft mouse models. This compound is useful for research on non-small cell lung cancer (NSCLC).Fórmula:C34H36N2O9Peso molecular:616.66
