P-gp
La P-glicoproteína es una bomba de eflujo dependiente de ATP que transporta una amplia variedad de sustratos, incluidos medicamentos, toxinas y lípidos, fuera de las células. Desempeña un papel crucial en la resistencia a los medicamentos, particularmente en el cáncer, al reducir la concentración intracelular de agentes quimioterapéuticos. La P-gp también está involucrada en la barrera hematoencefálica, influyendo en la exposición del sistema nervioso central a varios compuestos. En CymitQuimica, ofrecemos una gama de moduladores de la P-gp para apoyar su investigación en resistencia a los medicamentos, farmacocinética y desarrollo terapéutico.
Se han encontrado 64 productos para "P-gp".
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DM-4103
CAS:DM-4103 is a primary metabolite of Tolvaptan, predominantly metabolized by the CYP3A4 enzyme in the liver. In SCHH cells, DM-4103 inhibits the human liver transport proteins NTCP, BSEP, MRP2, MRP3, and MRP4 with IC50 values of 16.3, 4.15, 51.0, 44.6, and 4.26 μM, respectively, and affects bile acid transport. DM-4103 is applicable for research in autosomal dominant polycystic kidney disease (ADPKD).Fórmula:C26H23ClN2O5Peso molecular:478.92P-gp-IN-30
CAS:P-gp-IN-30 (Compound 13) is an inhibitor of P-glycoprotein (P-gp) that targets YB-1. It reduces the expression of total YB-1 protein and nuclear YB-1 protein, thereby inhibiting the expression and function of downstream P-gp, which significantly enhances sensitivity to paclitaxel by inhibiting its efflux rate. When combined with paclitaxel, P-gp-IN-30 effectively suppresses tumor growth in A549/Taxol xenograft mouse models. This compound is useful for research on non-small cell lung cancer (NSCLC).Fórmula:C34H36N2O9Peso molecular:616.66NSC73306
CAS:NSC73306 is a thiosemicarbazone known for its role as a cell-permeable agent, exhibiting increased toxicity towards cells expressing p-glycoprotein.Fórmula:C16H14N4O2SForma y color:SolidPeso molecular:326.373Doxorubamine
CAS:Doxorubamine, a derivative of Doxorubicin, serves as a weak substrate for P-glycoprotein and is effective in killing reagent-sensitive ovarian cancer.Fórmula:C27H30N2O10Peso molecular:542.54
