Canal de sodio
Los canales de sodio son proteínas de membrana esenciales que permiten el paso de iones de sodio (Na+) a través de la membrana celular, generando y propagando señales eléctricas en neuronas, células musculares y otros tejidos excitables. Estos canales son vitales para la iniciación y conducción de potenciales de acción, lo que los hace cruciales en procesos como la transmisión de impulsos nerviosos, la contracción muscular y la función cardíaca. La desregulación de los canales de sodio puede llevar a trastornos neurológicos, arritmias y condiciones de dolor crónico. En CymitQuimica, ofrecemos una variedad de moduladores de canales de sodio para apoyar su investigación en neurobiología, cardiología y manejo del dolor.
Se han encontrado 202 productos de "Canal de sodio"
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Mexiletine hydrochloride
CAS:<p>Mexiletine hydrochloride is a lidocaine-like antiarrhythmic (Class IB) and anesthetic, stabilizing heartbeats by inhibiting sodium in cardiac cells.</p>Fórmula:C11H18ClNOPureza:99.88%Forma y color:White To Off-White SolidPeso molecular:215.72DSP-2230
CAS:<p>DSP-2230 is a selective blocker of Nav1.7/Nav1.8.</p>Fórmula:C20H20F3N5O2Pureza:97.14%Forma y color:SolidPeso molecular:419.4Propafenone
CAS:<p>Propafenone: a drug for ventricular arrhythmias with mild beta-blocker activity, prolongs refractory period, and reduces heart automaticity.</p>Fórmula:C21H27NO3Pureza:99.02%Forma y color:SolidPeso molecular:341.44Eleclazine hydrochloride
CAS:<p>Eleclazine hydrochloride (GS 6615 hydrochloride) is a novel inhibitor of late Na+ current (IC50: 0.7 uM).</p>Fórmula:C21H17ClF3N3O3Pureza:99.86%Forma y color:SolidPeso molecular:451.83Ropivacaine
CAS:<p>Ropivacaine (LEA-103 HCl) is a local anaesthetic drug belonging to the amino amide group.</p>Fórmula:C17H26N2OPureza:97.75% - >99.99%Forma y color:SolidPeso molecular:274.40Nav1.8-IN-4
CAS:<p>Nav1.8-IN-4 is a potent Nav1.8 channel inhibitor with potential analgesic activity.Nav1.8-IN-4 can be used for pain and neurological related disorders.</p>Fórmula:C20H14F4N2O3Pureza:99.83%Forma y color:SoildPeso molecular:406.33Oxcarbazepine
CAS:<p>Oxcarbazepine (GP 47680), an anti-epileptic, reduces CNS disorganized electrical activity.</p>Fórmula:C15H12N2O2Pureza:98.46%Forma y color:Crystals From Ethanol SolidPeso molecular:252.27Tocainide hydrochloride
CAS:<p>Tocainide hydrochloride (2-amino-n-(2,6-dimethylphenyl)propanamide hydrochloride) is a sodium channel blocker.</p>Fórmula:C11H17ClN2OPureza:97%Forma y color:SolidPeso molecular:228.72Dibucaine
CAS:<p>Dibucaine (Cinchocaine), a local anesthetic of the amide type, is now usually used for surface anesthesia.</p>Fórmula:C20H29N3O2Pureza:99.698% - 99.88%Forma y color:Colorless Or Almost Colorless Powder SolidPeso molecular:343.46Phenytoin sodium
CAS:<p>Phenytoin sodium (Diphantoine) is an inactive stabilizer for voltage-gated sodium channel .</p>Fórmula:C15H11N2NaO2Pureza:99.88% - 99.92%Forma y color:SolidPeso molecular:274.25Ranolazine dihydrochloride
CAS:<p>Ranolazine 2HCl, an antianginal, treats arrhythmia by inhibiting sodium current without changing blood pressure or heart rate.</p>Fórmula:C24H35Cl2N3O4Pureza:99.30% - >99.99%Forma y color:White Crystalline PowderPeso molecular:500.46Bupivacaine hydrochloride
CAS:<p>Bupivacaine hydrochloride (Vivacaine) is a long-lasting, amide local anesthetic that blocks sodium channels, inhibiting nerve impulses and sensation.</p>Fórmula:C18H28N2O·HClPureza:99.9% - >99.99%Forma y color:SolidPeso molecular:324.89PF-04885614
CAS:<p>PF-04885614 is a potent inhibitor of NaV1.8, has potential for neurological and neurodevelopmental diseases treatment.</p>Fórmula:C13H14F3N3OPureza:98.02%Forma y color:SolidPeso molecular:285.27Butamben
CAS:<p>Butamben (Butyl 4-aminobenzoate) is a long-duration local anesthetic used for the treatment of chronic pain.</p>Fórmula:C11H15NO2Pureza:99.43%Forma y color:Crystals From Alc Physical Description Yellow Powder Insoluble In Water (Ntp 1992)Peso molecular:193.24Amitriptyline hydrochloride
CAS:<p>Amitriptyline hydrochloride (Annoyltin) is the hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and antinociceptive</p>Fórmula:C20H24ClNPureza:97% - 99.94%Forma y color:Crystals White To Off-White PowderPeso molecular:313.86Oxybuprocaine hydrochloride
CAS:<p>Oxybuprocaine hydrochloride (Oxybuprocaine HCl), a local anesthetic, is used especially in otolaryngology and ophthalmology.</p>Fórmula:C17H29ClN2O3Pureza:>99.99%Forma y color:White Crystalline PowderPeso molecular:344.88Diphenidol hydrochloride
CAS:<p>Diphenidol hydrochloride (Difenidol hydrochloride), a muscarinic antagonist, is employed as an anti-vertigo and as an antiemetic drug.</p>Fórmula:C21H28ClNOPureza:99.15% - 99.33%Forma y color:Crystals Soluble In Methanol WaterPeso molecular:345.91E 0747 FA
<p>E 0747 FA is an antiarrhythmic compound that inhibits the voltage of action potential Vmax in Purkinje fibers of porcine heart.E 0747 FA inhibits Na channels in cardiac cells.</p>Fórmula:C22H30ClN3O6Pureza:98.54%Forma y color:SolidPeso molecular:467.94NaV1.7 inhibitor-1
CAS:<p>NaV1.7 inhibitor-1, an efficacious inhibitor of voltage-gated sodium channel (NaV) 1.7 (IC50 of 0.6 nM for hNaV1.7).</p>Fórmula:C23H30FNO4SPureza:99.89%Forma y color:SolidPeso molecular:435.55Articaine hydrochloride
CAS:<p>Articaine hydrochloride (Hoe-045) is a thiophene-containing local anesthetic pharmacologically similar to MEPIVACAINE.</p>Fórmula:C13H21ClN2O3SPureza:99.76%Forma y color:White Crystalline PowderPeso molecular:320.84Ropivacaine hydrochloride
CAS:<p>Ropivacaine hydrochloride (Ropivacaine monohydrochloride) is the hydrochloride salt of ropivacaine, a local anesthetic of the amide type with analgesic activity</p>Fórmula:C17H26N2O·HClPureza:99.85% - 99.95%Forma y color:SolidPeso molecular:310.86Primidone
CAS:<p>Primidone (NCI-C56360) is a potent anticonvulsant agent.</p>Fórmula:C12H14N2O2Pureza:99.91%Forma y color:Crystals (Ntp 1992)Peso molecular:218.25Amiloride hydrochloride
CAS:<p>Amiloride hydrochloride (Amiloride HCl) 是上皮钠通道和尿激酶型纤溶酶原激活物受体的抑制剂，也是 polycystin-2通道阻断剂。</p>Fórmula:C6H9Cl2N7OPureza:99.72% - 99.95%Forma y color:Physical Description Crystalline Solid Or Very Light Yellow Powder (Ntp 1992)Peso molecular:266.09Tocainide
CAS:<p>Tocainide is a blocker of the sodium channel and used for the treatment of tinnitus.</p>Fórmula:C11H16N2OPureza:99.84%Forma y color:SolidPeso molecular:192.26Lidocaine
CAS:<p>Lidocaine, an amide local anesthetic, reduces pain and inflammation by dampening ICAM-1, cytokines, and neutrophil influx.</p>Fórmula:C14H22N2OPureza:99.95% - >99.99%Forma y color:Needles From Benzene Or Alcohol SolidPeso molecular:234.34BIIB 722 Mesylate
CAS:<p>BIIB 722 Mesylate is a sodium-hydrogen exchange inhibitor with cardioprotective properties and can be used to study myocardial ischemia.</p>Fórmula:C19H23F3N6O5SPureza:99.57%Forma y color:SoildPeso molecular:504.483Vinpocetine
CAS:<p>Vinpocetine (RGH-4405) is a selective inhibitor of cyclic GMP phosphodiesterase (PDE).</p>Fórmula:C22H26N2O2Pureza:99.85% - 99.98%Forma y color:White Crystalline SolidPeso molecular:350.45Topiramate
CAS:<p>Topiramate (RWJ 17021) is a unique antiseizure medication that is used in the treatment of partial and generalized seizures.</p>Fórmula:C12H21NO8SPureza:99.79% - 99.92%Forma y color:White To Off-White Crystalline PowderPeso molecular:339.36Flunarizine dihydrochloride
CAS:<p>Flunarizine dihydrochloride: a calcium blocker also targeting calmodulin and histamine H1, used for migraine, vertigo, vascular disease, and epilepsy aid.</p>Fórmula:C26H28Cl2F2N2Pureza:99.53% - 99.89%Forma y color:White Crystalline Powder Odorless And TastelessPeso molecular:477.42Meticrane
CAS:<p>Meticrane (Arresten) is a sulphonamide-derivative with thiazide-like diuretic activity.</p>Fórmula:C10H13NO4S2Pureza:99.16%Forma y color:SolidPeso molecular:275.34Benzocaine
CAS:<p>Benzocaine is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings.</p>Fórmula:C9H11NO2Pureza:99.16% - 99.88%Forma y color:Rhombohedra From Ether DrypowderPeso molecular:165.19Brompheniramine maleate
CAS:<p>Brompheniramine maleate (Dimotane) is an antagonist against histamine H1 receptors.</p>Fórmula:C16H19BrN2·C4H4O4Pureza:99.80%Forma y color:Crystal PowderPeso molecular:435.31QX-314 chloride
CAS:<p>QX-314 chloride is a membrane-impermeable permanently charged blocker of sodium channel.</p>Fórmula:C16H27ClN2OPureza:99.73%Forma y color:SolidPeso molecular:298.85Disopyramide
CAS:<p>Disopyramide, or Triombrin, a class I anti-arrhythmic with membrane-stabilizing effects, has heart depressant, anticholinergic, and anesthetic properties.</p>Fórmula:C21H29N3OPureza:99.62%Forma y color:SolidPeso molecular:339.47Phenytoin
CAS:<p>Phenytoin: a non-sedative hydantoin, antiepileptic with anticonvulsant effects, stabilizes neurons, prevents seizure spread, and relaxes muscles.</p>Fórmula:C15H12N2O2Pureza:99.95%Forma y color:Needles (Alcohol) Tasteless (Ntp 1992)Peso molecular:252.27Phenazopyridine hydrochloride
CAS:<p>Phenazopyridine HCl, an oral urinary analgesic, may cause nausea, anemia, and liver/kidney toxicity. Possibly carcinogenic.</p>Fórmula:C11H12ClN5Pureza:99.27%Forma y color:Brownish-Yellow Crystals Aqueous Solutions Are Yellow To Brick-Red And Slightly Acidic; They May Be Stabilized By The AdditionPeso molecular:249.7Lidocaine hydrochloride
CAS:<p>Lidocaine HCl: local anesthetic, antiarrhythmic, stronger & longer-lasting than procaine but shorter than bupivacaine/prilocaine.</p>Fórmula:C14H23ClN2OPureza:99.81% - 99.92%Forma y color:White Crystal PowderPeso molecular:270.798Lamotrigine
CAS:<p>Lamotrigine (BW430C) is an Anti-epileptic Agent and Mood Stabilizer.</p>Fórmula:C9H7Cl2N5Pureza:99.76% - 99.95%Forma y color:White To Pale Cream-Colored Powder Crystals From Isopropanol SolidPeso molecular:256.09Methocarbamol
CAS:<p>Methocarbamol (AHR 85) is a centrally acting muscle relaxant whose mode of action has not been established.</p>Fórmula:C11H15NO5Pureza:99.96%Forma y color:Crystals From Benzene SolidPeso molecular:241.24Mebeverine hydrochloride
CAS:<p>Mebeverine hydrochloride (Colofac Hydrochloride), a β-phenylethylamine derivative, is a potent α1 repector inhibitor, relaxing the muscles in and around the gut</p>Fórmula:C25H35NO5Pureza:99.81% - 99.81%Forma y color:SolidPeso molecular:429.55Lidocaine Hydrochloride hydrate
CAS:<p>Lidocaine Hydrochloride hydrate is an amide local anesthetic, has anti-inflammatory property.</p>Fórmula:C14H22N2O·HCl·H2OPureza:99.95%Forma y color:SolidPeso molecular:288.825-Tridecanol
CAS:<p>5-Tridecanol blocks ion flux in sodium channels.</p>Fórmula:C13H28OPureza:97.87%Forma y color:SolidPeso molecular:200.36Nav1.7-IN-18
<p>Nav1.7-IN-18 (Compound 31) is a Nav1.7 inhibitor with a Ki value of 4.9 nM and an IC50 of 13 nM, demonstrating analgesic effects in transgenic mice with inherited erythromelalgia (IEM).</p>Fórmula:C30H33Cl2F2NO4Forma y color:SolidPeso molecular:580.49Indenebart
<p>Indenebart is a humanized IgG1λ2 monoclonal antibody targeting SNCA, with HumanIgG1lambda2, Isotype Control serving as the corresponding isotype control.</p>Forma y color:Odour LiquidCL-424032
CAS:<p>CL-424032 is an inhibitor of sodium channels (sodium channel).</p>Fórmula:C12H7F3N4O2Forma y color:SolidPeso molecular:296.21LTGO-33
CAS:<p>LTGO-33 is a voltage-gated sodium channel NaV1.8 inhibitor that inhibits NaV1.8, NaV1.1-NaV1.7, and NaV1.9.</p>Fórmula:C21H17F4N3O3SPureza:97.6%Forma y color:SoildPeso molecular:467.44ASG-5ME
<p>ASG-5ME is a drug-antibody coupling targeting SLC44A4 that shows anti-tumor activity in xenograft models and may be used to study pancreatic and gastric cancer.</p>Pureza:98.1% (SDS-PAGE); 98.5% (SEC-HPLC) - 98.1% (SDS-PAGE); 98.5% (SEC-HPLC)Forma y color:LiquidPeso molecular:145.5 kDaSodium Channel Targeted Library
<p>A unique collection of xnum sodium channel blockers and agonists for high throughput and high content screening;</p>Forma y color:Odour SolidTrapencaine
CAS:<p>Trapencaine is a newly synthesized carbamate type local anesthetic that induces conformational changes in sodium channels on hypertrophic cell membranes.</p>Fórmula:C22H34N2O3Pureza:98.96%Forma y color:SolidPeso molecular:374.52Zoniporide
CAS:<p>Zoniporide (CP-597396) is an NHE-1 inhibitor that inhibits platelet swelling and can be used in the study of cardiovascular diseases.</p>Fórmula:C17H16N6OPureza:99.74%Forma y color:SolidPeso molecular:320.35Amlenetug
<p>Amlenetug is a humanized IgG1κ antibody targeting SNCA, with its corresponding isotype control being HumanIgG1kappa, Isotype Control.</p>Forma y color:Odour LiquidETD001
CAS:<p>ETD001 is a long-acting ENaC inhibitor with an IC50 value of 57.5 nM in HBE cells. It is applicable for research in cystic fibrosis.</p>Fórmula:C41H57F6N9O16Forma y color:SolidPeso molecular:1045.93Ion Channel Targeted Library
<p>A unique collection of 931 compounds targeting ion channels for research in ion channels-related diseases and ion channel drug discovery;</p>Forma y color:Odour SolidSolpecainol
CAS:<p>solpecainol is a sodium channel blocker used in the study of neurological and cardiovascular diseases.</p>Fórmula:C18H23NO3Pureza:99.71%Forma y color:SoildPeso molecular:301.38Benzonatate (PEGn)
CAS:<p>Benzonatate (PEGn) is a unique non-narcotic cough suppressant featuring sodium channel blocking properties and anesthetic effects on respiratory tract stretch receptors.</p>Fórmula:(C2H4O)nC12H17NO2Forma y color:SolidProTx II
CAS:<p>Selective NaV1.7 inhibitor, alters activation, reduces current, 100x more selective for 1.7 over other Na+ channels.</p>Fórmula:C168H250N46O41S8Pureza:98%Forma y color:SolidPeso molecular:3826.59Mambalgin 1
CAS:<p>ASIC1a inhibitor; IC50: 192 nM (human), 72 nM (dimer); inactive channel binding; selective; pain response delay.</p>Fórmula:C272H429N85O84S10Pureza:98%Forma y color:SolidPeso molecular:6554.51APETx2
CAS:<p>ASIC3 inhibitor; IC50: 63 nM (rat), 175 nM (human). Blocks NaV1.8, NaV1.2; analgesic for acid/inflammatory pain.</p>Fórmula:C196H280N54O61S6Pureza:98%Forma y color:SolidPeso molecular:4561.06Zandatrigine
CAS:<p>Zandatrigine (NBI-921352) is a blocker of sodium channel protein type 8 subunit alpha and can be used in studies about nervous system pathologies of epilepsy</p>Fórmula:C22H25FN4O2S2Pureza:99.98%Forma y color:SolidPeso molecular:460.59Mepivacaine hydrochloride
CAS:<p>Mepivacaine hydrochloride (Mepivacaine HCl) is the hydrochloride salt form of mepivacaine, an amide derivative with local anesthetic properties.</p>Fórmula:C15H22N2O·HClPureza:98.76% - 99.94%Forma y color:White Or Off White Crystalline PowderPeso molecular:282.81PF-06456384 trihydrochloride
CAS:<p>PF-06456384 trihydrochloride is a selective NaV1.7 inhibitor acting through protein-ligand binding. intravenous infusion and pain research.</p>Fórmula:C35H35Cl3F3N7O3S2Pureza:99.16%Forma y color:SolidPeso molecular:829.181-(1-Methyl-1h-pyrazol-4-yl)-ethanone
CAS:<p>1-(1-Methyl-1h-pyrazol-4-yl)-ethanone is a high purity biochemical reagent that can be used in research related to life sciences.</p>Fórmula:C6H8N2OPureza:99.92%Forma y color:SolidPeso molecular:124.14Myomodulin
CAS:<p>Myomodulin is a neuropeptide present in molluscs, insects, and gastropods.Myomodulin is present in two identified aplysia neurons that contain myomodulin A the</p>Fórmula:C36H67N11O8S2Pureza:98%Forma y color:SolidPeso molecular:846.12SLC26A3-IN-2
CAS:<p>Vilobelimab (CaCP-29) is a human-mouse chimeric IgG antibody targeting human complement component 5a, a C5a inhibitor that inhibits neutrophil activation.</p>Fórmula:C19H13ClN2O2SPureza:99.86%Forma y color:SolidPeso molecular:368.84Nav1.3 channel inhibitor 1
<p>Nav1.3 Channel Inhibitor 1 (Compound 15b) is a state-dependent inhibitor of the voltage-gated sodium channel Na v 1.3, with an IC50 value of 20 nM.</p>Fórmula:C19H15F2N3O3S2Pureza:98%Forma y color:SolidPeso molecular:435.47Zoniporide hydrochloride
CAS:<p>Zoniporide hydrochloride: selective NHE-1 inhibitor, IC50 14 nM, >150x selectivity over other NHEs, inhibits platelet swelling (IC50 59 nM).</p>Fórmula:C17H17ClN6OPureza:99.68%Forma y color:SolidPeso molecular:356.81GpTx-1 TFA
<p>GpTx-1 TFA is a polypeptide NaV1.7 sodium channel antagonist isolated from the venom of the Chilean spider Grammostola porter. It exhibits potent inhibitory activity on the NaV1.7 channel with an IC50 value of 10 nM, demonstrating excellent selectivity over NaV1.4 (IC50 = 0.301 μM) and NaV1.5 (IC50 = 4.20 μM) with >20-fold and >950-fold selectivity, respectively.</p>Forma y color:Odour SolidVeratridine
CAS:<p>Veratridine is a benzoate-cevane found in Veratrum and Schoenocaulon. It activates sodium channels to stay open longer than normal.</p>Fórmula:C36H51NO11Pureza:98.07% - 99.27%Forma y color:Yellowish-White Amorphous Powder PowderPeso molecular:673.79Ancistrotecine B
<p>Ancistrotecine B (Compound 2), a Nav1.7 channel inhibitor (IC50: 0.73 μM), has been shown to alleviate inflammatory pain in mice [1].</p>Fórmula:C26H31NO4Pureza:98%Forma y color:SolidPeso molecular:421.53Lifarizine FA
<p>Lifarizine FA is a sodium channel blocker used in the treatment of neurological disorders and cardiovascular diseases, study of stroke.</p>Fórmula:C30H34N4O2Pureza:99.55%Forma y color:SolidPeso molecular:482.62GX 201
CAS:<p>GX 201 is a selective NaV1.7 inhibitor, IC50 of < 3.2 nM for hNaV1.7.</p>Fórmula:C25H27ClF4N2O4SPureza:99.81%Forma y color:SolidPeso molecular:563Phrixotoxin 3
CAS:<p>Potent NaV blocker: IC50 - 0.6 nM (NaV1.2), 42 nM (NaV1.3), 72 nM (NaV1.5); voltage-dependent inhibition.</p>Fórmula:C176H269N51O48S6Pureza:98%Forma y color:SolidPeso molecular:4059.74OD1
<p>Activates rat Nav1.7, human Nav1.4, rat Nav1.6 (EC50: 7, 10, 47 nM); minimal on Nav1.2, 1.3, 1.5 (EC50 >3 μM); blocks fast inactivation; triggers pain.</p>Fórmula:C308H466N90O95S8Pureza:98%Forma y color:SolidPeso molecular:7206.1Huwentoxin-IV
CAS:<p>Selective NaV1.7 blocker; also inhibits NaV1.2, 1.3; less effect on NaV1.4, 1.5. Binds to neurotoxin site, traps voltage sensor. IC50: 26-338 nM.</p>Fórmula:C174H278N52O51S6Pureza:98%Forma y color:SolidPeso molecular:4106.79ProTx II TFA
<p>ProTx-II TFA is a potent and highly selective Nav1.7 sodium channel blocker, exhibiting an IC50 of 0.3 nM and demonstrating at least 100-fold selectivity over</p>Fórmula:C168H250N46O41S8·xC2HF3O2Pureza:98%Forma y color:SolidPeso molecular:3826.59 (free base)NHE-1-IN-2
NHE-1-IN-2 (compound 7g) is a potent NHE-1 inhibitor with an IC50 of 0.78 μM. It mitigates left ventricular systolic dysfunction in mouse models of heart failure.Fórmula:C23H20ClN3O3Forma y color:SolidPeso molecular:421.11932Halazone
CAS:<p>Halazone (Pantocid) is fine white powder with an odor of chlorine. It has been widely used to disinfect drinking water.</p>Fórmula:C7H5Cl2NO4SPureza:98.64%Forma y color:Physical Description Fine White Powder With An Odor Of Chlorine (Ntp 1992)Peso molecular:270.09Analgesic agent-2
<p>Analgesic Agent-2, a selective orally active inhibitor of the NaV1.8 channel, demonstrates an IC50 of 50.18 nM in HEK293 cells that stably express the human</p>Fórmula:C21H21ClF2N4O2Pureza:98%Forma y color:SolidPeso molecular:434.87Bulleyaconitine A
CAS:<p>Bulleyaconitine A, an analgesic and antiinflammatory drug isolated from Aconitum plants, has several potential targets, such as voltage-gated Na+ channels.</p>Fórmula:C35H49NO9Pureza:99.56% - 99.76%Forma y color:SolidPeso molecular:627.76AM-2099
CAS:<p>AM-2099 is a selective voltage-gated sodium channel Nav1.7 inhibitor used in pain research.</p>Fórmula:C19H13F3N4O3S2Forma y color:SolidPeso molecular:466.46Dibucaine hydrochloride
CAS:<p>Dibucaine hydrochloride (Cinchocaine hydrochloride), a long-acting local amide anestheticsis, is usually used for surface anesthesia.</p>Fórmula:C20H30ClN3O2Pureza:99.66%Forma y color:White PowderPeso molecular:379.92Poneratoxin acetate
<p>Poneratoxin acetate is a neurotoxic peptide and modulator of NaV1.6/NaV1.7, lowering the activation threshold of voltage-gated sodium channels and causing pain.</p>Fórmula:C129H215N33O31S·xC2H4O2Forma y color:SolidPeso molecular:2756.35 (free base)PF-04856264
CAS:<p>PF-04856264 is a Nav1.7 blocker.,modulates intracellular Ca 2+ signaling and chondrocyte secretome, raises the threshold of mechanical pain analgesic.</p>Fórmula:C20H15N5O3S2Pureza:97.43%Forma y color:SolidPeso molecular:437.5Ethacizine hydrochloride
CAS:<p>Ethacizine hydrochloride (NIK-244) has antiarrhythmic activity and can be used to study arrhythmias and myocardial infarction.</p>Fórmula:C22H28ClN3O3SPureza:98.08% - 98.08%Forma y color:SolidPeso molecular:449.99Mexiletine-d6 hydrochloride
CAS:<p>Mexiletine D6 hydrochloride is a non-selective voltage-gated sodium channel blocker,is a Class IB antianhythmic.</p>Fórmula:C11H18ClNOPureza:98%Forma y color:SolidPeso molecular:221.76Mepivacaine
CAS:<p>Mepivacaine (Carbocaine) is an amide local anesthetic, blocking sodium channels for nerve blocks and epidurals.</p>Fórmula:C15H22N2OPureza:99.35%Forma y color:SolidPeso molecular:246.35Triamterene D5
CAS:<p>Triamterene D5 is a deuterium-labeled Triamterene and can block epithelial Na+ channel (ENaC) in a voltage-dependent manner, used as a mild diuretic.</p>Fórmula:C12H11N7Pureza:98%Forma y color:SolidPeso molecular:258.29BI-9627
CAS:<p>BI-9627 is an inhibitor of sodium-hydrogen exchanger isoform 1 (NHE1) (EC50: 31 nM).</p>Fórmula:C16H19F3N4O2Pureza:99.77%Forma y color:SolidPeso molecular:356.34Pilsicainide HCl
CAS:<p>Pilsicainide HCl (SUN 1165) is a pure sodium channel blocker</p>Fórmula:C17H25ClN2OPureza:99.01% - 99.80%Forma y color:SolidPeso molecular:308.85Ropivacaine hydrochloride monohydrate
CAS:<p>Ropivacaine hydrochloride monohydrate (LEA-103 HCl) is an anaesthetic agent and blocks impulse conduction through inhibiting sodium ion influx reversibly.</p>Fórmula:C17H29ClN2O2Pureza:99.94% - 99.95%Forma y color:White SolidPeso molecular:328.88GNE-131
CAS:<p>GNE-131 is a potent and specific inhibitor of human sodium channel NaV1.7 (IC50: 3 nM).</p>Fórmula:C23H30N4O3SPureza:98.54% - 99.59%Forma y color:SolidPeso molecular:442.57Flecainide acetate
CAS:<p>Flecainide acetate (R-818) is a class Ic antiarrhythmic agent used to prevent and treat tachyarrhythmias (abnormal fast rhythms of the heart).</p>Fórmula:C19H24F6N2O5Pureza:99.42%Forma y color:SolidPeso molecular:474.39Fosphenytoin disodium
CAS:<p>Fosphenytoin disodium (ACC-9653) is a prodrug of phenytoin that is rapidly converted to phenytoin, a voltage-gated sodium channel blocker</p>Fórmula:C16H13N2Na2O6PPureza:99.97%Forma y color:White Crystalline PowderPeso molecular:406.24DS-1971a
CAS:<p>DS-1971a is a highly potent and selective NaV1.7 inhibitor. DS-1971a exhibits a favorable toxicological profile and analgesic effects.</p>Fórmula:C20H21ClFN5O3SPureza:99.66%Forma y color:SolidPeso molecular:465.93Cariporide
CAS:<p>Cariporide (HOE-642), an NHE1 inhibitor, reduces human platelet degranulation, platelet-leukocyte aggregates, and GPIIb/IIIa activation.</p>Fórmula:C12H17N3O3SPureza:95.4% - 99.88%Forma y color:SolidPeso molecular:283.35Rimeporide hydrochloride
CAS:<p>Rimeporide hydrochloride (EMD-87580 hydrochloride) is a potent and selective Sodium hydrogen exchange 1 (NHE-1) inhibitor.</p>Fórmula:C11H16ClN3O5S2Pureza:99.82%Forma y color:SolidPeso molecular:369.84Licarbazepine
CAS:<p>Licarbazepine (10,11-hydroxy-10,11 Dihydrocarbamezer) is the pharmacologically active metabolite of oxcarbazepine, a drug indicated for the treatment of partial</p>Fórmula:C15H14N2O2Pureza:99.11%Forma y color:SolidPeso molecular:254.28Nav1.8-IN-1
CAS:<p>Nav1.8-IN-1 (CHEMBL1270208) is an inhibitor of human NaV1.8</p>Fórmula:C20H15ClF3N3O2Pureza:97.59%Forma y color:SolidPeso molecular:421.8QX-222 chloride
CAS:<p>QX-222 chloride (Lidocaine N-Methyl Hydrochloride) is a sodium channel blocker.</p>Fórmula:C13H21ClN2OPureza:97.37%Forma y color:SolidPeso molecular:256.77Carbamazepine
CAS:<p>Carbamazepine: a tricyclic with anticonvulsant and analgesic effects, treats trigeminal neuralgia.</p>Fórmula:C15H12N2OPureza:99.78% - 99.79%Forma y color:SolidPeso molecular:236.27λ-Cyhalothrin
CAS:<p>λ-Cyhalothrin (Icon) is a type II synthetic pyrethroid insecticide featuring a high-efficiency, broad-spectrum formula with an α-cyano group.</p>Fórmula:C23H19ClF3NO3Pureza:99.76%Forma y color:SolidPeso molecular:449.85Rimeporide
CAS:<p>Rimeporide (EMD-87580) (EMD-87580) is a potent and selective Sodium hydrogen exchange 1 (NHE-1) inhibitor.</p>Fórmula:C11H15N3O5S2Pureza:97.66%Forma y color:SolidPeso molecular:333.38Flecainide hydrochloride
CAS:<p>Flecainide is a medication used to prevent and treat abnormally fast heart rates. This includes ventricular and supraventricular tachycardias.</p>Fórmula:C17H21ClF6N2O3Pureza:97.79%Forma y color:SolidPeso molecular:450.81Raxatrigine
CAS:<p>Raxatrigine (CNV 1014802) has been investigated for the treatment of Bipolar Disorder and Bipolar Depression.</p>Fórmula:C18H19FN2O2Pureza:98% - 99.43%Forma y color:SolidPeso molecular:314.35N-Me-aminopyrimidinone9
CAS:<p>N-Me-aminopyrimidinone9 is a sodium channel antagonist</p>Fórmula:C16H21N3OSPureza:99.21%Forma y color:SolidPeso molecular:303.42Levobupivacaine
CAS:<p>Levobupivacaine is an amino-amide local anaesthetic drug belonging to the family of n-alkylsubstituted pipecoloxylidide.</p>Fórmula:C18H28N2OPureza:99.72%Forma y color:SolidPeso molecular:288.43Propafenone hydrochloride
CAS:<p>Propafenone hydrochloride (Arythmol8) is a classic anti-arrhythmic medication, which treats illnesses associated with rapid heartbeats such as atrial.</p>Fórmula:C21H27NO3·HClPureza:99.67%Forma y color:White SolidPeso molecular:377.9Benzocaine xHCl(94-09-7(free base))
<p>Benzocaine shares a common receptor with all othe rLAs in the voltage-gated Na+ channel(IC50 of 0.8 mM tested with a potential of +30 mV).</p>Fórmula:C9H11NO2·xHClPureza:99.37%Forma y color:SolidPeso molecular:N/AVX-150
CAS:<p>VX-150 is a highly selective NaV1.8 inhibitor relative to the other sodium channel subtypes (>400-fold).</p>Fórmula:C21H17F4N2O7PPureza:97.58%Forma y color:SolidPeso molecular:516.34PF-01247324
CAS:<p>PF-01247324 is a selective and orally bioavailable Nav1.8 channel blocker (IC50: 196 nM).</p>Fórmula:C13H10Cl3N3OPureza:99.22%Forma y color:SolidPeso molecular:330.6PF 05089771
CAS:<p>PF 05089771 is a Selective inhibitor of Nav1.7 (IC50 = 11 nM) that interacts with the voltage-sensor domain of domain IV.</p>Fórmula:C18H12Cl2FN5O3S2Pureza:99.03% - 99.42%Forma y color:SolidPeso molecular:500.35PF-05186462
CAS:<p>PF-05186462 (PF-05150122) is a potent, state-dependent, subtype selective Nav1.7 inhibitor with IC50 of 21 nM, no significant activity against Nav1.5.</p>Fórmula:C19H10ClF4N5O3S2Pureza:99.10% - 99.37%Forma y color:SolidPeso molecular:531.89Ralfinamide mesylate
CAS:<p>Ralfinamide mesylate (FCE-26742A (mesylate)) is an orally available Na+ channel blocker.</p>Fórmula:C18H23FN2O5SPureza:99.83%Forma y color:SolidPeso molecular:398.45Ajmaline
CAS:<p>Ajmaline, a class Ia anti-arrhythmic, diagnoses Brugada syndrome and treats tachycardia; inhibits cardiac Kv1.5/Kv4.3 channels.</p>Fórmula:C20H26N2O2Pureza:99.67% - 99.87%Forma y color:SolidPeso molecular:326.43ICA-121431
CAS:<p>ICA-121431: a potent Nav1.7 inhibitor (IC50=19 nM for rat), minimal effect on human Nav1.5/Nav1.7.</p>Fórmula:C23H19N3O3S2Pureza:98.06%Forma y color:SolidPeso molecular:449.55(+)-Kavain
CAS:<p>(+)-Kavain ((R)-KAWAIN) is one of the six major kavalactones found in the Piper methysticum (kava) plant; reversible inhibitor of MAO-B.</p>Fórmula:C14H14O3Pureza:97% - ≥95%Forma y color:White Fine PowderPeso molecular:230.26Benzamil
CAS:<p>Benzamil blocks ENaC, inhibiting sodium transport (IC50=4 nM) and binds with Kd=5 nM to bovine kidney membranes.</p>Fórmula:C13H14ClN7OPureza:99.79%Forma y color:SolidPeso molecular:319.7520(S)-Ginsenoside Rg3
CAS:<p>20(S)-Ginsenoside Rg3 (Rg3) possess an ability to inhibit the lung metastasis of tumor cells via inhibition of the adhesion and invasion of tumor cells.</p>Fórmula:C42H72O13Pureza:98.11% - 99.93%Forma y color:SolidPeso molecular:785.01Dronedarone
CAS:<p>Dronedarone (SR 33589) is an amiodarone analogue which has an effective and promising treatment for Atrial fibrillation.</p>Fórmula:C31H44N2O5SPureza:98.85% - 99.58%Forma y color:SolidPeso molecular:556.76Evenamide
CAS:<p>Evenamide (NW-3509) is a sodium channel blocker. Which shows efficacy in a broad spectrum of rodent models of psychosis, mania, depression, and aggressiveness.</p>Fórmula:C16H26N2O2Pureza:96.74% - 99.15%Forma y color:SolidPeso molecular:278.39Metaflumizone
CAS:<p>Metaflumizone (BAS-320I) is a sodium channel blocker insecticide.</p>Fórmula:C24H16F6N4O2Pureza:98.73%Forma y color:SolidPeso molecular:506.40Cyfluthrin
CAS:<p>Cyfluthrin binds to voltage-sensitive sodium channel such as Nav 1.8 sodium channel and modify their gating kinetics, thereby disrupting nerve function of pests</p>Fórmula:C22H18Cl2FNO3Pureza:99.76%Forma y color:SolidPeso molecular:434.29A-803467
CAS:<p>A-803467 is a selective NaV1.8 channel blocker.</p>Fórmula:C19H16ClNO4Pureza:96.94% - 98%Forma y color:SolidPeso molecular:357.79Metergoline
CAS:<p>Metergoline (Methergoline) is a dopamine agonist and serotonin antagonist.</p>Fórmula:C25H29N3O2Pureza:99.83% - 99.97%Forma y color:SolidPeso molecular:403.52Tenapanor
CAS:<p>Tenapanor (RDX 5791), an NHE3 inhibitor, regulates sodium in the gut and kidney with a strong preclinical safety record and minimal side effects.</p>Fórmula:C50H66Cl4N8O10S2Pureza:99.49% - 99.85%Forma y color:SolidPeso molecular:1145.05Dimethyl lithospermate B
CAS:<p>Dimethyl lithospermate B (dmLSB) is a selective Na+ channel agonist.</p>Fórmula:C38H34O16Pureza:98.34% - 99.62%Forma y color:SolidPeso molecular:746.67Eslicarbazepine Acetate
CAS:<p>Eslicarbazepine Acetate (Zebinix) is an anticonvulsant medication approved for use as an adjunctive therapy for partial-onset seizures.</p>Fórmula:C17H16N2O3Pureza:99.58% - >99.99%Forma y color:White To Off-White SolidPeso molecular:296.32Nicainoprol
CAS:<p>Nicainoprol (RU-42924) is a fast-sodium-channel blocking drug. Nicainoprol is a potent antiarrhythmic agent.</p>Fórmula:C21H27N3O3Pureza:99.54%Forma y color:SolidPeso molecular:369.46Sodium ionophore III
CAS:<p>Sodium ionophore III (ETH2120) is a Na+ ionophore suitable for the test of sodium activity in plasma, serum, and blood.</p>Fórmula:C34H52N2O4Pureza:99.51% - 99.78%Forma y color:SolidPeso molecular:552.79BI 01383298
CAS:<p>BI 01383298 is a selective inhibitor of the sodium-citrate co-transporter (SLC13A5).</p>Fórmula:C19H19Cl2FN2O3SPureza:99.71%Forma y color:SolidPeso molecular:445.34GS967
CAS:<p>GS967 is a potent, and selective inhibitor of cardiac late sodium current (late INa ).</p>Fórmula:C14H7F6N3OPureza:98% - >99.99%Forma y color:SolidPeso molecular:347.22Ranolazine
CAS:<p>Ranolazine (RS 43285-003) inhibits calcium uptake, treats chronic angina by targeting sodium/calcium channels to modulate intracellular sodium.</p>Fórmula:C24H33N3O4Pureza:98.13%Forma y color:White SolidPeso molecular:427.54AZ194
CAS:<p>CRMP2-Ubc9-NaV1.7 inhibitor 194, is a CRMP2-Ubc9-NaV1.7 inhibitor.</p>Fórmula:C34H31F2N3O3Pureza:99.61%Forma y color:SolidPeso molecular:567.62RY785
CAS:<p>RY785 is a potent and selective inhibitor of voltage-gated potassium channel such as KV2.2 (IC50 = 50 nM). RY785 may be used in pain relief studies.</p>Fórmula:C21H20N4O2SPureza:99.78%Forma y color:SolidPeso molecular:392.476-Benzoylheteratisine
CAS:<p>6-Benzoylheteratisine (Heteratisan-14-one, 6-(benzoyloxy)-20-ethyl-8-hydroxy-1-methoxy-4-meth) is a Aconitum alkaloid.</p>Fórmula:C29H37NO6Pureza:99.87%Forma y color:SolidPeso molecular:495.61Benzonatate
CAS:<p>Benzonatate is an antagonist of sodium channel protein.</p>Fórmula:C30H53NO11Pureza:99.92%Forma y color:Colorless To Faintly Yellow Oil LiquidPeso molecular:603.74PF-06869206
CAS:<p>PF-06869206 is an oral selective inhibitor of the sodium-phosphate cotransporter NaPi2a (SLC34A1, IC50: 380 nM).</p>Fórmula:C15H14ClF3N4O2Pureza:99.79% - 99.88%Forma y color:SolidPeso molecular:374.75Levobupivacaine hydrochloride
CAS:<p>Levobupivacaine hydrochloride ((S)-(-)-Bupivacaine monohydrochloride) is a reversible neuronal sodium channel inhibitor, used as a long-acting local anesthetic.</p>Fórmula:C18H28N2O·HClPureza:99.74%Forma y color:White Crystalline PowderPeso molecular:324.893-Deoxyaconitine
CAS:<p>3- Deoxyaconitine is a derivative of Aconitine (A189875), which activates tetrodotoxin-sensitive Na+ channels, inducing presynaptic depolarization, thus</p>Fórmula:C34H47NO10Pureza:98.31%Forma y color:SolidPeso molecular:629.74Ralfinamide
CAS:<p>Ralfinamide (Priralfinamide) is an orally available Na-channel blocker for the treatment of neuropathic pain and other pain conditions.</p>Fórmula:C17H19FN2O2Pureza:99.41%Forma y color:SolidPeso molecular:302.34Riluzole
CAS:<p>Riluzole (RP-54274) is an anticonvulsant, glutamate antagonist, and prolongs ALS patient survival.</p>Fórmula:C8H5F3N2OSPureza:99.71% - 99.88%Forma y color:PowderPeso molecular:234.2Benzocaine N-Glucoside (a/b mixture)
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications The N-Glucoside of Benzocaine (B202970) with anesthetic activity. A potential sun-screening agent.<br>References Rybczynska, B. et al.: Parfum. Kosm., 48, 125 (1967); Nikolin, A. et al.: Glas. Hemi. Tehnol. Bosne Herceg., 16, 93 (1968);<br></p>Fórmula:C15H21NO7Forma y color:NeatPeso molecular:327.33Propoxycaine hydrochloride
CAS:<p>Propoxycaine hydrochloride is an ester local anesthetic that inhibits voltage-gated sodium channels, modulates nerve impulses, and induces loss of sensation.</p>Fórmula:C16H27ClN2O3Pureza:97.25%Forma y color:SolidPeso molecular:330.85Eleclazine
CAS:<p>Eleclazine (GS-6615) is a novel and selective voltage-gated sodium channel inhibitor with antiarrhythmic properties that reduces peak sodium current (INaP).</p>Fórmula:C21H16F3N3O3Pureza:98.67%Forma y color:SolidPeso molecular:415.37Deacetamide Acetonitrile-pentisomide
CAS:Producto controlado<p>Applications Deacetamide Acetonitrile-pentisomide is an intermediate in the synthesis of Pentisomide (P275600). Pentisomide is a sodium channel blocker; derivative of disopyramide. Antiarrhythmic (class I).<br>References Kuhlkamp, V., et al.: Int. J. Cardiol., 36, 69 (1992); Yuan, S., et al.: Cardiovasc. Drug Rev., 11, 74 (1993)<br></p>Fórmula:C19H31N3Forma y color:NeatPeso molecular:301.47N-(Chloroacetyl)-2,5-dimethylaniline
CAS:Producto controlado<p>Applications N-(Chloroacetyl)-2,5-dimethylaniline is an intermediate in the synthesis of impurities of Lidocaine (L397800), an anesthetic local agent and antiarrythmic class IB agent.<br>References Groningsson, K., et al.: Anal. Profiles Drug Subs., 14, 207 (1985), Davies, P.S., et al.: Drugs, 64, 937 (2004),<br></p>Fórmula:C10H12ClNOForma y color:NeatPeso molecular:197.663-(2-Chloropropionyl)amino-4-methyl-2-methoxycarbonylthiophene
CAS:Producto controlado<p>Applications 3-(2-Chloropropionyl)amino-4-methyl-2-methoxycarbonylthiophene is an intermediate in the synthesis of Articaine-d7 Hydrochloride which is the labelled form of Articaine Hydrochloride (A777905). Articaine Hydrochloride is the Hydrochloride Salt of Articaine (A777900). Articaine is an amide based short-acting local anesthetic use for regional anaesthesia in day-case settings such arthroscopy, hand, food surgery and in dentistry.<br>References Malamed, S.F., et al.: J. Am. Dent. Assoc., 132, 177 (2001); Luan, F., et al.: Bioorg. Med. Chem., 21, 1870 (2013)<br></p>Fórmula:C10H12ClNO3SForma y color:NeatPeso molecular:261.73Methocarbamol D5
CAS:<p>Methocarbamol is a central muscle relaxant. Methocarbamol D5 is deuterium labeled Methocarbamol.</p>Fórmula:C11H15NO5Pureza:98%Forma y color:SolidPeso molecular:246.27Propafenone D7 hydrochloride
CAS:<p>Propafenone D7 hydrochloride is the deuterium labeled Propafenone, and is a classic anti-arrhythmic medication.</p>Fórmula:C21H28ClNO3Pureza:98%Forma y color:SolidPeso molecular:384.953-Deoxyyunaconitine
CAS:Producto controlado<p>Applications 3-Deoxyyunaconitine is a metabolite of Aconitine (A189875), a neurotoxin that binds, activates tetrodotoxin-sensitive Na+ channels and prolongs the opening of the sodium-ion channel by suppressing conformational changes.<br>References Derbre, S., et al.: Anal. Bioanal. Chem., 398, 1747 (2010), Li, M., et al.: J. Pharm. Biomed. Anal., 53, 1063 (2010),<br></p>Fórmula:C35H49NO10Forma y color:NeatPeso molecular:643.761,2,4-Oxadiazol-3-amine
CAS:Producto controlado<p>Applications 1,2,4-oxadiazol-3-amine (cas# 39512-64-6) is a useful research chemical.<br></p>Fórmula:C2H3N3OForma y color:NeatPeso molecular:85.066-(Propylamino)-2-hydroxy-N-(2,6-dimethylphenyl)hexanamide
Producto controlado<p>Applications 6-(Propylamino)-2-hydroxy-N-(2,6-dimethylphenyl)-hexanamide is a derivative of Bupivacaine (B689560), a sodium channel blocker, local anesthetic.<br>References Wilson, T.D., et al.: Anal. Profiles Drug Subs., 19, 59 (1990), McClellan, K.J., et al.: Drugs, 56, 355 (1998),<br></p>Fórmula:C17H28N2O2Forma y color:NeatPeso molecular:292.416Halofuginone
CAS:<p>Halofuginone (RU-19110) inhibits prolyl-tRNA synthetase (Ki=18.3 nM), down-regulates Smad3, and blocks TGF-β at 10 ng/ml.</p>Fórmula:C16H17BrClN3O3Pureza:99.53%Forma y color:Off-White SolidPeso molecular:414.68Clopamide
CAS:<p>Clopamide (Brinaldix) is a piperidine and sulfamoylbenzamide-based diuretic with thiazide-like diuretic activity.</p>Fórmula:C14H20ClN3O3SPureza:99.71%Forma y color:White To Yellowish Crystalline PowderPeso molecular:345.84Nav1.7 inhibitor
CAS:<p>Nav1.7 inhibitor is a Nav1.7 inhibitor for research in the field of pain and anesthesia.</p>Fórmula:C15H11Cl3FNO4SPureza:97.52%Forma y color:SolidPeso molecular:426.68GX-585
CAS:<p>GX-585 is a novel potent inhibitor of NaV1.7 and highly selective against NaV1.5, having limited selectivity against NaV1.1 and NaV1.2.</p>Fórmula:C24H25Cl2FN4O3SPureza:99.02% - 99.03%Forma y color:SolidPeso molecular:539.45(5R)-BW-4030W92
CAS:<p>(5R)-BW-4030W92 is the R-type of BW-4030W92, the active enantiomer.</p>Fórmula:C11H9Cl2FN4Pureza:98.27%Forma y color:SolidPeso molecular:287.12Sodium Channel inhibitor 2
CAS:<p>Sodium Channel inhibitor 2 is a blocker of sodium channel.</p>Fórmula:C26H25Cl2N3OPureza:98%Forma y color:SolidPeso molecular:466.4GNE-0439
CAS:<p>GNE-0439 is a Nav1.7-selective inhibitor (IC50 0.34 μM), also targeting Nav1.5 and mutant N1742K channels, valuable for ion channel research.</p>Fórmula:C21H31NO3Pureza:99.60%Forma y color:SolidPeso molecular:345.48E 0747
CAS:<p>E 0747 is an antiarrhythmic agent of class 1C type. E-0747 suppresses arrhythmia by inhibiting the Na channels of cardiac cells.</p>Fórmula:C21H28ClN3O4Pureza:95.17%Forma y color:SolidPeso molecular:421.92GX-674
CAS:<p>GX-674 is a highly potent and selective voltage-gated sodium channel 1.7 (Nav1.7) antagonist with an IC50 value of 0.1 nM measured at -40 mV for the study of</p>Fórmula:C21H13ClF2N6O3S2Pureza:98.60%Forma y color:SolidPeso molecular:534.95DPI 201-106
CAS:<p>DPI 201-106: cardioselective h1 Na channel inhibitor, enhances heart contraction, blocks potassium and calcium currents.</p>Fórmula:C29H30N4O2Pureza:99.94%Forma y color:SolidPeso molecular:466.57PF 05089771 tosylate
CAS:<p>PF-05089771 inhibits Nav1.7 channels (IC50: 11-33 nM), selective over Nav1.1-1.6/1.8, Ca+, K+ channels, TRPV1; 1000x affinity for half-inactivated state.</p>Fórmula:C18H12Cl2FN5O3S2·C7H8O3SPureza:98.55%Forma y color:SolidPeso molecular:672.56NHE3-IN-2
CAS:<p>NHE3-IN-2 is an inhibitor of NHE3 (Na+/H+ exchanger-3), applicable for treating hypertension, thrombosis, and ischaemic diseases.</p>Fórmula:C15H12ClN5Forma y color:SolidPeso molecular:297.74Halofuginone hydrobromide
CAS:<p>Halofuginone specifically inhibits collagen type I and MMP-2 gene expression, which may result in the suppression of angiogenesis and tumor cell growth.</p>Fórmula:C16H17BrClN3O3·HBrPureza:97.01% - 99.73%Forma y color:SolidPeso molecular:495.59Phenamil
CAS:<p>Phenamil is an inhibitor of epithelial sodium channels, activates the osteomorphin protein pathway to promote bone repair and induces significant fat formation.</p>Fórmula:C12H12ClN7OPureza:99.07%Forma y color:SolidPeso molecular:305.72GDC-0276
CAS:<p>GDC-0276 is an orally active, selective, and potent NaV1.7 inhibitor that can be used for the study of pain-related diseases.</p>Fórmula:C24H31FN2O4SPureza:99.77%Forma y color:SolidPeso molecular:462.58KR-32568
CAS:<p>KR-32568 is a sodium/hydrogen exchanger 1 (NHE-1) inhibitor (IC50: 230 nM).</p>Fórmula:C13H12FN3O2Pureza:99.91%Forma y color:SolidPeso molecular:261.25Nisoxetine hydrochloride
CAS:<p>Nisoxetine hydrochloride is a noradrenaline transporter (NET) inhibitor</p>Fórmula:C17H21NO2·HClPureza:99.21%Forma y color:White SolidPeso molecular:307.82Silperisone HCl
CAS:<p>Silperisone HCl is a muscle relaxant and vasodilator, treating myoclonus, hypertonia, dystonia, and myospasm by blocking Na+ and Ca2+ channels.</p>Fórmula:C15H25ClFNSiPureza:99.62%Forma y color:SolidPeso molecular:301.9Elpetrigine
CAS:<p>Elpetrigine (GW273293) is a potential sodium channel blocker with antiepileptic activity that can be used to study epilepsy.</p>Fórmula:C10H7Cl3N4Pureza:99.04% - 99.43%Forma y color:SolidPeso molecular:289.55NaV1.2/1.6 channel blocker-1
CAS:<p>NaV1.2/1.6 channel blocker-1 is a NaV1.2/1.6 channel blocker that inhibits rNaV1.6 and can be used to study generalised epilepsy and movement disorders.</p>Fórmula:C14H14N2OSPureza:99.54%Forma y color:SolidPeso molecular:258.34NHE3-IN-1
CAS:<p>NHE3-IN-1 是钠/质子交换剂 3 (NHE-3) 的抑制剂。</p>Fórmula:C12H10ClN3SPureza:99.93%Forma y color:SolidPeso molecular:263.75TC-N 1752
CAS:<p>TC-N 1752 is an orally active inhibitor of Nav1.7 channel with IC50 of 0.17 μM. TC-N 1752 shows analgesic activities.</p>Fórmula:C25H27F3N6O3Pureza:99.71%Forma y color:SolidPeso molecular:516.52Ralitoline
CAS:<p>Ralitoline (Ralitolinum) is an anticonvulsant with anticancer activity and sodium channel blocking activity.</p>Fórmula:C13H13ClN2O2SPureza:98.45%Forma y color:SolidPeso molecular:296.77(Rac)-AMG8379
CAS:<p>(Rac)-AMG8379 ((Rac)-AMG8380) is a racemate of AMG8379 which is an orally active and selective sulfonamide NaV1.7 antagonist.</p>Fórmula:C25H16ClF2N3O5SPureza:99.6%Forma y color:SolidPeso molecular:543.93SLC13A5-IN-1
CAS:<p>SLC13A5-IN-1 is a selective inhibitor of sodium-citrate co-transporter (SLC13A5),completely blocks the uptake of 14C-citrate(IC50 : 0.022 μM in HepG2 cells).</p>Fórmula:C19H19Cl3N2O3SPureza:99.67%Forma y color:SolidPeso molecular:461.79PF 04531083
CAS:<p>PF 04531083 is a selective blocker of the NaV1.8 channel. PF 04531083 can be used for neuropathic and inflammatory pain studies.</p>Fórmula:C17H16ClN5O2Pureza:99.85%Forma y color:SolidPeso molecular:357.79Aneratrigine
CAS:<p>Aneratrigine is a blocker of the sodium channel protein type 9 subunit alpha, utilized in research on neuropathic pain diseases [1].</p>Fórmula:C19H20ClF2N5O2S2Pureza:98%Forma y color:SolidPeso molecular:487.97Sodium Channel inhibitor 4
CAS:<p>Sodium Channel Inhibitor 4 is a compound that functions as a sodium channel inhibitor [1].</p>Fórmula:C19H18ClN3O4S2Pureza:98%Forma y color:SolidPeso molecular:451.95Co 102862
CAS:<p>Co 102862 is a voltage-gated sodium channel blocker. Co 102862 can be used for anticonvulsant studies.</p>Fórmula:C14H12FN3O2Pureza:99.82%Forma y color:SolidPeso molecular:273.26GDC-0310
CAS:<p>GDC-0310 is a selective, orally available Nav1.7 inhibitor with an IC50 of 0.6 nM for human Nav1.7, suitable for pain research.</p>Fórmula:C25H29Cl2FN2O4SPureza:99.877%Forma y color:SolidPeso molecular:543.486-Iodoamiloride
CAS:<p>6-Iodoamiloride is a potent inhibitor of acid-sensing ion channel 1 (ASIC1), exhibiting an IC50 value of 88 nM.</p>Fórmula:C6H8IN7OPureza:98%Forma y color:SolidPeso molecular:321.08Aneratrigine hydrochloride
CAS:<p>Aneratrigine hydrochloride is a Nav 1.9 blocker that may be used to prevent or treat sodium channel blocker-related disorders.</p>Fórmula:C19H21Cl2F2N5O2S2Pureza:98.37% - 99.16%Forma y color:SolidPeso molecular:524.43VGSCs-IN-1
CAS:<p>VGSCs-IN-1, a VGSC inhibitor and Riluzole analog, exhibits good blocking activity on Nav1.4 and can be used to study cellular excitability disorders.</p>Fórmula:C12H12F3N3OSPureza:99.88%Forma y color:SolidPeso molecular:303.3Funapide
CAS:<p>Funapide (TV 45070) is a potent Nav1.7 inhibitor, potentially treating inflammation and various pains.</p>Fórmula:C22H14F3NO5Pureza:99.91%Forma y color:SolidPeso molecular:429.35PF-05661014
CAS:<p>PF-05661014, a demethylated analogue of PF-06526290, selectively inhibits Nav1.3 and Nav1.7 currents by stabilizing the inactivated state through interaction with the D4 VSD. This compound is utilized in research focused on sodium channel modulation.</p>Fórmula:C17H16N4O3S2Forma y color:SolidPeso molecular:388.46Olisutrigine bromide
CAS:<p>Olisutrigine bromide is a sodium channel blocker used as an analgesic.</p>Fórmula:C25H35BrN2Forma y color:SolidPeso molecular:443.463N-Depropylpropafenone
CAS:<p>N-Depropylpropafenone, an active metabolite of Propafenone, is produced through the metabolism by the CYP450 enzyme system (primarily CYP2D6). It functions by blocking sodium ion channels, thereby delaying the depolarization process in myocardial cells and exhibiting antiarrhythmic properties.</p>Fórmula:C18H21NO3Forma y color:SolidPeso molecular:299.36Vormatrigine
CAS:<p>Vormatrigine effectively inhibits sodium channels (sodium channel).</p>Fórmula:C16H12F6N4O2Forma y color:SolidPeso molecular:406.28Tizolemide
CAS:<p>Tizolemide, a sulfonamide diuretic compound with alkaline properties, is cleared through the tubular transport system. It induces changes in the passive transport components across the basolateral membrane of isolated frog skin.</p>Fórmula:C11H14ClN3O3S2Forma y color:SolidPeso molecular:335.83Lubeluzole dihydrochloride
CAS:<p>Lubeluzole (dihydrochloride) acts as a neuroprotective agent by blocking neuronal voltage-gated sodium channels and also affects cardiac sodium channels, exhibiting both tonic and blocking effects. This compound is considered promising in the research of antiarrhythmic agents.</p>Fórmula:C22H27Cl2F2N3O2SForma y color:SolidPeso molecular:506.44Quinacainol dihydrochloride
CAS:<p>Quinacainol dihydrochloride (PK 10139 dihydrochloride) is the bis(2 hydrochloride) salt form of Quinacainol. It acts as an inhibitor of the sodium current, with an EC50 of 95 µM. This compound displays antiarrhythmic activity by modulating the electrophysiological properties of the heart.</p>Fórmula:C21H32Cl2N2OForma y color:SolidPeso molecular:399.398Zilvetrigine
CAS:<p>Zilvetrigine is a sodium channel (sodium channel) blocker. It can be used as an analgesic.</p>Fórmula:C20H20ClN3O2Forma y color:SolidPeso molecular:369.845(R)-Duloxetine
CAS:<p>(R)-Duloxetine, an isomer of Duloxetine, induces tonic and use-dependent blockade of neuronal Na+ channels. This compound is utilized in pain research.</p>Fórmula:C18H19NOSForma y color:SolidPeso molecular:297.42Olorigliflozin
CAS:<p>Olorigliflozin is a sodium glucose co-transporter (SGLT) inhibitor with antihyperglycemic properties.</p>Fórmula:C23H27ClO7Forma y color:SolidPeso molecular:450.909ErSO-TFPy
CAS:<p>ErSO-TFPy activates the sodium ion channel TRPM4, resulting in an imbalance of intracellular calcium and sodium ions. It exhibits low nanomolar-level cytotoxicity (IC50 = 5-25 nM) by inducing necrosis in ERα+ breast cancer cell lines. Additionally, ErSO-TFPy shows antitumor activity in mouse models.</p>Fórmula:C19H13F7N2O2Forma y color:SolidPeso molecular:434.307Suzetrigine
CAS:<p>Suzetrigine (VX-548) is an oral NaV1.8 inhibitor with analgesic properties for acute pain research.</p>Fórmula:C21H20F5N3O4Pureza:98.08% - 99.27%Forma y color:SolidPeso molecular:473.39SYM2206
CAS:<p>SYM2206 is a low affinity non-competitive AMPA receptor antagonist with an IC50 value of 1.6 μM.SYM2206 exhibits anticancer activity by blocking Nav1.6-mediated</p>Fórmula:C20H22N4O3Pureza:99.88%Forma y color:SolidPeso molecular:366.41
