OAT
Los transportadores de aniones orgánicos son una familia de proteínas de membrana que median la captación y excreción de varios aniones orgánicos endógenos y exógenos, incluyendo medicamentos, toxinas y subproductos metabólicos. Los OAT se expresan principalmente en los riñones y el hígado, donde juegan un papel crucial en la desintoxicación y la eliminación de medicamentos. La disfunción de la función de los OAT puede llevar a toxicidad por medicamentos y trastornos renales. En CymitQuimica, ofrecemos una variedad de moduladores de OAT para apoyar su investigación en farmacología, toxicología y función renal.
Se han encontrado 31 productos para "OAT".
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URAT1 inhibitor 7
CAS:URAT1 inhibitor 7, a uric acid transporter protein URAT1 inhibitor.URAT1 inhibitor 7 inhibits CYP2C9 and can be used in the study of hyperuricemia and gout.Fórmula:C19H10ClFN4O3SPureza:97.14%Forma y color:SoildPeso molecular:428.82URAT1 inhibitor 10
URAT1 inhibitor10 (Compound 23a) is a URAT1 inhibitor with an IC50 of 0.052 μM. It exhibits oral efficacy and low cytotoxicity. The compound demonstrates high selectivity for OAT1, with an IC50 of 9.17 μM.4'-hydroxy Trazodone
CAS:4’-hydroxy Trazodone is a metabolite of the antidepressant and sedative trazodone.1It is an inhibitor of organic anion transporter 3 (OAT3; Ki= 16.9 μM) and isFórmula:C19H22ClN5O2Forma y color:SolidPeso molecular:387.87Epaminurad HCl
CAS:Epaminurad HCl is a URAT1 inhibitor with partial inhibition of OAT1 and OAT3 (organic anion transporters).Epaminurad HCl is a pro-uric acid excretory agent used for the prevention and treatment of gout and hyperuricemia.Fórmula:C14H11Br2ClN2O3Pureza:99.01% - 99.42%Forma y color:SoildPeso molecular:450.51Ruzinurad
CAS:Ruzinurad (WO2020088641, compound I) is a potent URAT1 inhibitor, exhibiting high selectivity.Fórmula:C14H12BrNO2SForma y color:SolidPeso molecular:338.22URAT1 inhibitor 11
CAS:URAT1 inhibitor11 (Compound 7) is a potent URAT1 inhibitor, exhibiting an IC50 of 0.18 μM. It effectively reduces uric acid levels in zebrafish with hyperuricemia induced by Potassium oxonate and Xanthinesodium salt.Fórmula:C20H16F4N2O2Forma y color:SolidPeso molecular:392.35hURAT1 inhibitor 1
Compound 27b, also known as hURAT1 inhibitor 1, is an isomarine-derived, orally active inhibitor that targets both hURAT1 and GLUT9 with IC50 values of 0.16 μM and 4.47 μM, respectively. This compound exhibits significant anti-hyperuricemia effects and has demonstrated potent uric acid-lowering activity in a hyperuricemia mouse model at a dose of 10 mg/kg. Importantly, Compound 27b displays no notable in vitro cytotoxicity or in vivo hepatotoxicity, and possesses favorable pharmacokinetic (PK) characteristics.Fórmula:C24H19BrO4Forma y color:SolidPeso molecular:451.31URAT1/GLUT9-IN-1
URAT1/GLUT9-IN-1 (compound 29) effectively inhibits urate transporter 1 (URAT1) with an IC50 value of 2.01 μM and glucose transporter 9 (GLUT9) with an IC50 of 18.21 μM. This compound exhibits favorable pharmacokinetic properties and oral bioavailability, making it useful for research in gout and hyperuricemia.Lesinurad sodium
CAS:Lesinurad sodium (RDEA594 sodium) is a selective inhibitor of uric acid reabsorption and is used in the study of cardiovascular diseases.Fórmula:C17H13BrN3NaO2SPureza:99.97%Forma y color:SolidPeso molecular:426.26Dotinurad
CAS:Dotinurad ((3,5-dichloro-4-hydroxyphenyl)(1,1-dioxidobenzo[d]thiazol-3(2H)-yl)methanone) is a potent agent of uricosuric (IC50: 3.6 μM for uric acid).Fórmula:C14H9Cl2NO4SPureza:97.43% - 98.04%Forma y color:SolidPeso molecular:358.2Ref: TM-T15160
1mg123,00€1mL*10mM (DMSO)226,00€5mg289,00€10mg447,00€25mg737,00€50mg982,00€100mg1.341,00€Verinurad
CAS:Verinurad (RDEA3170) (RDEA3170) is an organic anion transporter URAT1 (SLC22A12) inhibitor for the treatment of gout and hyperuricemia.Fórmula:C20H16N2O2SPureza:97.36% - 99.22%Forma y color:SolidPeso molecular:348.42Cabotegravir
CAS:Cabotegravir (S/GSK1265744) (GSK744, GSK1265744) is a long-acting HIV integrase inhibitor and inhibits the HIV-1 integrase catalyzed strand transfer reaction (Fórmula:C19H17F2N3O5Pureza:98.55% - 99.92%Forma y color:SolidPeso molecular:405.35Lesinurad
CAS:Lesinurad (RDEA594), a selective uric acid reabsorption inhibitor, is used to treat gout without causing liver damage.Fórmula:C17H14BrN3O2SPureza:99.83% - 99.86%Forma y color:SolidPeso molecular:404.28Ref: TM-T6875
1mL*10mM (DMSO)34,00€10mg44,00€25mg80,00€50mg126,00€100mg197,00€200mg294,00€500mg494,00€Epaminurad
CAS:Epaminurad (UR-1102) is an oral URAT1 inhibitor for gout research with a Ki of 0.057 μM, modestly affects OAT1/3.Fórmula:C14H10Br2N2O3Forma y color:SolidPeso molecular:414.05XOR/URAT1-IN-1
CAS:Compound II15, known as XOR/URAT1-IN-1, serves as a dual inhibitor targeting xanthine oxidoreductase (XOR) and uric acid transporter 1 (URAT1), exhibiting IC50 values of 6 nM and 12.9 μM, respectively. This compound effectively reduces uric acid levels in a mouse model of acute hyperuricemia induced by potassium oxonate and hypoxanthine.Fórmula:C18H13ClN2O3Forma y color:SolidPeso molecular:340.76Xininurad
CAS:Xininurad (XNW3009) is a urate transporter (URAT) inhibitor.Fórmula:C15H10Br2FN3O2Forma y color:SolidPeso molecular:443.07URAT1 inhibitor 4
CAS:URAT1 inhibitor 4 is a potent, orally active Lesinurad derivative with a 7.56 μM IC50, showing greater in vivo efficacy.Fórmula:C27H20BrN3O4S3Forma y color:SolidPeso molecular:626.56JTT-552
CAS:JTT-552, a uric acid transporter 1 (URAT1) inhibitor, is used potentially for the treatment of hyperuricemia.Fórmula:C15H12ClNO3Pureza:98%Forma y color:SolidPeso molecular:289.71Puliginurad
CAS:Puliginurad (YL-90148) is a urate transporter protein inhibitor that inhibits the reabsorption of uric acid.Puliginurad is used in the treatment of gout.Fórmula:C19H16N2O2SPureza:99.50% - 99.96%Forma y color:White SolidPeso molecular:336.41URAT1&XO inhibitor 2
CAS:Compound BDEO (URAT1&XO inhibitor 2) serves as a dual-action inhibitor targeting both xanthine oxidase (XO) and URAT1, demonstrating an IC50 value of 3.3 μM forFórmula:C14H12BrNO3Pureza:98%Forma y color:SolidPeso molecular:322.15
