OAT
Los transportadores de aniones orgánicos son una familia de proteínas de membrana que median la captación y excreción de varios aniones orgánicos endógenos y exógenos, incluyendo medicamentos, toxinas y subproductos metabólicos. Los OAT se expresan principalmente en los riñones y el hígado, donde juegan un papel crucial en la desintoxicación y la eliminación de medicamentos. La disfunción de la función de los OAT puede llevar a toxicidad por medicamentos y trastornos renales. En CymitQuimica, ofrecemos una variedad de moduladores de OAT para apoyar su investigación en farmacología, toxicología y función renal.
Se han encontrado 27 productos de "OAT"
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URAT1 inhibitor 7
CAS:<p>URAT1 inhibitor 7, a uric acid transporter protein URAT1 inhibitor.URAT1 inhibitor 7 inhibits CYP2C9 and can be used in the study of hyperuricemia and gout.</p>Fórmula:C19H10ClFN4O3SPureza:97.65%Forma y color:SoildPeso molecular:428.82Ruzinurad
CAS:<p>Ruzinurad (WO2020088641, compound I) is a potent URAT1 inhibitor, exhibiting high selectivity.</p>Fórmula:C14H12BrNO2SForma y color:SolidPeso molecular:338.22URAT1/GLUT9-IN-1
<p>URAT1/GLUT9-IN-1 (compound 29) effectively inhibits urate transporter 1 (URAT1) with an IC50 value of 2.01 μM and glucose transporter 9 (GLUT9) with an IC50 of 18.21 μM. This compound exhibits favorable pharmacokinetic properties and oral bioavailability, making it useful for research in gout and hyperuricemia.</p>URAT1 inhibitor 11
CAS:<p>URAT1 inhibitor11 (Compound 7) is a potent URAT1 inhibitor, exhibiting an IC50 of 0.18 μM. It effectively reduces uric acid levels in zebrafish with hyperuricemia induced by Potassium oxonate and Xanthinesodium salt.</p>Fórmula:C20H16F4N2O2Forma y color:SolidPeso molecular:392.354'-hydroxy Trazodone
CAS:<p>4’-hydroxy Trazodone is a metabolite of the antidepressant and sedative trazodone.1It is an inhibitor of organic anion transporter 3 (OAT3; Ki= 16.9 μM) and is</p>Fórmula:C19H22ClN5O2Forma y color:SolidPeso molecular:387.87Epaminurad HCl
CAS:<p>Epaminurad HCl is a URAT1 inhibitor with partial inhibition of OAT1 and OAT3 (organic anion transporters).Epaminurad HCl is a pro-uric acid excretory agent used for the prevention and treatment of gout and hyperuricemia.</p>Fórmula:C14H11Br2ClN2O3Pureza:99.01% - 99.42%Forma y color:SoildPeso molecular:450.51Lesinurad sodium
CAS:<p>Lesinurad sodium (RDEA594 sodium) is a selective inhibitor of uric acid reabsorption and is used in the study of cardiovascular diseases.</p>Fórmula:C17H13BrN3NaO2SPureza:99.97%Forma y color:SolidPeso molecular:426.26Verinurad
CAS:<p>Verinurad (RDEA3170) (RDEA3170) is an organic anion transporter URAT1 (SLC22A12) inhibitor for the treatment of gout and hyperuricemia.</p>Fórmula:C20H16N2O2SPureza:97.36% - 99.22%Forma y color:SolidPeso molecular:348.42Epaminurad
CAS:<p>Epaminurad (UR-1102) is an oral URAT1 inhibitor for gout research with a Ki of 0.057 μM, modestly affects OAT1/3.</p>Fórmula:C14H10Br2N2O3Forma y color:SolidPeso molecular:414.05Cabotegravir
CAS:<p>Cabotegravir (S/GSK1265744) (GSK744, GSK1265744) is a long-acting HIV integrase inhibitor and inhibits the HIV-1 integrase catalyzed strand transfer reaction (</p>Fórmula:C19H17F2N3O5Pureza:98.55% - 99.92%Forma y color:SolidPeso molecular:405.35Dotinurad
CAS:<p>Dotinurad ((3,5-dichloro-4-hydroxyphenyl)(1,1-dioxidobenzo[d]thiazol-3(2H)-yl)methanone) is a potent agent of uricosuric (IC50: 3.6 μM for uric acid).</p>Fórmula:C14H9Cl2NO4SPureza:97.43% - 98.04%Forma y color:SolidPeso molecular:358.2Lesinurad
CAS:<p>Lesinurad (RDEA594), a selective uric acid reabsorption inhibitor, is used to treat gout without causing liver damage.</p>Fórmula:C17H14BrN3O2SPureza:99.83% - 99.86%Forma y color:SolidPeso molecular:404.28JTT-552
CAS:<p>JTT-552, a uric acid transporter 1 (URAT1) inhibitor, is used potentially for the treatment of hyperuricemia.</p>Fórmula:C15H12ClNO3Pureza:98%Forma y color:SolidPeso molecular:289.71URAT1 inhibitor 4
CAS:<p>URAT1 inhibitor 4 is a potent, orally active Lesinurad derivative with a 7.56 μM IC50, showing greater in vivo efficacy.</p>Fórmula:C27H20BrN3O4S3Forma y color:SolidPeso molecular:626.56URAT1&XO inhibitor 2
CAS:<p>Compound BDEO (URAT1&XO inhibitor 2) serves as a dual-action inhibitor targeting both xanthine oxidase (XO) and URAT1, demonstrating an IC50 value of 3.3 μM for</p>Fórmula:C14H12BrNO3Pureza:98%Forma y color:SolidPeso molecular:322.15Xininurad
CAS:<p>Xininurad (XNW3009) is a urate transporter (URAT) inhibitor.</p>Fórmula:C15H10Br2FN3O2Forma y color:SolidPeso molecular:443.07Puliginurad
CAS:<p>Puliginurad (YL-90148) is a urate transporter protein inhibitor that inhibits the reabsorption of uric acid.Puliginurad is used in the treatment of gout.</p>Fórmula:C19H16N2O2SPureza:99.96% - 99.96%Forma y color:SolidPeso molecular:336.41Lingdolinurad
CAS:<p>Lingdolinurad is a uric acid transporter protein inhibitor targeting hURAT1 for the study of hyperuricemia or gout.</p>Fórmula:C17H12BrN3O2Pureza:96.26%Forma y color:SolidPeso molecular:370.2URAT1 inhibitor 6
CAS:<p>URAT1 inhibitor 6 (Compound 1h), with an IC50 of 35 nM for hURAT1, demonstrates 200-fold and 8-fold greater potency compared to Lesinurad and Benzbromarone,</p>Fórmula:C9H7BrN3NaO2S2Forma y color:SolidPeso molecular:356.2URAT1 inhibitor 8
CAS:<p>URAT1 Inhibitor 8 (example 247) serves as a highly potent inhibitor of URAT1, demonstrating an IC50 value of 0.001 μM.</p>Fórmula:C19H13ClFN3O4SForma y color:SolidPeso molecular:433.84
