PDE
Las fosfodiesterasas (PDEs) son enzimas que hidrolizan nucleótidos cíclicos, como el AMPc y el GMPc, en sus formas inactivas, desempeñando un papel clave en la regulación de las vías de señalización intracelular. Los inhibidores de PDE se utilizan en el tratamiento de diversas afecciones, como enfermedades cardiovasculares, disfunción eréctil y trastornos respiratorios, debido a su capacidad para modular los niveles de nucleótidos cíclicos. En CymitQuimica, ofrecemos una gama de inhibidores de PDE para apoyar su investigación en señalización celular, farmacología y desarrollo terapéutico.
Se han encontrado 178 productos para "PDE".
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Carbodenafil
CAS:Carbodenafil is a Sildenafil related compound found in healthy foods. Sildenafil is a PDE5 inhibitor (IC50: 5.22 nM).Fórmula:C24H32N6O3Pureza:98.96% - 99.89%Forma y color:White SolidPeso molecular:452.55Zomepirac sodium salt
CAS:Zomepirac sodium salt (McN-2783-21-98) is a prostaglandin synthetase inhibitor.Fórmula:C15H13ClNNaO3Pureza:98.65% - ≥95%Forma y color:Yellow SolidPeso molecular:313.71Trapidil
CAS:Trapidil (Avantrin) is a coronary vasodilator agent.Fórmula:C10H15N5Pureza:99.42%Forma y color:White SolidPeso molecular:205.26Enpp-1-IN-14
CAS:Enpp-1-IN-14: potent ENPP1 inhibitor, IC50 = 32.38 nM, exhibits anti-tumor properties.Fórmula:C15H22ClN5O4SPureza:99.83%Forma y color:SoildPeso molecular:403.88EMD57439
CAS:EMD57439 is a selective PDE-III inhibitor, showing no significant increase in c-AMP concentration and producing little change in Ca(50).Fórmula:C22H23N3O4SPureza:99.35% - 99.57%Forma y color:SolidPeso molecular:425.5NSP-805
CAS:NSP-805 is a potent and selective guinea pig cardiac phosphodiesterase 3 (PDE3) inhibitor.Fórmula:C17H19N3O2Pureza:99.85%Forma y color:Yellow SolidPeso molecular:297.35Ref: TM-T12267
1mg38,00€5mg86,00€1mL*10mM (DMSO)94,00€10mg129,00€25mg216,00€50mg309,00€100mg427,00€200mg577,00€N-Methylbenzamide
CAS:N-Methylbenzamide is a potent phosphodiesterase 10A (PDE10A) inhibitor,with anti-cancer activity.Fórmula:C8H9NOPureza:99.83%Forma y color:Physical Description Off-White Crystalline Solid (Ntp 1992)Peso molecular:135.16Amrinone
CAS:Amrinone (Inocor) is a positive inotropic cardiotonic (cardiotonic agent) with vasodilator properties, phosphodiesterase 3 inhibitory activity.Fórmula:C10H9N3OPureza:98.88% - 99.45%Forma y color:SolidPeso molecular:187.2ATX inhibitor 1
CAS:ATX inhibitor 1 is a potent ATX inhibitor (IC50: 1.23 nM, FS-3 and 2.18 nM, bis-pNPP).Fórmula:C21H23Cl2N2O6PPureza:99.52%Forma y color:White SolidPeso molecular:501.3Roflumilast
CAS:Roflumilast (APTA 2217) is an orally available, long-acting inhibitor of phosphodiesterase (PDE) type 4 (PDE4), with anti-inflammatory and potentialFórmula:C17H14Cl2F2N2O3Pureza:99.76% - 99.86%Forma y color:SolidPeso molecular:403.21ITI-214
CAS:ITI-214 is a picomolar PDE1 inhibitor with excellent selectivity against other PDE family members, exhibits potent PDE1 inhibitory activity.Fórmula:C29H29FN7O5PPureza:98.21%Forma y color:SolidPeso molecular:605.56Ref: TM-T11689
1mg71,00€2mg92,00€5mg158,00€1mL*10mM (DMSO)207,00€10mg286,00€25mg505,00€50mg712,00€100mg1.009,00€Pimobendan
CAS:Pimobendan (UD-CG 115 BS) is a selective inhibitor of PDE3 (IC50: 0.32 μM).Fórmula:C19H18N4O2Pureza:99.91%Forma y color:White SolidPeso molecular:334.37Pumafentrine
CAS:Pumafentrine（BY 343） is a dual PDE3/PDE4 inhibitor that reduces clinical scores and TNF expression in experimental colitis in mice.Fórmula:C29H39N3O3Pureza:99.85%Forma y color:White SolidPeso molecular:477.64Milrinone
CAS:Milrinone (Win 47203) is a Phosphodiesterase 3 Inhibitor. The mechanism of action of milrinone is as a Phosphodiesterase 3 Inhibitor.Fórmula:C12H9N3OPureza:99.22% - 99.92%Forma y color:SolidPeso molecular:211.22Zatolmilast
CAS:Zatolmilast (BPN14770) is an allosteric inhibitor of selective phosphodiesterase 4D (PDE4D; IC50s: 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3).Fórmula:C21H15ClF3NO2Pureza:98.20%Forma y color:SolidPeso molecular:405.8Ref: TM-T10590
1mg66,00€5mg128,00€1mL*10mM (DMSO)141,00€10mg231,00€25mg388,00€50mg532,00€100mg740,00€200mg973,00€MR-L2
CAS:MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4).Fórmula:C19H16Cl3FN4OPureza:98.09% - 98.94%Forma y color:SolidPeso molecular:441.71Ref: TM-T12103
1mg138,00€2mg197,00€5mg334,00€1mL*10mM (DMSO)358,00€10mg500,00€25mg807,00€50mg1.099,00€100mg1.485,00€500mg2.962,00€Theodrenaline hydrochloride
CAS:Theodrenaline hydrochloride is an inhibitor targeting SARS-CoV-2 for the study of hypotension induced by spinal anesthesia.Fórmula:C17H22ClN5O5Pureza:97.05% - 98.18%Forma y color:SolidPeso molecular:411.84PDE10A-IN-5
PDE10A-IN-5 (Compound A30) is an orally active inhibitor of phosphodiesterase 10A (PDE10A) with an IC50 value of 3.5 nM. By inhibiting PDE10A, it activates the cyclic adenosine monophosphate (cAMP)-related signaling pathway, exhibiting activity against pulmonary vascular remodeling. This compound is applicable to research in the field of pulmonary arterial hypertension.Forma y color:Odour SolidPDE4B-IN-4
PDE4B-IN-4 is an inhibitor of PDE4B (IC50: 2.82 nM) and TNF-α (IC50: 7.20 nM). It demonstrates anti-inflammatory properties by reducing neutrophilia in a mouse model of lipopolysaccharide (LPS)-induced sepsis.Fórmula:C26H27N5O5Forma y color:SolidPeso molecular:489.52PDE4-IN-21
PDE4-IN-21 (Compound L19) is an effective PDE4 inhibitor with an IC50 of 0.48 μM. It demonstrates substantial inhibitory activity and notable metabolic stability in rat liver microsomes.Fórmula:C15H10Cl2N6SForma y color:SolidPeso molecular:377.25
