PDE
Las fosfodiesterasas (PDEs) son enzimas que hidrolizan nucleótidos cíclicos, como el AMPc y el GMPc, en sus formas inactivas, desempeñando un papel clave en la regulación de las vías de señalización intracelular. Los inhibidores de PDE se utilizan en el tratamiento de diversas afecciones, como enfermedades cardiovasculares, disfunción eréctil y trastornos respiratorios, debido a su capacidad para modular los niveles de nucleótidos cíclicos. En CymitQuimica, ofrecemos una gama de inhibidores de PDE para apoyar su investigación en señalización celular, farmacología y desarrollo terapéutico.
Se han encontrado 178 productos para "PDE".
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BRL-50481
CAS:BRL-50481 is a novel and selective inhibitor of PDE7 with IC50s of 0.15, 12.1, 62 and 490 μM for PDE7A, PDE7B, PDE4 and PDE3, respectively.Fórmula:C9H12N2O4SPureza:99.66%Forma y color:SolidPeso molecular:244.27Cilomilast
CAS:Cilomilast (SB-207499) is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory activity and low central nervous system activity. Phase 3.Fórmula:C20H25NO4Pureza:97.37% - 99.52%Forma y color:White SolidPeso molecular:343.42[11C]MP 10
CAS:[11C]MP 10 (PF-2545920), a specific and effective PDE10A inhibitor (IC50=0.37 nM), is with more than1000-fold specificity activity over the PDE.Fórmula:C25H20N4OPureza:99.5%Forma y color:SolidPeso molecular:391.45K-Ras-PDEδ-IN-1
CAS:K-Ras-PDEδ-IN-1 is a potent inhibitor of competitive K-Ras-PDEδ.It binds to the farnesyl binding pocket of PDEδ(Kd of 8 nM).Fórmula:C25H26FN5O2Pureza:99.48%Forma y color:SolidPeso molecular:447.5THPP-1
CAS:THPP-1 is a potent and orally bioavailable inhibitor of PDE10A(Ki of 1 nM and 1.3 nM for human and rat PDE10A, respectively).Fórmula:C23H21ClN6O3Pureza:99.46%Forma y color:SolidPeso molecular:464.9Balipodect
CAS:Balipodect (TAK063) is a highly effective and selective PDE10A inhibitor (IC50: 0.30 nM); Its selectivity is >15000-fold over other PDEs.Fórmula:C23H17FN6O2Pureza:98% - 99.79%Forma y color:SolidPeso molecular:428.42Ref: TM-T1745
1mg37,00€2mg50,00€5mg74,00€1mL*10mM (DMSO)74,00€10mg87,00€25mg147,00€50mg244,00€100mg421,00€200mg617,00€Udenafil
CAS:Udenafil is an inhibitor of PDE5 .Fórmula:C25H36N6O4SPureza:99.90%Forma y color:SolidPeso molecular:516.66Ref: TM-T17199
5mg48,00€1mL*10mM (DMSO)50,00€10mg75,00€25mg133,00€50mg207,00€100mg301,00€200mg434,00€Lodenafil
CAS:Lodenafil (Hydroxyhomosildenafil) is a potent PDE5 inhibitor, with treatment of erectile dysfunction (ED)Fórmula:C23H32N6O5SPureza:99.92%Forma y color:SolidPeso molecular:504.6Ref: TM-T7346
2mg34,00€5mg52,00€1mL*10mM (DMSO)52,00€10mg77,00€25mg122,00€50mg177,00€100mg245,00€200mg353,00€BW-A 78U
CAS:BW-A 78U is a PDE4 inhibitor (IC50: 3 μM). It is not inhibition on the lipopolysaccharide (LPS)-induced TNF-α release.Fórmula:C13H12FN5Pureza:99.45%Forma y color:SolidPeso molecular:257.27Ref: TM-T5101
1mg37,00€1mL*10mM (DMSO)42,00€5mg96,00€10mg144,00€25mg235,00€50mg339,00€100mg480,00€200mg658,00€Mardepodect
CAS:Mardepodect (PF-2545920) is a phosphodiesterase inhibitor selective for the PDE10A subtype with an IC50 of 0.37 nM, >1000-fold selectivity over PDE.Fórmula:C25H20N4OPureza:99.81% - 99.94%Forma y color:SolidPeso molecular:392.45Ref: TM-T16499
1mg40,00€5mg87,00€1mL*10mM (DMSO)96,00€10mg142,00€25mg222,00€50mg346,00€100mg518,00€200mg742,00€Ro 20-1724
CAS:Ro 20-1724 (4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone) is a widely used inhibitor of cyclic nucleotide phosphodiesterase with IC50 of 2.0 μM and Ki of 3.1Fórmula:C15H22N2O3Pureza:98.82% - 99.79%Forma y color:SolidPeso molecular:278.35HA130
CAS:HA130 is a selective ATX (autotaxin) inhibitor.Fórmula:C24H19BFNO5SPureza:98.26% - ≥95%Forma y color:SolidPeso molecular:463.29Ref: TM-T2646
2mg37,00€5mg54,00€1mL*10mM (DMSO)55,00€10mg88,00€25mg138,00€50mg222,00€100mg334,00€200mg500,00€Roflumilast N-oxide
CAS:Roflumilast N-oxide is an inhibitor of PDE type 4.Fórmula:C17H14Cl2F2N2O4Pureza:98.19% - 99.69%Forma y color:SolidPeso molecular:419.21Olprinone
CAS:Olprinone (Loprinone)(Loprinone) is a selective phosphodiesterase 3 (PDE3) inhibitor.Olprinone has been reported to improve microcirculation and attenuateFórmula:C14H10N4OPureza:99.68%Forma y color:SolidPeso molecular:250.262,5-dichloro-4-(difluoromethoxy)-N,N-dimethylbenzene-1-sulfonamide
CAS:2,5-dichloro-4-(difluoromethoxy)-N,N-dimethylbenzene-1-sulfonamide is a PDE inhibitor.Fórmula:C9H9Cl2F2NO3SPureza:98.60%Forma y color:SolidPeso molecular:320.14Ref: TM-T50062
1mg52,00€2mg71,00€5mg98,00€1mL*10mM (DMSO)102,00€10mg146,00€25mg243,00€50mg355,00€100mg507,00€200mg690,00€D159687
CAS:D159687 is a selective PDE4D inhibitor,had a procognitive profile as it improved memory in the novel object recognition test but had no antidepressant benefit.Fórmula:C21H19ClN2O2Pureza:97.57%Forma y color:SolidPeso molecular:366.84MY-5445
CAS:MY-5445 (N-(3-chlorophenyl)-4-phenylphthalazin-1-amine) is a specific inhibitor of phosphodiesterase type 5 (PDE5).Fórmula:C20H14ClN3Pureza:99.77%Forma y color:White SolidPeso molecular:331.8Amino Tadalafil
CAS:Amino tadalafil is a potent phosphodiesterase 5 (PDE5) inhibitor.Fórmula:C21H18N4O4Pureza:99.85%Forma y color:White PowderPeso molecular:390.39Cilostamide
CAS:Cilostamide (OPC3689) is a selective phosphodiesterase (PDE)3A and PDE3B inhibitor(IC50 values of 27 and 50 nM, respectively)Fórmula:C20H26N2O3Pureza:98.87%Forma y color:White To Off-White SolidPeso molecular:342.43YM976
CAS:YM976 is an orally active PDE4 inhibitor (IC50:2.2 nM)Fórmula:C17H16ClN3OPureza:99.84%Forma y color:SolidPeso molecular:313.78
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