PDE
Las fosfodiesterasas (PDEs) son enzimas que hidrolizan nucleótidos cíclicos, como el AMPc y el GMPc, en sus formas inactivas, desempeñando un papel clave en la regulación de las vías de señalización intracelular. Los inhibidores de PDE se utilizan en el tratamiento de diversas afecciones, como enfermedades cardiovasculares, disfunción eréctil y trastornos respiratorios, debido a su capacidad para modular los niveles de nucleótidos cíclicos. En CymitQuimica, ofrecemos una gama de inhibidores de PDE para apoyar su investigación en señalización celular, farmacología y desarrollo terapéutico.
Se han encontrado 178 productos para "PDE".
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RS-25344 hydrochloride
CAS:RS 25344 hydrochloride is a phosphodiesterase (PDE) 4 inhibitorFórmula:C19H14ClN5O4Pureza:99.25%Forma y color:SolidPeso molecular:411.8BRL-50481
CAS:BRL-50481 is a novel and selective inhibitor of PDE7 with IC50s of 0.15, 12.1, 62 and 490 μM for PDE7A, PDE7B, PDE4 and PDE3, respectively.Fórmula:C9H12N2O4SPureza:99.66%Forma y color:SolidPeso molecular:244.27Piclamilast
CAS:Piclamilast (RP 73401) is a PDE4 inhibitor.Fórmula:C18H18Cl2N2O3Pureza:98.28% - 99.57%Forma y color:White SolidPeso molecular:381.25Ensifentrine
CAS:Ensifentrine (Ensifentrinum) is a PDE3/4 inhibitor, although its affinity for PDE3(IC50: 0.4 nM) is 3,440 times higher than that for PDE4(IC50: 1479 nM), thatFórmula:C26H31N5O4Pureza:99.76% - 99.94%Forma y color:Green SolidPeso molecular:477.56Ref: TM-T25376
1mg34,00€1mL*10mM (DMSO)92,00€5mg93,00€10mg136,00€25mg268,00€50mg429,00€100mg685,00€200mg888,00€Z-HA155
CAS:Z-HA155 (CS-963) selectively and potently inhibits autotaxin with an IC50 of 5.7 nM.Fórmula:C24H19BFNO5SPureza:99.18%Forma y color:SolidPeso molecular:463.29Ref: TM-T11533
1mg34,00€5mg71,00€1mL*10mM (DMSO)73,00€10mg101,00€25mg200,00€50mg321,00€100mg475,00€200mg680,00€Crisaborole
CAS:Crisaborole (AN-2728) is a Phosphodiesterase 4 Inhibitor.Fórmula:C14H10BNO3Pureza:99.70%Forma y color:SolidPeso molecular:251.05Udenafil
CAS:Udenafil is an inhibitor of PDE5 .Fórmula:C25H36N6O4SPureza:99.90%Forma y color:SolidPeso molecular:516.66Ref: TM-T17199
5mg48,00€1mL*10mM (DMSO)50,00€10mg75,00€25mg133,00€50mg207,00€100mg301,00€200mg434,00€GSK256066
CAS:GSK256066 is a selective PDE4B(equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, >380, 000-fold selectivity versus PDE1/2/3/5/6 and >2500-foldFórmula:C27H26N4O5SPureza:99.60% - 99.91%Forma y color:Yellow SolidPeso molecular:518.58Nortadalafil
CAS:Nortadalafil, a demethylated form of Tadalafil, is a PDE5 inhibitor used to treat ED and pulmonary arterial hypertension as Adcirca.Fórmula:C21H17N3O4Pureza:99.42%Forma y color:White SolidPeso molecular:375.38Ref: TM-T6147
1mg34,00€2mg49,00€5mg74,00€1mL*10mM (DMSO)82,00€10mg105,00€25mg192,00€50mg334,00€100mg537,00€200mg762,00€500mg1.134,00€Homo Sildenafil
CAS:Homo Sildenafil is an analog of Sildenafil, It acts as a phosphodiesterase inhibitor.Fórmula:C23H32N6O4SPureza:99.88%Forma y color:SolidPeso molecular:488.6Ref: TM-T8919
2mg39,00€5mg60,00€1mL*10mM (DMSO)73,00€10mg96,00€25mg177,00€50mg266,00€100mg371,00€200mg523,00€GEBR-7b
CAS:GEBR-7b (3-(Cyclopentyloxy)-4-methoxybenzaldehyde) is a phosphodiesterase-4 (PDE4) inhibitor.Fórmula:C13H16O3Pureza:99.53%Forma y color:SolidPeso molecular:220.26MY-5445
CAS:MY-5445 (N-(3-chlorophenyl)-4-phenylphthalazin-1-amine) is a specific inhibitor of phosphodiesterase type 5 (PDE5).Fórmula:C20H14ClN3Pureza:99.77%Forma y color:White SolidPeso molecular:331.8Amino Tadalafil
CAS:Amino tadalafil is a potent phosphodiesterase 5 (PDE5) inhibitor.Fórmula:C21H18N4O4Pureza:99.85%Forma y color:White PowderPeso molecular:390.39Sildenafil Mesylate
CAS:Sildenafil Mesylate is a mesylate form of Sildenafil, an inhibitor of Phosphodiesterase 5.Fórmula:C22H30N6O4S·xCH4O3SPureza:99.84%Forma y color:SolidPeso molecular:570.68Lodenafil
CAS:Lodenafil (Hydroxyhomosildenafil) is a potent PDE5 inhibitor, with treatment of erectile dysfunction (ED)Fórmula:C23H32N6O5SPureza:99.92%Forma y color:SolidPeso molecular:504.6Ref: TM-T7346
2mg34,00€5mg52,00€1mL*10mM (DMSO)52,00€10mg77,00€25mg122,00€50mg177,00€100mg245,00€200mg353,00€[11C]MP 10
CAS:[11C]MP 10 (PF-2545920), a specific and effective PDE10A inhibitor (IC50=0.37 nM), is with more than1000-fold specificity activity over the PDE.Fórmula:C25H20N4OPureza:99.5%Forma y color:SolidPeso molecular:391.45Osoresnontrine
CAS:Osoresnontrine is a potent and selective inhibitor of PDE9A (IC50 of 52 nM),and can be used in the research of memory.Fórmula:C16H17N5O2Pureza:99.93%Forma y color:SolidPeso molecular:311.34Ref: TM-T8515
1mg35,00€2mg52,00€5mg77,00€1mL*10mM (DMSO)85,00€10mg113,00€25mg178,00€50mg333,00€100mg495,00€200mg710,00€CP671305
CAS:CP671305 is an orally active, potent and selective inhibitor of phosphodiesterase-4-D.Fórmula:C23H19FN2O7Pureza:99.39%Forma y color:SolidPeso molecular:454.4Ziritaxestat
CAS:Ziritaxestat (GLPG1690), an autotaxin inhibitor, currently being evaluated in an exploratory phase 2 study in idiopathic pulmonary fibrosis patients.Fórmula:C30H33FN8O2SPureza:97% - 99.85%Forma y color:White SolidPeso molecular:588.7PDE10-IN-1
CAS:PDE10-IN-1 (SEP-0372814) is used for treating CNS and metabolic disorders.Fórmula:C21H19N7Pureza:99.65%Forma y color:SolidPeso molecular:369.42
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