PDE
Las fosfodiesterasas (PDEs) son enzimas que hidrolizan nucleótidos cíclicos, como el AMPc y el GMPc, en sus formas inactivas, desempeñando un papel clave en la regulación de las vías de señalización intracelular. Los inhibidores de PDE se utilizan en el tratamiento de diversas afecciones, como enfermedades cardiovasculares, disfunción eréctil y trastornos respiratorios, debido a su capacidad para modular los niveles de nucleótidos cíclicos. En CymitQuimica, ofrecemos una gama de inhibidores de PDE para apoyar su investigación en señalización celular, farmacología y desarrollo terapéutico.
Se han encontrado 170 productos de "PDE"
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K-Ras-PDEδ-IN-1
CAS:K-Ras-PDEδ-IN-1 is a potent inhibitor of competitive K-Ras-PDEδ.It binds to the farnesyl binding pocket of PDEδ(Kd of 8 nM).
Fórmula:C25H26FN5O2Pureza:99.48%Forma y color:SolidPeso molecular:447.5Sildenafil Mesylate
CAS:Sildenafil Mesylate is a mesylate form of Sildenafil, an inhibitor of Phosphodiesterase 5.Fórmula:C22H30N6O4S·xCH4O3SPureza:99.84%Forma y color:SolidPeso molecular:570.68Lodenafil
CAS:Lodenafil (Hydroxyhomosildenafil) is a potent PDE5 inhibitor, with treatment of erectile dysfunction (ED)Fórmula:C23H32N6O5SPureza:99.92%Forma y color:SolidPeso molecular:504.6Ref: TM-T7346
2mg34,00€5mg52,00€1mL*10mM (DMSO)52,00€10mg77,00€25mg122,00€50mg177,00€100mg245,00€200mg353,00€[11C]MP 10
CAS:[11C]MP 10 (PF-2545920), a specific and effective PDE10A inhibitor (IC50=0.37 nM), is with more than1000-fold specificity activity over the PDE.Fórmula:C25H20N4OPureza:99.5%Forma y color:SolidPeso molecular:391.45THPP-1
CAS:THPP-1 is a potent and orally bioavailable inhibitor of PDE10A(Ki of 1 nM and 1.3 nM for human and rat PDE10A, respectively).Fórmula:C23H21ClN6O3Pureza:99.46%Forma y color:SolidPeso molecular:464.9Balipodect
CAS:Balipodect (TAK063) is a highly effective and selective PDE10A inhibitor (IC50: 0.30 nM); Its selectivity is >15000-fold over other PDEs.Fórmula:C23H17FN6O2Pureza:98% - 99.79%Forma y color:SolidPeso molecular:428.42Ref: TM-T1745
1mg37,00€2mg50,00€5mg74,00€1mL*10mM (DMSO)74,00€10mg87,00€25mg147,00€50mg244,00€100mg421,00€200mg617,00€Osoresnontrine
CAS:Osoresnontrine is a potent and selective inhibitor of PDE9A (IC50 of 52 nM),and can be used in the research of memory.Fórmula:C16H17N5O2Pureza:99.93%Forma y color:SolidPeso molecular:311.34Ref: TM-T8515
1mg35,00€2mg52,00€5mg77,00€1mL*10mM (DMSO)85,00€10mg113,00€25mg178,00€50mg333,00€100mg495,00€200mg710,00€CP671305
CAS:CP671305 is an orally active, potent and selective inhibitor of phosphodiesterase-4-D.Fórmula:C23H19FN2O7Pureza:99.39%Forma y color:SolidPeso molecular:454.4Ziritaxestat
CAS:Ziritaxestat (GLPG1690), an autotaxin inhibitor, currently being evaluated in an exploratory phase 2 study in idiopathic pulmonary fibrosis patients.Fórmula:C30H33FN8O2SPureza:97% - 99.85%Forma y color:SolidPeso molecular:588.7Roflumilast N-oxide
CAS:Roflumilast N-oxide is an inhibitor of PDE type 4.Fórmula:C17H14Cl2F2N2O4Pureza:98.19% - 99.69%Forma y color:SolidPeso molecular:419.21PDE10-IN-1
CAS:PDE10-IN-1 (SEP-0372814) is used for treating CNS and metabolic disorders.Fórmula:C21H19N7Pureza:99.65%Forma y color:SolidPeso molecular:369.42RS-25344
CAS:RS-25344: a strong PDE4 blocker, curbs eosinophil movement, boosts sperm motility in vitro.Fórmula:C19H13N5O4Pureza:98.98%Forma y color:SolidPeso molecular:375.34Ref: TM-T9239
1mg84,00€5mg168,00€1mL*10mM (DMSO)177,00€10mg245,00€25mg404,00€50mg567,00€100mg767,00€200mg1.018,00€Lotamilast
CAS:Lotamilast (RVT-501) is a phosphodiesterase 4 (PDE-4) inhibitor (IC50: 2.8 nM) potentially for the treatment of atopic dermatitis.Fórmula:C26H24N4O5Pureza:97.03% - 99.29%Forma y color:SolidPeso molecular:472.49PQ-10
CAS:PQ-10 (A-844337) is a PDE-10 inhibitor. PQ-10 induces brain glucose metabolism patterns, which may be a potential translational biomarker.
Fórmula:C22H21N5O3Pureza:99.86%Forma y color:SolidPeso molecular:403.43Enpp-1-IN-1
CAS:Enpp-1-IN-1 is an inhibitor of Ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1)Fórmula:C17H17N3O3SPureza:97.52%Forma y color:SolidPeso molecular:343.4Ref: TM-T7888
1mg126,00€5mg260,00€1mL*10mM (DMSO)286,00€10mg394,00€25mg677,00€50mg954,00€100mg1.288,00€GSK256066 Trifluoroacetate
CAS:GSK 256066 Trifluoroacetate: selective PDE4 inhibitor, IC50: 3.2 pM for PDE4B, treats COPD.Fórmula:C29H27F3N4O7SForma y color:SolidPeso molecular:632.61PF-8380
CAS:PF-8380 is an effective and orally available autotaxin inhibitor (IC50: 2.8 nM, in isolated enzyme assay; 101 nM, in the human whole blood).Fórmula:C22H21Cl2N3O5Pureza:98.70% - 99.25%Forma y color:SolidPeso molecular:478.33BW-A 78U
CAS:BW-A 78U is a PDE4 inhibitor (IC50: 3 μM). It is not inhibition on the lipopolysaccharide (LPS)-induced TNF-α release.Fórmula:C13H12FN5Pureza:99.45%Forma y color:SolidPeso molecular:257.27Ref: TM-T5101
1mg37,00€1mL*10mM (DMSO)42,00€5mg96,00€10mg144,00€25mg235,00€50mg339,00€100mg480,00€200mg658,00€MBCQ
CAS:MBCQ is an inhibitor of cGMP-specific phosphodiesterase PDE5.Fórmula:C16H12ClN3O2Pureza:99.45%Forma y color:SolidPeso molecular:313.74Ref: TM-T21965
5mg44,00€1mL*10mM (DMSO)50,00€10mg75,00€25mg138,00€50mg220,00€100mg318,00€200mg442,00€Crisaborole-d4
Crisaborole-d4 (AN-2728-d4) is the deuterated form of Crisaborole. Crisaborole is a PDE4 inhibitor and also a cytokine release inhibitor.Fórmula:C14H6D4BNO3Forma y color:SolidPeso molecular:255.07
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