IDO
La indoleamina 2,3-dioxigenasa (IDO) es una enzima involucrada en el catabolismo del triptófano, que lleva a la producción de quinurenina y otros metabolitos. La IDO juega un papel en la tolerancia inmune y a menudo está sobreexpresada en el cáncer y en condiciones inflamatorias crónicas. Los inhibidores de IDO se están explorando como posibles agentes inmunoterapéuticos en el cáncer y en enfermedades autoinmunes. En CymitQuimica, ofrecemos inhibidores de IDO para apoyar su investigación en inmunología, oncología y regulación metabólica.
Se han encontrado 84 productos de "IDO"
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GNF-PF-3777
CAS:<p>GNF-PF-3777 (8-Nitrotryptanthrin) (8-Nitrotryptanthrin) is a potent inhibitor of human indoleamine 2,3-dioxygenase 2 (hIDO2; Ki: 0.97 μM).</p>Fórmula:C15H7N3O4Pureza:97.88%Forma y color:SolidPeso molecular:293.23LY3381916
CAS:<p>IDO1-IN-5 is a selective, potent and brain penetrated inhibitor of IDO1 activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1.</p>Fórmula:C23H25FN2O3Pureza:99.3%Forma y color:SolidPeso molecular:396.45IDO-IN-13
CAS:<p>IDO-IN-13 (GS-4361) is a potent indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor (EC50: 17 nM).</p>Fórmula:C26H17F3N4OPureza:99.29%Forma y color:SolidPeso molecular:458.43BMT-297376
CAS:<p>BMT-297376, the optimized Linrodostat, is a potent IDO1 inhibitor.</p>Fórmula:C23H29F2N3O3Forma y color:SolidPeso molecular:433.5IDO-IN-15
CAS:IDO-IN-15 is an IDO1 inhibitor ( IC 50 < 0.51 nM).Fórmula:C29H39N5O4Forma y color:SolidPeso molecular:521.662NLG802
CAS:<p>NLG802 is a prodrug of indoximod, an orally active indoleamine 2,3-dioxygenase (IDO) inhibitor.</p>Fórmula:C20H30ClN3O3Pureza:99.61%Forma y color:SolidPeso molecular:395.92IDO1-IN-11
CAS:<p>IDO1-IN-11 is an IDO1 inhibitor with an IC 50 value of 0.6 nM.</p>Fórmula:C22H17ClFN3O3Forma y color:SolidPeso molecular:425.84IDO1-IN-7
CAS:IDO1-IN-7 is a potent IDO1 inhibitor with a 6.1 nM IC50 and immunomodulatory effects for cancer research.Fórmula:C22H19ClFN3O3Forma y color:SolidPeso molecular:427.86IDO1/TDO-IN-8
<p>IDO1/TDO-IN-8 (Compound CZ-17) is a dual IDO1 and TDO inhibitor capable of crossing the blood-brain barrier, with EC50 values of 0.33 μM and 1.78 μM, respectively. It modulates the kynurenine pathway of tryptophan metabolism, reducing the kynurenine/tryptophan ratio. IDO1/TDO-IN-8 has neuroprotective effects, alleviating motor dysfunction and improving depressive behavior, making it relevant for research into Parkinson's disease with comorbid depression.</p>Fórmula:C17H14N2SForma y color:SolidPeso molecular:278.37PROTAC IDO1 Degrader-1
CAS:First potent PROTAC IDO1 degrader; links IDO1 to CRBN E3 ligase for UPS-induced degradation (DC50=2.84 μM), boosts H ER2 CAR-T cell efficacy.Fórmula:C40H53BrFN9O13Forma y color:SolidPeso molecular:966.816CAY10581
CAS:CAY10581, a derivative of pyranonaphthoquinone, serves as a highly specific and reversible uncompetitive inhibitor of IDO, demonstrating potency with an IC50Fórmula:C22H21NO4Forma y color:SolidPeso molecular:363.41XW-032
<p>XW-032 is an apo-IDO1 inhibitor with an IC50 of 21 nM. In the CT26 syngeneic mouse model, XW-032 demonstrates significant in vivo antitumor efficacy with a TGI of 63%, showing potential for cancer research applications.</p>Forma y color:Odour Solidhuman TDO2-IN-1
<p>Human TDO2-IN-1 (Cpd-2) is a potent inhibitor of human TDO2, with an IC50 of 14.8 nM. It plays a significant role in studies related to metabolism, inflammation, and tumor immune surveillance.</p>Fórmula:C30H36N4O5Forma y color:SolidPeso molecular:532.631NU227326
CAS:<p>NU227326 is a PROTAC degrader of indoleamine 2,3-dioxygenase 1 (IDO1) with a DC50 value of 4.5 nM. It effectively degrades IDO1 in U87 and GBM43 cells, with DC50 values of 7.1 nM and 11.8 nM, respectively. NU227326 exhibits favorable pharmacokinetic properties, with a plasma half-life of 5.7 hours and a brain tissue half-life of 11.8 hours. (Pink: ligand for target protein IDO1 ligand-1; Black: linker; Blue: ligand for E3 ligase Cereblon).</p>Fórmula:C53H61FN8O7Forma y color:SolidPeso molecular:941.099TDO-IN-2
TDO-IN-2 is an orally active TDO inhibitor with an IC50 of 1.25 μM. It exhibits antitumor activity in a Hepa1-6 liver cancer allograft mouse model. Additionally, TDO-IN-2 works synergistically with PD-1/PD-L1 inhibitor BMS-202, making it useful for studying tumor immune tolerance.Fórmula:C20H15N3O3Forma y color:SolidPeso molecular:345.11134β-Cembrenediol
CAS:β-Cembrenediol (β-CBT) is a natural product from tobacco plants that is found in cigarette smoke condensate.Fórmula:C20H34O2Forma y color:SolidPeso molecular:306.49IDO1-IN-23
<p>IDO1-IN-23 (compound 41) is a potent inhibitor of human indoleamine 2,3-dioxygenase 1 (IDO1), exhibiting an IC50 of 13 μM [1].</p>Pureza:98%Forma y color:Odour SolidIDO1/TDO-IN-7
<p>IDO1/TDO-IN-7 (Compound 43b), an isochinoline derivative, functions as a potent dual inhibitor of IDO1/TDO with IC50 values of 0.31 μM and 0.08 μM, respectively. Demonstrating favorable pharmacokinetics and strong antitumor efficacy in the B16-F10 tumor model, this compound also exhibits low toxicity.</p>Forma y color:Odour SolidIDO1-IN-24
IDO1-IN-24 (compound 2c) inhibits the production of IDO1 during cell assays, with an IC50 value of 17 μM.Fórmula:C18H22N2O4Peso molecular:330.15796NU223612
CAS:<p>"NU223612 is a potent IDO1-degrading PROTAC with Kd 640 nM, binds CRBN at 290 nM, and crosses the BBB."</p>Fórmula:C49H55FN6O9Forma y color:SolidPeso molecular:890.99IDO1-IN-12
CAS:IDO1-IN-12 is a potent and orally available IDO1 inhibitor.Fórmula:C21H19F3N2O2Forma y color:SolidPeso molecular:388.39IDO1/TDO-IN-4
CAS:<p>IDO1/TDO-IN-4 is a novel dual inhibitor of IDO1/TDO with antidepressant activity, forming hydrogen bonds with IDO1 and π-π stacking interactions with TDO.</p>Fórmula:C14H10N4Pureza:98.88%Forma y color:SolidPeso molecular:234.26IDO1 Protein, Mouse, Recombinant (His)
IDO Protein, Mouse, Recombinant (His) is expressed in E.Pureza:≥ 90 % as determined by SDS-PAGE. - ≥ 90 % as determined by SDS-PAGE.Forma y color:Lyophilized PowderPeso molecular:46.47 kDa (predicted)(Rac)-IDO1-IN-5
CAS:(Rac)-IDO1-IN-5 is a racemic, potent IDO1 inhibitor; selective for apo-IDO1, it crosses the blood-brain barrier.Fórmula:C23H25FN2O3Forma y color:SolidPeso molecular:396.45IDO1 Protein, Human, Recombinant (His)
IDO Protein, Human, Recombinant (His) is expressed in E.Forma y color:Lyophilized PowderPeso molecular:46 kDa (predicted); 44 kDa (reducing conditions)(S)-IDO1-IN-5
CAS:(S)-IDO1-IN-5 is an active S-isomer of IDO1-IN-5. (S)-IDO1-IN-5 binds to IDOL(IC50 value less than 1.5 μΜ).Fórmula:C23H25FN2O3Forma y color:SolidPeso molecular:396.45Anti-IDO1 Antibody (9Y885)
Anti-IDO1 Antibody (9Y885) is an antibody targeting IDO1. Anti-IDO1 Antibody (9Y885) can be used in ELISA, IHC.Forma y color:Odour LiquidIDO1 Protein, Human, Recombinant
IDO Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 45.2 kDa and the accession number is A0A348GSI3.Forma y color:Lyophilized PowderPeso molecular:45.2 kDa (predicted); 46 kDa (reducing conditions)BMS-986242
CAS:BMS-986242 is an orally active, potent and selective inhibitor of indoleamine-2,3-dioxygenase 1 (IDO1), and it can be used for the research of cancer.Fórmula:C24H24ClFN2OPureza:98.9%Forma y color:SolidPeso molecular:410.91Linrodostat
CAS:Linrodostat (BMS-986205) is a selective indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitor.Fórmula:C24H24ClFN2OPureza:99.54% - 99.71%Forma y color:SolidPeso molecular:410.91(S)-Indoximod
CAS:(S)-Indoximod (L-Abrine) is an indoleamine-2,3-dioxygenase (IDO) inhibitor for cancer research.Fórmula:C12H14N2O2Pureza:95.39%Forma y color:SolidPeso molecular:218.253-TYP
CAS:<p>3-TYP (3-(1H-1,2,3-triazol-4-yl) pyridine) is a selective SIRT3 inhibitor.</p>Fórmula:C7H6N4Pureza:99.16% - >99.99%Forma y color:SolidPeso molecular:146.15Indoximod
CAS:<p>Indoximod (NLG-8189) is a methylated tryptophan that inhibits IDO to boost T cell function by preventing tryptophan depletion.</p>Fórmula:C12H14N2O2Pureza:97.82% - 99.55%Forma y color:SolidPeso molecular:218.25IDO-IN-7
CAS:IDO-IN-7 (NLG-919 analogue) is a potent IDO (indoleamine-(2, 3)-dioxygenase) pathway inhibitor.Fórmula:C18H22N2OPureza:99.32% - 99.9%Forma y color:SolidPeso molecular:282.38Epacadostat
CAS:Epacadostat (INCB 024360) is an oral, potent and selective IDO1 inhibitor with IC50 value of 71.8 nM.Cost-effective and quality-assured.Fórmula:C11H13BrFN7O4SPureza:98% - >99.99%Forma y color:SolidPeso molecular:438.23IDO-IN-1
CAS:<p>IDO-IN-1: potent IDO inhibitor, IC50 of 59 nM (enzyme), 12 nM (HeLa cells).</p>Fórmula:C9H7BrFN5O2Pureza:99.91%Forma y color:SolidPeso molecular:316.09Navoximod
CAS:Navoximod (GDC-0919) (NLG- 919, GDC-0919) is a potent indoleamine-(2,3)-dioxygenase (IDO) pathway inhibitor (Ki/EC50: 7 nM/75 nM).Fórmula:C18H21FN2O2Pureza:99.37%Forma y color:SolidPeso molecular:316.37Linrodostat mesylate
CAS:Linrodostat (BMS-986205) is an oral IDO1 inhibitor that boosts immune response and has anti-cancer properties.Fórmula:C25H28ClFN2O4SPureza:98%Forma y color:SolidPeso molecular:507.02IDO1-IN-1
CAS:IDO1-IN-1 (2 HzBTZ) is an indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor.Fórmula:C7H7N3SPureza:99.36%Forma y color:Slightly Yellow To Beige-Green Crystalline PowderPeso molecular:165.22LM10
CAS:TDO inhibitor; IC50: human 0.62 μM, mouse 2 μM; selective over IDO, MAOs; hinders TDO+ tumor growth in mice; orally active.Fórmula:C11H8FN5Pureza:98.78% - 99.94%Forma y color:SolidPeso molecular:229.21PCC0208009
CAS:PCC0208009 (IDO-IN-2) is an IDO inhibitor.Fórmula:C29H35N7OPureza:99.89%Forma y color:SolidPeso molecular:497.63IDO5L
CAS:IDO5L (INCB024360 analogue) is an effective IDO1 inhibitor(IC50=10 nM).Fórmula:C9H7ClFN5O2Pureza:99.49% - 99.75%Forma y color:SolidPeso molecular:271.64PF-06840003
CAS:PF-06840003 (EOS200271) is a specific and oral active IDO-1 inhibitor.Fórmula:C12H9FN2O2Pureza:99.10%Forma y color:SolidPeso molecular:232.21Necrostatin 2 racemate
CAS:<p>Necrostatin 2 racemate (Necrostatin-2 racemate) is an potent and specific inhibitor of RIPK1.</p>Fórmula:C13H12ClN3O2Pureza:98% - 99.5%Forma y color:SolidPeso molecular:277.71DP00477
CAS:DP00477, a potent inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), exhibits an inhibitory concentration (IC50) of 7.0 µM.Fórmula:C17H11ClF3N3OSForma y color:SolidPeso molecular:397.8IDO-IN-12
CAS:IDO-IN-12 is an inhibitor of indoleamine 2,3-dioxygenase (IDO).Fórmula:C13H11BrFN5O3SPureza:99.727%Forma y color:SolidPeso molecular:416.23IACS-8968 S-enantiomer
CAS:IACS-8968 S-enantiomer is the S-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and <5 for TDO).Fórmula:C17H18F3N5O2Pureza:98%Forma y color:SolidPeso molecular:381.35IACS-8968
CAS:IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and <5 for TDO).Fórmula:C17H18F3N5O2Pureza:98%Forma y color:SolidPeso molecular:381.35IDO1-IN-18
CAS:IDO1-IN-18 (Compound 14) is a potent inhibitor of IDO1. IDO1-IN-18 has potential for cancer disease research.Fórmula:C23H18F4N2O3Forma y color:SolidPeso molecular:446.39IDO-IN-8
CAS:IDO-IN-8 is an indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 1-10 μM).Fórmula:C18H21FN2O2Pureza:98%Forma y color:SolidPeso molecular:316.37
