IDO
La indoleamina 2,3-dioxigenasa (IDO) es una enzima involucrada en el catabolismo del triptófano, que lleva a la producción de quinurenina y otros metabolitos. La IDO juega un papel en la tolerancia inmune y a menudo está sobreexpresada en el cáncer y en condiciones inflamatorias crónicas. Los inhibidores de IDO se están explorando como posibles agentes inmunoterapéuticos en el cáncer y en enfermedades autoinmunes. En CymitQuimica, ofrecemos inhibidores de IDO para apoyar su investigación en inmunología, oncología y regulación metabólica.
Se han encontrado 84 productos de "IDO"
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IDO1-IN-15
CAS:IDO1-IN-15 is an effective IDO1 inhibitor with IC50 of 127 nM. The potency of IDO1-IN-15 against IDO1 enzyme is comparable with Epacadostat in vitro.Fórmula:C13H14BrFN6O3Forma y color:SolidPeso molecular:401.19IDO-IN-16
CAS:IDO-IN-16 (compound 5) is an IDO inhibitor (IC50: 36 nM).Fórmula:C22H21F3N4OForma y color:SolidPeso molecular:414.42IDO1-IN-17
CAS:IDO1-IN-17 (I-4) is an IDO1 inhibitor, with an IC 50 of 0.44 μM in hela cells .Fórmula:C28H32BrClFN5O2Forma y color:SolidPeso molecular:604.94IDO-IN-14
CAS:IDO-IN-14 is an IDO inhibitor (IC50: 0.6928 nM).Fórmula:C23H23ClN4O2Forma y color:SolidPeso molecular:422.91MMG-0358
CAS:MMG-0358 is a novel potent IDO1 inhibitor, showing low cytotoxicity and higher selectivity for IDO1 over TDO enzyme.Fórmula:C8H6ClN3OForma y color:SolidPeso molecular:195.61IDO1-IN-21
CAS:IDO1-IN-21 (compound 10m), with an IC50 of 0.64 μM, acts as an IDO1 inhibitor and has demonstrated efficacy in suppressing tumor growth in murine models [1].Fórmula:C21H19F2N3O6SPureza:98%Forma y color:SolidPeso molecular:479.45IDO-IN-5
CAS:IDO-IN-5 is an indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 1-10 μM).Fórmula:C18H21FN2O2Pureza:98%Forma y color:SolidPeso molecular:316.37Roxyl-9
CAS:Roxyl-9 is an inhibitor of IDO1 (Indoleamine 2,3-dioxygenase 1) [1].Fórmula:C18H13N3O2Forma y color:SolidPeso molecular:303.31TDO-IN-1
CAS:<p>TDO-IN-1 is a tryptophan 2,3-dioxygenase (TDO) inhibitor with antitumor activity that acts by reversing local immune tolerance in tumor tissues.</p>Fórmula:C16H13F3N4O2Pureza:99.86%Forma y color:SolidPeso molecular:350.3IDO1/2-IN-1
CAS:First potent oral dual IDO1/IDO2 inhibitor with antitumor properties; IC50: 28 nM (IDO1), 144 nM (IDO2).Fórmula:C16H18BrFN8O4Forma y color:SolidPeso molecular:485.27(R)-IDO/TDO-IN-1
CAS:(R)-IDO/TDO-IN-1 (compound 25), an indoleamine-2,3-dioxygenase (IDO) inhibitor, demonstrates good pharmacokinetic properties and exerts anti-tumor effects in the MC38 xenograft model. This compound exhibits synergy when combined with the anti-PD-1 monoclonal antibody (SHR-1210) [1].Fórmula:C25H24FN5Forma y color:SolidPeso molecular:413.49NUCC-0223619
CAS:NUCC-0223619 is an IDO1 inhibitor that induces the degradation of IDO protein and can be involved in the synthesis of PROTAC.Fórmula:C24H24ClFN2O2Forma y color:SolidPeso molecular:426.91IDO1/2-IN-1 hydrochloride
CAS:IDO1/2-IN-1 hydrochloride: Dual IDO1/2 inhibitor, IC50 of 28/144 nM, oral, with antitumor properties.Fórmula:C16H19BrClFN8O4Forma y color:SolidPeso molecular:521.73IDO1/TDO-IN-6
CAS:IDO1/TDO-IN-6 (compound 11) is a dual inhibitor targeting IDO1 and TDO, exhibiting IC50 values of 2.25 μM for IDO1 and 2.89 μM for TDO.Fórmula:C20H17NO5Pureza:98%Forma y color:SolidPeso molecular:351.35IDO-IN-9
CAS:IDO-IN-9 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50s of 0.011 μM (Kinase) and 0.0018 μM (Hela Cell).Fórmula:C13H13BrFN7O3SPureza:98%Forma y color:SolidPeso molecular:446.251-Isopropyltryptophan
CAS:1-Isopropyltryptophan (1-IsoPT), an IDO1 inhibitor, suppresses the expression of IDO-1 and IDO-2 mRNA induced by IFN-γ stimulation [1].Fórmula:C14H18N2O2Pureza:98%Forma y color:SolidPeso molecular:246.3IDO1 ligand-1
CAS:<p>IDO1ligand-1 is the target protein ligand for PROTAC NU227326, which is utilized for degrading IDO1.</p>Fórmula:C29H34FN3O2Forma y color:SolidPeso molecular:475.598IDO2-IN-1
CAS:<p>IDO2-IN-1: potent oral IDO2 inhibitor, IC50 = 112 nM, for inflammatory autoimmunity research.</p>Fórmula:C21H21BrN10O3Forma y color:SolidPeso molecular:541.36VS-15
CAS:VS-15 is a selective inhibitor of IDO1, specifically binding to its apo-heme form. Additionally, VS-15 serves as an inhibitor of iNOS.Fórmula:C29H27N5O3Forma y color:SolidPeso molecular:493.56IDO1-IN-13
IDO1-IN-13 is a potent IDO1 inhibitor (IC50: 61.6 nM, EC50: 30 nM in HeLa) that reduces kyn/trp ratio by 51% in SK-OV-3 tumors.Fórmula:C20H16BrN5O2SForma y color:SolidPeso molecular:470.34
