HIF / HIF Prolilhidroxilasa
El Factor Inducible por Hipoxia (HIF) es un factor de transcripción que desempeña un papel crucial en las respuestas celulares a bajos niveles de oxígeno (hipoxia). La actividad del HIF está regulada estrictamente por las prolil-hidroxilasas de HIF, que dirigen al HIF para su degradación en condiciones normóxicas. Los inhibidores de la prolil-hidroxilasa de HIF pueden estabilizar el HIF, promoviendo la expresión de genes involucrados en la angiogénesis, la eritropoyesis y el metabolismo. Estos inhibidores son de gran interés en el tratamiento de afecciones como la anemia, las enfermedades isquémicas y el cáncer. En CymitQuimica, ofrecemos inhibidores de HIF/prolil-hidroxilasa HIF para apoyar su investigación en biología de la hipoxia, terapia del cáncer y regulación metabólica.
Se han encontrado 145 productos para "HIF / HIF Prolilhidroxilasa".
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ISM012-042
ISM012-042 is an orally active inhibitor of PHD1 and PHD2, with IC50 values of 1.9 and 2.5 nM, respectively. At a concentration of 2.5 μM, ISM012-042 protects Caco-2 cells from DSS-induced barrier damage. Additionally, in LPS-induced bone marrow-derived dendritic cells (BMDC) from mice, ISM012-042 exhibits anti-inflammatory properties by dose-dependently reducing the expression of IL-12 subunit IL-12p35 and TNF. It also restores intestinal barrier function and alleviates intestinal inflammation in various experimental colitis models. ISM012-042 is useful for studying intestinal mucosal repair and immune disorders.Fórmula:C26H28N6O4Forma y color:SolidPeso molecular:488.538Izilendustat
CAS:Tert-butyl compound inhibits human EGLN-1; confirmed by spectrometry after 20 mins.Fórmula:C22H28ClN3O4Pureza:99.86%Forma y color:White SolidPeso molecular:433.93HIF1-IN-3
CAS:HIF1-IN-3 (Benzenepropanamide, N-[(8-hydroxy-7-quinolinyl)(4-methoxyphenyl)methyl]-) is an effective inhibitor of HIF-1 (EC50 = 0.9 μM) and can be used inFórmula:C26H24N2O3Pureza:99.59%Forma y color:White SolidPeso molecular:412.48Fibrostatin C
CAS:Fibrostatin C is an inhibitor of prolyl 4-hydroxylase. It is produced by Streptomyces catenulae subsp.Fórmula:C18H19NO8SForma y color:SolidPeso molecular:409.41Mersalyl
CAS:Mersalyl is an organic mercurial diuretic.Fórmula:C13H16HgNNaO6Forma y color:SolidPeso molecular:505.8541,4-DPCA
CAS:1,4-DPCA is an inhibitor of prolyl-hydroxylase with an IC50 of 2.4 µM for collagen hydroxylation in human foreskin fibroblasts and 60 μM for factor inhibitingFórmula:C13H8N2O3Pureza:97.77%Forma y color:SolidPeso molecular:240.21Ref: TM-T21653
5mg49,00€1mL*10mM (DMSO)54,00€10mg79,00€25mg144,00€50mg222,00€100mg356,00€200mg525,00€500mg837,00€HIF-1 α (556-574) (TFA)
HIF-1 alpha (556-574) TFA is a 19-residue fragment of hypoxia-inducible factor-1 (HIF-1), which serves as the master regulator of oxygen homeostasis [1].Pureza:98%Forma y color:Odour SolidZG-2033
CAS:ZG-2033 (Compound 26) is an orally active HIF-2α agonist that exhibits nanomolar activity (EC50 = 490 nM) in a luciferase reporter assay. It demonstrates an anti-anemic effect and shows synergistic effects with AKB-6548 in anemia, making it useful for the study of renal anemia.Fórmula:C15H14N2O2SForma y color:SolidPeso molecular:286.35ML228
CAS:ML228 activates HIF pathway and VEGF, with EC50 of 1μM, effective in vitro.Fórmula:C27H21N5Pureza:99.54%Forma y color:SolidPeso molecular:415.49Zifcasiran
CAS:Zifcasiran reduces HIF synthesis, has antitumor properties, useful in renal carcinoma studies.Fórmula:C737H972F20N211O349P43S8Forma y color:SolidPeso molecular:20339.13HIF-1α-IN-2
CAS:HIF-1α-IN-2 is a HIF-1α inhibitor with anticancer activity that inhibits the expression of HIF-1α and VEGF, and inhibits cell migration.Fórmula:C21H19N3OSPureza:99.90% - >99.99%Forma y color:White SolidPeso molecular:361.46Ref: TM-T61349
2mg85,00€5mg124,00€1mL*10mM (DMSO)133,00€10mg175,00€25mg293,00€50mg434,00€100mg622,00€1,4-DPCA ethyl ester
CAS:1,4-DPCA ethyl ester is a form of 1,4-DPCA modified, which has potential anticancer activity based on growth inhibition assays with the mlh1 rad18 yeast strain.Fórmula:C15H12N2O3Pureza:99.54%Forma y color:SolidPeso molecular:268.27Ref: TM-T36796
2mg34,00€5mg50,00€1mL*10mM (DMSO)55,00€10mg84,00€25mg145,00€50mg236,00€100mg400,00€200mg585,00€KG-548
CAS:KG-548 is a dual inhibitor of ARNT/TACC3 and HIF-1α, inhibiting lactate production, and can be used in cancer research.Fórmula:C9H4F6N4Pureza:99.62%Forma y color:SolidPeso molecular:282.15HIF-IN-1
CAS:HIF-IN-1 is a inhibitor of hypoxia-inducible factor, which is associated with tumor and cancer cell proliferation and inhibits HIF-1α protein aggregation.Fórmula:C17H12N2OPureza:99.48%Forma y color:Orange SolidPeso molecular:260.29Glucosamine sulfate
CAS:Glucosamine sulfate (D-Glucosaminesulfate) was extracted from synthetic product;Store the product in sealed, cool and dry condition.Fórmula:C6H13NO5·H2SO4Pureza:99.64%Forma y color:SolidPeso molecular:277.25ZINC13466751
CAS:ZINC13466751 is a potent HIF-1α/von Hippel-Lindau interaction inhibitor(IC50 = 2.0 µM).Fórmula:C20H21N5O2Pureza:99.8%Forma y color:SolidPeso molecular:363.41dencichine
CAS:Dencichine (ODAP) is a neurotoxic agent and a haemostatic agent, which relates to modulation of the coagulation system, and fibrinolytic system.Fórmula:C5H8N2O5Pureza:99.93% - ≥95%Forma y color:SolidPeso molecular:176.13N-Oxalylglycine
CAS:N-Oxalylglycine (Oxalylglycine) is a cell permeable inhibitor of α-ketoglutarate-dependent enzymes.Fórmula:C4H5NO5Pureza:99.23%Forma y color:SolidPeso molecular:147.09FG-2216
CAS:FG-2216 (YM-311) is a HIF-prolyl hydroxylase inhibitor for the PDH2 enzyme; orally bioavailable and induced reversible and significant Epo induction in vivo.Fórmula:C12H9ClN2O4Pureza:97.1% - >99.99%Forma y color:SolidPeso molecular:280.66M1001
CAS:M1001 is a HIF-2α agonist.Fórmula:C17H17N3O2SPureza:98.83%Forma y color:Yellow SolidPeso molecular:327.4
