HIF / HIF Prolilhidroxilasa
El Factor Inducible por Hipoxia (HIF) es un factor de transcripción que desempeña un papel crucial en las respuestas celulares a bajos niveles de oxígeno (hipoxia). La actividad del HIF está regulada estrictamente por las prolil-hidroxilasas de HIF, que dirigen al HIF para su degradación en condiciones normóxicas. Los inhibidores de la prolil-hidroxilasa de HIF pueden estabilizar el HIF, promoviendo la expresión de genes involucrados en la angiogénesis, la eritropoyesis y el metabolismo. Estos inhibidores son de gran interés en el tratamiento de afecciones como la anemia, las enfermedades isquémicas y el cáncer. En CymitQuimica, ofrecemos inhibidores de HIF/prolil-hidroxilasa HIF para apoyar su investigación en biología de la hipoxia, terapia del cáncer y regulación metabólica.
Se han encontrado 142 productos de "HIF / HIF Prolilhidroxilasa"
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FG-2216
CAS:<p>FG-2216 (YM-311) is a HIF-prolyl hydroxylase inhibitor for the PDH2 enzyme; orally bioavailable and induced reversible and significant Epo induction in vivo.</p>Fórmula:C12H9ClN2O4Pureza:97.1% - >99.99%Forma y color:SolidPeso molecular:280.66N-Oxalylglycine
CAS:<p>N-Oxalylglycine (Oxalylglycine) is a cell permeable inhibitor of α-ketoglutarate-dependent enzymes.</p>Fórmula:C4H5NO5Pureza:99.23%Forma y color:Colourless SolidPeso molecular:147.09IDF-11774
CAS:<p>IDF-11774 is a HIF-1 inhibitor.It reduces hif-1α HRE luciferase activity (IC50 = 3.65 μM).</p>Fórmula:C23H32N2O2Pureza:98.05%Forma y color:SolidPeso molecular:368.51IOX2
CAS:<p>IOX2 is a selective HIF PHD inhibitor, active in cells with 21 nM IC50 for PHD2/ELGN-1, not inhibiting FIH at 20uM.</p>Fórmula:C19H16N2O5Pureza:98% - 99.59%Forma y color:SolidPeso molecular:352.34ZINC13466751
CAS:<p>ZINC13466751 is a potent HIF-1α/von Hippel-Lindau interaction inhibitor(IC50 = 2.0 µM).</p>Fórmula:C20H21N5O2Pureza:99.8%Forma y color:SolidPeso molecular:363.41Glucosamine sulfate
CAS:<p>Glucosamine sulfate (D-Glucosaminesulfate) was extracted from synthetic product;Store the product in sealed, cool and dry condition.</p>Fórmula:C6H13NO5·H2SO4Pureza:99.64%Forma y color:White CrystalPeso molecular:277.25M1001
CAS:<p>M1001 is a HIF-2α agonist.</p>Fórmula:C17H17N3O2SPureza:98.83%Forma y color:SolidPeso molecular:327.4Deoxyshikonin
CAS:<p>1.</p>Fórmula:C16H16O4Pureza:99.36% - ≥95%Forma y color:SolidPeso molecular:272.3VH-298
CAS:<p>VH-298 blocks VHL:HIF-α interaction, stabilizes HIF-α, and triggers hypoxic response differently by inhibiting VHL post-HIF-α PHD hydroxylation.</p>Fórmula:C27H33N5O4SPureza:99.17% - >99.99%Forma y color:SolidPeso molecular:523.65PHD-1-IN-1
CAS:<p>PHD-1-IN-1 is a potent inhibitor of hypoxia-inducible factor prolylhydroxylase domain-1 (PHD-1) enzyme(IC50 = 0.034 μM).</p>Fórmula:C13H8N4Pureza:99.74%Forma y color:SolidPeso molecular:220.23GN44028
CAS:<p>GN44028 is a HIF-1 inhibitor with an IC50 of 14 nM, stopping HIF-1α activity but not mRNA or protein levels, or dimerization.</p>Fórmula:C18H15N3O2Pureza:99.52%Forma y color:SolidPeso molecular:305.33B2
CAS:<p>B2 (Linazolamide intermediate B impurity 2) promotes inclusion formation in cellular models of Huntington's disease and Parkinson's disease</p>Fórmula:C20H17ClN4O3Pureza:99.66%Forma y color:SolidPeso molecular:396.83BAY 87-2243
CAS:<p>BAY 87-2243 is a potent and selective inhibitor of hypoxia-inducible factor-1 (HIF-1).</p>Fórmula:C26H26F3N7O2Pureza:98% - 99.95%Forma y color:SolidPeso molecular:525.53Chlorogenic Acid
CAS:<p>Chlorogenic acid is a natural phenol. Chlorogenic acid has anti-inflammatory, antitumor, and antimicrobial effects. Cost-effective and quality-assured.</p>Fórmula:C16H18O9Pureza:98.84% - 99.67%Forma y color:SolidPeso molecular:354.31JNJ-42041935
CAS:<p>JNJ-42041935 (HIF-PHD Inhibitor II) is a potent (pKi = 7.3-7.9), 2-oxoglutarate competitive, reversible, and selective inhibitor of PHD enzymes.</p>Fórmula:C12H6ClF3N4O3Pureza:99.58% - ≥95%Forma y color:SolidPeso molecular:346.65dencichine
CAS:<p>Dencichine (ODAP) is a neurotoxic agent and a haemostatic agent, which relates to modulation of the coagulation system, and fibrinolytic system.</p>Fórmula:C5H8N2O5Pureza:99.93% - ≥95%Forma y color:SolidPeso molecular:176.13Dapagliflozin
CAS:<p>Dapagliflozin (BMS-512148) is a selective sodium-glucose co-transporter subtype 2 (SGLT2) inhibitor with antihyperglycemic activity.</p>Fórmula:C21H25ClO6Pureza:99.5% - 99.93%Forma y color:SolidPeso molecular:408.87DMOG
CAS:<p>DMOG (Dimethyloxalylglycine), an antagonist of the α-ketoglutarate cofactor, is an inhibitor for HIF prolyl hydroxylase.</p>Fórmula:C6H9NO5Pureza:80.23% - 99.98%Forma y color:SolidPeso molecular:175.14MK-8617
CAS:<p>MK-8617 is an orally available HIF PHD1 3 pan-inhibitor, inhibiting PHD1/2/3 (IC50: 1.0/1.0/14 nM).</p>Fórmula:C24H21N5O4Pureza:99.38% - >99.99%Forma y color:SolidPeso molecular:443.45KC7F2
CAS:<p>KC7F2 is a potent HIF-1 pathway inhibitor with potential anti-cancer activity.</p>Fórmula:C16H16Cl4N2O4S4Pureza:98% - 99.11%Forma y color:SolidPeso molecular:570.38
