HIF / HIF Prolilhidroxilasa
El Factor Inducible por Hipoxia (HIF) es un factor de transcripción que desempeña un papel crucial en las respuestas celulares a bajos niveles de oxígeno (hipoxia). La actividad del HIF está regulada estrictamente por las prolil-hidroxilasas de HIF, que dirigen al HIF para su degradación en condiciones normóxicas. Los inhibidores de la prolil-hidroxilasa de HIF pueden estabilizar el HIF, promoviendo la expresión de genes involucrados en la angiogénesis, la eritropoyesis y el metabolismo. Estos inhibidores son de gran interés en el tratamiento de afecciones como la anemia, las enfermedades isquémicas y el cáncer. En CymitQuimica, ofrecemos inhibidores de HIF/prolil-hidroxilasa HIF para apoyar su investigación en biología de la hipoxia, terapia del cáncer y regulación metabólica.
Se han encontrado 145 productos para "HIF / HIF Prolilhidroxilasa".
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Izilendustat hydrochloride
CAS:Izilendustat hydrochloride inhibits prolyl hydroxylase, stabilizing HIF-1α/HIF-2, with potential to treat various HIF-1α diseases.Fórmula:C22H29Cl2N3O4Forma y color:SolidPeso molecular:470.39FG-2216
CAS:FG-2216 (YM-311) is a HIF-prolyl hydroxylase inhibitor for the PDH2 enzyme; orally bioavailable and induced reversible and significant Epo induction in vivo.Fórmula:C12H9ClN2O4Pureza:97.1% - >99.99%Forma y color:SolidPeso molecular:280.66N-Oxalylglycine
CAS:N-Oxalylglycine (Oxalylglycine) is a cell permeable inhibitor of α-ketoglutarate-dependent enzymes.Fórmula:C4H5NO5Pureza:99.23%Forma y color:SolidPeso molecular:147.09IDF-11774
CAS:IDF-11774 is a HIF-1 inhibitor.It reduces hif-1α HRE luciferase activity (IC50 = 3.65 μM).Fórmula:C23H32N2O2Pureza:98.05%Forma y color:SolidPeso molecular:368.51IOX2
CAS:IOX2 is a selective HIF PHD inhibitor, active in cells with 21 nM IC50 for PHD2/ELGN-1, not inhibiting FIH at 20uM.Fórmula:C19H16N2O5Pureza:98% - 99.59%Forma y color:SolidPeso molecular:352.34ZINC13466751
CAS:ZINC13466751 is a potent HIF-1α/von Hippel-Lindau interaction inhibitor(IC50 = 2.0 µM).Fórmula:C20H21N5O2Pureza:99.8%Forma y color:SolidPeso molecular:363.41Glucosamine sulfate
CAS:Glucosamine sulfate (D-Glucosaminesulfate) was extracted from synthetic product;Store the product in sealed, cool and dry condition.Fórmula:C6H13NO5·H2SO4Pureza:99.64%Forma y color:SolidPeso molecular:277.25M1001
CAS:M1001 is a HIF-2α agonist.Fórmula:C17H17N3O2SPureza:98.83%Forma y color:Yellow SolidPeso molecular:327.4VH-298
CAS:VH-298 blocks VHL:HIF-α interaction, stabilizes HIF-α, and triggers hypoxic response differently by inhibiting VHL post-HIF-α PHD hydroxylation.Fórmula:C27H33N5O4SPureza:99.06% - >99.99%Forma y color:SolidPeso molecular:523.65PHD-1-IN-1
CAS:PHD-1-IN-1 is a potent inhibitor of hypoxia-inducible factor prolylhydroxylase domain-1 (PHD-1) enzyme(IC50 = 0.034 μM).Fórmula:C13H8N4Pureza:99.74%Forma y color:White SolidPeso molecular:220.23Ref: TM-T9627
1mg42,00€1mL*10mM (DMSO)90,00€5mg92,00€10mg132,00€25mg231,00€50mg349,00€100mg522,00€200mg710,00€Amifostine sodium
CAS:Amifostine sodium is a phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia.Fórmula:C5H15N2NaO3PSForma y color:SolidPeso molecular:237.21GN44028
CAS:GN44028 is a HIF-1 inhibitor with an IC50 of 14 nM, stopping HIF-1α activity but not mRNA or protein levels, or dimerization.Fórmula:C18H15N3O2Pureza:99.52%Forma y color:SolidPeso molecular:305.33B2
CAS:B2 (Linazolamide intermediate B impurity 2) promotes inclusion formation in cellular models of Huntington's disease and Parkinson's diseaseFórmula:C20H17ClN4O3Pureza:99.66%Forma y color:SolidPeso molecular:396.83BAY 87-2243
CAS:BAY 87-2243 is a potent and selective inhibitor of hypoxia-inducible factor-1 (HIF-1).Fórmula:C26H26F3N7O2Pureza:98% - 99.95%Forma y color:White SolidPeso molecular:525.53Ref: TM-T2488
1mg34,00€2mg40,00€5mg59,00€1mL*10mM (DMSO)70,00€10mg96,00€25mg200,00€50mg334,00€100mg557,00€Chlorogenic Acid
CAS:Chlorogenic acid is a natural phenol. Chlorogenic acid has anti-inflammatory, antitumor, and antimicrobial effects. Cost-effective and quality-assured.Fórmula:C16H18O9Pureza:98.84% - 99.67%Forma y color:White SolidPeso molecular:354.31JNJ-42041935
CAS:JNJ-42041935 (HIF-PHD Inhibitor II) is a potent (pKi = 7.3-7.9), 2-oxoglutarate competitive, reversible, and selective inhibitor of PHD enzymes.Fórmula:C12H6ClF3N4O3Pureza:99.58% - ≥95%Forma y color:SolidPeso molecular:346.65Ref: TM-T3180
1mg38,00€2mg50,00€5mg84,00€1mL*10mM (DMSO)93,00€10mg113,00€25mg200,00€50mg334,00€100mg537,00€500mg1.134,00€dencichine
CAS:Dencichine (ODAP) is a neurotoxic agent and a haemostatic agent, which relates to modulation of the coagulation system, and fibrinolytic system.Fórmula:C5H8N2O5Pureza:99.93% - ≥95%Forma y color:SolidPeso molecular:176.13Dapagliflozin
CAS:Dapagliflozin (BMS-512148) is a selective sodium-glucose co-transporter subtype 2 (SGLT2) inhibitor with antihyperglycemic activity.Fórmula:C21H25ClO6Pureza:99.5% - 99.93%Forma y color:SolidPeso molecular:408.87Ref: TM-T2389
1500mgA consultar5mg47,00€1mL*10mM (DMSO)52,00€10mg60,00€25mg77,00€50mg94,00€100mg107,00€200mg142,00€DMOG
CAS:DMOG (Dimethyloxalylglycine), an antagonist of the α-ketoglutarate cofactor, is an inhibitor for HIF prolyl hydroxylase.Fórmula:C6H9NO5Pureza:80.23% - 99.98%Forma y color:SolidPeso molecular:175.14
