HIF / HIF Prolilhidroxilasa
El Factor Inducible por Hipoxia (HIF) es un factor de transcripción que desempeña un papel crucial en las respuestas celulares a bajos niveles de oxígeno (hipoxia). La actividad del HIF está regulada estrictamente por las prolil-hidroxilasas de HIF, que dirigen al HIF para su degradación en condiciones normóxicas. Los inhibidores de la prolil-hidroxilasa de HIF pueden estabilizar el HIF, promoviendo la expresión de genes involucrados en la angiogénesis, la eritropoyesis y el metabolismo. Estos inhibidores son de gran interés en el tratamiento de afecciones como la anemia, las enfermedades isquémicas y el cáncer. En CymitQuimica, ofrecemos inhibidores de HIF/prolil-hidroxilasa HIF para apoyar su investigación en biología de la hipoxia, terapia del cáncer y regulación metabólica.
Se han encontrado 142 productos de "HIF / HIF Prolilhidroxilasa"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
2,4-DPD
CAS:<p>2,4-DPD is competitive inhibitor of the oxygen-sensing enzyme HIF-α prolyl hydroxylase (HIF-PH)</p>Fórmula:C11H13NO4Pureza:99.74%Forma y color:Yellow Solid CrystallinePeso molecular:223.23HIF-2α-IN-4
CAS:<p>HIF-2a translation inhibitor is a compound used as a molecular building block.</p>Fórmula:C9H9N3O4S2Pureza:≥98%Forma y color:SolidPeso molecular:287.32PT-2385
CAS:<p>PT-2385 is a selective HIF-2α inhibitor (Kd<50 nM).</p>Fórmula:C17H12F3NO4SPureza:98.91% - 99.55%Forma y color:SolidPeso molecular:383.34Oroxylin A
CAS:<p>Oroxylin A fights tumors, aids RAS therapy, promotes CaCo-2 cell apoptosis, blocks MCF-7 cell invasion and enhances leukemia treatment.</p>Fórmula:C16H12O5Pureza:98.72% - 99.55%Forma y color:SolidPeso molecular:284.26IOX4
CAS:<p>IOX4 is a potent PHD2 inhibitor (IC50 = 1.6 nM)</p>Fórmula:C15H16N6O3Pureza:99.97%Forma y color:SolidPeso molecular:328.33Panaxadiol
CAS:<p>Panaxadiol (20(R)-Panaxadiol) is a novel antitumor agent extracted from the Chinese medical herb Panax ginseng.</p>Fórmula:C30H52O3Pureza:98% - 99.9%Forma y color:SolidPeso molecular:460.73LW6
CAS:<p>LW6 (HIF-1α inhibitor) is a novel HIF-1 inhibitor.</p>Fórmula:C26H29NO5Pureza:98.1% - 98.22%Forma y color:SolidPeso molecular:435.51Belzutifan
CAS:<p>"Belzutifan (MK-6482) is an oral HIF-2α inhibitor for ccRCC, with enhanced potency (IC50: 9 nM)."</p>Fórmula:C17H12F3NO4SPureza:99.34% - 99.88%Forma y color:SolidPeso molecular:383.34Amifostine trihydrate
CAS:<p>Amifostine trihydrate (WR2721) is the first approved radioprotective drug, used to decrease the risk of kidney problems caused by treatment with cisplatin.</p>Fórmula:C5H15N2O3PS·3H2OPureza:99.71% - 99.80%Forma y color:SolidPeso molecular:268.27PX-478
CAS:PX-478 is a HIF-1α inhibitor with selectivity, oral activity, and blood-brain barrier permeability.Fórmula:C13H20Cl4N2O3Pureza:97% - 99.79%Forma y color:SolidPeso molecular:394.12Diethyl bipy55'DC
CAS:<p>"Diethyl bipy55'DC blocks CP4H, crucial for collagen stability via hydroxylation in cells."</p>Fórmula:C16H16N2O4Pureza:98%Forma y color:SolidPeso molecular:300.31E3330
CAS:<p>E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.</p>Fórmula:C21H30O6Pureza:99.52%Forma y color:SolidPeso molecular:378.46OHM1
CAS:<p>OHM1, an analog of HIF1α CTAD, effectively inhibits the interaction between HIF1α CTAD and p300/CBP by targeting the CH1 domain with a binding affinity of 0.53</p>Fórmula:C24H42N6O5Forma y color:SolidPeso molecular:494.63CL67
CAS:<p>CL67 is a hypoxia-inducible factor pathway inhibitor. It acts by binding to a G-quadruplex higher-order structure in the HIF promoter sequence in vitro.</p>Fórmula:C38H42N10O2Forma y color:SolidPeso molecular:670.81ZK-261991
CAS:<p>ZK-261991 is an orally active inhibitor of VEGFR tyrosine kinase(IC50 of 5 nM, VEGFR2).</p>Fórmula:C24H25N7O2Pureza:98%Forma y color:SolidPeso molecular:443.5Dimethyl-bisphenol A
CAS:<p>DMBPA inhibits HIF-1α, promotes its degradation by detaching Hsp90, and reduces Vegfa mRNA expression.</p>Fórmula:C17H20O2Forma y color:SolidPeso molecular:256.34FM19G11
CAS:<p>FM19G11 is an inhibitor of hypoxia inducible factor (HIF) α-subunit (IC50 = 80 nM in hypoxia induced luciferase assay).</p>Fórmula:C23H17N3O8Pureza:99.70%Forma y color:SolidPeso molecular:463.4GSK360A
CAS:<p>GSK360A is a novel prolyl hydroxylase (PHD) domain-containing enzyme inhibitor.</p>Fórmula:C17H17FN2O5Pureza:98%Forma y color:SolidPeso molecular:348.33HIF-1α-IN-3
CAS:<p>HIF-1α-IN-3, also known as Compound (S)-3f, is a hypoxia-selective inhibitor of HIF-1α. It exhibits potent antiestrogenic activity [1].</p>Fórmula:C19H17N5O2Forma y color:SolidPeso molecular:347.37TM6008
CAS:<p>TM6008 is an inhibitor of prolyl hydroxylase that protects against cell death after hypoxia.</p>Fórmula:C21H17N5O3Pureza:98%Forma y color:SolidPeso molecular:387.39
