Anhídrido carbónico
La anhidrasa carbónica es una enzima que cataliza la conversión reversible de dióxido de carbono y agua en bicarbonato y protones. Esta enzima juega un papel crucial en el mantenimiento del equilibrio ácido-base, la respiración y el transporte de dióxido de carbono en la sangre. Los inhibidores de la anhidrasa carbónica se utilizan en el tratamiento del glaucoma, la epilepsia y el mal de altura, así como en la investigación sobre la homeostasis ácido-base y el intercambio de gases. En CymitQuimica, ofrecemos una gama de inhibidores de la anhidrasa carbónica y reactivos de alta calidad para apoyar su investigación en enzimología, fisiología respiratoria y desarrollo terapéutico.
Se han encontrado 196 productos de "Anhídrido carbónico"
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DOTA-XYIMSR-01
CAS:DOTA-XYIMSR-01 is a molecular probe targeting CAIX, capable of being labeled with 177Lu for the treatment and localization of malignant gliomas. The uptake of [177Lu]Lu-XYIMSR-01 in U87MG tumors is 6.19% injected dose per gram (% ID/g), with a tumor-to-muscle uptake ratio of 20.14. In an orthotopic glioma model, co-administration with temozolomide significantly enhances survival rates and inhibits tumor growth in mice. DOTA-XYIMSR-01 shows potential for research in the field of cancer treatment.Fórmula:C61H88N16O22S2Forma y color:SolidPeso molecular:1461.57CAII/CAXII-IN-1
CAII/CAXII-IN-1 (compound 8d) is an inhibitor of CAII and CAXII, with IC50 values of 0.38 µM for CAII and 0.61 µM for CAXII.Forma y color:Odour SolidhCAI/II-IN-10
hCAI/II-IN-10 (Compound 5d) is an inhibitor of human carbonic anhydrase I and II (hCA I and hCA II), with IC50 values of 4.32 nM and 3.89 nM, respectively.Fórmula:C24H17Cl2N3O3S2Forma y color:SolidPeso molecular:530.446Acesulfame
CAS:Acesulfame inhibits CA9/12 and can be used to study inflammation-related diseases.Fórmula:C4H5NO4SForma y color:SolidPeso molecular:163.15CAIX/CAXII-IN-3
CAIX/CAXII-IN-3 (compound 11) serves as an inhibitor for CAIX/CAXII, exhibiting an IC50 value of less than 65 nM. Additionally, this compound effectively inhibits the proliferation of human melanoma cells.Forma y color:Odour SolidhCA/VEGFR-2-IN-4
hCA/VEGFR-2-IN-4 (compound 15b), an indolinylbenzenesulfonamide, serves as a potential dual inhibitor targeting cancer-related human carbonic anhydrases hCA IX/Fórmula:C22H23FN6O5SPureza:98%Forma y color:SolidPeso molecular:502.52hCA/VEGFR-2-IN-3
hCA/VEGFR-2-IN-3 (compound 8j) is an indolinonylbenzenesulfonamide with potential as a dual inhibitor of cancer-associated hCA IX/XII and VEGFR-2.Fórmula:C24H28N6O6SPureza:98%Forma y color:SolidPeso molecular:528.58hCAIX/XII-IN-11
hCAIX/XII-IN-11 (Compound 6c) is an inhibitor of hCA IX and hCA XII, exhibiting Ki values of 0.7 μM for both isoforms. This compound is applicable in cancer research.Fórmula:C13H10FN3O4Peso molecular:291.06553CAIX Inhibitor S4
CAS:CAIX Inhibitor S4 (S4) is an effective inhibitor of carbonic anhydrase IX/XII with a Ki of 7 nM and 2 nM, respectively.
Fórmula:C15H17N3O4SPureza:99.07%Forma y color:SolidPeso molecular:335.38TSPO/Carbonic Anhydrase Modulator 1
TSPO/Carbonic Anhydrase Modulator 1 (Compound 3) acts as a dual modulator of mitochondrial translocator protein and carbonic anhydrase, with a TSPOKi of 1.340 μM and a CAVII KA of 10.7 μM. It enhances neurosteroid production, increases BDNF gene expression, and demonstrates neuroprotective activity.Fórmula:C35H51N3O3Forma y color:SolidPeso molecular:561.798hCAIX-IN-17
hCA IX-IN-1 inhibits hCA I/II/IX/XII with Ki of 331.4/28.4/9.4/17.8 nM, has anticancer properties.Fórmula:C19H18N2O3SForma y color:SolidPeso molecular:354.42hCAIX/XII-IN-14
hCAIX/XII-IN-14 (Compound 1i) is an inhibitor of hCAIX and hCAXII, with Ki values of 9.4 nM for hCAII, 5.6 nM for hCAIX, and 6.3 nM for hCAXII.Fórmula:C16H14F3N3O4SForma y color:SolidPeso molecular:401.36hCAIX-IN-19
hCAIX-IN-19 is a sulfonamide inhibitor with an inhibition constant (KI) of 6.2 nM for hCAIX, exhibiting significant selectivity towards hCAIX over hCAI (hCA I/Forma y color:Odour SolidhCAII-IN-8
CAS:Compound CDy9 is a highly selective inhibitor of carbonic anhydrase (CA) with an IC50 value of 0.18 μM for hCA II.Fórmula:C15H16N2O5SPureza:99.73%Forma y color:SoildPeso molecular:336.36Ref: TM-T67774
5mg42,00€10mg64,00€25mg116,00€50mg167,00€100mg241,00€200mg339,00€1mL*10mM (DMSO)52,00€DPP IV/hCA II-IN-1
CAS:DPP IV/hCA II-IN-1: strong DPP IV & CA inhibitor, IC50=0.049μM (DPP IV), Ki=0.0361-3.034μM (CA II-IV).Fórmula:C17H20N2O5SForma y color:SolidPeso molecular:364.42hCAII-IN-6
"hCAII-IN-6 (S-13) inhibits hCA II (4.4 nM) and isoforms I, IV, IX (9.2, 480.2, 14.7 nM). For glaucoma research."Fórmula:C20H25N3O4SForma y color:SolidPeso molecular:403.5Carbonic anhydrase inhibitor 32
Carbonic anhydrase inhibitor32 (compound 5B) is an orally active, selective inhibitor of hCA (carbonic anhydrase) II/VII, with Ki values of 6.3 nM for hCA II, 10.1 nM for hCA VII, and 681 nM for hCA I. It shows potential for neuroprotection and anticonvulsant effects by reducing mTOR activation and increasing hippocampal KCC2 levels.Fórmula:C17H16N6O3SForma y color:SolidPeso molecular:384.41(E)-Dehydrodiconiferyl alcohol
CAS:(E)-Dehydrodiconiferyl alcohol inhibits hCA IX/XII enzymes and blocks NF-κB nuclear translocation in healing tissues.Fórmula:C20H22O6Forma y color:SolidPeso molecular:358.39Carbonic anhydrase inhibitor 30
Carbonic anhydrase inhibitor30 (compound 17) is an inhibitor of carbonic anhydrase with Ki values of 2.13 μM for hCA I and 0.161 μM for hCA II[1].Fórmula:C23H22FN3O5SForma y color:SolidPeso molecular:471.12642hCAIX/XII-IN-10
hCAIX/XII-IN-10 (compound DK-8) is an inhibitor of Carbonic Anhydrase, showing potent inhibitory activity against the tumor-associated membrane-bound isoforms hCA IX and XII, with Ki values of 32.5 nM and 29.2 nM, respectively.Fórmula:C17H13N3O5SPeso molecular:371.05759
