ROR
Los receptores órfanos relacionados con el ácido retinoico (RORs) son receptores nucleares que regulan diversos procesos fisiológicos, incluyendo el ritmo circadiano, la respuesta inmunitaria y el metabolismo. Los inhibidores de ROR son de interés en el estudio de enfermedades autoinmunes, trastornos metabólicos y cáncer, ya que pueden modular la expresión génica e influir en las funciones celulares. En CymitQuimica, ofrecemos inhibidores de ROR para apoyar su investigación en inmunología, endocrinología y oncología.
Se han encontrado 48 productos para "ROR".
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RORγt inverse agonist 33
RORγt inverse agonist 33 (compound (R)-D4) is an orally bioavailable RORγt inverse agonist with an IC50 of 21 nM, playing a significant role in rheumatoid arthritis research.Fórmula:C27H37NO5SForma y color:SolidPeso molecular:487.651XY039
XY039 (compound 13e) is an RORγ inverse agonist with an IC50 value of 0.55 μM. XY039 induces cell apoptosis and exhibits antiproliferative activity both in vivo and in vitro.Fórmula:C23H19F5N2O4S2Forma y color:SolidPeso molecular:546.07064Antitumor agent-127
Antitumor agent-127 (compound 1) is a parent macrocyclic peptide that demonstrates nanomolar binding affinity to ROR1 and shows relatively good internalization in 786-O and MDA-MB-231 tumor cell lines.Fórmula:C86H107N15O18SPeso molecular:1669.76392RORγ agonist 2
RORγ agonist2 (Compound 34) is a selective RORγ agonist with an EC50 of 0.03 μM for hRORγ. It significantly inhibits tumor growth in an MC38 tumor mouse model with the same genetic background.Forma y color:Odour SolidTMP-778
CAS:TMP-778 is a selective inverse agonist of RORγt.Fórmula:C31H30N2O4Pureza:99.68%Forma y color:SolidPeso molecular:494.58Bevurogant
CAS:Bevurogant is an antagonist of RORγt receptor and can be used in studies about the treatment of chronic inflammatory diseases.Fórmula:C26H28N8O3SPureza:99.32%Forma y color:SolidPeso molecular:532.617ROR1 ligand-1
ROR1ligand-1 (9-1) serves as the ligand for PROTAC ROR1 degrader-1. By linking with ligands of either the VHL type or CRBN, the first selective and efficient ROR1 PROTAC molecule was designed and synthesized.Fórmula:C23H30BrN7Forma y color:SolidPeso molecular:484.44RORγ antagonist 1
RORγ antagonist 1 (compound 22), a potent derivative of betulinic acid, acts as an antagonist to RORγ with a dissociation constant (K D) of 0.18 μM.Fórmula:C35H60N2O2Pureza:98%Forma y color:SolidPeso molecular:540.86RORγt inverse agonist 31
RORγt inverse agonist 31 (14g) is a potent antagonist of the retinoic acid receptor-related orphan receptor γt (RORγt), exhibiting an inhibitory concentration (Fórmula:C23H15Cl2F3N4O3SPureza:98%Forma y color:SolidPeso molecular:555.36TMP920
CAS:TMP920 inhibits RORγt binding to the SRC1 peptide (IC50: 0.03 μM). TMP920 is a highly potent and selective RORγt antagonist.Fórmula:C29H30N2O3Pureza:99%Forma y color:SolidPeso molecular:454.5601XY018
CAS:XY018 is a ROR-γ antagonist with anti-tumor activity, inhibits ROR-γ activity, and can be used to study drug-resistant prostate cancer.Fórmula:C23H15F7N2O4Pureza:99.95% - 99.96%Forma y color:SolidPeso molecular:516.365Cedirogant
CAS:Cedirogant (ABBV-157) is an orally active retinoid-related orphan receptor-γt(RORγt) inverse agonist that is used for psoriasis study.Fórmula:C24H20Cl3F3N2O3Pureza:99.20%Forma y color:White SolidPeso molecular:547.781SR0987
CAS:SR0987 is a RORγt agonist,Fórmula:C16H10ClF6NO2Pureza:99.43%Forma y color:SolidPeso molecular:397.7SR1001
CAS:SR 1001 is an inverse agonist for RORα/RORγ (Kis: 172/111 nM).Fórmula:C15H13F6N3O4S2Pureza:98.93%Forma y color:SolidPeso molecular:477.4Cintirorgon
CAS:Cintirorgon (LYC-55716) is a selective, oral agonist of RORγ. Cintirorgon modulates gene expression of RORγ expressing T lymphocyte immune cells.Fórmula:C27H23F6NO6SPureza:99.92%Forma y color:SolidPeso molecular:603.53SR3335
CAS:SR3335 (ML 176) is a selective inverse agonist of RORα, competitively inhibiting the binding of 25-hydroxycholesterol to the ligand binding domain (Ki: 220 nM).Fórmula:C13H9F6NO3S2Pureza:99.77%Forma y color:SolidPeso molecular:405.336SR1078
CAS:SR1078 is an agonist of retinoic acid receptor-related orphan receptor (ROR)α/γ.Fórmula:C17H10F9NO2Pureza:99.58%Forma y color:SolidPeso molecular:431.25Neoruscogenin
CAS:1. Neoruscogenin represents a universal pharmacological tool for RORα research due to its specific selectivity profile versus other nuclear receptors.Fórmula:C27H40O4Pureza:99.5% - 99.92%Forma y color:SolidPeso molecular:428.6041S18-000003
CAS:S18-000003: Oral retinoic acid receptor gamma-t inhibitor, IC50 29 nM, reduces IL-17 production.Fórmula:C26H25F3N2O4SPureza:99.24% - 99.31%Forma y color:White SolidPeso molecular:518.548RORγt inverse agonist 13
CAS:RORγt inverse agonist 13 (Compound 3i) is a potent, orally active and selective RORγt inverse agonist (IC50=63.8 nM), with improved drug-like properties[1].Fórmula:C23H17Cl2F3N2O4Pureza:99.04%Forma y color:White SolidPeso molecular:513.293
