ROR
Los receptores órfanos relacionados con el ácido retinoico (RORs) son receptores nucleares que regulan diversos procesos fisiológicos, incluyendo el ritmo circadiano, la respuesta inmunitaria y el metabolismo. Los inhibidores de ROR son de interés en el estudio de enfermedades autoinmunes, trastornos metabólicos y cáncer, ya que pueden modular la expresión génica e influir en las funciones celulares. En CymitQuimica, ofrecemos inhibidores de ROR para apoyar su investigación en inmunología, endocrinología y oncología.
Se han encontrado 47 productos para "ROR".
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
XY039
XY039 (compound 13e) is an RORγ inverse agonist with an IC50 value of 0.55 μM. XY039 induces cell apoptosis and exhibits antiproliferative activity both in vivo and in vitro.Fórmula:C23H19F5N2O4S2Forma y color:SolidPeso molecular:546.07064TMP-778
CAS:TMP-778 is a selective inverse agonist of RORγt.Fórmula:C31H30N2O4Pureza:99.68%Forma y color:SolidPeso molecular:494.58Bevurogant
CAS:Bevurogant is an antagonist of RORγt receptor and can be used in studies about the treatment of chronic inflammatory diseases.Fórmula:C26H28N8O3SPureza:99.32%Forma y color:SolidPeso molecular:532.62RORγ agonist 2
RORγ agonist2 (Compound 34) is a selective RORγ agonist with an EC50 of 0.03 μM for hRORγ. It significantly inhibits tumor growth in an MC38 tumor mouse model with the same genetic background.Forma y color:Odour SolidAntitumor agent-127
Antitumor agent-127 (compound 1) is a parent macrocyclic peptide that demonstrates nanomolar binding affinity to ROR1 and shows relatively good internalization in 786-O and MDA-MB-231 tumor cell lines.Fórmula:C86H107N15O18SPeso molecular:1669.76392RORγt inverse agonist 33
RORγt inverse agonist 33 (compound (R)-D4) is an orally bioavailable RORγt inverse agonist with an IC50 of 21 nM, playing a significant role in rheumatoid arthritis research.Fórmula:C27H37NO5SForma y color:SolidPeso molecular:487.651RORγt inverse agonist 31
RORγt inverse agonist 31 (14g) is a potent antagonist of the retinoic acid receptor-related orphan receptor γt (RORγt), exhibiting an inhibitory concentration (Fórmula:C23H15Cl2F3N4O3SPureza:98%Forma y color:SolidPeso molecular:555.36ROR1 ligand-1
ROR1ligand-1 (9-1) serves as the ligand for PROTAC ROR1 degrader-1. By linking with ligands of either the VHL type or CRBN, the first selective and efficient ROR1 PROTAC molecule was designed and synthesized.Fórmula:C23H30BrN7Forma y color:SolidPeso molecular:484.44RORγ antagonist 1
RORγ antagonist 1 (compound 22), a potent derivative of betulinic acid, acts as an antagonist to RORγ with a dissociation constant (K D) of 0.18 μM.Fórmula:C35H60N2O2Pureza:98%Forma y color:SolidPeso molecular:540.86XY018
CAS:XY018 is a ROR-γ antagonist with anti-tumor activity, inhibits ROR-γ activity, and can be used to study drug-resistant prostate cancer.Fórmula:C23H15F7N2O4Pureza:99.95% - 99.96%Forma y color:SolidPeso molecular:516.37TMP920
CAS:TMP920 inhibits RORγt binding to the SRC1 peptide (IC50: 0.03 μM). TMP920 is a highly potent and selective RORγt antagonist.Fórmula:C29H30N2O3Pureza:98%Forma y color:SolidPeso molecular:454.56SR1001
CAS:SR 1001 is an inverse agonist for RORα/RORγ (Kis: 172/111 nM).Fórmula:C15H13F6N3O4S2Pureza:98.93%Forma y color:SolidPeso molecular:477.4SR0987
CAS:SR0987 is a RORγt agonist,Fórmula:C16H10ClF6NO2Pureza:99.43%Forma y color:SolidPeso molecular:397.7GSK2981278
CAS:GSK2981278 (ROR gama modulator 1) is a highly potent and selective inverse agonist of retinoic acid receptor-related orphan receptor gamma (ROR gamma).Fórmula:C25H35NO5SPureza:99.31% - 99.67%Forma y color:SolidPeso molecular:461.61SR3335
CAS:SR3335 (ML 176) is a selective inverse agonist of RORα, competitively inhibiting the binding of 25-hydroxycholesterol to the ligand binding domain (Ki: 220 nM).Fórmula:C13H9F6NO3S2Pureza:99.77%Forma y color:SolidPeso molecular:405.34Ref: TM-T5160
1mg34,00€5mg74,00€1mL*10mM (DMSO)82,00€10mg119,00€25mg233,00€50mg371,00€100mg595,00€200mg833,00€Cedirogant
CAS:Cedirogant (ABBV-157) is an orally active retinoid-related orphan receptor-γt(RORγt) inverse agonist that is used for psoriasis study.Fórmula:C24H20Cl3F3N2O3Pureza:99.20%Forma y color:White SolidPeso molecular:547.78Ref: TM-T9635
1mg81,00€5mg167,00€1mL*10mM (DMSO)197,00€10mg259,00€25mg470,00€50mg703,00€100mg1.044,00€200mg1.404,00€Cintirorgon
CAS:Cintirorgon (LYC-55716) is a selective, oral agonist of RORγ. Cintirorgon modulates gene expression of RORγ expressing T lymphocyte immune cells.Fórmula:C27H23F6NO6SPureza:99.92%Forma y color:SolidPeso molecular:603.53Ref: TM-TQ0007
1mg66,00€5mg130,00€1mL*10mM (DMSO)167,00€10mg178,00€25mg313,00€50mg447,00€100mg620,00€S18-000003
CAS:S18-000003: Oral retinoic acid receptor gamma-t inhibitor, IC50 29 nM, reduces IL-17 production.Fórmula:C26H25F3N2O4SPureza:99.24% - 99.31%Forma y color:White SolidPeso molecular:518.55Ref: TM-T16832
1mg54,00€5mg118,00€1mL*10mM (DMSO)135,00€10mg178,00€25mg318,00€50mg445,00€100mg627,00€500mg1.251,00€SR1078
CAS:SR1078 is an agonist of retinoic acid receptor-related orphan receptor (ROR)α/γ.Fórmula:C17H10F9NO2Pureza:99.58%Forma y color:SolidPeso molecular:431.25Ref: TM-T4594
1mg39,00€2mg52,00€5mg85,00€1mL*10mM (DMSO)87,00€10mg109,00€25mg215,00€50mg349,00€100mg517,00€Neoruscogenin
CAS:1. Neoruscogenin represents a universal pharmacological tool for RORα research due to its specific selectivity profile versus other nuclear receptors.Fórmula:C27H40O4Pureza:99.5% - 99.92%Forma y color:SolidPeso molecular:428.60
