PPAR
Los receptores activados por proliferadores de peroxisomas (PPARs) son un grupo de proteínas receptoras nucleares que funcionan como factores de transcripción regulando la expresión de genes involucrados en el metabolismo, particularmente en el almacenamiento de ácidos grasos y el metabolismo de la glucosa. Los inhibidores de PPAR son herramientas importantes para estudiar trastornos metabólicos como la diabetes, la obesidad y las enfermedades cardiovasculares. Estos inhibidores pueden modular el metabolismo de los lípidos, la sensibilidad a la insulina y la inflamación, lo que los convierte en valiosos en la investigación terapéutica. En CymitQuimica, ofrecemos una gama de inhibidores de PPAR para apoyar su investigación en enfermedades metabólicas, endocrinología y desarrollo de fármacos.
Se han encontrado 169 productos de "PPAR"
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Licarin B
CAS:1.(-)-Licarin B (Licarine B) has anti-mycobacterial activity.Fórmula:C20H20O4Pureza:99.82% - ≥95%Forma y color:SolidPeso molecular:324.37Troglitazone
CAS:Troglitazone (Romglizone) is a PPARγ agonist with anti-inflammatory and anti-tumor activity.Fórmula:C24H27NO5SPureza:98% - 99.8%Forma y color:Yellow SolidPeso molecular:441.54Eupatilin
CAS:<p>Eupatilin (NSC-122413), a flavone derived from Artemisia princepsPampanini, is a PPARα agonist, with pharmacological activity.</p>Fórmula:C18H16O7Pureza:98.53% - 99%Forma y color:SolidPeso molecular:344.32DG172 dihydrochloride
CAS:<p>DG172 dihydrochloride (DG-172 dihydrochloride) is an antagonist of PPARβ/δ(IC50 : 27 nM).</p>Fórmula:C20H22BrCl2N3Pureza:99.87%Forma y color:SolidPeso molecular:455.2Tetradecylthioacetic acid
CAS:<p>Synthetic fatty acid TTA has β-sulfur, resists β-oxidation, and activates PPARs, especially PPARα.</p>Fórmula:C16H32O2SPureza:99.93%Forma y color:SolidPeso molecular:288.49T0070907
CAS:<p>T0070907(IC50=1 nM) , an effective and specific PPARγ inhibitor, with the >800-fold selectivity over PPARα and PPARδ.</p>Fórmula:C12H8ClN3O3Pureza:98.25% - 99.98%Forma y color:SolidPeso molecular:277.66Seladelpar
CAS:Seladelpar (MBX 8025) has been used in trials studying the treatment of Hyperlipidemia.Fórmula:C21H23F3O5SPureza:99.18% - 99.41%Forma y color:SolidPeso molecular:444.46Rosiglitazone
CAS:<p>Rosiglitazone (BRL49653) is a PPARγ agonist, TRPC5 activator, and TRPM3 inhibitor with oral activity.</p>Fórmula:C18H19N3O3SPureza:98.61% - 99.87%Forma y color:White To Off-White Crystalline PowderPeso molecular:357.43Angeloylgomisin H
CAS:Angeloylgomisin H shows moderate cytotoxic activities with IC50 values ranging from 100 to 200 ug/mL against MCF7, HEK293 and CAL27 cell lines.Fórmula:C28H36O8Pureza:99.84% - 99.95%Forma y color:SolidPeso molecular:500.58GW9662
CAS:GW9662 (TIMTEC-BB SBB006523) is a PPARγ antagonist (IC50=3.3 nM) with selectivity. GW9662 has anti-tumor effect. High-Quality, Low-Cost!Fórmula:C13H9ClN2O3Pureza:98% - 99.98%Forma y color:Off-White SolidPeso molecular:276.68SR1664
CAS:<p>SR1664 is a potent and selective PPARγ inhibitor with potential antidiabetic activity.</p>Fórmula:C33H29N3O5Pureza:98.02%Forma y color:SolidPeso molecular:547.6FH535
CAS:FH535, a Wnt/β-catenin signaling and PPAR inhibitor, exhibits anti-tumor activities.Fórmula:C13H10Cl2N2O4SPureza:98.25% - 99.5%Forma y color:SolidPeso molecular:361.2Icariin
CAS:Icariin (Ieariline) is a flavonol glycoside that inhibits PDE5 and PDE4 activity and is a PPARα activator. Cost-effective and quality-assured.Fórmula:C33H40O15Pureza:97.82% - 98.3%Forma y color:SolidPeso molecular:676.66GW6471
CAS:GW6471 is an antagonist of PPARα. GW6471 enhances the binding affinity of the PPAR α ligand-binding domain to the co-repressor proteins SMRT and NCoR.Fórmula:C35H36F3N3O4Pureza:98.23% - 99.55%Forma y color:SolidPeso molecular:619.67Palmitelaidic Acid
CAS:Palmitelaidic Acid (trans-Palmitoleic acid) is one of the most abundant fatty acids in serum and tissue.Fórmula:C16H30O2Pureza:99.76%Forma y color:SolidPeso molecular:254.41NSC-87877 disodium
CAS:NSC-87877 disodium (NSC87877) is a cell-permeable inhibitor of both SHP-1 and SHP-2. NSC-87877 also inhibits EGF-induced Erk1/2 activation in HEK293 cells.Fórmula:C19H13N3O7S2·2NaPureza:97.89%Forma y color:SolidPeso molecular:503.42Glabrone
CAS:<p>Glabrone shows antiviral activity against influenza virus.</p>Fórmula:C20H16O5Pureza:99.08% - 99.55%Forma y color:SolidPeso molecular:336.34Tesaglitazar
CAS:<p>Tesaglitazar is a potent and selective peroxide PPARα / γ receptor dual agonist with a more potent affinity for PPARγ than PPARα, The EC50 values for rat PPARα</p>Fórmula:C20H24O7SPureza:99.95%Forma y color:SolidPeso molecular:408.47THR-0921
CAS:THR-0921 (CLX-0921) is a peroxisome proliferator-activated receptor (PPAR) agonist that can be used to study cardiovascular and metabolic diseases.Fórmula:C28H25NO7SPureza:100% - 99.83%Forma y color:SolidPeso molecular:519.5713-Oxo-9E,11E-octadecadienoic acid
CAS:<p>13-Oxo-9E,11E-octadecadienoic acid from tomato juice, an isomer of 9-oxo-ODA, activates PPARα and lowers triglycerides in diabetic mice.</p>Fórmula:C18H30O3Pureza:98%Forma y color:SolidPeso molecular:294.43AVE-8134
CAS:AVE-8134 is an agonist of PPARα. For human and rodent PPARα receptor, the EC50 values are 100 and 3000 nM, respectively.Fórmula:C22H23NO5Pureza:98%Forma y color:SolidPeso molecular:381.42GW 9578
CAS:GW 9578 is a PPARα agonist with potent lipid-lowering activity for the study of psoriasis, arthritis, alopecia, asthma and type I diabetes.Fórmula:C26H34F2N2O3SPureza:98%Forma y color:SolidPeso molecular:492.62Peliglitazar racemate
CAS:<p>Peliglitazar racemate(BMS 426707-01 racemate) is the racemate of Peliglitazar.Peliglitazar racemate may be used as a potential antidiabetic and anti-obesity</p>Fórmula:C30H30N2O7Pureza:97.75%Forma y color:SolidPeso molecular:530.57BVT.13
CAS:BVT.13 is an orally active selective PPARγ agonist with antidiabetic activity comparable to rosiglitazone, supporting research in metabolic regulation.Fórmula:C18H11Cl2N3O4Pureza:98.59%Forma y color:SolidPeso molecular:404.2FTX-6746
CAS:FTX-6746 is an orally active and selective PPARG reverse inhibitor with anticancer activity. It can be used in research on urothelial carcinoma.Fórmula:C16H7ClF2N2OPureza:98.68%Forma y color:SolidPeso molecular:316.69GSK376501A
CAS:<p>GSK376501A is a selective and effective modulator of peroxisome proliferator-activated receptor γ (PPARγ) for the study of type 2 diabetes.</p>Fórmula:C32H37NO6Pureza:>99.99%Forma y color:SolidPeso molecular:531.64Pparδ agonist 2
CAS:Pparδ agonist 2 is an agonist of PPARδ.Fórmula:C20H18F3N3O3SPureza:98%Forma y color:SolidPeso molecular:437.44Daltroban
CAS:<p>Daltroban (SKF 96148) is a specific thromboxane A2 (TXA2) receptor antagonist.</p>Fórmula:C16H16ClNO4SPureza:99.74%Forma y color:SolidPeso molecular:353.82Saroglitazar
CAS:Saroglitazar (Lipaglyn) is an agonist of PPAR with EC50 values of 0.65 pM and 3 nM for PPARα and PPARγ.Fórmula:C25H29NO4SPureza:98.51%Forma y color:SolidPeso molecular:439.57PPARα-MO-1
CAS:PPARα-MO-1 is a potent modulator of PPARα.Fórmula:C27H37NO5Pureza:98%Forma y color:SolidPeso molecular:455.59LG100754
CAS:LG100754 (UVI 2112) is an insulin sensitizer and RXR modulator, antagonizing RXR homodimers while agonizing RXR:PPARα/γ heterodimers.Fórmula:C26H36O3Forma y color:SolidPeso molecular:396.56Chiglitazar
CAS:Chiglitazar is a PPAR α/γ/δ agonist and insulin sensitizer used in the treatment of type 2 diabetes mellitus , anti-inflammatory and anti-fibrotic.Fórmula:C36H29FN2O4Forma y color:SolidPeso molecular:572.63Inolitazone dihydrochloride
CAS:Inolitazone dihydrochloride is an effective, high-affinity PPARγ agonist; its biological activity is dependent on PPARγ (IC50:0.8 nM) to inhibit cell growth.Fórmula:C27H28Cl2N4O4SForma y color:SolidPeso molecular:575.51ARH-049020
CAS:ARH-049020, a peroxisome proliferator-activated receptor (PPAR) agonist, is used potentially for the treatment of insulin resistance and type 2 diabetes.Fórmula:C24H31NO6Pureza:97.19% - 99.82%Forma y color:SolidPeso molecular:429.51Reglitazar
CAS:Reglitazar, a dual PPARα/γ agonist, enhances insulin signaling, reduces insulin resistance, and lowers hypertriglyceridemia in obese rats.Fórmula:C22H20N2O5Pureza:97.07% - 98.72%Forma y color:SolidPeso molecular:392.4BAY-0069
CAS:<p>BAY-0069 is a potent and selective PPARγ transactivator that inhibits human PPARγ and murine PPARγ with IC50s of 6.3 nM and 24 nM, respectively.BAY-0069 can be</p>Fórmula:C22H16BrN3O4Pureza:99.41%Forma y color:SoildPeso molecular:466.28Indeglitazar
CAS:Indeglitazar (PPM 204) is orally available pan-agonist of PPAR (PPAR subtypes alpha (α), delta (δ), and gamma (γ)).Fórmula:C19H19NO6SPureza:99.45%Forma y color:SolidPeso molecular:389.42Farglitazar
CAS:Farglitazar (GI-262570) is a PPAR-γ agonist and insulin sensitizer used in the study of diabetes.Fórmula:C34H30N2O5Pureza:99.4% - 99.52%Forma y color:SolidPeso molecular:546.61Dazmegrel
CAS:<p>Dazmegrel (UK 38,485) is a thromboxane A2 (TXA2) synthase inhibitor for the prevention of increased whole platelet aggregation in normal pregnancy.</p>Fórmula:C16H17N3O2Pureza:98.81%Forma y color:SolidPeso molecular:283.33Cevoglitazar
CAS:Cevoglitazar (LBM-642) is a PPARɑ agonist and PPARγ agonist. Cevoglitazar potently reduces food intake and body weight in obese mice and cynomolgus monkeys.Fórmula:C27H21F3N2O6SPureza:97%Forma y color:SolidPeso molecular:558.53K-111
CAS:K-111 is a PPAR alpha agonist. K-111 improves insulin resistance, reducing bodyweight, and ameliorating atherogenic dyslipidemia.Fórmula:C18H25Cl3O2Pureza:99.64% - 99.88%Forma y color:SolidPeso molecular:379.75BAY-4931
CAS:<p>BAY-4931 is a powerful, covalent, and selective inverse-agonist of PPARγ, exhibiting an IC50 value of 0.17 nM.</p>Fórmula:C22H16ClN3O4Pureza:99.47%Forma y color:SoildPeso molecular:421.83Linotroban
CAS:Linotroban（CL-871502） is a potent selective thromboxane (TXA2) receptor antagonist with antithrombotic activity.Fórmula:C14H15NO5S2Pureza:97.95% - >99.99%Forma y color:SolidPeso molecular:341.4Darglitazone
CAS:Darglitazone (CP-86325) is a potent, selective agonist of PPAR-γ with antidiabetic actions.Fórmula:C23H20N2O4SPureza:99.76%Forma y color:SolidPeso molecular:420.48KD-3010
CAS:<p>KD-3010 (Kalypsys) is an orally active potent and selective PPARδ agonist for the study of liver injury.</p>Fórmula:C30H33F3N2O8S2Pureza:99.61%Forma y color:SolidPeso molecular:670.72PPARγ agonist 8
CAS:PPARγ agonist 8, a compound that acts on the peroxisome proliferator-activated receptor gamma (PPARγ), has been shown to stimulate peroxisome proliferatorFórmula:C19H12F4O2SPureza:98%Forma y color:SolidPeso molecular:380.36U-46619
CAS:U-46619 is an effective thromboxane A2 (TXA2) agonist and a thromboxane A2 analog (endoperoxide), capable of inducing contraction in the aortic smooth muscle (Fórmula:C21H34O4Pureza:98%Forma y color:SolidPeso molecular:350.49PPARδ agonist 9
CAS:PPARδ agonist 9 (compound 21), with an EC50 of 3.6 nM, is effective in vivo, decreasing serum MCP-1 concentrations in mice and markedly reducing atheroscleroticFórmula:C26H28ClF3N4O3SPureza:98%Forma y color:SolidPeso molecular:569.04PPAR agonist 1
CAS:PPAR agonist 1 is an agonist of PPAR α/γ, used for reducing blood glucose, lipid levels, reducing body weight, and lowering cholesterol.Fórmula:C20H25NO6SPureza:98%Forma y color:SolidPeso molecular:407.48LCB-2853
CAS:LCB-2853 is a potent thromboxane A2/prostaglandin H2 (TXA2/PGH2) receptor antagonist with antiplatelet aggregation, antivasospasm, and antithrombotic effects.Fórmula:C21H24ClNO4SPureza:97.15%Forma y color:SolidPeso molecular:421.94Edaglitazone
CAS:Edaglitazone (R-483) is a PPARγ agonist with antiplatelet activity that can be used in studies of diabetes and obesity.Fórmula:C24H20N2O4S2Pureza:98%Forma y color:SolidPeso molecular:464.56Imiglitazar
CAS:<p>Imiglitazar (TAK559) is a potent PPAR-β/δ receptor agonist with hypoglycemic effects.</p>Fórmula:C28H26N2O5Pureza:97.33%Forma y color:SolidPeso molecular:470.52CRX000227
CAS:<p>CRX000227 is a PPAR modulator suitable for researching metabolic and cell proliferative disorders [1].</p>Fórmula:C25H24N4O2SPureza:98%Forma y color:SolidPeso molecular:444.55Ragaglitazar
CAS:Ragaglitazar(NNC-61-0029) is a potent dual activator of PPARγ and PPARα.Cost-effective and quality-assured.Fórmula:C25H25NO5Pureza:97.46% - 98.56%Forma y color:SolidPeso molecular:419.47Inolitazone
CAS:Inolitazone (RS5444) a high-affinity PPARγ agonist. Inolitazone exhibits IC50 for growth inhibition is ~0.8 nM in vitro.Fórmula:C27H26N4O4SPureza:99.41% - 99.53%Forma y color:SolidPeso molecular:502.58PPARγ agonist 10
CAS:PPARγ agonist 10 (compound 33g) serves as a PPARγ agonist, enhancing insulin secretion, glucose uptake, and insulin sensitivity in βTC6 cells [1].Fórmula:C17H14N4O3S2Forma y color:SolidPeso molecular:386.45Anti-NASH agent 2
CAS:<p>Anti-NASH agent 2 (compound 21) is an inhibitor of neolipogenesis activity and α-SMA gene expression. It improves hepatic steatosis, edema, inflammatory infiltration, and liver fibrosis in NASH mouse models.</p>Fórmula:C32H51N3O2Forma y color:SolidPeso molecular:509.766PPARγ agonist 17
CAS:PPARγ agonist17 (Compound C1) is an orally active PPARγ agonist. It enhances PPARγ activity, arrests the cell cycle of HT-29 cells at the G2/M phase, inhibits cell migration, and induces apoptosis. PPARγ agonist17 exhibits broad-spectrum antiproliferative activity against cancer cells with relatively low toxicity to normal cells and does not cross the blood-brain barrier.Fórmula:C48H63NO7Forma y color:SolidPeso molecular:766.016PPARγ modulator-2
CAS:PPARγmodulator-2 (Compound (R)-2n) is a reversible modulator of PPARγ, inhibiting the PPARγ ligand-binding domain (LBD) with an IC50 of 41 nM. It helps lower blood glucose levels, improves glucose tolerance and insulin sensitivity, and demonstrates antidiabetic activity in db/db mouse models.Fórmula:C26H21NO7S3SeForma y color:SolidPeso molecular:634.6Amezalpat
CAS:Amezalpat is a PPARα antagonist with an IC50 of 58 nM [nanomolar]. Amezalpat also exhibits antitumor activity.Fórmula:C34H41N3O4Forma y color:SolidPeso molecular:555.707PPARγ-IN-5
CAS:<p>PPARγ-IN-5 (Compound A3) is an inhibitor of PPARγ. In liver cells, it reduces lipid accumulation and shows no significant cytotoxicity in HepG2 cells at a concentration of 400 µM. PPARγ-IN-5 is applicable for research on non-alcoholic fatty liver disease.</p>Fórmula:C22H23ClO7Forma y color:SolidPeso molecular:434.867PPARα/δ agonist 3
CAS:PPARα/δ agonist 3 (Compound 8) is an orally active PPAR agonist capable of activating PPARα, PPARδ, and PPARγ, with EC50 values of 5.6 nM, 3.4 nM, and 1278 nM, respectively. It exhibits anti-cholestatic activity in mouse models of cholestatic liver disease induced by ANIT or CDCA.Fórmula:C23H25F3N2O4Forma y color:SolidPeso molecular:450.451PPARδ agonist 11
CAS:<p>Compound 11, a selective PPARδ agonist, demonstrates an EC50 of 20 nM, indicating its high affinity for PPARδ receptors. This compound efficiently reduces levels of nitric oxide (NO), as well as the pro-inflammatory cytokines TNFα and IL-6 in LPS-stimulated RAW264.7 cells via the NF-κB pathway, showcasing its anti-inflammatory properties. Additionally, Compound 11 exhibits remarkable stability in human liver microsomes and plasma. It significantly ameliorates foot edema induced by Carrageenan, displaying favorable pharmacokinetic properties with a bioavailability of approximately 100%.</p>Fórmula:C19H15F3N2O3S2Forma y color:SolidPeso molecular:440.46Fonadelpar
CAS:Fonadelpar is an agonist of PPARδ. It also is used in the research of neuroparalytic keratopathy.Fórmula:C25H23F3N2O4SPureza:98%Forma y color:SolidPeso molecular:504.52SR 11023
CAS:SR 11023, an orally active PPAR γ antagonist, exhibits an IC 50 value of 109 nM and is significant in diabetes research [1].Fórmula:C33H36N2O3Forma y color:SolidPeso molecular:508.65Aleglitazar
CAS:<p>Aleglitazar (R1439) (R1439) is a potent dual PPARα/γ agonist, with IC50s of 38 nM and 19 nM for human PPARa and PPARγ, respectively.</p>Fórmula:C24H23NO5SPureza:99.03%Forma y color:SolidPeso molecular:437.51PPARγ-IN-2
CAS:<p>"PPARγ-IN-2 (Compound 5a), a PPARγ inhibitor, exhibits an EC50 of 0.106 μM in inhibiting TG accumulation in 3T3-L1 preadipocytes.</p>Fórmula:C19H21N5OPureza:98%Forma y color:SolidPeso molecular:335.4Ref: TM-T79678
Producto descatalogadoMavodelpar free base
CAS:<p>Mavodelpar free acid (REN001 free acid) is an selective agonist of PPARδ.</p>Fórmula:C31H30FNO5Pureza:98%Forma y color:SolidPeso molecular:515.57Anti-NASH agent 1
CAS:<p>Anti-NASH Agent 1 (Compound 3d), derived from Elafibranor, serves as a strong PPAR-α/δ agonist aimed at treating nonalcoholic steatohepatitis (NASH).</p>Fórmula:C26H33NO4Pureza:98%Forma y color:SolidPeso molecular:423.54Ref: TM-T79454
Producto descatalogado
