PPAR
Los receptores activados por proliferadores de peroxisomas (PPARs) son un grupo de proteínas receptoras nucleares que funcionan como factores de transcripción regulando la expresión de genes involucrados en el metabolismo, particularmente en el almacenamiento de ácidos grasos y el metabolismo de la glucosa. Los inhibidores de PPAR son herramientas importantes para estudiar trastornos metabólicos como la diabetes, la obesidad y las enfermedades cardiovasculares. Estos inhibidores pueden modular el metabolismo de los lípidos, la sensibilidad a la insulina y la inflamación, lo que los convierte en valiosos en la investigación terapéutica. En CymitQuimica, ofrecemos una gama de inhibidores de PPAR para apoyar su investigación en enfermedades metabólicas, endocrinología y desarrollo de fármacos.
Se han encontrado 164 productos de "PPAR"
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Mifobate
CAS:<p>Mifobate (SR-202) 是一种有效且特异性的 PPARγ拮抗剂，可选择性抑制噻唑烷二酮 (TZD) 诱导的 PPARγ 转录活性，IC50为140 μM，具有抗肥胖和抗糖尿病作用。</p>Fórmula:C11H17ClO7P2Pureza:99.12%Forma y color:SolidPeso molecular:358.65Fenofibrate
CAS:<p>Fenofibrate (Lipanthyl) is a PPARα agonist. Fenofibrate inhibits cytochrome P450 isoforms. Fenofibrate exhibits antihyperlipidemic activity. Cost-effective and quality-assured.</p>Fórmula:C20H21ClO4Pureza:99.13% - 99.95%Forma y color:Crystals From Isopropanol SolidPeso molecular:360.83GED-0507-34 Levo
CAS:<p>GED-0507-34 Levo,(S)-3-(4-Aminophenyl)-2-methoxypropanoic acid,an orally available PPARγ modulator for amelioration of inflammation-driven intestinal fibrosis.</p>Fórmula:C10H13NO3Pureza:98.19%Forma y color:SolidPeso molecular:195.22Clofibric acid
CAS:<p>Clofibric acid (Chlorofibrinic acid) is an antilipemic agent that is the biologically active metabolite of CLOFIBRATE.</p>Fórmula:C10H11ClO3Pureza:99.47% - 99.8%Forma y color:Pale Yellow SolidPeso molecular:214.65Muraglitazar
CAS:<p>Muraglitazar (BMS-298585) is a PPAR α/γ dual agonist for the treatment of type 2 diabetes and associated dyslipidemia.</p>Fórmula:C29H28N2O7Pureza:99.17%Forma y color:SolidPeso molecular:516.54Retinoic acid
CAS:<p>Retinoic acid (Tretinoin) binds to and activates RARs, thereby inducing changes in gene expression that lead to inhibition of tumorigenesis.</p>Fórmula:C20H28O2Pureza:97.21% - 99.6%Forma y color:Yellow-Orange PowderPeso molecular:300.44MA-0204
CAS:<p>MA-0204 is a highly selective and orally available peroxisome proliferator-activated receptor δ (PPARδ) modulator (EC50s: 0.4 nM, 7.9 nM and 10 nM for human,</p>Fórmula:C25H27F3N2O4Pureza:97.8%Forma y color:SolidPeso molecular:476.49LY518674
CAS:<p>LY518674 (LY-674) decreases triglycerides and increases HDL-C and is used for the treatment of atherosclerosis.</p>Fórmula:C23H27N3O4Pureza:98.87%Forma y color:SolidPeso molecular:409.48Gemfibrozil
CAS:<p>Gemfibrozil, a fibric acid derivative, stimulates PPARalpha, boosts fatty acid oxidation, LPL, lowers VLDL-C, apoC-III, and raises HDL-C.</p>Fórmula:C15H22O3Pureza:99.53% - 99.88%Forma y color:Crystals From Hexane SolidPeso molecular:250.33Anandamide
CAS:<p>Anandamide ((5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide), an immune modulator, acts via not only cannabinoid receptors (CB1 and CB2) but also</p>Fórmula:C22H37NO2Pureza:95.037% - 99.22%Forma y color:Light Yellow OilPeso molecular:347.53Daidzein
CAS:<p>Daidzein (Isoflavone) is an isoflavone extract from soy, which is an inactive analog of the tyrosine kinase inhibitor genistein.</p>Fórmula:C15H10O4Pureza:98.08%Forma y color:SolidPeso molecular:254.24Magnolol
CAS:<p>Magnolol (5,5'-Diallyl-2,2'-biphenyldiol) is a dual agonist of RXRα( EC50=10.4 μM) and PPARγ(EC50=17.7 μM). It blocks TNF-α-induced NF-KB activation.</p>Fórmula:C18H18O2Pureza:99.49%Forma y color:A Bioactive Compound Found In The Bark Of The Houpu MagnoliaPeso molecular:266.33Oleoylethanolamide
CAS:<p>Oleoylethanolamide (N-Oleoylethanolamide) is a high affinity endogenous agonist of PPAR-α.</p>Fórmula:C20H39NO2Pureza:99.98%Forma y color:SolidPeso molecular:325.53Pioglitazone hydrochloride
CAS:<p>Pioglitazone hydrochloride (AD 4833) is the hydrochloride salt of an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic</p>Fórmula:C19H20N2O3S·HClPureza:99.64% - >99.99%Forma y color:White Crystals Or Crystalline PowderPeso molecular:392.90Bezafibrate
CAS:<p>Bezafibrate (BM15075) is an antilipemic agent that lowers CHOLESTEROL and TRIGLYCERIDES.</p>Fórmula:C19H20ClNO4Pureza:99.56% - 99.82%Forma y color:SolidPeso molecular:361.82Cloxiquine
CAS:<p>Cloxiquine (Dermofongin) is a monohalogenated 8-hydroxyquinoline with activity against bacteria, fungi, and protozoa.</p>Fórmula:C9H6ClNOPureza:99.82% - 99.87%Forma y color:Light Yellow CrystalsPeso molecular:179.6GW7647
CAS:<p>GW 7647 is an effective and highly selective PPARα agonist. GW 7647 can reduce the production of nitric oxide in macrophages. Cost-effective and quality-assured.</p>Fórmula:C29H46N2O3SPureza:99.3% - 99.34%Forma y color:SolidPeso molecular:502.75Fenofibric acid
CAS:<p>Fenofibric acid (FNF acid) is the active form of fenofibrate, a synthetic phenoxy-isobutyric acid derivate with antihyperlipidemic activity.</p>Fórmula:C17H15ClO4Pureza:99.36%Forma y color:White Or Almost White Crystalline PowderPeso molecular:318.75NTP42
CAS:<p>NTP42 is an antagonist of thromboxane A2 (TXA2) receptor(IC50 of 3.278 nM)</p>Fórmula:C25H23F2N3O5SPureza:97.55%Forma y color:SolidPeso molecular:515.53NSC-87877
CAS:<p>NSC-87877 inhibits Shp2 (IC50=0.318μM), Shp1 (IC50=0.355μM), and DUSP26 phosphatases.</p>Fórmula:C19H13N3O7S2Pureza:97.35%Forma y color:SolidPeso molecular:459.45Pioglitazone
CAS:<p>Pioglitazone (U 72107) is a selective and oral PPARγ agonist with EC50 of 0.93 and 0.99 μM on human and mouse PPARγ, respectively . High-Quality, Low-Cost!</p>Fórmula:C19H20N2O3SPureza:95% - 99.57%Forma y color:White PowderPeso molecular:356.445-Aminosalicylic Acid
CAS:<p>5-Aminosalicylic Acid (5-ASA) is a specific PPARγ agonist and also inhibits P21-activated kinase 1 (PAK1) and NF-Κb. High-Quality, Low-Cost!</p>Fórmula:C7H7NO3Pureza:98.88% - 99.49%Forma y color:Purplish-Tan Solid PowderPeso molecular:153.14Rosiglitazone maleate
CAS:<p>Rosiglitazone maleate (BRL 49653) is an oral antidiabetic and potential anticancer agent.</p>Fórmula:C22H23N3O7SPureza:99.33% - 99.51%Forma y color:Off-White SolidPeso molecular:473.50β-Amyrone
CAS:<p>beta-Amyrone (β-Amyron) has antifungal activity against Chikungunya virus replication with an EC50 of 86 uM.</p>Fórmula:C30H48OPureza:99.55%Forma y color:SolidPeso molecular:424.7Candesartan
CAS:<p>Candesartan (CV 11974) is an angiotensin II receptor blocker used widely in the therapy of hypertension and heart failure.</p>Fórmula:C24H20N6O3Pureza:98.3% - 99.55%Forma y color:Colorless Solid CrystallinePeso molecular:440.47MK-0533
CAS:<p>MK-0533 is a novel PPARγ partial agonist for the prevention of vascular endothelial dysfunction (VED) and VED-related cardiovascular disease.</p>Fórmula:C28H24F3NO6Pureza:99.03%Forma y color:SoildPeso molecular:527.49Arhalofenate
CAS:<p>Arhalofenate (JNJ 39659100) is a selective partial agonist of peroxisome proliferator-activated receptor PPARγ. It is used for the treatment of type 2 diabetes.</p>Fórmula:C19H17ClF3NO4Pureza:98.97%Forma y color:SolidPeso molecular:415.79EHP-101
CAS:<p>EHP-101 is a PPARγ/CB2 dual agonist with anti-inflammatory properties, inhibits fat formation, and combats diet-related obesity.</p>Fórmula:C28H35NO3Pureza:98.36%Forma y color:SolidPeso molecular:433.58Sulotroban potassium
<p>Sulotroban potassium is a small molecule thromboxane A2 receptor (TXA2R) antagonist that can be used to study myocardial infarction and thrombosis.</p>Fórmula:C16H16KNO5SPureza:98.02%Forma y color:SoildPeso molecular:373.46Mavodelpar free acid hydrochloride
<p>Mavodelpar free acid hydrochloride (Pparδ agonist HCl) is a potent PPARδ agonist.</p>Fórmula:C31H31ClFNO5Pureza:98.13%Forma y color:SoildPeso molecular:552.03Benzo[b]thiophene-7-propanoic acid, α-methoxy-4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]-, (αR)-
CAS:<p>Benzo[b]thiophene-7-propanoic acid, α-methoxy-4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]-, (αR)- is a dual PPARα/γ agonist with EC50 of 0.358μM and 1.21μM.</p>Fórmula:C24H23NO5SPureza:99.59%Forma y color:SoildPeso molecular:437.51GW590735
CAS:<p>GW590735: PPARα agonist, EC50=4 nM, >500x selective over PPARδ/γ, for dyslipidemia research.</p>Fórmula:C23H21F3N2O4SPureza:99.53%Forma y color:SolidPeso molecular:478.48PPARγ agonist 16
CAS:<p>PPARγ agonist16 (Compound 4G) is a PPARγ agonist that competitively binds to the ligand-binding domain (LBD) of PPARγ with an IC50 of 1790 nM. It reduces ear swelling in mouse models and exhibits antihyperglycemic activity in mice with Streptozotocin-induced diabetes.</p>Fórmula:C19H14BrNO4SForma y color:SolidPeso molecular:432.29Nuclear Receptor Compound Library
<p>A unique collection of 531 nuclear receptor signaling targeted compounds for high throughput and high content screening;</p>Forma y color:Odour SolidWAY-620472
CAS:<p>WAY-620472 is a PPAR regulator that can be used to alter the lifespan of eukaryotes.</p>Fórmula:C23H21N5OSPureza:98.07%Forma y color:SolidPeso molecular:415.51PPAR agonist 6
<p>PPAR agonist6 (compound 5a) acts as an agonist for PPAR, exhibiting EC50 values of 3.6 μM and 2.6 μM for PPARα and PPARβ/δ respectively. Additionally, PPAR agonist6 inhibits the transactivation of a TNFα-dependent NF-κB-driven reporter gene in L929 cells [1].</p>Forma y color:Odour SolidGQ-16
CAS:<p>GQ-16 is a partial agonist of PPARγ with a Ki of 160 nM. GQ-16 reduces adipogenic actions and promotes insulin Sensitization without weight gain.</p>Fórmula:C19H16BrNO3SPureza:99.84%Forma y color:SolidPeso molecular:418.3PPARγ agonist 15
<p>PPARγ agonist15 (Compound 7c) functions as an agonist of PPARγ, inhibiting the expression of α-amylase (HPA) and α-glucosidase (HLAG) with IC50 values of 28.35 µM and 26.21 µM, respectively. It enhances glucose uptake in L6 myotubes and improves glucose homeostasis, insulin sensitivity, and lipid metabolism in a rat model of Streptozotocin-induced diabetes.</p>Fórmula:C21H16N4O3S2Forma y color:SolidPeso molecular:436.51MCC-555
CAS:<p>MCC-555 (Isaglitazone) is a PPARα and PPARγ agonist exerting antihyperglycemic effects.</p>Fórmula:C21H16FNO3SPureza:99.07% - 99.82%Forma y color:SolidPeso molecular:381.42PPARγ-IN-3
<p>PPARγ-IN-3 (compound 9ga), a potent and orally active PPARγ inhibitor, effectively reduces triglyceride (TG) accumulation and exhibits low cytotoxicity. Additionally, it prevents excessive body weight gain, lessens fat and liver mass, and decreases lipid accumulation in both the liver and blood. PPARγ-IN-3 holds promise for research into diet-induced obesity.</p>Fórmula:C23H28FN7O3Forma y color:SolidPeso molecular:469.51Anti-obesity agent 1
<p>Compound 4 (Anti-obesity agent 1) demonstrates potential for enhanced lipolysis, highlighting its anti-obesity characteristics.</p>Fórmula:C21H22N2O6Forma y color:SolidPeso molecular:398.409CUDA
CAS:<p>CUDA is an effective soluble cyclohydrolase inhibitor with IC50 of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively.</p>Fórmula:C19H36N2O3Pureza:97.585%Forma y color:SolidPeso molecular:340.5CC618
CAS:<p>CC618 is a selective PPARβ/δ antagonist with an IC50 of 10.0 μM.</p>Fórmula:C20H15F6N3O3S2Pureza:99.94%Forma y color:SolidPeso molecular:523.47AZD-9574
CAS:<p>AZD-9574 is a selective inhibitor of PARP1 at the sites of SSBs.</p>Fórmula:C21H22F2N6O2Pureza:98.46% - 99.39%Forma y color:SolidPeso molecular:428.44Sulotroban
CAS:<p>sulotroban is a TXA2 receptor antagonist that acts synergistically with iloprost to inhibit TXA2-dependent platelet activation.</p>Fórmula:C16H17NO5SPureza:98.86% - 99.88%Forma y color:SolidPeso molecular:335.378-iso Prostaglandin F1β
CAS:<p>8-iso Prostaglandin F1β,inducet vasoconstrictor effects in (PA), (PV) and (MA) through the activation of TXA2R, tyrosine kinase and Rho kinase.</p>Fórmula:C20H36O5Forma y color:SolidPeso molecular:356.5Anti-osteoporosis agent-10
<p>Anti-osteoporosis agent-10 is an inhibitor of osteoporosis that suppresses the formation of osteoclasts with an IC50 of 0.042 μM. It also exhibits antagonistic activity towards PPARγ, with an EC50 value of 0.75 μM.</p>Forma y color:Odour SolidLipid Metabolism Compound Library
<p>A unique collection of 492 compounds targeting lipid metabolism, can be used for high-throughput screening (HTS) and high-content screening (HCS).</p>Forma y color:Odour Solid8-iso Prostaglandin F1α
CAS:<p>8-iso Prostaglandin F1α induces vasoconstrictor effects in (PA),(PV) and (MA) through activation of TXA2R, tyrosine kinases and Rho kinases.</p>Fórmula:C20H36O5Forma y color:SolidPeso molecular:356.5E0924G
CAS:<p>E0924G is an orally active PPARδ agonist with an EC50 of 2.82 μM. It enhances the upregulation of osteoprotegerin (OPG) expression, with an EC50 of 0.29 μM. E0924G reduces RANKL-induced osteoclast differentiation and inhibits F-actin ring formation in RAW264.7 macrophages. Additionally, E0924G modulates bone density and bone loss in models of ovariectomy (OVX) and age-related osteoporosis.</p>Fórmula:C12H12N2O3Forma y color:SolidPeso molecular:232.24
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