FXR
El receptor X de farnesoide (FXR) es un receptor nuclear que desempeña un papel clave en la regulación de la homeostasis de los ácidos biliares, el metabolismo de los lípidos y la regulación de la glucosa. El FXR es un objetivo terapéutico potencial para el tratamiento de enfermedades hepáticas, trastornos metabólicos y enfermedades cardiovasculares. Los inhibidores del FXR pueden modular estas vías, ofreciendo información sobre los mecanismos de las enfermedades y las estrategias terapéuticas. En CymitQuimica, ofrecemos una gama de inhibidores del FXR para apoyar su investigación en hepatología, metabolismo y desarrollo de fármacos.
Se han encontrado 64 productos para "FXR".
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LY2562175
CAS:LY2562175 is an effective and selective FXR agonist (EC50: 193 nM).Fórmula:C28H27Cl2N3O4Pureza:99.16% - 99.63%Forma y color:SolidPeso molecular:540.44Ref: TM-T15806
1mg99,00€5mg215,00€1mL*10mM (DMSO)255,00€10mg349,00€25mg700,00€50mg1.108,00€100mg1.485,00€200mg2.008,00€Chenodeoxycholic acid
CAS:Chenodeoxycholic acid (CDCA) is a bile acid that inhibits 11β-HSD2 with an IC50 value of 22 mM. High-Quality, Low-Cost!Fórmula:C24H40O4Pureza:99.70% - 99.93%Forma y color:White SolidPeso molecular:392.57Ursodeoxycholic acid
CAS:Ursodeoxycholic acid (UDCA) is a potent inhibitor of liver-specific fatty acid transporter 5 (FATP5),inhibits cholesterol absorption. High-Quality, Low-Cost!Fórmula:C24H40O4Pureza:99.48% - ≥95%Forma y color:White SolidPeso molecular:392.57FXR/TGR5 agonist 1
CAS:FXR/TGR5 agonist 1 acts as an agonist on both FXR and TGR5 receptors and is utilized for treating fatty liver disease.Fórmula:C31H32ClN3O3Forma y color:SolidPeso molecular:530.07Nuclear Receptor Compound Library
A unique collection of xnum nuclear receptor signaling targeted compounds for high throughput and high content screening;Forma y color:Odour SolidRef: TM-L1510
1mgA consultar10μL*10mM (DMSO)A consultar20μL*10mM (DMSO)A consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultar250μL*10mM (DMSO)A consultardual FXR/PPARδ agonist-2
Dual FXR/PPARδ agonist-2 is a dual agonist for FXR and PPARδ, derived from the hybridization of the FXR agonist GW-4064 and the PPARδ agonist GW-0742. It exhibits potent dual-target activity, with an EC50 of 12.28 nM for FXR activation and a 69% activation rate of PPARδ at a concentration of 100 nM. Additionally, dual FXR/PPARδ agonist-2 demonstrates antifibrotic effects in a mouse model of pulmonary fibrosis.F44-A13
CAS:F44-A13 is an orally active, highly selective farnesoid X receptor (FXR) antagonist with an IC50 value of 1.1 μM. It optimizes cholesterol metabolism and reduces activity by inducing CYP7A1 expression, lowering cholesterol, triglycerides, and low-density lipoprotein cholesterol (LDL-C) levels in mouse models. F44-A13 is applicable for studying metabolic diseases associated with lipid disorders [1].Fórmula:C28H40N4O5SForma y color:SolidPeso molecular:544.71Fexarene
CAS:Fexarene is a non-steroidal FXR agonist.Fórmula:C32H33NO3Pureza:98%Forma y color:SolidPeso molecular:479.62ZLY28
ZLY28 is a novel, first-in-class compound with specific intestinal restriction and oral activity, serving as a dual modulator of FXR and FABP1.Fórmula:C29H23Cl2NO4Pureza:98%Forma y color:SolidPeso molecular:520.4LZ-007
CAS:LZ-007 is an agonist of the Farnesoid X receptor (FXR), with an EC50 of 51 nM as determined by TR-FRET assay, and an EC50 of 76 nM in HepG2 cells. It exhibits favorable pharmacokinetic properties in SD rats and can improve metabolic dysfunction-associated steatohepatitis induced by high-fat diets and CCl4 in mice.Fórmula:C27H29F3N2O5Forma y color:SolidPeso molecular:518.53FXR agonist 10
FXR agonist10 (Compound 27) acts as an agonist for FXR with an EC50 of 14.26 μM. It increases the expression of SHP and BSEP proteins while decreasing the expression of NTCP and CYP7A1 proteins. Additionally, FXR agonist10 has been shown to ameliorate ANIT-induced cholestasis in mouse models.Fórmula:C15H22O4Forma y color:SolidPeso molecular:266.33LH10
LH10 is an FXR agonist based on fexaramine, with an EC50 of 0.14 μM. It offers hepatoprotective effects, mitigating conditions such as cholestasis induced by alpha naphthylisothiocyanate (ANIT), acute liver injury caused by APAP, and non-alcoholic steatohepatitis (NASH).Fórmula:C34H33N3O2Forma y color:SolidPeso molecular:515.64Tauro-β-muricholic acid sodium
CAS:Tauro-β-muricholic Acid sodium is a endogenous metabolite, is a competitive and reversible antagonist of farnesoid X receptor (FXR)(IC50 of 40 μM).Fórmula:C26H44NNaO7SPureza:98%Forma y color:SolidPeso molecular:537.69FXR agonist 5
CAS:FXR agonist 5 is an FXR agonist used in the study of liver diseases or diseases mediated by metabolic inflammation.Fórmula:C40H53N5O5Pureza:99.74%Forma y color:White SolidPeso molecular:683.88NR1H4 Protein, Human, Recombinant (His)
NR1H4 Protein, Human, Recombinant (His) is expressed in E.Forma y color:Lyophilized PowderPeso molecular:27.83 kDa (predicted)NDB
CAS:NDB is a hFXRα antagonist that inhibits GW4064-stimulated FXR/RXR interactions in primary mouse hepatocytes.NDB is used in the study of diabetes.Fórmula:C26H28Cl2N2O2Pureza:98.94%Forma y color:SolidPeso molecular:471.42NR1H4 Protein, Mouse, Recombinant (His)
NR1H4 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 27.80 kDa.Forma y color:Lyophilized PowderPeso molecular:27.80 kDa (predicted)Ref: TM-TMPY-06756
5µg101,00€10µg166,00€20µg266,00€50µg540,00€100µg954,00€200µg1.665,00€500µg4.078,00€FXR agonist 3
FXR agonist 3 is an anti NASH compound with anti-fibrotic and active properties that inhibits the expression of COL1A1, TGF-β1, α-SMA and TIMP1.Fórmula:C28H28BrNO4Pureza:95.04%Forma y color:Yellow SolidPeso molecular:521.12DY268
CAS:DY268 is a compound based on trisubstituted pyrazolamide without any FXR agonist activity and cytotoxicity and can be used as an effective FXR antagonist.Fórmula:C30H32N4O5SPureza:99.43% - 99.75%Forma y color:SolidPeso molecular:560.66Ref: TM-T31587
1mg38,00€5mg84,00€1mL*10mM (DMSO)93,00€10mg119,00€25mg233,00€50mg430,00€100mg620,00€500mg1.333,00€Tauro-Obeticholic acid
CAS:Tauro-Obeticholic acid is an active Obeticholic acid metabolite. Obeticholic acid is an orally bioavailable agonist of farnesoid-X receptor (FXR).Fórmula:C28H49NO6SPureza:99.74% - 99.82%Forma y color:SolidPeso molecular:527.76Ref: TM-T13092
1mg111,00€5mg260,00€1mL*10mM (DMSO)331,00€10mg393,00€25mg650,00€50mg888,00€100mg1.243,00€Ursodeoxycholic acid sodium
CAS:Ursodeoxycholic acid sodium (Sodium Ursodeoxycholate) is a naturally occurring secondary bile acid with anti-inflammatory and cytoprotective activities.Fórmula:C24H40NaO4Pureza:99.66% - 99.96%Forma y color:SolidPeso molecular:415.56GW 4064
CAS:GW 4064 is an effective farnesoid X receptor (FXR) agonist (EC50 =65 nM).Fórmula:C28H22Cl3NO4Pureza:98% - 99.94%Forma y color:White SolidPeso molecular:542.84Ref: TM-T2233
5mg52,00€1mL*10mM (DMSO)59,00€10mg79,00€25mg132,00€50mg222,00€100mg403,00€200mg605,00€500mg954,00€Obeticholic Acid
CAS:Obeticholic Acid (6-ECDCA, INT-747) is a high-affinity, semisynthetic, bile acid-derived FXR agonist.Cost-effective and quality-assured.Fórmula:C26H44O4Pureza:99.88% - 99.97%Forma y color:SolidPeso molecular:420.63Ref: TM-T1789
5mg46,00€10mg50,00€1mL*10mM (DMSO)50,00€25mg78,00€50mg94,00€100mg155,00€200mg259,00€500mg477,00€Sevelamer hydrochloride
CAS:Sevelamer hydrochloride (Sevelamer HCl) is a phosphate binding drug used to treat hyperphosphatemia via binding to dietary phosphate and prevents its absorptionFórmula:(C3H7N·C3H5ClO·HCl)xPureza:98%Forma y color:SolidPeso molecular:186.08Tropifexor
CAS:Tropifexor (LJN452) is a novel and highly potent agonist of FXR with an EC50 of 0.2 nM.Fórmula:C29H25F4N3O5SPureza:99.3% - 99.85%Forma y color:SolidPeso molecular:603.58Turofexorate Isopropyl
CAS:Turofexorate Isopropyl (XL335) is a potent, selective, and orally bioavailable FXR agonist with EC50 of 4 nMFórmula:C25H24F2N2O3Pureza:98.55% - 99.73%Forma y color:Yellow SolidPeso molecular:438.47BAR 501 impurity
CAS:BAR 501 impurity 在 BAR501 制剂中发现的一种杂质，可作为 G 蛋白偶联胆汁酸激活受体 (GP-BAR1) 的激动剂。 BAR501 杂质 (10 µM) 在 GP-BAR1 报告基因检测中诱导荧光素酶活性增加 150%。Fórmula:C26H46O3Pureza:98.78%Forma y color:White SolidPeso molecular:406.64Ref: TM-T8752
10mgA consultar25mgA consultar50mgA consultar100mgA consultar200mgA consultar1mg63,00€5mg137,00€1mL*10mM (DMSO)150,00€BAR502
CAS:BAR502 is a dual GPBAR1 and FXR agonist (IC50s: 0.4 μM and 2 μM).Fórmula:C25H44O3Pureza:99.95%Forma y color:SolidPeso molecular:392.62Guggulsterone
CAS:Guggulsterone (Guggulsterone E&Z) E&Z is a 3-hydroxy steroid. It has a role as an androgen.Fórmula:C21H28O2Pureza:99.4% - 99.80%Forma y color:SolidPeso molecular:312.45Ref: TM-T5574
1mg34,00€5mg50,00€1mL*10mM (DMSO)55,00€10mg93,00€25mg152,00€50mg205,00€100mg289,00€200mg432,00€Nidufexor
CAS:Nidufexor is an agonist for the farnesoid X receptor (FXR).Fórmula:C27H22ClN3O4Pureza:98.67%Forma y color:White SolidPeso molecular:487.93T0901317
CAS:T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively; it inhibits nuclear factor/κB (NF/κB).Fórmula:C17H12F9NO3SPureza:98% - 99.64%Forma y color:SolidPeso molecular:481.33Vidofludimus
CAS:Vidofludimus (SC12267) (4SC-101, SC12267) is a novel small molecule inhibitor of dihydroorotate dehydrogenase (DHODH).Fórmula:C20H18FNO4Pureza:98.33% - 99.58%Forma y color:SolidPeso molecular:355.36Glyco-Obeticholic acid
CAS:Glyco-Obeticholic acid is an active metabolite of Obeticholic acid. Obeticholic acid is an agonist of the farnesoid X receptor (FXR).Fórmula:C28H47NO5Pureza:99.77% - 99.95%Forma y color:SolidPeso molecular:477.68Fexaramine
CAS:Fexaramine is a small molecule farnesoid X receptor (FXR) agonist with 100-fold increased affinity compared to natural compounds.Fórmula:C32H36N2O3Pureza:98.87% - 99.61%Forma y color:Yellow SolidPeso molecular:496.64Forskolin
CAS:Forskolin (Coleonol) is a natural product, an adenylate cyclase activator (EC50=0.5 μM).Fórmula:C22H34O7Pureza:98.83% - 99.86%Forma y color:White SolidPeso molecular:410.50Ref: TM-T2939
5mg40,00€1mL*10mM (DMSO)44,00€10mg52,00€25mg81,00€50mg90,00€100mg137,00€200mg172,00€500mg290,00€Cilofexor
CAS:Cilofexor inhibits binding of a synthetic peptide, Cilofexor is a farnesoid X receptor (FXR) agonist.Fórmula:C28H22Cl3N3O5Pureza:99.86% - ≥95%Forma y color:SolidPeso molecular:586.85Ref: TM-T7436
1mg52,00€2mg73,00€5mg117,00€1mL*10mM (DMSO)149,00€10mg178,00€25mg356,00€50mg537,00€100mg708,00€200mg964,00€Vonafexor
CAS:Vonafexor (EYP001) is a farnesoid X receptor (FXR, NR1H4) agonist, with anti-HBV effectsFórmula:C19H15Cl3N2O5SPureza:98.74%Forma y color:White SolidPeso molecular:489.76Teduglutide
CAS:Teduglutide (ALX-0600) is a glucagon-like peptide-2 analog that increases intestinal absorption and can be used in research on short bowel syndrome (SBS).Fórmula:C164H252N44O55SPureza:98.08% - 99.29%Forma y color:White SolidPeso molecular:3752.08FXR agonist 11
CAS:FXR agonist11 (Compound 14) is an FXR activator with an EC50 of 1.2 μM and a maximal effect of 73.7%. It significantly increases GSH levels in the liver and is used to study drug-induced liver injury.Fórmula:C18H16N2O5Forma y color:SolidPeso molecular:340.33ST-1892
CAS:ST-1892 is a soluble partial FXR agonist.Fórmula:C16H12N2O3Pureza:98%Forma y color:SolidPeso molecular:280.28LY367385
CAS:LY367385 is a highly effective and selective mGluR1a antagonist.Fórmula:C10H11NO4Pureza:98%Forma y color:SolidPeso molecular:209.2EDP-305
CAS:EDP-305, an oral FXR agonist, has EC50s of 34 nM/8 nM in CHO/HEK cells, aids in PBC and NASH research with antifibrotic properties.Fórmula:C36H58N2O5SPureza:97.17%Forma y color:SolidPeso molecular:630.92Ref: TM-T73414
1mg109,00€5mg260,00€1mL*10mM (DMSO)353,00€10mg447,00€25mg888,00€50mg1.431,00€100mg2.250,00€PX20606
CAS:PX20606 is an orally active farnesoid X receptor (FXR) agonist, demonstrating EC50 values of 220 nM (mFXR) and 50 nM (hFXR) in Gal4-FXR assays. It induces the expression of the tumor suppressor gene NDRG2 and inhibits tumor growth and metastasis in a mouse HCC model. Additionally, PX20606 exhibits hepatoprotective properties.Fórmula:C29H22Cl3NO4Forma y color:SolidPeso molecular:554.85FXR agonist 4
FXR agonist 4: EC50 of 1.05μM, treats hyperlipidemia, steatosis, insulin resistance, inflammation in DIO mice, for NAFLD research.Fórmula:C21H28ClN3OForma y color:SolidPeso molecular:373.92Fexarine
CAS:Fexarine is a potent, selective agonist of farnesoid X receptor.Fórmula:C31H31NO5Forma y color:SolidPeso molecular:497.58HPG1860
CAS:HPG1860, an agonist of the farnesoid X receptor (FXR), induces luminescence in reporter gene assays utilizing HEK293T cells expressing human FXR, with an EC50 value of 18 nM. In vivo studies demonstrate that HPG1860 (administered at 1, 3, or 10 mg/kg daily) reduces serum alanine aminotransferase (ALT) and total cholesterol levels in a mouse model of non-alcoholic steatohepatitis (NASH), which was induced by a high-fat diet and carbon tetrachloride (CCl4). Additionally, this compound decreases hepatic inflammation, fat levels, and fibrosis.Fórmula:C27H26Cl2N4O4SForma y color:SolidPeso molecular:573.49FXR antagonist 1
CAS:"Oral FXR antagonist 1 selectively blocks intestinal FXR, with IC50 of 2.1 μM, aiding in NASH research by improving liver health."Fórmula:C36H59NO5Forma y color:SolidPeso molecular:585.86FXR antagonist 2
CAS:Compound A-26, a diarylamide FXR blocker, may aid hyperlipidemia and diabetes type 2 research.Fórmula:C22H26Cl2N2O2Forma y color:SolidPeso molecular:421.36GSK-8062
CAS:GSK-8062 is an agonist of farnesoid X receptor (FXR).Fórmula:C30H23Cl2NO4Pureza:98%Forma y color:SolidPeso molecular:532.41GSK2324
CAS:GSK2324 is a potent FXR agonist for the treatment of NAFLD by controlling hepatic lipids through reduced uptake and selective reduction of fatty acid synthesis.Fórmula:C29H22Cl2N2O4Pureza:98.09% - 99.76%Forma y color:SolidPeso molecular:533.4
