FXR
El receptor X de farnesoide (FXR) es un receptor nuclear que desempeña un papel clave en la regulación de la homeostasis de los ácidos biliares, el metabolismo de los lípidos y la regulación de la glucosa. El FXR es un objetivo terapéutico potencial para el tratamiento de enfermedades hepáticas, trastornos metabólicos y enfermedades cardiovasculares. Los inhibidores del FXR pueden modular estas vías, ofreciendo información sobre los mecanismos de las enfermedades y las estrategias terapéuticas. En CymitQuimica, ofrecemos una gama de inhibidores del FXR para apoyar su investigación en hepatología, metabolismo y desarrollo de fármacos.
Se han encontrado 58 productos de "FXR"
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Tauro-Obeticholic acid
CAS:<p>Tauro-Obeticholic acid is an active Obeticholic acid metabolite. Obeticholic acid is an orally bioavailable agonist of farnesoid-X receptor (FXR).</p>Fórmula:C28H49NO6SPureza:99.74% - 99.82%Forma y color:SolidPeso molecular:527.76Ursodeoxycholic acid sodium
CAS:<p>Ursodeoxycholic acid sodium (Sodium Ursodeoxycholate) is a naturally occurring secondary bile acid with anti-inflammatory and cytoprotective activities.</p>Fórmula:C24H40NaO4Pureza:99.66% - 99.96%Forma y color:SolidPeso molecular:415.56GW 4064
CAS:<p>GW 4064 is an effective farnesoid X receptor (FXR) agonist (EC50 =65 nM).</p>Fórmula:C28H22Cl3NO4Pureza:98% - 99.94%Forma y color:SolidPeso molecular:542.84Obeticholic Acid
CAS:<p>Obeticholic Acid (6-ECDCA, INT-747) is a high-affinity, semisynthetic, bile acid-derived FXR agonist.Cost-effective and quality-assured.</p>Fórmula:C26H44O4Pureza:99.88% - 99.97%Forma y color:SolidPeso molecular:420.63Sevelamer hydrochloride
CAS:<p>Sevelamer hydrochloride (Sevelamer HCl) is a phosphate binding drug used to treat hyperphosphatemia via binding to dietary phosphate and prevents its absorption</p>Fórmula:(C3H7N·C3H5ClO·HCl)xPureza:98%Forma y color:SolidPeso molecular:186.08Tropifexor
CAS:<p>Tropifexor (LJN452) is a novel and highly potent agonist of FXR with an EC50 of 0.2 nM.</p>Fórmula:C29H25F4N3O5SPureza:99.3% - 99.85%Forma y color:SolidPeso molecular:603.58Turofexorate Isopropyl
CAS:<p>Turofexorate Isopropyl (XL335) is a potent, selective, and orally bioavailable FXR agonist with EC50 of 4 nM</p>Fórmula:C25H24F2N2O3Pureza:98.55% - 99.73%Forma y color:SolidPeso molecular:438.47BAR 501 impurity
CAS:<p>BAR 501 impurity 在 BAR501 制剂中发现的一种杂质，可作为 G 蛋白偶联胆汁酸激活受体 (GP-BAR1) 的激动剂。 BAR501 杂质 (10 µM) 在 GP-BAR1 报告基因检测中诱导荧光素酶活性增加 150%。</p>Fórmula:C26H46O3Pureza:98.78%Forma y color:SolidPeso molecular:406.64BAR502
CAS:<p>BAR502 is a dual GPBAR1 and FXR agonist (IC50s: 0.4 μM and 2 μM).</p>Fórmula:C25H44O3Pureza:99.95%Forma y color:SolidPeso molecular:392.62Guggulsterone
CAS:<p>Guggulsterone (Guggulsterone E&Z) E&Z is a 3-hydroxy steroid. It has a role as an androgen.</p>Fórmula:C21H28O2Pureza:99.4% - 99.8%Forma y color:Light Yellow PowderPeso molecular:312.45Nidufexor
CAS:<p>Nidufexor is an agonist for the farnesoid X receptor (FXR).</p>Fórmula:C27H22ClN3O4Pureza:98.67%Forma y color:SolidPeso molecular:487.93T0901317
CAS:<p>T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively; it inhibits nuclear factor/κB (NF/κB).</p>Fórmula:C17H12F9NO3SPureza:98% - 99.64%Forma y color:SolidPeso molecular:481.33Vidofludimus
CAS:<p>Vidofludimus (SC12267) (4SC-101, SC12267) is a novel small molecule inhibitor of dihydroorotate dehydrogenase (DHODH).</p>Fórmula:C20H18FNO4Pureza:98.33% - 99.58%Forma y color:SolidPeso molecular:355.36Glyco-Obeticholic acid
CAS:<p>Glyco-Obeticholic acid is an active metabolite of Obeticholic acid. Obeticholic acid is an agonist of the farnesoid X receptor (FXR).</p>Fórmula:C28H47NO5Pureza:99.77% - 99.95%Forma y color:SolidPeso molecular:477.68Fexaramine
CAS:<p>Fexaramine is a small molecule farnesoid X receptor (FXR) agonist with 100-fold increased affinity compared to natural compounds.</p>Fórmula:C32H36N2O3Pureza:98.87% - 99.61%Forma y color:SolidPeso molecular:496.64Forskolin
CAS:<p>Forskolin (Coleonol) is a natural product, an adenylate cyclase activator (EC50=0.5 μM).</p>Fórmula:C22H34O7Pureza:98.83% - 99.96%Forma y color:Less Crystalline Solid Colorless Crystalline SolidPeso molecular:410.5Cilofexor
CAS:<p>Cilofexor inhibits binding of a synthetic peptide, Cilofexor is a farnesoid X receptor (FXR) agonist.</p>Fórmula:C28H22Cl3N3O5Pureza:99.86% - ≥95%Forma y color:SolidPeso molecular:586.85Vonafexor
CAS:<p>Vonafexor (EYP001) is a farnesoid X receptor (FXR, NR1H4) agonist, with anti-HBV effects</p>Fórmula:C19H15Cl3N2O5SPureza:98.74%Forma y color:SolidPeso molecular:489.76Teduglutide
CAS:<p>Teduglutide (ALX-0600) is a glucagon-like peptide-2 analog that increases intestinal absorption and can be used in research on short bowel syndrome (SBS).</p>Fórmula:C164H252N44O55SPureza:98.08%Forma y color:SolidPeso molecular:3752.08EDP-305
CAS:<p>EDP-305, an oral FXR agonist, has EC50s of 34 nM/8 nM in CHO/HEK cells, aids in PBC and NASH research with antifibrotic properties.</p>Fórmula:C36H58N2O5SForma y color:SolidPeso molecular:630.92
