FXR
El receptor X de farnesoide (FXR) es un receptor nuclear que desempeña un papel clave en la regulación de la homeostasis de los ácidos biliares, el metabolismo de los lípidos y la regulación de la glucosa. El FXR es un objetivo terapéutico potencial para el tratamiento de enfermedades hepáticas, trastornos metabólicos y enfermedades cardiovasculares. Los inhibidores del FXR pueden modular estas vías, ofreciendo información sobre los mecanismos de las enfermedades y las estrategias terapéuticas. En CymitQuimica, ofrecemos una gama de inhibidores del FXR para apoyar su investigación en hepatología, metabolismo y desarrollo de fármacos.
Se han encontrado 68 productos para "FXR".
Filtrar por
Porcentaje de pureza
0
100
|
0
|
50
|
90
|
95
|
100
- Precio más bajo
- Precio más alto
- Pureza más baja
- Pureza más alta
- Entrega estimada más rápida
Teduglutide
CAS:Teduglutide (ALX-0600) is a glucagon-like peptide-2 analog that increases intestinal absorption and can be used in research on short bowel syndrome (SBS).Fórmula:C164H252N44O55SPureza:98.08% - 99.29%Forma y color:White SolidPeso molecular:3752.08FXR agonist 11
CAS:FXR agonist11 (Compound 14) is an FXR activator with an EC50 of 1.2 μM and a maximal effect of 73.7%. It significantly increases GSH levels in the liver and is used to study drug-induced liver injury.Fórmula:C18H16N2O5Forma y color:SolidPeso molecular:340.33EDP-305
CAS:EDP-305 is an oral non-bile acid FXR agonist for NAFLD and fibrosis research.Fórmula:C36H58N2O5SPureza:97.17%Forma y color:SolidPeso molecular:630.921PX20606
CAS:PX20606 is an orally active farnesoid X receptor (FXR) agonist, demonstrating EC50 values of 220 nM (mFXR) and 50 nM (hFXR) in Gal4-FXR assays. It induces the expression of the tumor suppressor gene NDRG2 and inhibits tumor growth and metastasis in a mouse HCC model. Additionally, PX20606 exhibits hepatoprotective properties.Fórmula:C29H22Cl3NO4Forma y color:SolidPeso molecular:554.85ST-1892
CAS:ST-1892 is a soluble partial FXR agonist.Fórmula:C16H12N2O3Pureza:98%Forma y color:SolidPeso molecular:280.28LY367385
CAS:LY367385 is a highly effective and selective mGluR1a antagonist.Fórmula:C10H11NO4Pureza:98%Forma y color:SolidPeso molecular:209.2Fexarine
CAS:Fexarine is a potent, selective agonist of farnesoid X receptor.Fórmula:C31H31NO5Forma y color:SolidPeso molecular:497.58FXR agonist 4
FXR agonist 4: EC50 of 1.05μM, treats hyperlipidemia, steatosis, insulin resistance, inflammation in DIO mice, for NAFLD research.Fórmula:C21H28ClN3OForma y color:SolidPeso molecular:373.92BMS-986318
CAS:BMS-986318: potent FXR agonist, EC50=53/350 nM, good ADME, effective in liver disease models, for nonalcoholic steatohepatitis research.Fórmula:C30H23Cl2F3N4O3Forma y color:SolidPeso molecular:615.43FXR antagonist 2
CAS:Compound A-26, a diarylamide FXR blocker, may aid hyperlipidemia and diabetes type 2 research.Fórmula:C22H26Cl2N2O2Forma y color:SolidPeso molecular:421.36HPG1860
CAS:HPG1860 is an FXR agonist for NASH, liver fibrosis, bile acid signaling, and metabolic disease research.Fórmula:C27H26Cl2N4O4SPureza:99.02%Forma y color:SolidPeso molecular:573.49FXR antagonist 1
CAS:"Oral FXR antagonist 1 selectively blocks intestinal FXR, with IC50 of 2.1 μM, aiding in NASH research by improving liver health."Fórmula:C36H59NO5Forma y color:SolidPeso molecular:585.86GSK2324
CAS:GSK2324 is a potent FXR agonist for the treatment of NAFLD by controlling hepatic lipids through reduced uptake and selective reduction of fatty acid synthesis.Fórmula:C29H22Cl2N2O4Pureza:98.09% - 99.76%Forma y color:SolidPeso molecular:533.402Chenodeoxycholic Acid 3-Glucuronide
CAS:Chenodeoxycholic acid 3-glucuronide (CDCA-3G), a metabolite of Chenodeoxycholic acid (CDCA), is synthesized in human liver microsomes.Fórmula:C30H48O10Forma y color:SolidPeso molecular:568.7GSK-8062
CAS:GSK-8062 is an agonist of farnesoid X receptor (FXR).Fórmula:C30H23Cl2NO4Pureza:98%Forma y color:SolidPeso molecular:532.41Chenodeoxycholic Acid 24-Acyl-β-D-Glucuronide
CAS:Chenodeoxycholic acid 24-acyl-β-D-glucuronide (CDCA-24G), a metabolite of CDCA, is synthesized from CDCA via the action of the UDP-glucuronosyltransferase (UG UT) isoform UGT1A3.Fórmula:C30H48O10Forma y color:SolidPeso molecular:568.7BMS-986339
CAS:BMS-986339: oral, potent FXR agonist; binds to His298/ASN287; for PBC, PSC, NASH, anti-fibrosis research.Fórmula:C35H41F4N3O4Forma y color:SolidPeso molecular:643.71Omesdafexor
CAS:Omesdafexor is an FXR agonist that can be used to study diseases caused by liver disease or metabolic inflammation.Fórmula:C34H43N3O3Forma y color:SolidPeso molecular:541.72V023-9340
CAS:V023-9340 is a powerful FXR inhibitor with an IC50 of 4.27 μM, suitable for research in NASH (nonalcoholic steatohepatitis) [1].Fórmula:C30H32N2O4Forma y color:SolidPeso molecular:484.59FXR/CES2 modulator 1
CAS:Compound LE-77, known as FXR/CES2 modulator 1, functions as a dual regulator that activates FXR and inhibits CES2. It effectively mitigates the intestinal toxicity of irinotecan.Fórmula:C27H21Cl2NO5Forma y color:SolidPeso molecular:510.36
