FXR
El receptor X de farnesoide (FXR) es un receptor nuclear que desempeña un papel clave en la regulación de la homeostasis de los ácidos biliares, el metabolismo de los lípidos y la regulación de la glucosa. El FXR es un objetivo terapéutico potencial para el tratamiento de enfermedades hepáticas, trastornos metabólicos y enfermedades cardiovasculares. Los inhibidores del FXR pueden modular estas vías, ofreciendo información sobre los mecanismos de las enfermedades y las estrategias terapéuticas. En CymitQuimica, ofrecemos una gama de inhibidores del FXR para apoyar su investigación en hepatología, metabolismo y desarrollo de fármacos.
Se han encontrado 58 productos de "FXR"
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ST-1892
CAS:<p>ST-1892 is a soluble partial FXR agonist.</p>Fórmula:C16H12N2O3Pureza:98%Forma y color:SolidPeso molecular:280.28PX20606
CAS:<p>PX20606 is an orally active farnesoid X receptor (FXR) agonist, demonstrating EC50 values of 220 nM (mFXR) and 50 nM (hFXR) in Gal4-FXR assays. It induces the expression of the tumor suppressor gene NDRG2 and inhibits tumor growth and metastasis in a mouse HCC model. Additionally, PX20606 exhibits hepatoprotective properties.</p>Fórmula:C29H22Cl3NO4Forma y color:SolidPeso molecular:554.85FXR agonist 4
<p>FXR agonist 4: EC50 of 1.05μM, treats hyperlipidemia, steatosis, insulin resistance, inflammation in DIO mice, for NAFLD research.</p>Fórmula:C21H28ClN3OForma y color:SolidPeso molecular:373.92LY367385
CAS:<p>LY367385 is a highly effective and selective mGluR1a antagonist.</p>Fórmula:C10H11NO4Pureza:98%Forma y color:SolidPeso molecular:209.2Fexarine
CAS:<p>Fexarine is a potent, selective agonist of farnesoid X receptor.</p>Fórmula:C31H31NO5Forma y color:SolidPeso molecular:497.58GSK-8062
CAS:<p>GSK-8062 is an agonist of farnesoid X receptor (FXR).</p>Fórmula:C30H23Cl2NO4Pureza:98%Forma y color:SolidPeso molecular:532.41BMS-986318
CAS:<p>BMS-986318: potent FXR agonist, EC50=53/350 nM, good ADME, effective in liver disease models, for nonalcoholic steatohepatitis research.</p>Fórmula:C30H23Cl2F3N4O3Forma y color:SolidPeso molecular:615.43FXR antagonist 1
CAS:<p>"Oral FXR antagonist 1 selectively blocks intestinal FXR, with IC50 of 2.1 μM, aiding in NASH research by improving liver health."</p>Fórmula:C36H59NO5Forma y color:SolidPeso molecular:585.86GSK2324
CAS:<p>GSK2324 is a potent FXR agonist for the treatment of NAFLD by controlling hepatic lipids through reduced uptake and selective reduction of fatty acid synthesis.</p>Fórmula:C29H22Cl2N2O4Pureza:98.09% - 99.02%Forma y color:SolidPeso molecular:533.4FXR agonist 9
CAS:<p>FXR agonist9 (compound 26) is a selective, orally active partial agonist of FXR with an EC50 of 0.09 µM (maximum efficacy of 75.13%). It ameliorates the pathological features of fatty liver disease in mice induced by HFD and CCl4-related metabolic dysfunction.</p>Fórmula:C28H30N2O5Forma y color:SolidPeso molecular:474.55Omesdafexor
CAS:<p>Omesdafexor is an FXR agonist that can be used to study diseases caused by liver disease or metabolic inflammation.</p>Fórmula:C34H43N3O3Forma y color:SolidPeso molecular:541.72NR1H4 activator 1
CAS:<p>NR1H4 activator 1 is a potent and selective agonist of Famesoid X Receptor (FXR).</p>Fórmula:C34H53NO7SPureza:98%Forma y color:SolidPeso molecular:619.85FXR agonist 12
CAS:<p>FXR agonist12 (Compound C7) is an orally active FXR agonist. It downregulates bile acid synthesis-related genes and upregulates bile acid transport-related genes in HepG2 cells. FXR agonist12 alleviates ANIT-induced cholestasis and reduces liver damage and fibrosis in a mouse model of NASH.</p>Fórmula:C26H44O3Forma y color:SolidPeso molecular:404.626BMS-986339
CAS:<p>BMS-986339: oral, potent FXR agonist; binds to His298/ASN287; for PBC, PSC, NASH, anti-fibrosis research.</p>Fórmula:C35H41F4N3O4Forma y color:SolidPeso molecular:643.71Danifexor
CAS:<p>Danifexor is an agonist of the farnesoid X receptor (Farnesoid X receptor).</p>Fórmula:C29H20Cl2N2O5Forma y color:SolidPeso molecular:547.386FXR/CES2 modulator 1
CAS:<p>Compound LE-77, known as FXR/CES2 modulator 1, functions as a dual regulator that activates FXR and inhibits CES2. It effectively mitigates the intestinal toxicity of irinotecan.</p>Fórmula:C27H21Cl2NO5Forma y color:SolidPeso molecular:510.36Lecufexor
CAS:<p>Lecufexor is an agonist of the farnesoid X receptor (FXR).</p>Fórmula:C32H21Cl3N2O5Forma y color:SolidPeso molecular:619.88BAR-2227
CAS:<p>BAR-2227 (compound 3a) functions as an FXR agonist and a LIFR inhibitor. It is utilized in the study of liver fibrosis and inflammation.</p>Fórmula:C24H17Cl2NO4Forma y color:SolidPeso molecular:454.30
