Fosfolipasa
Las fosfolipasas son un grupo de enzimas que hidrolizan fosfolípidos en ácidos grasos y otras sustancias lipofílicas, desempeñando un papel crítico en la biología de las membranas y la generación de moléculas de señalización. Los inhibidores de fosfolipasas se utilizan para estudiar su papel en enfermedades inflamatorias, trastornos cardiovasculares y neurodegeneración. Estos inhibidores también son valiosos para explorar las vías de señalización de lípidos y sus implicaciones en los mecanismos de enfermedades. En CymitQuimica, ofrecemos una variedad de inhibidores de fosfolipasas para apoyar su investigación en inflamación, metabolismo de lípidos y señalización celular.
Se han encontrado 82 productos de "Fosfolipasa"
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2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide
CAS:<p>2-Decenoylaminoethyl cyclohexylethyl sulfide prevents stress ulcers, stabilizes phospholipase A2 and prostaglandin E2.</p>Fórmula:C20H37NOSPureza:98%Forma y color:SolidPeso molecular:339.58ML299
CAS:<p>ML299 (VU0463568) is a dual PLD1/2 inhibitor (PLD1 and PLD2, IC50 of 6 nM, 20 nM, respectively).</p>Fórmula:C23H26BrFN4O2Pureza:98%Forma y color:SolidPeso molecular:489.38Lp-PLA2-IN-3
CAS:<p>Lp-PLA2-IN-3: Potent oral inhibitor of human Lp-PLA2 with a 14 nM IC50.</p>Fórmula:C20H13ClF3N3O3SPureza:99.65%Forma y color:SolidPeso molecular:467.85ASM-IN-1
CAS:<p>ASM-IN-1: Oral acid sphingomyelinase inhibitor, IC50 = 1.5 µM; reduces lipid plaques, plasma ceramide, Ox-LDL.</p>Fórmula:C16H12BrN3O4Pureza:98%Forma y color:SolidPeso molecular:390.19GK187
CAS:<p>GK187 is a selective and potent Group VIA calcium-independent phospholipase A2 (GVIA iPLA2) inhibitor, used in the study of neurological disorders.</p>Fórmula:C14H15F5O2Forma y color:SolidPeso molecular:310.26Halopemide
CAS:<p>Halopemide is a potent inhibitor of PLD (IC50 = 220 and 310 nM for human PLD1 and PLD2).</p>Fórmula:C21H22ClFN4O2Pureza:96.57%Forma y color:SolidPeso molecular:416.88Giripladib
CAS:<p>Giripladib (PLA695/PLX-695) blocks radiation-boosted phosphorylation of ERK and Akt in endothelial cells.</p>Fórmula:C41H36ClF3N2O4SPureza:99.64%Forma y color:SolidPeso molecular:745.25VU0155069
CAS:<p>VU0155069, a selective PLD1 inhibitor (IC50: 46 nM), halts cancer cell migration in transwell assays.</p>Fórmula:C26H27ClN4O2Pureza:99.5%Forma y color:SolidPeso molecular:462.97VU0364739
CAS:<p>VU0364739, a selective phospholipase D2 (PLD2) inhibitor with an IC50 of 22 nM, effectively reduces cancer cell proliferation [1].</p>Fórmula:C26H27FN4O2Pureza:98%Forma y color:SolidPeso molecular:446.52Lp-PLA2-IN-13
CAS:<p>Lp-PLA2-IN-13 (compound 15), a potent Lp-PLA2 inhibitor, holds potential for research in neurodegenerative-related diseases [1].</p>Fórmula:C22H17F5N4O4Pureza:98%Forma y color:SolidPeso molecular:496.39Lp-PLA2-IN-2
CAS:<p>Lp-PLA2-IN-2 is a selective and potent lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor, with an IC50 0f 120 nM for recombinant human Lp-PLA2.</p>Fórmula:C19H23FN2O4SPureza:98%Forma y color:SolidPeso molecular:394.46Lp-PLA2-IN-14
CAS:<p>Lp-PLA2-IN-14 (Compound 19), an inhibitor of rhLp-PLA2, exhibits a potent inhibitory effect with a pIC50 value of 8.4.</p>Fórmula:C16H14F3N3O3Pureza:98%Forma y color:SolidPeso molecular:353.37,7-Dimethyl-(5Z,8Z)-eicosadienoic acid
CAS:<p>7,7-Dimethyl-(5Z,8Z)-eicosadienoic acid (DEDA, 5 μM) significantly impacts the response to βA(25-35) stimulation. It reduces the formation of ROS.</p>Fórmula:C22H40O2Forma y color:SolidPeso molecular:336.55Varespladib methyl
CAS:<p>Varespladib methyl (LY333013), a bioavailable prodrug of Varespladib, is a selective group II secretory phospholipase A2 inhibitor.</p>Fórmula:C22H22N2O5Pureza:99.42% - 99.97%Forma y color:SolidPeso molecular:394.42Ecopladib
CAS:<p>Ecopladib inhibits cPLA2α with IC50 of 0.15 μM (micelles) & 0.11 μM (rat blood).</p>Fórmula:C39H33Cl3N2O5SPureza:95.15%Forma y color:SolidPeso molecular:748.11Rilapladib
CAS:<p>Rilapladib (SB 659032) is a selective inhibitor of Lipoprotein-Associated Phospholipase A2(Lp-PLA2, IC50 = 230 pM) and an antagonist of the platelet activating</p>Fórmula:C40H38F5N3O3SPureza:99.92%Forma y color:SolidPeso molecular:735.8MAFP
CAS:<p>MAFP (Methyl Arachidonyl Fluorophosphonate) is an effective irreversible inhibitor of anandamide amidase.</p>Fórmula:C21H36FO2PForma y color:SolidPeso molecular:370.48GK420
CAS:<p>GK420 (AVX420) is a potent inhibitor of cytoplasmic phospholipase A2α (cPLA2α), with an XI(50) value of 0.0016. It effectively inhibits the release of arachidonic acid, with an EC50 of 0.09 μM. GK420 plays a significant role in cancer research.</p>Fórmula:C20H25NO5SForma y color:SolidPeso molecular:391.481Ro 23-9358
CAS:<p>Ro 23-9358 is a potent inhibitor of secretory phospholipase A2, exhibiting anti-inflammatory properties.</p>Fórmula:C30H51NO6Forma y color:SolidPeso molecular:521.729Lp-PLA2-IN-16
CAS:<p>Lp-PLA2-IN-16 (Example 1) is an inhibitor of lipoprotein-associated phospholipase A2 (Lp-PLA2) with potential applications in Alzheimer's disease research [1].</p>Fórmula:C22H17F5N4O3Pureza:98%Forma y color:SolidPeso molecular:480.39Ref: TM-T79076
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