Fosfolipasa
Las fosfolipasas son un grupo de enzimas que hidrolizan fosfolípidos en ácidos grasos y otras sustancias lipofílicas, desempeñando un papel crítico en la biología de las membranas y la generación de moléculas de señalización. Los inhibidores de fosfolipasas se utilizan para estudiar su papel en enfermedades inflamatorias, trastornos cardiovasculares y neurodegeneración. Estos inhibidores también son valiosos para explorar las vías de señalización de lípidos y sus implicaciones en los mecanismos de enfermedades. En CymitQuimica, ofrecemos una variedad de inhibidores de fosfolipasas para apoyar su investigación en inflamación, metabolismo de lípidos y señalización celular.
Se han encontrado 86 productos para "Fosfolipasa".
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2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide
CAS:2-Decenoylaminoethyl cyclohexylethyl sulfide prevents stress ulcers, stabilizes phospholipase A2 and prostaglandin E2.Fórmula:C20H37NOSPureza:98%Forma y color:SolidPeso molecular:339.58VU0155056
CAS:VU0155056 is a dual PLD1/2 inhibitor with IC50 < 1 µM in cellular assays, inhibits breast cancer cell invasion.Fórmula:C25H26N4O2Pureza:98.6% - 99.15%Forma y color:SolidPeso molecular:414.5Omeprazole Sodium
CAS:Omeprazole Sodium is a proton pump inhibitor(PPI) and suppresses gastric acid secretion.Fórmula:C17H18N3NaO3SPureza:99.84%Forma y color:Clear In WaterPeso molecular:367.4Lp-PLA2-IN-3
CAS:Lp-PLA2-IN-3: Potent oral inhibitor of human Lp-PLA2 with a 14 nM IC50.Fórmula:C20H13ClF3N3O3SPureza:99.84%Forma y color:SolidPeso molecular:467.849ASB 14780
CAS:ASB 14780 is a 4-phenoxy derivative that exhibits highly selective inhibition of cytosolic phospholipase A2α (cPLA2α), with an IC₅₀ value as low as 20 nM.Fórmula:C35H38N2O6Pureza:99.71%Forma y color:White SolidPeso molecular:582.686LCL521
CAS:LCL521 inhibits lysosomal acid sphingomyelinase (ASMase).LCL521 is an acid ceramidase (ACDase) inhibitor.Fórmula:C31H52N4O7Pureza:98%Forma y color:SolidPeso molecular:592.77ML299
CAS:ML299 (VU0463568) is a dual PLD1/2 inhibitor (PLD1 and PLD2, IC50 of 6 nM, 20 nM, respectively).Fórmula:C23H26BrFN4O2Pureza:98.23%Forma y color:SolidPeso molecular:489.381ASM-IN-1
CAS:ASM-IN-1: Oral acid sphingomyelinase inhibitor, IC50 = 1.5 µM; reduces lipid plaques, plasma ceramide, Ox-LDL.Fórmula:C16H12BrN3O4Pureza:98%Forma y color:SolidPeso molecular:390.19GK187
CAS:GK187 is a selective and potent Group VIA calcium-independent phospholipase A2 (GVIA iPLA2) inhibitor, used in the study of neurological disorders.Fórmula:C14H15F5O2Pureza:98%Forma y color:SolidPeso molecular:310.2597Giripladib
CAS:Giripladib (PLA695/PLX-695) blocks radiation-boosted phosphorylation of ERK and Akt in endothelial cells.Fórmula:C41H36ClF3N2O4SPureza:99.64%Forma y color:White SolidPeso molecular:745.249VU0155069
CAS:VU0155069, a selective PLD1 inhibitor (IC50: 46 nM), halts cancer cell migration in transwell assays.Fórmula:C26H27ClN4O2Pureza:99.5%Forma y color:White SolidPeso molecular:462.97Halopemide
CAS:Halopemide is a potent inhibitor of PLD (IC50 = 220 and 310 nM for human PLD1 and PLD2).Fórmula:C21H22ClFN4O2Pureza:96.57%Forma y color:SolidPeso molecular:416.876Lp-PLA2-IN-2
CAS:Lp-PLA2-IN-2 is a selective and potent lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor, with an IC50 0f 120 nM for recombinant human Lp-PLA2.Fórmula:C19H23FN2O4SPureza:98%Forma y color:SolidPeso molecular:394.467,7-Dimethyl-(5Z,8Z)-eicosadienoic acid
CAS:7,7-Dimethyl-(5Z,8Z)-eicosadienoic acid (DEDA, 5 μM) significantly impacts the response to βA(25-35) stimulation. It reduces the formation of ROS.Fórmula:C22H40O2Forma y color:SolidPeso molecular:336.55VU0364739
CAS:VU0364739, a selective phospholipase D2 (PLD2) inhibitor with an IC50 of 22 nM, effectively reduces cancer cell proliferation [1].Fórmula:C26H27FN4O2Pureza:98%Forma y color:SolidPeso molecular:446.52Lp-PLA2-IN-13
CAS:Lp-PLA2-IN-13 (compound 15), a potent Lp-PLA2 inhibitor, holds potential for research in neurodegenerative-related diseases [1].Fórmula:C22H17F5N4O4Pureza:98%Forma y color:SolidPeso molecular:496.39AZD2716
CAS:AZD2716 is a selective sPLA2 inhibitor reducing pro-inflammatory lipids and macrophage activation, used in atherosclerosis research.Fórmula:C24H23NO3Pureza:99.04%Forma y color:White SolidPeso molecular:373.44PtdIns-(4,5)-P2 (1,2-dipalmitoyl) sodium
CAS:PtdIns-(4,5)-P2 (1,2-dipalmitoyl) sodium is a synthetic C16:0 phosphoinositide that mimics natural PtdIns and is hydrolyzed to IP3 and DAG second messengers.Fórmula:C41H78Na3O19P3Forma y color:SolidPeso molecular:1036.9Lp-PLA2-IN-14
CAS:Lp-PLA2-IN-14 (Compound 19), an inhibitor of rhLp-PLA2, exhibits a potent inhibitory effect with a pIC50 value of 8.4.Fórmula:C16H14F3N3O3Pureza:98%Forma y color:SolidPeso molecular:353.3CAY10502
CAS:CAY10502 inhibits cPLA2α (85 kDa), crucial in inflammation/arachidonic cascade, with 4.3 nM IC50, reducing arachidonic acid in human platelets.Fórmula:C30H37NO7Forma y color:SolidPeso molecular:523.6173
