LRRK2
Los inhibidores de LRRK2 son compuestos que se dirigen y inhiben la actividad de la quinasa rica en repeticiones de leucina 2 (LRRK2), una enzima involucrada en varios procesos celulares, como la autofagia, el tráfico vesicular y la inflamación. Las mutaciones en el gen LRRK2 están asociadas con un mayor riesgo de desarrollar la enfermedad de Parkinson, lo que convierte a LRRK2 en un objetivo significativo para la investigación de enfermedades neurodegenerativas. Los inhibidores de LRRK2 son cruciales para explorar su papel en la enfermedad de Parkinson y para desarrollar posibles estrategias terapéuticas. En CymitQuimica, ofrecemos una selección de inhibidores de LRRK2 para apoyar su investigación en neurodegeneración, señalización de quinasas y desarrollo terapéutico.
Se han encontrado 33 productos de "LRRK2"
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GNE-9605
CAS:<p>GNE-9605 is a highly effective, specifical, and brain-penetrant LRRK2 inhibitor (IC50: 19 nM).</p>Fórmula:C17H20ClF4N7OPureza:98.55% - 98.75%Forma y color:SolidPeso molecular:449.83GNE-7915
CAS:<p>GNE-7915 is a highly potent, selective and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) inhibitor.</p>Fórmula:C19H21F4N5O3Pureza:98% - ≥95%Forma y color:SolidPeso molecular:443.4CZC-54252
CAS:<p>CZC-54252 is a potent inhibitor of LRRK2.</p>Fórmula:C22H25ClN6O4SPureza:99.39%Forma y color:SolidPeso molecular:504.99PF-06455943
CAS:<p>PF-06455943: LRRK2 inhibitor, IC50=3nM, PET radioligand, used for ADME/neuro PK & Parkinson's research.</p>Fórmula:C17H14FN5OForma y color:SolidPeso molecular:323.32PF-06371900
CAS:<p>PF-06371900 is a potent and highly selective inhibitor of leucine-rich repeat kinase 2 (LRRK2).</p>Fórmula:C17H16N6O2SForma y color:SolidPeso molecular:368.41LRRK2-IN-10
CAS:<p>LRRK2-IN-10 (compound 34) is a potent, mutation-selective, brain-penetrant inhibitor targeting G2019S-LRRK2 kinase with IC50 values of 11 nM for G2019S-LRRK2</p>Fórmula:C20H15N5OPureza:98%Forma y color:SolidPeso molecular:341.37LRRK2-IN-7
CAS:<p>LRRK2-IN-7: potent, selective CNS-active LRRK2 inhibitor, IC50 0.9 nM, >1000x selectivity vs kinases/channels/CYPs.</p>Fórmula:C24H26N6OPureza:99.26%Forma y color:SolidPeso molecular:414.5LRRK2-IN-16
CAS:<p>LRRK2-IN-16 (compound 25) is an inhibitor of the LRRK2 kinase with an IC50 value of less than 5 μM. It is applicable for research in neurodegenerative and autoimmune diseases.</p>Fórmula:C18H19N5OSForma y color:SolidPeso molecular:353.441LRRK2-IN-4
CAS:<p>LRRK2-IN-4: Potent, selective LRRK2 inhibitor, oral, BBB-penetrating, IC50=2.6 nM, potential for Parkinson's.</p>Fórmula:C25H29ClF2N6O2Forma y color:SolidPeso molecular:518.99LRRK2-IN-5
<p>LRRK2-IN-5 is an oral, BBB-penetrating selective inhibitor for LRRK2 with IC50s: 1.2μM (GS) and 16μM (WT); halts LRRK2 autophosphorylation.</p>Fórmula:C24H26F2N4O2SForma y color:SolidPeso molecular:472.55LRRK2-IN-2
CAS:<p>LRRK2-IN-2: selective, potent LRRK2 inhibitor, IC50 of 0.6 nM, oral, crosses blood-brain barrier, for Parkinson's research.</p>Fórmula:C23H23Cl2F3N6O2Forma y color:SolidPeso molecular:543.37LRRK2-IN-3
CAS:<p>LRRK2-IN-3: potent, selective oral LRRK2 blocker, BBB-penetrant, IC50 of 0.6 nM in hPBMCs, for Parkinson's research.</p>Fórmula:C25H29ClF2N6O2Forma y color:SolidPeso molecular:518.99LRRK2-IN-6
<p>LRRK2-IN-6 is an oral, selective LRRK2 inhibitor crossing the blood-brain barrier, targeting GS (IC50: 4.6μM) and WT LRRK2 (IC50: 49μM).</p>Fórmula:C23H24F2N4O2SForma y color:SolidPeso molecular:458.52
