GlyT
Inhibidores del Transportador de Glicina (GlyT) son compuestos que bloquean la recaptación de glicina, un importante neurotransmisor inhibidor en la médula espinal y el tronco encefálico. Al inhibir los transportadores de glicina, estos compuestos aumentan la disponibilidad de glicina en la hendidura sináptica, mejorando sus efectos inhibitorios sobre la actividad neuronal. Los inhibidores de GlyT son de interés por su potencial aplicación terapéutica en condiciones como el dolor crónico, la espasticidad y la esquizofrenia. En CymitQuimica, ofrecemos inhibidores de GlyT para apoyar su investigación en el manejo del dolor, el control motor y los trastornos neuropsiquiátricos.
Se han encontrado 24 productos de "GlyT"
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LY2365109 hydrochloride
CAS:<p>LY2365109 hydrochloride is a potent and selective GlyT1 inhibitor, with an IC50 of 15.8 nM for glycine uptake in cells over-expressing hGlyT1a.</p>Fórmula:C22H28ClNO5Pureza:98.27%Forma y color:SolidPeso molecular:421.91DCCCyb
CAS:<p>DCCCyb: oral GlyT1 inhibitor with high in vivo occupancy in rhesus monkeys, confirmed by PET tracer displacement.</p>Fórmula:C22H29Cl2NO3SPureza:98%Forma y color:SolidPeso molecular:458.448-hydroxy Amoxapine
CAS:<p>8-hydroxy Amoxapine is a metabolite of the tetracyclic antidepressant amoxapine .1,2</p>Fórmula:C17H16ClN3O2Forma y color:SolidPeso molecular:329.78SSR504734 HCl
CAS:<p>SSR504734 inhibits GlyT1 in humans, rats, mice (IC50=18, 15, 38 nM); treats schizophrenia, anxiety, depression orally.</p>Fórmula:C20H21Cl2F3N2OPureza:98.05% - 99.93%Forma y color:SolidPeso molecular:433.30Sarcosine
CAS:<p>Sarcosine (Methylglycine) is a competitive inhibitor of the type I glycine transporter (GlyT1) and an N-methyl-D-aspartate receptor (NMDAR) co-agonist.</p>Fórmula:C3H7NO2Pureza:99.90%Forma y color:Deliquescent Water Soluble Physical Description Deliquescent Crystals Or Powder Has A Sweetish Taste (Ntp 1992)Peso molecular:89.09SSR504734
CAS:<p>SSR504734 is a novel potent glycine transporter 1 (GlyT1) inhibitor.</p>Fórmula:C20H20ClF3N2OForma y color:SolidPeso molecular:396.83Bitopertin
CAS:<p>Bitopertin (Paliflutine) (RG1678, RO-4917838) is a potent inhibitor of glycine transporter 1 (GlyT1), with Ki of 8.1 nM for human hGlyT1b and IC50 of 22-25 nM</p>Fórmula:C21H20F7N3O4SPureza:98.57% - 98.71%Forma y color:SolidPeso molecular:543.46Org 25543 hydrochloride
CAS:<p>Org 25543 hydrochloride is a potent and selective glycine transporter type 2 (GlyT2) inhibitor (IC50 = 16 nM for hGlyT2).</p>Fórmula:C24H33ClN2O4Pureza:99.26%Forma y color:SolidPeso molecular:448.983Opiranserin hydrochloride
CAS:<p>Opiranserin (VVZ-149) hydrochloride is a dual antagonist of glycine transporter type 2 (GlyT2) and serotonin receptor 2A (5HT2A), with IC50s of 0.86 and 1.3 μM</p>Fórmula:C21H35ClN2O5Pureza:99.33%Forma y color:SolidPeso molecular:430.97Opiranserin
CAS:<p>Opiranserin is a development as an injectable agent for the treatment of postoperative pain.</p>Fórmula:C21H34N2O5Pureza:98%Forma y color:SolidPeso molecular:394.51ASP2535
CAS:<p>ASP2535 is a potent, selective, orally bioavailable, brain permeable and centrally-active glycine transporter-1 (GlyT1) inhibitor.ASP2535 can improve cognitive</p>Fórmula:C22H18N6OPureza:98%Forma y color:SolidPeso molecular:382.42Org-25935
CAS:<p>Org-25935, a GlyT-1 inhibitor, is used potentially for the treatment of schizophrenia and alcohol dependence.</p>Fórmula:C21H26ClNO3Forma y color:SolidPeso molecular:375.89Tilapertin
CAS:Tilapertin is an oral glycine transporter type-1 inhibitor.Fórmula:C20H21F3N2O2Pureza:98%Forma y color:SolidPeso molecular:378.39Org 24598
CAS:<p>Potent GlyT1b inhibitor, IC50 = 6.9 nM; little effect on GlyT-2, adrenoceptors, dopamine, 5HT receptors, GABA transporters.</p>Fórmula:C19H20F3NO3Forma y color:SolidPeso molecular:367.36NFPS
CAS:<p>NFPS exerts neuroprotection via glyR alpha1 subunit in the rat model of transient focal cerebral ischaemia and reperfusion.</p>Fórmula:C24H24FNO3Pureza:98%Forma y color:SolidPeso molecular:393.45MPDC
CAS:<p>MPDC acts as a competitive inhibitor against the Na+-dependent high-affinity glutamate transporter within forebrain synaptosomes.</p>Fórmula:C7H9NO4Pureza:98%Forma y color:SolidPeso molecular:171.15LY 2365109 hydrochloride
CAS:<p>glycine transporter 1 (GlyT1) inhibitor</p>Fórmula:C22H27NO5Pureza:98%Forma y color:SolidPeso molecular:385.45PF-03463275 2HCl
CAS:<p>PF-03463275 is an orally available, CNS-penetrant inhibitor of SLC6A9, a GlyT1 glycine transporter.</p>Fórmula:C19H24Cl3FN4OPureza:98%Forma y color:SolidPeso molecular:449.78Bitopertin (R enantiomer)
CAS:<p>Bitopertin R enantiomer (RG1678 R enantiomer) is the R-enantiomer of Bitopertin.</p>Fórmula:C21H20F7N3O4SPureza:98%Forma y color:SolidPeso molecular:543.46GSK931145
CAS:<p>GSK931145 is a positron emission tomography (PET) radioligand, it is suitable for quantifying glycine transporter (GlyT1) availability in the living brain.</p>Fórmula:C23H30N2OPureza:98%Forma y color:SolidPeso molecular:350.5
