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Inhibidores de ciclooxigenasa (COX)

Inhibidores de ciclooxigenasa (COX)

Cyclooxygenase (COX) inhibitors are a class of compounds that inhibit the activity of COX enzymes, which play a critical role in the biosynthesis of prostaglandins—lipid compounds that mediate inflammation, pain, and fever. In the field of neuroscience, COX inhibitors are extensively studied for their potential to alleviate neuroinflammation, a key factor in the progression of various neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. By blocking COX activity, these inhibitors may help reduce inflammation in the brain, thereby protecting neurons from damage and slowing disease progression. At CymitQuimica, we offer a wide range of high-quality COX inhibitors to support your research in neuroinflammation, pain management, and the study of neurodegenerative disorders.

Se han encontrado 562 productos de "Inhibidores de ciclooxigenasa (COX)"

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  • Safrole oxide

    CAS:
    <p>Safrole oxide inhibits neuronal growth, induces apoptosis, elevates COX-2, IL-8, ROS, promoting endothelial-to-neuron-like cell transdifferentiation.</p>
    Fórmula:C10H10O3
    Pureza:100%
    Forma y color:Solid
    Peso molecular:178.18
  • (-)-Ibuprofenamide

    CAS:
    <p>(-)-Ibuprofenamide is an amide prodrug of Ibuprofen with anti-inflammatory activity.</p>
    Fórmula:C13H19NO
    Pureza:98%
    Forma y color:Solid
    Peso molecular:205.3
  • Piroxicam cinnamate

    CAS:
    <p>Cinnoxicam is a COX inhibitor used for bone/joint inflammation, rheumatic issues, and varicocele-related oligospermia.</p>
    Fórmula:C24H19N3O5S
    Forma y color:Solid
    Peso molecular:461.49
  • GW-406381

    CAS:
    <p>GW-406381 is a highly selective COX-2 inhibitor peripherally and centrally, reducing spontaneous ectopic discharges following chronic compressive injury.</p>
    Fórmula:C21H19N3O3S
    Pureza:99.54%
    Forma y color:Solid
    Peso molecular:393.46
  • COX-2/5-LOX-IN-2

    CAS:
    <p>COX-2/5-LOX-IN-2, a benzothiophen derivative, inhibits COX-1, COX-2, 5-LOX with IC50s of 5.40, 0.01, 1.78 μM. More effective than Celecoxib, Indomethacin.</p>
    Fórmula:C18H13N3O4S2
    Forma y color:Solid
    Peso molecular:399.44
  • COX-2-IN-19

    CAS:
    <p>COX-2-IN-19, a potent COX-2 inhibitor, IC50 of 1.76 μM, has strong anti-inflammatory effects in vivo.</p>
    Fórmula:C18H18N4O2S
    Forma y color:Solid
    Peso molecular:354.43
  • Timegadine

    CAS:
    <p>Timegadine is a competitive inhibitor of COX and lipo-oxygenase, with IC50s ranging from 5 nM (washed rabbit platelets) to 20 μM (rat brain) for COX and 100 μM</p>
    Fórmula:C20H23N5S
    Pureza:98%
    Forma y color:Solid
    Peso molecular:365.5
  • ADU-S100

    CAS:
    <p>ADU-S100 (MIW815) is a STING agonist that significantly induces the production of IFN-β,TNF-α,IL-6,and MCP-1,induces TBK1 and IRF3 phosphorylation,antitumour.</p>
    Fórmula:C20H24N10O10P2S2
    Pureza:99.83%
    Forma y color:Solid
    Peso molecular:690.54
  • COX-2/5-LOX-IN-1

    CAS:
    <p>COX-2/5-LOX-IN-1, a benzothiophen-2-yl pyrazole, inhibits COX-2 &amp; 5-LOX with IC50: COX-1 (12.13μM), COX-2 (0.4μM), 5-LOX (4.96μM). Better than Celecoxib.</p>
    Fórmula:C14H10ClN3O4S2
    Forma y color:Solid
    Peso molecular:383.83
  • Heterophdoid A

    CAS:
    <p>Heterophdoid A is an anti-inflammatory agent that inhibits NO production in BV-2 cells (IC50: 5.93 μM).</p>
    Fórmula:C26H42O10
    Forma y color:Solid
    Peso molecular:514.61
  • Naproxcinod

    CAS:
    <p>Naproxcinod is a derivative of naproxen, analgesic and anti-inflammatory, a COX-inhibitory nitric oxide donor (CINOD), osteoarthritis and inflammatory.</p>
    Fórmula:C18H21NO6
    Forma y color:Solid
    Peso molecular:347.36
  • Nitroflurbiprofen

    CAS:
    <p>Nitroflurbiprofen (Nitroxybutyl flurbiprofen) is a NO-releasing COX inhibitor and modulates the increased intrahepatic vascular tone in portal hypertensive</p>
    Fórmula:C19H20FNO5
    Pureza:99.88%
    Forma y color:Solid
    Peso molecular:361.36
  • COX-2-IN-28

    CAS:
    <p>COX-2-IN-28 is a potent and selective COX-2 inhibitor capable of acting on COX-2 (IC50: 0.054 μM), 15-LOX (IC50: 2.14 μM) and COX-1 (IC50: 13.21 μM).</p>
    Fórmula:C30H27N7S3
    Forma y color:Solid
    Peso molecular:581.78
  • COX-2-IN-11

    CAS:
    <p>COX-2-IN-11 (compound 7b2) is a potent and selective COX-2 inhibitor. COX-2-IN-11 has the potential in inflammation disease research[1].</p>
    Fórmula:C12H12OS3
    Forma y color:Solid
    Peso molecular:268.42
  • Naproxen etemesil

    CAS:
    <p>Naproxen, a COX-1/2 inhibitor, has IC50s of 8.72/5.15 μM. Its prodrug, naproxen etemesil, is lipophilic and converts to active form upon absorption.</p>
    Fórmula:C17H20O5S
    Pureza:98%
    Forma y color:Solid
    Peso molecular:336.4
  • Apyramide

    CAS:
    <p>Apyramide, an NSAID and prodrug of indomethacin, inhibits COX1/COX2 and permeates the blood-brain barrier.</p>
    Fórmula:C27H23ClN2O5
    Pureza:99.93%
    Forma y color:Solid
    Peso molecular:490.93
  • ABT-963

    CAS:
    <p>ABT-963: COX-2 inhibitor for osteoarthritis/pain with high selectivity, potency, and gastric safety.</p>
    Fórmula:C22H22F2N2O5S
    Pureza:98% - 99.85%
    Forma y color:Solid
    Peso molecular:464.48
  • ER-34122

    CAS:
    <p>ER-34122, a novel orally available dual 5-lipoxygenase/cyclooxygenase inhibitor with potent anti-inflammatory activity.</p>
    Fórmula:C27H26ClN3O5
    Pureza:>99.99%
    Forma y color:Solid
    Peso molecular:507.96
  • Eltenac

    CAS:
    <p>Eltenac, a cyclooxygenase (COX) inhibitor, is used potentially for the treatment of pain.</p>
    Fórmula:C12H9Cl2NO2S
    Pureza:98.53%
    Forma y color:Solid
    Peso molecular:302.18
  • Sudoxicam

    CAS:
    <p>Sudoxicam (4-Hydroxy-2-methyl-N-2-thiazolyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide) is a reversible antagonist of COX with anti-inflammatory, anti-edema</p>
    Fórmula:C13H11N3O4S2
    Pureza:99.93%
    Forma y color:Solid
    Peso molecular:337.37