
GluR
Inhibidores del Receptor de Glutamato son compuestos que bloquean la actividad de los receptores de glutamato, los principales receptores de neurotransmisores excitatorios en el cerebro. Estos receptores desempeñan un papel crucial en la transmisión sináptica, la plasticidad, el aprendizaje y la memoria. La desregulación de la señalización de glutamato está asociada con varios trastornos neurológicos, como la epilepsia, el accidente cerebrovascular y las enfermedades neurodegenerativas. Los inhibidores de los receptores de glutamato son esenciales para investigar los mecanismos de la excitotoxicidad y desarrollar estrategias neuroprotectoras. En CymitQuimica, ofrecemos una gama de inhibidores de receptores de glutamato para apoyar su investigación en la función sináptica, la neuroprotección y los trastornos cognitivos.
Se han encontrado 265 productos de "GluR"
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LY487379
CAS:LY487379: human mGluR2 PAM, boosts glutamate binding, aids cognitive flexibility, may treat schizophrenia. EC50: 1.7 μM (mGlu2), >10 μM (mGlu3).Fórmula:C21H19F3N2O4SForma y color:SolidPeso molecular:452.45EGLU
CAS:EGLU, an antidepressant and potent mGluR-2 antagonist, binds with a 66 μM Kd to (lS,3S)-ACPD sites.Fórmula:C7H13NO4Pureza:99.98%Forma y color:SolidPeso molecular:175.18γ-DGG
CAS:gamma-DGG is a competitive blocker of AMPA receptor.Fórmula:C7H12N2O5Pureza:98%Forma y color:SolidPeso molecular:204.18AMN082
CAS:AMN082 is an mGluR7 agonist with antidepressant effects. Neuroprotective effect of AMN082 on neuronal apoptosis in rats with traumatic brain injury.Fórmula:C28H30Cl2N2Pureza:97.13% - 98.63%Forma y color:SolidPeso molecular:465.46GYKI 53655 hydrochloride
CAS:GYKI 53655 hydrochloride (LY300168 hydrochloride) is an antagonist of AMPA and is used in the study of neurological disorders.Fórmula:C19H21ClN4O3Pureza:98.02%Forma y color:SolidPeso molecular:388.85LY341495
CAS:LY341495 is a potent metabotropic glutamate receptor antagonist and can be used to study neurological disorders.Fórmula:C20H19NO5Pureza:98.53% - 99.37%Forma y color:SolidPeso molecular:353.37VU0364770 hydrochloride
CAS:VU0364770 hydrochloride: potent, selective mGlu4 PAM; EC50=290 nM (rat), 1.1 μM (human).Fórmula:C12H10Cl2N2OPureza:98%Forma y color:SolidPeso molecular:269.13VU0422288
CAS:VU0422288 (ML396) is a type III mGlu receptor (mGlus) orthosteric modulator with inhibitory effects on mGluR4.VU0422288 can be used to study Rett syndrome.Fórmula:C17H11Cl2N3O2Pureza:99.77%Forma y color:SolidPeso molecular:360.19Ro 01-6128
CAS:Positive allosteric modulator of mGlu1 receptorsFórmula:C17H17NO3Pureza:98%Forma y color:SolidPeso molecular:283.32JNJ-46778212
CAS:JNJ-46778212 (VU 0409551) is a selective and potent mGlu5 allosteric modulator (EC50: 260 nM) for the study of neurodissection.Fórmula:C20H17FN2O3Pureza:99.24%Forma y color:SolidPeso molecular:352.36CFMTI
CAS:CFMTI: potent mGluR1 allosteric antagonist, 2000x selectivity over mGluR5, IC50: 2.6 nM.Fórmula:C19H16FN5OPureza:97.23%Forma y color:SolidPeso molecular:349.36Ref: TM-T3482
1mg57,00€2mg82,00€5mg120,00€1mL*10mM (DMSO)133,00€10mg170,00€25mg304,00€50mg432,00€100mg602,00€(S)-ATPO
CAS:(S)-ATPO is Competitive antagonist at GluR1-4 (AMPA-preferring) receptors.
Fórmula:C11H19N2O7PPureza:98.37% - 99.41%Forma y color:SolidPeso molecular:322.25MTEP
CAS:MTEP: potent, selective mGluR5 antagonist; IC50=5 nM, Ki=16 nM; may have antidepressant/anxiolytic effects; useful in Parkinson's research.Fórmula:C11H8N2SForma y color:SolidPeso molecular:200.26Ro0711401
CAS:Ro0711401 is an agonist of mGlu1 receptor.Fórmula:C18H11F3N2O3Pureza:97.57%Forma y color:SolidPeso molecular:360.29DNQX
CAS:DNQX (FG 9041) is a competitive, non-NMDA glutamate receptor antagonist (IC50s = 0.5 and 0.1 μM for AMPA and kainate receptors, respectively)
Fórmula:C8H4N4O6Pureza:97.27% - 99.1%Forma y color:Off-White Powder With A Yellow TingePeso molecular:252.14VU0155041
CAS:VU0155041 is an effective and positive allosteric modulator/allosteric agonist at mGlu4 receptors (EC50: 798/693 nM, at human/rat).Fórmula:C14H15Cl2NO3Pureza:99.52% - 99.56%Forma y color:SolidPeso molecular:316.18Ref: TM-T3565
2mg38,00€5mg55,00€1mL*10mM (DMSO)60,00€10mg80,00€25mg138,00€50mg178,00€100mg285,00€200mg413,00€VU0361737
CAS:VU0361737 (ML-128) is a mGlu4 PAM; EC50 is 240 nM (human) and 110 nM (rat), weak at mGlu5/8, inactive at mGlu1/2/3/6/7, CNS-penetrant.Fórmula:C13H11ClN2O2Pureza:99.60% - 99.85%Forma y color:SolidPeso molecular:262.69ADX88178
CAS:ADX88178 is a potent positive allosteric modulator for metabotropic glutamate receptor 4 (mGluR4) with EC50 of 4 nM for human mGluR4.Fórmula:C12H12N6SPureza:99.55%Forma y color:SolidPeso molecular:272.33JNJ-40411813
CAS:JNJ-40411813 (ADX-71149) (ADX-71149) is a new positive allosteric modulator of the metabotropic glutamate 2 receptor (mGlu2R, EC50: 147 nM).
Fórmula:C20H25ClN2OPureza:99.74%Forma y color:SolidPeso molecular:344.88CX614
CAS:CX614 is a positive allosteric modulator of the AMPA receptor concerning AMPA.Fórmula:C13H13NO4Pureza:97.37%Forma y color:SolidPeso molecular:247.25Ref: TM-T19698
5mg52,00€1mL*10mM (DMSO)55,00€10mg78,00€25mg119,00€50mg172,00€100mg259,00€200mg388,00€
