Glutaminasa
Los inhibidores de la glutaminasa son compuestos que inhiben la glutaminasa, una enzima que cataliza la conversión de glutamina en glutamato, un paso crítico en el metabolismo celular, especialmente en las células cancerosas. La glutaminasa desempeña un papel clave en la provisión de energía y precursores biosintéticos para las células en rápida proliferación. Los inhibidores de la glutaminasa son importantes para explorar las dependencias metabólicas en las células cancerosas y desarrollar posibles estrategias terapéuticas. En CymitQuimica, proporcionamos inhibidores de la glutaminasa para apoyar su investigación en metabolismo del cáncer, bioenergética celular y descubrimiento terapéutico.
Se han encontrado 46 productos para "Glutaminasa".
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LDN-27219
CAS:LDN-27219 is a potent hTGase inhibitor with IC50 of 0.6 uM.Fórmula:C20H16N4O2S2Pureza:99.01% - 99.38%Forma y color:SolidPeso molecular:408.5Ref: TM-T11831
1mg34,00€5mg63,00€1mL*10mM (DMSO)67,00€10mg96,00€25mg152,00€50mg221,00€100mg334,00€200mg489,00€BJJF078
CAS:BJJF078, an aminopiperidine, inhibits human/mouse TG2 (IC50: 41/54 nM) and TG1 (IC50: 0.16 μM), may be used in MS studies.Fórmula:C27H29N3O6SPureza:99.56%Forma y color:SoildPeso molecular:523.6L-Methionine-DL-sulfoximine
CAS:MSO blocks glutamine synthetase, impacts astroglia, and is used in convulsant research.Fórmula:C5H12N2O3SPureza:99.56% - ≥98%Forma y color:White SolidPeso molecular:180.23Trivalent hydroxyarsinothricn
Trivalent hydroxyarsinothricn (R-AST-OH) is a covalent and irreversible inhibitor of kidney-type glutaminase (KGA). It binds to the glutamine binding site and forms a covalent bond with the cysteine residue at the active site. This compound selectively kills triple-negative breast cancer (TNBC) cells without being cytotoxic to control cell lines. KGA is an enzyme that regulates glutamine metabolism and is associated with tumor malignancy.Fórmula:C4H10AsNO4Forma y color:SolidPeso molecular:210.98258PROTAC TG2 degrader-2
PROTAC TG2 degrader-2 (compound 7) is a selective competitive degrader of Transglutaminase 2 (TG2), exhibiting a dissociation constant (Kd) greater than 100 μM.Fórmula:C47H57N9O6SPureza:98%Forma y color:SolidPeso molecular:876.08PROTAC TG2 degrader-1
PROTAC TG2 Degrader-1 (Compound 11) is a VHL-based PROTAC that targets tissue transglutaminase (TG2) and exhibits a binding affinity with a K D of 68.9 μM.Fórmula:C55H73N9O10SPureza:98%Forma y color:SolidPeso molecular:1052.296-Diazo-5-oxo-L-nor-Leucine
CAS:6-Diazo-5-oxo-L-nor-Leucine (L-6-Diazo-5-oxonorleucine) is an antagonist of glutaminases (Ki : 6 μM).Fórmula:C6H9N3O3Pureza:98.04% - 98.93%Forma y color:Yellow SolidPeso molecular:171.15Glutaminase C-IN-3
GlutaminaseC-IN-3 is a potent allosteric inhibitor of glutaminase C (GAC) with an EC50 of 116 nM. It modulates cellular metabolites and elevates reactive oxygen species (ROS) production by inhibiting glutamine metabolism. In A549 xenograft mouse models, GlutaminaseC-IN-3 demonstrates significant antitumor activity. This compound is applicable for research on non-small cell lung cancer (NSCLC).LM11
LM11 is a transglutaminase 2 (TG2) inhibitor that exhibits activity against glioblastoma cells by maintaining TG2 in a cytotoxic conformational state.Fórmula:C26H18Cl2N4O5Forma y color:SolidPeso molecular:536.06543Glutaminase C-IN-2
Glutaminase C-IN-2 (compound 11), an allosteric inhibitor of glutaminase C (GAC), exhibits potent inhibitory activity with an IC50 of 10.64 nM.Fórmula:C24H23N7O2SPureza:98%Forma y color:SolidPeso molecular:473.55GLS1 Inhibitor-7
GLS1 Inhibitor-7 (compound 4d) serves as a GLS1 antagonist with an IC50 value of 46.7 μM, demonstrating potential applications in anticancer, antiaging, andFórmula:C20H17F3N4O3S2Pureza:98%Forma y color:SolidPeso molecular:482.5Glutaminase-IN-3
CAS:Glutaminase-IN-3 is a potent Glutaminase 1 inhibitor with potential antitumor activity and inhibits GLS1 for cancer research.Fórmula:C19H19F3N6O2SPureza:98.51%Forma y color:Yellow SolidPeso molecular:452.45Glutaminase-IN-1
CAS:Glutaminase-IN-1 (CB839 derivative), a glutaminase (KGA) inhibitor, has antitumor activity in an aggressive H22 hepatocellular carcinoma xenograft model.Fórmula:C26H24F3N7O3SePureza:98.65% - 98.65%Forma y color:SolidPeso molecular:618.47BPTES
CAS:BPTES(IC50 of 0.16 μM) is an effective and specific GlutamiN/Ase GLS1 (KGA) inhibitor.Fórmula:C24H24N6O2S3Pureza:95.83% - 99.64%Forma y color:Yellow SolidPeso molecular:524.68Ref: TM-T6791
1mg34,00€2mg49,00€5mg65,00€10mg84,00€1mL*10mM (DMSO)84,00€25mg142,00€50mg207,00€100mg308,00€200mg447,00€500mg732,00€L-Albizziin
CAS:L-Albizziin (L-beta-Ureidoalanine) is a glutamase inhibitor and is a glutaminyl-tRNA synthetase inhibitor.Fórmula:C4H9N3O3Pureza:99.98%Forma y color:SolidPeso molecular:147.13Glutaminase C-IN-1
CAS:Glutaminase C-IN-1 (Compound 968) is a Glutaminase C allosteric inhibitor.Fórmula:C27H27BrN2OPureza:99.91% - >99.99%Forma y color:Yellow SolidPeso molecular:475.42Ref: TM-T3964
2mg39,00€5mg57,00€1mL*10mM (DMSO)64,00€10mg93,00€25mg154,00€50mg259,00€100mg358,00€200mg528,00€GK921
CAS:GK921 is a transglutaminase 2 (TGase) inhibitor.Fórmula:C21H20N4OPureza:97.44% - 99.92%Forma y color:Yellow SolidPeso molecular:344.41Telaglenastat
CAS:Telaglenastat (CB 839) (IC50 of 24 nM), an effective, specific, and oral inhibitor, which is bioavailable glutaminase, for recombinant human GAC.Fórmula:C26H24F3N7O3SPureza:97.57% - 99.89%Forma y color:SolidPeso molecular:571.57Zampilimab
CAS:Zampilimab (UCB-7858) is a humanised monoclonal antibody targeting TGM2, inhibits the cross-linking transamidase activity of TG2, renal fibrosis.Pureza:95%Forma y color:LiquidPeso molecular:~150 kDaIrbesartan-D4
CAS:Irbesartan-d4 (Irbesartan D4), a deuterated compound of Irbesartan, is an angiotensin receptor blocker and is used in the study of cardiovascular disease.Fórmula:C25H28N6OPureza:>99.99%Forma y color:SolidPeso molecular:432.55
