Wnt / beta-catenina
Los inhibidores de Wnt/beta-catenina son compuestos que inhiben la vía de señalización Wnt/beta-catenina, la cual es crucial para la regulación del desarrollo embrionario, la proliferación celular y el mantenimiento de las células madre. La desregulación de esta vía está relacionada con varios tipos de cáncer y enfermedades degenerativas. Los inhibidores de la señalización Wnt/beta-catenina son valiosos en la investigación enfocada en comprender el papel de esta vía en enfermedades y en el desarrollo de terapias dirigidas. En CymitQuimica, ofrecemos inhibidores de Wnt/beta-catenina para apoyar su investigación en biología de células madre, biología del desarrollo e investigación oncológica.
Se han encontrado 62 productos de "Wnt / beta-catenina"
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CCT251545
CAS:CCT251545 is an potent and oral-bioavailable WNT signaling inhibitor(IC50 of 5 nM in 7dF3 cells).Fórmula:C23H24ClN5OPureza:98.29% - 98.69%Forma y color:SolidPeso molecular:421.92BML-286
CAS:BML-286 is a WNT pathway modulator with potential anticancer activity and induces β-catenin- and TCF- dependent transcriptional activity.Fórmula:C22H18N2O4Pureza:98.44%Forma y color:SolidPeso molecular:374.39CWP232228
CAS:CWP232228 is a selective Wnt/β-catenin pathway inhibitor targeting β-catenin/TCF binding, halting breast/liver CSC growth and metastasis safely.Fórmula:C33H34N7Na2O7PPureza:98.87%Forma y color:SolidPeso molecular:717.63TNIK-IN-5
CAS:TNIK-IN-5: strong TNIK inhibitor (IC50=0.05μM), halts Wnt signaling, effective against colorectal cancer in vitro.Fórmula:C22H17N3O3Pureza:99.58%Forma y color:SolidPeso molecular:371.39KY1220
CAS:KY1220 destabilizes both β-catenin and Ras by targeting the Wnt/β-catenin pathway. It has an IC50 of 2.1 μM in HEK293 reporter cells.Fórmula:C14H10N4O3SPureza:99.9%Forma y color:SolidPeso molecular:314.32Ref: TM-T15677
2mg34,00€5mg66,00€10mg101,00€25mg200,00€50mg319,00€100mg515,00€200mg702,00€1mL*10mM (DMSO)70,00€Vantictumab
CAS:Vantictumab (OMP-18R5) is a humanized anti-FZD1/2/5/7/8 monoclonal antibody that inhibits Wnt pathway signaling.Pureza:99% (SDS-PAGE); 97.7% (SEC-HPLC) - 99% (SDS-PAGE); 97.7% (SEC-HPLC)Forma y color:LiquidPeso molecular:142.69 kDaJW74
CAS:JW74 antagonizes LiCl-induced activation of the canonical Wnt signaling (IC50: 420 nM).Fórmula:C24H20N6O2SPureza:95.00%Forma y color:SolidPeso molecular:456.52Blosozumab
CAS:Blosozumab (LY2541546) is a monoclonal antibody targeting sclerostin that promotes bone formation, used in the research of osteoporosis.Pureza:98.7% (SEC-HPLC) - 99.53% (SEC-HPLC)Forma y color:LiquidPeso molecular:144.88 kDaNLS-StAx-h
Wnt inhibitor; halts cancer cell growth & spread by blocking β-catenin, IC50=1.4μM, cell-permeable.Fórmula:C161H275N55O29Pureza:98%Forma y color:SolidPeso molecular:3445.26LP-922056
CAS:LP-922056 is an inhibitor of Notum Pectinacetylesterase with EC50 values of 21 nM, 55 nM for human and mouse, respectively.
Fórmula:C11H9ClN2O2S2Pureza:99.84%Forma y color:SolidPeso molecular:300.78Wnt/β-catenin agonist 3
CAS:Wnt/β-catenin agonist 3 is a Wnt/beta-catenin agonist.
Fórmula:C16H15ClN4O2Pureza:99.52%Forma y color:SolidPeso molecular:330.77Tabituximab
CAS:BMS-986148 is a CHO-expressed humanized antibody-drug coupling targeting mesothelin-expressing cells for cytotoxic load delivery.Pureza:98.7% (SDS-PAGE); 96.4% (SEC-HPLC) - 98.7% (SDS-PAGE); 96.4% (SEC-HPLC)Forma y color:LiquidPeso molecular:145.5 kDaABC99
CAS:ABC99 irreversibly inhibits wnt-deacylating enzyme NOTUM (IC50: 13 nM) with high serine hydrolase family selectivity.Fórmula:C22H21ClN4O5Pureza:99.89%Forma y color:SoildPeso molecular:456.88Ref: TM-T23602
1mg114,00€2mg155,00€5mg222,00€10mg334,00€25mg595,00€50mg893,00€100mg1.243,00€200mg1.674,00€1mL*10mM (DMSO)224,00€Foxy-5 Ammonium Salt
Foxy-5 Ammonium Salt, a WNT5A mimetic, blocks epithelial cancer cell migration without β-catenin impact and curbs prostate cancer spread.Fórmula:C26H46N7O12S2Pureza:97.70%Forma y color:SolidPeso molecular:712.26Ref: TM-TP1565L1
1mg90,00€5mg288,00€10mg430,00€25mg705,00€50mg982,00€100mg1.324,00€1mL*10mM (DMSO)309,00€Foxy-5
CAS:Foxy-5 is a wnt5a peptide mimeticFórmula:C26H42N6O12S2Pureza:98%Forma y color:SolidPeso molecular:694.771(R),2(S)-epoxy Cannabidiol
CAS:1(R),2(S)-epoxy Cannabidiol (Compound 2a) is a structural analog of phytocannabinoids, exhibiting significant inhibitory activity on the Wnt/β-catenin pathway. It holds potential for research as a neuroprotective agent.Fórmula:C21H30O3Forma y color:SolidPeso molecular:330.46WIC1
CAS:2H-1-Benzopyran-3-carboxamide, N-[4-(4-ethyl-1-piperazinyl)phenyl]-2-oxo- is a compound that is potential for the treatment of tumours.
Fórmula:C22H23N3O3Pureza:99.82%Forma y color:SoildPeso molecular:377.44Foxy-5 acetate
Foxy-5 acetate: Wnt 5A agonist, inhibits cancer cell migration/invasion, boosts calcium signaling, doesn't activate β-catenin.Fórmula:C28H46N6O14S2Pureza:98%Forma y color:SolidPeso molecular:754.83YW2036
CAS:YW2036 is an inhibitor of Wnt signaling pathway.Fórmula:C20H16N4OPureza:99.94%Forma y color:SoildPeso molecular:328.37β-catenin peptide
CAS:β-catenin peptide,(βCATp) is a naturally occurring self-peptide presented by Kb that very efficiently mediates positive selection of the OT-I thymocytes.Fórmula:C49H76N12O15Pureza:98%Forma y color:SolidPeso molecular:1073.2
