Gamma-secretasa
Inhibidores de la gamma-secretasa son compuestos que se dirigen al complejo enzimático de la gamma-secretasa, involucrado en la escisión de la proteína precursora de amiloide (APP) para producir péptidos beta-amiloides. Estos péptidos pueden agregarse y formar placas amiloides, una característica distintiva de la enfermedad de Alzheimer. Al inhibir la gamma-secretasa, estos compuestos buscan reducir la producción de beta-amiloide y su acumulación en el cerebro, convirtiéndose en un enfoque clave en la investigación sobre la enfermedad de Alzheimer. En CymitQuimica, ofrecemos una selección de inhibidores de la gamma-secretasa para apoyar su investigación en biología del amiloide, terapia para el Alzheimer y enfermedades neurodegenerativas.
Se han encontrado 61 productos de "Gamma-secretasa"
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Rovalpituzumab
CAS:Rovalpituzumab: humanized antibody against DLL3, forms ADCs, treats small cell lung cancer.Pureza:> 95%Forma y color:LiquidPeso molecular:145.02 kDaCB-103
CAS:CB-103 is a orally active inhibitor of notch signaling pathway, with anti-tumor activity.Fórmula:C15H18N2OPureza:99.44%Forma y color:SolidPeso molecular:242.32Brontictuzumab
CAS:Brontictuzumab (OMP 52M5) is an anti-Notch1 monoclonal antibody with antitumor activity that inhibits tumor cell proliferation.Pureza:98.1% (SDS-PAGE); 97.6% (SEC-HPLC) - 98.1% (SDS-PAGE); 97.6% (SEC-HPLC)Forma y color:LiquidPeso molecular:143.93 kDaDemcizumab
CAS:Demcizumab (OMP 21M18), an anti-DLL4 antibody, inhibits the Notch pathway and fights various cancers solo or with chemo.Pureza:> 95%Forma y color:LiquidPeso molecular:145.34 kDaγ-Secretase modulator 10
CAS:γ-Secretase modulator 10 is a novel γ-secretase modulator.Fórmula:C25H23F3N4O2Forma y color:SolidPeso molecular:468.48PSEN1-IN-1
PSEN1-IN-1 (Compound (+)-13b) functions as an inhibitor of PSEN1, displaying potent inhibition of the PSEN1-APH1A and PSEN1-APH1B complexes with respective IC50Fórmula:C20H19ClF3NO3SForma y color:SolidPeso molecular:445.88BMS-906024
CAS:BMS-906024 (Osugacestat) is a gamma secretase inhibitor, a Notch inhibitor.BMS-906024 has broad-spectrum antitumour activity.Fórmula:C26H26F6N4O3Pureza:99.88% - >99.99%Forma y color:SolidPeso molecular:556.5FRM-024
CAS:FRM-024 is a powerful gamma secretase modulator with the ability to penetrate the central nervous system (CNS), designed specifically for the treatment ofFórmula:C22H22ClN5O2Forma y color:SolidPeso molecular:423.9RBPJ Inhibitor-1
CAS:RBPJ Inhibitor-1 (RIN1), a compound that impedes the functional interaction between RBPJ and SHARP, effectively inhibits NOTCH-dependent tumor cellFórmula:C17H14FN3O2Pureza:99.79%Forma y color:SoildPeso molecular:311.31Ref: TM-T35566
1mg38,00€2mg50,00€5mg84,00€10mg130,00€25mg215,00€50mg371,00€100mg537,00€1mL*10mM (DMSO)93,00€Notch 1 TFA
Notch 1 TFA encodes a member of the NOTCH family of proteins.Fórmula:C64H98N15F3O25S3Pureza:98%Forma y color:SolidPeso molecular:1614.815β-Cholanic acid
CAS:5β-Cholanic acid (5beta-Cholanic acid) is a potent γ-secretase modulator used in Alzheimer's disease research.
Fórmula:C24H40O2Pureza:98.91% - 99.89%Forma y color:SoildPeso molecular:360.57CIA-1 (Free base)
CAS:CIA-1, a COUP-TFII inhibitor, has IC50 of 1.2-7.6 μM in prostate cancer cells; inhibits tumor growth in mouse prostate cancer.Fórmula:C17H19N3O2SPureza:99%Forma y color:SolidPeso molecular:329.42SPL-707
CAS:SPL-707 is an effective and selective signal peptide peptidase-like 2a inhibitor (IC50: 80 nM).Fórmula:C27H28FN5O4Pureza:98%Forma y color:SolidPeso molecular:505.54Navicixizumab
CAS:Navicixizumab, a bispecific VEGF/DLL4 inhibitor, pairs with Paclitaxel in ovarian and other cancer research.Forma y color:LiquidNotch 1
CAS:Notch1 (Notchhomolog 1, translocation-associated) encodes a protein that is a member of the NOTCH family. This type I transmembrane protein family is characterized by common structural features, including an extracellular domain made up of multiple epidermal growth factor-like (EGF) repeats and an intracellular domain composed of various types of domains.Fórmula:C62H97N15O22S3Forma y color:SolidPeso molecular:1500.72SAHM1 TFA
SAHM1 TFA inhibits the Notch pathway, stabilizes alpha helices, and blocks Notch complex formation.Fórmula:C96H163N36F3O25SForma y color:SolidPeso molecular:2310.6PSEN1-IN-2
PSEN1-IN-2 (Compound 13K) is a potent inhibitor of both PSEN1-APH1A and PSEN1-APH1B complexes, exhibiting IC50 values of 6.9 nM and 2.4 nM, respectively.Fórmula:C20H18ClFN2O3SForma y color:SolidPeso molecular:420.88SAHM1
CAS:Notch pathway inhibitor - stabilized hydrocarbon-stapled alpha helical peptide. Targets the protein-protein interface and prevents Notch complex assembly.Fórmula:C94H162N36O23SPureza:98%Forma y color:SolidPeso molecular:2196.58Enoticumab
CAS:Enoticumab (REGN421) is a fully human IgG1 monoclonal antibody with anticancer activity that inhibits cancer cell growth.Pureza:98.2% (SDS-PAGE); 98.9% (SEC-HPLC) - 98.2% (SDS-PAGE); 98.9% (SEC-HPLC)Forma y color:LiquidPeso molecular:146.22 kDaγ-secretase modulator 3
CAS:Gamma-secretase modulator 3 (γ-secretase modulator 3) is a γ-secretase modulator that reduces Aβ production.Fórmula:C24H23FN4OSPureza:98%Forma y color:SolidPeso molecular:434.53
