ALK
Los inhibidores de ALK son compuestos que específicamente atacan e inhiben la quinasa del linfoma anaplásico (ALK), una tirosina quinasa receptora involucrada en el desarrollo y progresión de ciertos tipos de cáncer, incluyendo el cáncer de pulmón de células no pequeñas y el neuroblastoma. Al inhibir ALK, estos compuestos bloquean las vías de señalización que promueven el crecimiento y la supervivencia de las células tumorales. En CymitQuimica, ofrecemos inhibidores de ALK para apoyar su investigación en oncología, terapias dirigidas contra el cáncer y transducción de señales.
Se han encontrado 157 productos para "ALK".
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ALK-IN-9
CAS:ALK-IN-9 effectively inhibits cell growth with IC50 <0.2 nM for Ba/F3-EML4-ALK, KM12, KG-1.Fórmula:C20H21FN6O3Forma y color:SolidPeso molecular:412.425EW-7195
CAS:EW-7195 inhibits ALK5/TGFβR1 (>300x selective over p38α) with 4.83 nM IC50, blocking TGF-β1 signaling, EMT, and breast cancer lung metastasis.Fórmula:C23H18N8Pureza:99.98%Forma y color:White SolidPeso molecular:406.4426LDN-193189 Tetrahydrochloride
CAS:LDN193189 is a BMPI receptor inhibitor, blocking ALK2 and ALK3 effectively, while weak on ALK4, ALK5, ALK7.Fórmula:C25H26Cl4N6Pureza:98.21%Forma y color:SolidPeso molecular:552.326Crizotinib acetate
CAS:Crizotinib is an oral c-met/HGFR tyrosine kinase inhibitor with potential cancer-fighting properties.Fórmula:C23H26Cl2FN5O3Forma y color:SolidPeso molecular:510.39Crizotinib hydrochloride
CAS:Crizotinib hydrochloride (PF-02341066 hydrochloride) is a novel inhibitor of anaplastic lymphoma kinase and c-Met(IC50s of 20 and 8 nM)Fórmula:C21H23Cl3FN5OPureza:98.73% - 98.87%Forma y color:SolidPeso molecular:486.798LDN-214117
CAS:LDN-214117 is a potent and selective ALK2 inhibitor.Fórmula:C25H29N3O3Pureza:98% - 99.83%Forma y color:SolidPeso molecular:419.5161LDN193189
CAS:LDN193189 blocks BMP signaling by inhibiting ALK2/3; IC50: ALK1/2/3/6 = 0.8/0.8/5.3/16.7 nM.Fórmula:C25H22N6Pureza:98% - 99.86%Forma y color:SolidPeso molecular:406.4824Entrectinib
CAS:Entrectinib (RXDX-101) is an orally Trk, ROS1, and ALK inhibitor. Entrectinib exhibits antitumor activity. Cost-effective and quality-assured.Fórmula:C31H34F2N6O2Pureza:98.03% - 99.67%Forma y color:SolidPeso molecular:560.64AZD-3463
CAS:AZD-3463 (ALK/IGF1R inhibitor) , an orally bioavailable ALK inhibitor (Ki: 0.75 nM), can inhibit IGF1R with equivalent potency.Fórmula:C24H25ClN6OPureza:99.13% - 99.97%Forma y color:Cyan SolidPeso molecular:448.948A 77-01
CAS:A 77-01 is a potent inhibitor of TGF-(beta) type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM.Fórmula:C18H14N4Pureza:98.82% - ≥95%Forma y color:SolidPeso molecular:286.3306Alectinib
CAS:Alectinib (RG-7853) is an ALK inhibitor that is selective, orally active, and ATP-competitive. Alectinib has antitumor activity. Cost-effective and quality-assured.Fórmula:C30H34N4O2Pureza:98% - 99.94%Forma y color:White SolidPeso molecular:482.6166GSK1838705A
CAS:GSK1838705A: IGF-1R inhibitor (IC50=2.0nM), IR (1.6nM), ALK (0.5nM), minimal other kinase impact.Fórmula:C27H29FN8O3Pureza:98.89% - >99.99%Forma y color:Yellow SolidPeso molecular:532.57CEP-28122
CAS:CEP-28122 is a highly potent and selective orally active ALK inhibitor.Fórmula:C28H35ClN6O3Pureza:99.87% - >99.99%Forma y color:SolidPeso molecular:539.069NVP-TAE 684
CAS:NVP-TAE 684 (TAE684) is a excellently effective and specific ALK inhibitor(IC50=3 nM).Fórmula:C30H40ClN7O3SPureza:98% - 99.82%Forma y color:White SolidPeso molecular:614.2Vactosertib
CAS:Vactosertib (EW-7197) is an oral TGFBR1/ALK5 inhibitor with potential cancer-fighting properties.Fórmula:C22H18FN7Pureza:98.85% - 99.81%Forma y color:White SolidPeso molecular:399.4236R-268712
CAS:R-268712 is a potent ALK5 inhibitor with a 2.5 nM IC50, also targeting TGF-β type I receptor orally.Fórmula:C20H18FN5OPureza:99.61%Forma y color:SolidPeso molecular:363.39ALK5-IN-10
CAS:Compound 12d is a potent ALK5 inhibitor with an IC50 of 7nM.Fórmula:C22H18BrN7Pureza:99.93%Forma y color:SolidPeso molecular:460.329CAY10594
CAS:CAY10594, a PLD2 inhibitor, mitigates acetaminophen liver damage via the p-GSK-3β/JNK pathway.Fórmula:C26H28N4O2Pureza:97.76%Forma y color:White SolidPeso molecular:428.5261SM 16
CAS:SM 16 is a ALK5/ALK4 kinase inhibitor (Ki: 10/1.5 nM).Fórmula:C25H26N4O3Pureza:99.72%Forma y color:SolidPeso molecular:430.4989K02288
CAS:K 02288 is a novel small molecule inhibitor of ALK1/2/3/6.Fórmula:C20H20N2O4Pureza:98% - 99.83%Forma y color:SolidPeso molecular:352.38
