ALK
Los inhibidores de ALK son compuestos que específicamente atacan e inhiben la quinasa del linfoma anaplásico (ALK), una tirosina quinasa receptora involucrada en el desarrollo y progresión de ciertos tipos de cáncer, incluyendo el cáncer de pulmón de células no pequeñas y el neuroblastoma. Al inhibir ALK, estos compuestos bloquean las vías de señalización que promueven el crecimiento y la supervivencia de las células tumorales. En CymitQuimica, ofrecemos inhibidores de ALK para apoyar su investigación en oncología, terapias dirigidas contra el cáncer y transducción de señales.
Se han encontrado 136 productos de "ALK"
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Crizotinib
CAS:Crizotinib (PF-02341066) is an ATP-competitive small-molecule tyrosine kinases inhibitor of c-MET (IC50: 8 nM) and ALK (IC50: 20 nM) receptor.Fórmula:C21H22Cl2FN5OPureza:99% - 99.87%Forma y color:SolidPeso molecular:450.34Ref: TM-T1661
2mgA consultar5mg33,00€10mg49,00€25mg55,00€50mg64,00€100mg88,00€500mg147,00€1mL*10mM (DMSO)50,00€CEP-37440
CAS:CEP-37440 is an effective and specific Dual FAK/ALK inhibitor with IC50s of 120 nM(ALK cellular in 75% human plasma) and 2.3 nM (FAK).Fórmula:C30H38ClN7O3Pureza:98.86% - 99.98%Forma y color:SolidPeso molecular:580.12SM 16
CAS:SM 16 is a ALK5/ALK4 kinase inhibitor (Ki: 10/1.5 nM).Fórmula:C25H26N4O3Pureza:99.72%Forma y color:SolidPeso molecular:430.5GSK1838705A
CAS:GSK1838705A: IGF-1R inhibitor (IC50=2.0nM), IR (1.6nM), ALK (0.5nM), minimal other kinase impact.Fórmula:C27H29FN8O3Pureza:98.89% - >99.99%Forma y color:SolidPeso molecular:532.57Entrectinib
CAS:Entrectinib (RXDX-101) is an orally Trk, ROS1, and ALK inhibitor. Entrectinib exhibits antitumor activity. Cost-effective and quality-assured.Fórmula:C31H34F2N6O2Pureza:98.03% - 99.61%Forma y color:SolidPeso molecular:560.64Ref: TM-T3678
2mg42,00€5mg59,00€10mg88,00€25mg111,00€50mg168,00€100mg283,00€500mg692,00€1mL*10mM (DMSO)69,00€ALK-IN-1
CAS:ALK-IN-1 is a potent ALK inhibitor, demonstrating the ability to overcome Crizotinib resistance mediated by an L1196M mutation.Fórmula:C26H34ClN6O2PPureza:99.74% - 99.80%Forma y color:SolidPeso molecular:529.01A 83-01
CAS:A 83-01 (ALK5 Inhibitor IV) is a selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7.Fórmula:C25H19N5SPureza:97% - 98.2%Forma y color:SolidPeso molecular:421.52LDN193189
CAS:LDN193189 blocks BMP signaling by inhibiting ALK2/3; IC50: ALK1/2/3/6 = 0.8/0.8/5.3/16.7 nM.Fórmula:C25H22N6Pureza:98% - 99.86%Forma y color:SolidPeso molecular:406.48DMH-1
CAS:DMH-1 is a BMP inhibitor that inhibits ALK1, ALK2, ALK3 and ALK6. DMH-1 promotes pluripotent stem cell differentiation. Cost-effective and quality-assured.
Fórmula:C24H20N4OPureza:98% - 99.92%Forma y color:SolidPeso molecular:380.44Brigatinib
CAS:Brigatinib (AP-26113) is a highly potent and selective ALK inhibitor.
Fórmula:C29H39ClN7O2PPureza:97.18% - >99.99%Forma y color:SolidPeso molecular:584.09AZD-3463
CAS:AZD-3463 (ALK/IGF1R inhibitor) , an orally bioavailable ALK inhibitor (Ki: 0.75 nM), can inhibit IGF1R with equivalent potency.Fórmula:C24H25ClN6OPureza:99.13%Forma y color:SolidPeso molecular:448.95Crizotinib acetate
CAS:Crizotinib is an oral c-met/HGFR tyrosine kinase inhibitor with potential cancer-fighting properties.Fórmula:C23H26Cl2FN5O3Forma y color:SolidPeso molecular:510.39ALK kinase inhibitor-1
CAS:SAR348830 is an ALK inhibitor, targeting anaplastic lymphoma kinase.Fórmula:C28H32FN5O3SPureza:99.84%Forma y color:SolidPeso molecular:537.65Alectinib
CAS:Alectinib (RG-7853) is an ALK inhibitor that is selective, orally active, and ATP-competitive. Alectinib has antitumor activity. Cost-effective and quality-assured.Fórmula:C30H34N4O2Pureza:98% - 99.38%Forma y color:SolidPeso molecular:482.62Ref: TM-T1936
2mg47,00€5mg69,00€10mg87,00€50mg105,00€100mg168,00€200mg259,00€500mg437,00€1mL*10mM (DMSO)73,00€Vactosertib
CAS:Vactosertib (EW-7197) is an oral TGFBR1/ALK5 inhibitor with potential cancer-fighting properties.Fórmula:C22H18FN7Pureza:98.85% - 99.81%Forma y color:SolidPeso molecular:399.42RepSox
CAS:RepSox (ALK5 Inhibitor II) is a TGFβR-1/ALK5 inhibitor that selectively inhibits the binding of ATP to ALK5 and the autophosphorylation of ALK5 (IC50=23/4 nM).Fórmula:C17H13N5Pureza:98.8% - 99.73%Forma y color:SolidPeso molecular:287.32Ref: TM-T6337
1mg34,00€2mg46,00€5mg63,00€10mg80,00€25mg116,00€50mg169,00€100mg241,00€500mg597,00€1mL*10mM (DMSO)69,00€GW788388
CAS:GW788388 is a potent and selective inhibitor of ALK5, also inhibits TGF-(beta) type II receptor and activin type II receptor activities.
Fórmula:C25H23N5O2Pureza:98.03% - 99.58%Forma y color:SolidPeso molecular:425.48CH5424802 analog
CAS:CH5424802 analog is a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant.Fórmula:C28H30N4O2Pureza:98.96%Forma y color:SolidPeso molecular:454.56Ref: TM-T9224
1mg124,00€5mg271,00€10mg408,00€25mg672,00€50mg945,00€100mg1.279,00€1mL*10mM (DMSO)324,00€A 77-01
CAS:A 77-01 is a potent inhibitor of TGF-(beta) type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM.Fórmula:C18H14N4Pureza:98.82% - ≥95%Forma y color:SolidPeso molecular:286.33Ref: TM-T2098
1mg40,00€2mg52,00€5mg86,00€10mg118,00€25mg200,00€50mg280,00€100mg394,00€200mg580,00€1mL*10mM (DMSO)95,00€LDN-214117
CAS:LDN-214117 is a potent and selective ALK2 inhibitor.
Fórmula:C25H29N3O3Pureza:98% - 99.82%Forma y color:SolidPeso molecular:419.52
