ALK
Los inhibidores de ALK son compuestos que específicamente atacan e inhiben la quinasa del linfoma anaplásico (ALK), una tirosina quinasa receptora involucrada en el desarrollo y progresión de ciertos tipos de cáncer, incluyendo el cáncer de pulmón de células no pequeñas y el neuroblastoma. Al inhibir ALK, estos compuestos bloquean las vías de señalización que promueven el crecimiento y la supervivencia de las células tumorales. En CymitQuimica, ofrecemos inhibidores de ALK para apoyar su investigación en oncología, terapias dirigidas contra el cáncer y transducción de señales.
Se han encontrado 136 productos de "ALK"
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M4K2234
CAS:M4K2234 (26b) inhibits ALK2/ALK5 (IC50: 5/2144 nM), used as a probe for ALK1/2 kinases in cancer research.Fórmula:C27H31FN4O2Pureza:99.99%Forma y color:SolidPeso molecular:462.56ALK5 Inhibitor II (hydrochloride)
CAS:ALK5 Inhibitor II has IC50s: 4 nM (auto), 18 nM (TGF-β assay), 23 nM (binding, HepG2).Fórmula:C17H13N5·HClPureza:98%Forma y color:SolidPeso molecular:323.82-Keto Crizotinib
CAS:2-Keto Crizotinib is an active lactam metabolite of crizotinib.Fórmula:C21H20Cl2FN5O2Pureza:98%Forma y color:SolidPeso molecular:464.32TL13-12
CAS:TL13-12 is a selective degrader of ALK-PROTAC and inhibits ALK activity (IC50: 0.69 nM).Fórmula:C45H53ClN10O10SPureza:98%Forma y color:SolidPeso molecular:961.49ALK-IN-9
CAS:ALK-IN-9 effectively inhibits cell growth with IC50 <0.2 nM for Ba/F3-EML4-ALK, KM12, KG-1.Fórmula:C20H21FN6O3Forma y color:SolidPeso molecular:412.425ALK/ROS1-IN-3
ALK/ROS1-IN-3 (compound C01) is a dual inhibitor targeting ROS1 and ALK, with IC50 values of 42.3 nM for ROS1G2032R and 49.1 nM for ALKG1202R.Fórmula:C32H32N4O2Peso molecular:504.25253TL13-112
CAS:TL13-112 is a selective degrader of ALK-PROTAC and inhibits ALK activity (IC50: 0.14 nM).Fórmula:C49H60ClN9O10SPureza:98%Forma y color:SolidPeso molecular:1002.57TL13-22
CAS:TL13-22 is a potent inhibitor of ALK and does not lead to degradation of ALK proteins.TL13-22 is often used as a negative control for TL13-12 .Fórmula:C45H55ClN10O9SPureza:99.13%Forma y color:SolidPeso molecular:947.5ALKBH5-IN-5
CAS:ALKBH5-IN-5 is a highly selective, potent and covalently binding ALKBH5 inhibitor that alters m6A levels on mRNA, induces apoptosis, antitumo.Fórmula:C13H13NO3Pureza:99.54%Forma y color:SoildPeso molecular:231.25Ref: TM-T203011
5mg34,00€10mg46,00€25mg84,00€50mg120,00€100mg178,00€200mg268,00€1mL*10mM (DMSO)49,00€ALK-IN-12
CAS:ALK-IN-12: potent ALK inhibitor (IC50: 0.18 nM), affects IGF1R and InsR (IC50: 20.3/90.6 nM), potential for cancer therapy.Fórmula:C24H30ClN6O2PForma y color:SolidPeso molecular:500.97LDN 193688
CAS:LDN 193688 is a BMP kinase inhibitor preferential for the ALK2 site, acting by binding to the ALK site,progressive osseous fibrodysplasia.Fórmula:C22H16N4OPureza:99.48%Forma y color:SoildPeso molecular:352.39PROTAC ALK degrader-3
PROTAC ALK degrader-3 (4B) is an orally active PROTAC-based ALK degrader, efficiently inducing sustained degradation of ALK fusion protein and significant inhibition of downstream pathways in Karpas 299 cells with an IC50 of 119.33 nM. This compound exhibits antitumor activity.Fórmula:C50H60ClN9O7SForma y color:SolidPeso molecular:966.59CPD-1224
CAS:CPD-1224, an oral ALK inhibitor derivative, binds cereblon, targets EML4-ALK fusions, and degrades ALK plus L1196M/G1202R mutants.Fórmula:C43H47ClN8O7SForma y color:SolidPeso molecular:855.4Multi-kinase-IN-6
Multi-kinase-IN-6 (compound 10e) is a multikinase inhibitor that effectively impedes the activity of TrkA, ALK2, c-KIT, EGFR, PIM1, CK2α, CHK1, and CDK2.Pureza:98%Forma y color:Odour SolidALK/ROS1-IN-5
ALK/ROS1-IN-5 (compound X4) is a selective inhibitor of ALK and ROS1 kinases, with IC50 values of 0.512 μM for ALK and 0.766 μM for ROS1. It inhibits H2228 cells with an IC50 of 0.034 μM and induces apoptosis in cancer cells in a dose-dependent manner. Additionally, ALK/ROS1-IN-5 effectively suppresses the expression of p-ALK and p-ERK in cancer cells.
Fórmula:C32H28F2N4O3Forma y color:SolidPeso molecular:554.586LDN-193189 Tetrahydrochloride
CAS:LDN193189 is a BMPI receptor inhibitor, blocking ALK2 and ALK3 effectively, while weak on ALK4, ALK5, ALK7.Fórmula:C25H26Cl4N6Pureza:98.21%Forma y color:SolidPeso molecular:552.33EW-7195
CAS:EW-7195 inhibits ALK5/TGFβR1 (>300x selective over p38α) with 4.83 nM IC50, blocking TGF-β1 signaling, EMT, and breast cancer lung metastasis.
Fórmula:C23H18N8Pureza:98.76%Forma y color:SolidPeso molecular:406.44CEP-28122 mesylate salt
CEP-28122 mesylate, a diaminopyrimidine, selectively inhibits ALK with IC50 of 1.9 nM and exhibits antitumor effects.Fórmula:C29H39ClN6O6SForma y color:SolidPeso molecular:635.17GW788388
CAS:GW788388 is a potent and selective inhibitor of ALK5, also inhibits TGF-(beta) type II receptor and activin type II receptor activities.
Fórmula:C25H23N5O2Pureza:98.03% - 99.58%Forma y color:SolidPeso molecular:425.48AZD-3463
CAS:AZD-3463 (ALK/IGF1R inhibitor) , an orally bioavailable ALK inhibitor (Ki: 0.75 nM), can inhibit IGF1R with equivalent potency.Fórmula:C24H25ClN6OPureza:99.13%Forma y color:SolidPeso molecular:448.95
