ALK
Los inhibidores de ALK son compuestos que específicamente atacan e inhiben la quinasa del linfoma anaplásico (ALK), una tirosina quinasa receptora involucrada en el desarrollo y progresión de ciertos tipos de cáncer, incluyendo el cáncer de pulmón de células no pequeñas y el neuroblastoma. Al inhibir ALK, estos compuestos bloquean las vías de señalización que promueven el crecimiento y la supervivencia de las células tumorales. En CymitQuimica, ofrecemos inhibidores de ALK para apoyar su investigación en oncología, terapias dirigidas contra el cáncer y transducción de señales.
Se han encontrado 116 productos de "ALK"
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LDN-193189 2HCl
CAS:<p>LDN-193189 2HCl inhibits BMP signaling (ALK1/2/3/6), IC50: 0.8-16.7 nM; selective over TGF-β by 200-fold in C2C12 cells.</p>Fórmula:C25H24Cl2N6Pureza:99.78%Forma y color:SolidPeso molecular:479.4ALK-IN-13
CAS:<p>ALK-IN-13 is an ALK inhibitor.</p>Fórmula:C29H39ClN7O2PForma y color:SolidPeso molecular:584.1ALK-IN-9
CAS:<p>ALK-IN-9 effectively inhibits cell growth with IC50 <0.2 nM for Ba/F3-EML4-ALK, KM12, KG-1.</p>Fórmula:C20H21FN6O3Forma y color:SolidPeso molecular:412.425TL13-12
CAS:<p>TL13-12 is a selective degrader of ALK-PROTAC and inhibits ALK activity (IC50: 0.69 nM).</p>Fórmula:C45H53ClN10O10SPureza:98%Forma y color:SolidPeso molecular:961.49ALKBH5-IN-5
CAS:<p>ALKBH5-IN-5 is a highly selective, potent and covalently binding ALKBH5 inhibitor that alters m6A levels on mRNA, induces apoptosis, antitumo.</p>Fórmula:C13H13NO3Pureza:99.54%Forma y color:SoildPeso molecular:231.25dALK-3
<p>dALK-3 is a degrader of anaplastic lymphoma kinase (ALK) that effectively induces the degradation of EML4-ALK with a DC50 of 0.182 μM. It exhibits significant antiproliferative activity against H3122 cells and is applicable for tumor research.</p>Fórmula:C39H45ClN7O5PForma y color:SolidPeso molecular:758.245LAE-102
<p>LAE-102 is a monoclonal antibody that acts as an antagonist of activin receptor II-A (ACTRIIA/ACVR2). It shows potential for research in the fields of endocrine and metabolic disorders, oncology, and respiratory diseases.</p>Forma y color:Odour LiquidLDN 193688
CAS:<p>LDN 193688 is a BMP kinase inhibitor preferential for the ALK2 site, acting by binding to the ALK site,progressive osseous fibrodysplasia.</p>Fórmula:C22H16N4OPureza:99.16%Forma y color:SoildPeso molecular:352.39Kinase Inhibitor Library
<p>A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;</p>Forma y color:Odour SolidALK-IN-12
CAS:<p>ALK-IN-12: potent ALK inhibitor (IC50: 0.18 nM), affects IGF1R and InsR (IC50: 20.3/90.6 nM), potential for cancer therapy.</p>Fórmula:C24H30ClN6O2PForma y color:SolidPeso molecular:500.97Multi-kinase-IN-6
<p>Multi-kinase-IN-6 (compound 10e) is a multikinase inhibitor that effectively impedes the activity of TrkA, ALK2, c-KIT, EGFR, PIM1, CK2α, CHK1, and CDK2.</p>Pureza:98%Forma y color:Odour SolidLDN-193189 Tetrahydrochloride
CAS:<p>LDN193189 is a BMPI receptor inhibitor, blocking ALK2 and ALK3 effectively, while weak on ALK4, ALK5, ALK7.</p>Fórmula:C25H26Cl4N6Pureza:98.21%Forma y color:SolidPeso molecular:552.33EW-7195
CAS:<p>EW-7195 inhibits ALK5/TGFβR1 (>300x selective over p38α) with 4.83 nM IC50, blocking TGF-β1 signaling, EMT, and breast cancer lung metastasis.</p>Fórmula:C23H18N8Pureza:98.76%Forma y color:SolidPeso molecular:406.44CEP-28122 mesylate salt
<p>CEP-28122 mesylate, a diaminopyrimidine, selectively inhibits ALK with IC50 of 1.9 nM and exhibits antitumor effects.</p>Fórmula:C29H39ClN6O6SForma y color:SolidPeso molecular:635.17GW788388
CAS:<p>GW788388 is a potent and selective inhibitor of ALK5, also inhibits TGF-(beta) type II receptor and activin type II receptor activities.</p>Fórmula:C25H23N5O2Pureza:98.03% - 99.58%Forma y color:SolidPeso molecular:425.48CEP-28122
CAS:<p>CEP-28122 is a highly potent and selective orally active ALK inhibitor.</p>Fórmula:C28H35ClN6O3Pureza:99.87% - >99.99%Forma y color:SolidPeso molecular:539.07ALK kinase inhibitor-1
CAS:<p>SAR348830 is an ALK inhibitor, targeting anaplastic lymphoma kinase.</p>Fórmula:C28H32FN5O3SPureza:99.84%Forma y color:SolidPeso molecular:537.65SM 16
CAS:<p>SM 16 is a ALK5/ALK4 kinase inhibitor (Ki: 10/1.5 nM).</p>Fórmula:C25H26N4O3Pureza:99.72%Forma y color:SolidPeso molecular:430.5Vactosertib
CAS:<p>Vactosertib (EW-7197) is an oral TGFBR1/ALK5 inhibitor with potential cancer-fighting properties.</p>Fórmula:C22H18FN7Pureza:98.85% - 99.81%Forma y color:SolidPeso molecular:399.42DMH-1
CAS:<p>DMH-1 is a BMP inhibitor that inhibits ALK1, ALK2, ALK3 and ALK6. DMH-1 promotes pluripotent stem cell differentiation. Cost-effective and quality-assured.</p>Fórmula:C24H20N4OPureza:98% - 99.92%Forma y color:SolidPeso molecular:380.44
