ALK
Los inhibidores de ALK son compuestos que específicamente atacan e inhiben la quinasa del linfoma anaplásico (ALK), una tirosina quinasa receptora involucrada en el desarrollo y progresión de ciertos tipos de cáncer, incluyendo el cáncer de pulmón de células no pequeñas y el neuroblastoma. Al inhibir ALK, estos compuestos bloquean las vías de señalización que promueven el crecimiento y la supervivencia de las células tumorales. En CymitQuimica, ofrecemos inhibidores de ALK para apoyar su investigación en oncología, terapias dirigidas contra el cáncer y transducción de señales.
Se han encontrado 136 productos de "ALK"
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CJ-2360
CAS:CJ-2360 is a potent ALK inhibitor, effective on wild-type and various mutants, with IC50 values ranging from 2.2 to 8.9 nM, also targeting 468 kinases.Fórmula:C27H30FN5O2Forma y color:SolidPeso molecular:475.56ALK5-IN-30
CAS:ALK5-IN-30 (EX-07) is a potent inhibitor of ALK with inhibitory effects on ALK5 (IC50< 10 nM) and TGFβ-R1 (IC50< 10 nM).Fórmula:C24H25FN8Forma y color:SolidPeso molecular:444.51XST-14
CAS:XST-14 is a ULK1 inhibitor.XST-14 induces apoptosis and inhibits the growth of HCC cells.Fórmula:C16H21NO4Pureza:99.84% - 99.84%Forma y color:SolidPeso molecular:291.34ALK-IN-5
CAS:ALK-IN-5 is a potent, selective, and brain-penetrant inhibitor of anaplastic lymphoma kinase (ALK, IC50: 2.9 nM).Fórmula:C24H25FN6O3Pureza:98%Forma y color:SolidPeso molecular:464.49ALK2-IN-5
CAS:ALK2-IN-5, a pyrazolopyrimidine compound, serves as an inhibitor of ALK2 and FGFR, targeting disorders linked with their activity, including cancer [1].Fórmula:C24H32N8O2Forma y color:SolidPeso molecular:464.56Ficonalkib
CAS:Ficonalkib is a potent antineoplastic agent that inhibits the Anaplastic Lymphoma Kinase (ALK) tyrosine kinase receptor.Fórmula:C29H39N7O3SForma y color:SolidPeso molecular:565.73WY-135
CAS:WY-135 is a dual inhibitor of ALK and ROS1 (IC50 of 1.4 nM and 1.1 nM, respectively).Fórmula:C28H34ClN9O3SPureza:98%Forma y color:SolidPeso molecular:612.15SMU-B
CAS:SMU-B is a well-tolerated c-Met/ALK dual inhibitor.Fórmula:C26H25Cl2FN4O2Pureza:98%Forma y color:SolidPeso molecular:515.41ALK5-IN-29
CAS:ALK5-IN-29: selective ALK inhibitor, IC50 ≤ 10 nM, curbs tumor growth, aids in cancer research.Fórmula:C24H25FN8Forma y color:SolidPeso molecular:444.51MY10
CAS:MY10, a potent and orally active inhibitor of the receptor protein tyrosine phosphatase (RPTPβ/ζ), effectively reduces binge-like ethanol consumption andFórmula:C15H10F6OS2Pureza:98.64%Forma y color:SolidPeso molecular:384.36Ref: TM-T61678
1mg58,00€5mg126,00€10mg197,00€25mg394,00€50mg628,00€100mg982,00€200mg1.314,00€1mL*10mM (DMSO)167,00€Conteltinib
CAS:Conteltinib (CT-707) is an enzyme inhibitor with antitumor activity targeting FAK, ALK and Pyk2. It can be used to study lymphoma.Fórmula:C32H45N9O3SPureza:98.12% - 99.54%Forma y color:SolidPeso molecular:635.82Ref: TM-T14997
1mg70,00€5mg150,00€10mg216,00€25mg369,00€50mg517,00€100mg722,00€1mL*10mM (DMSO)205,00€JH-VIII-157-02
CAS:JH-VIII-157-02 inhibits ALK, specifically EML4-ALK variants, with IC50s of 2 nM.Fórmula:C28H27N5O2Pureza:99.58%Forma y color:SolidPeso molecular:465.55Ref: TM-T15612
1mg110,00€5mg227,00€10mg339,00€25mg530,00€50mg713,00€100mg982,00€1mL*10mM (DMSO)234,00€TP0427736 hydrochloride
CAS:TP0427736 hydrochloride is a novel and selective ALK5 inhibitor, capable of inhibiting Smad2/3 phosphorylation in A549 cells.Fórmula:C14H11ClN4S2Pureza:98.99%Forma y color:SolidPeso molecular:334.85ALK/EGFR-IN-2
CAS:ALK/EGFR-IN-2 is a potent dual inhibitor targeting ALK and EGFR, promoting apoptosis and G0/G1 cell cycle arrest in cancer cells.Fórmula:C27H34ClN7O3SForma y color:SolidPeso molecular:572.12ALK/ROS1-IN-1
CAS:ALK/ROS1-IN-1 is a potent and selective anti-crizotinib-resistant ALK/ROS1 dual inhibitor (IC50s: 0.530 μM and 0.174 μM for ROS1 and ALK enzyme).Fórmula:C30H35F3N6O3Pureza:98%Forma y color:SolidPeso molecular:584.63ALK/EGFR-IN-3
CAS:ALK/EGFR-IN-3 is a dual ALK and EGFR inhibitor that demonstrates potent anti-proliferative effects on various cancer cell lines, including H1975, PC9, and Baf3-Fórmula:C27H34ClN7O3SForma y color:SolidPeso molecular:572.12GW-6604
CAS:GW-6604 is an ALK5 inhibitor and shows clear antifibrotic effects resulting in liver function improvement.Fórmula:C19H14N4Pureza:99.6%Forma y color:SolidPeso molecular:298.34ALK/EGFR-IN-1
CAS:ALK/EGFR-IN-1 (Compound 8l) is a dual inhibitor targeting both ALK and EGFR, effectively blocking their phosphorylation.Fórmula:C27H34ClN7O3SPureza:98%Forma y color:SolidPeso molecular:572.12ALK-IN-6
CAS:ALK-IN-6 is an orally bioavailable inhibitor of anaplastic lymphoma kinase (ALK, IC50s: 71 nM, 18.72 nM, and 36.81 nM for ALK wild, ALK F1196M and ALK F1174L).Fórmula:C26H29ClD3N5O3SPureza:98%Forma y color:SolidPeso molecular:533.1UNC5293
CAS:UNC5293: potent oral MERTK inhibitor, Ki=190 pM, IC50=0.9 nM; selective vs Axl/Tyro3/Flt3; good mouse PK; used in leukemia research.Fórmula:C30H42N6O2Forma y color:SolidPeso molecular:518.69
