Receptor de Trk
Los inhibidores de los receptores Trk se dirigen a las quinasa de receptor de tropomiosina (Trk), una familia de tirosina quinasas receptoras que desempeñan un papel significativo en el desarrollo y la función del sistema nervioso. Los receptores Trk están involucrados en la señalización de neurotrofinas, esencial para la supervivencia, diferenciación y crecimiento de las neuronas. La desregulación de la señalización de Trk está asociada con trastornos neurológicos y ciertos tipos de cáncer. En CymitQuimica, ofrecemos inhibidores de receptores Trk para apoyar su investigación en neurobiología, oncología y enfermedades neurodegenerativas.
Se han encontrado 53 productos de "Receptor de Trk"
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N-Acetyl-5-hydroxytryptamine
CAS:N-Acetyl-5-hydroxytryptamine, or Normelatonin, is melatonin's precursor, made from serotonin, and activates TrkB receptor.
Fórmula:C12H14N2O2Pureza:98.31% - 99.91%Forma y color:SolidPeso molecular:218.25CE-245677
CAS:CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases. With a cellular IC50s of 4.7 and 1 nM.
Fórmula:C24H22Cl2N6O3Pureza:98.99% - 99.23%Forma y color:SolidPeso molecular:513.38Amitriptyline hydrochloride
CAS:Amitriptyline hydrochloride (Annoyltin) is the hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and antinociceptiveFórmula:C20H24ClNPureza:97% - 99.94%Forma y color:Crystals White To Off-White PowderPeso molecular:313.86CRB-0089
CRB-0089 is a human monoclonal antibody targeting NGF/bNGF. It is used in the study of analgesia.Forma y color:Odour LiquidAnti-NGF/bNGF Antibody (AS2886401-00)
Anti-NGF/bNGF Antibody (AS2886401-00) is a human monoclonal antibody (mAb) targeting NGF/bNGF. It inhibits intracellular calcium (Ca2+) influx and provides sustained analgesic effects during movement in an osteoarthritis (OA) rat model. This antibody is applicable for research in osteoarthritis.Forma y color:Odour LiquidGNF-8625 monopyridin-N-piperazine hydrochloride
CAS:GNF-8625 monopyridin-N-piperazine hydrochloride is a protomyosin receptor kinase (TRK) inhibitor.Fórmula:C25H27ClFN7Pureza:98.97%Forma y color:SolidPeso molecular:479.98TrkA-IN-6
TrkA-IN-6 (compound R48) is a hydrazone-based, selective inhibitor of the tropomyosin receptor kinase A (TrkA). It exhibits greater cytotoxicity towards U87 GBM cells compared to Temozolomide, with an IC50 of 68.99 μM.Fórmula:C16H13N3O5Peso molecular:327.08552Protein kinase inhibitor 5 sulfate hydrate
Protein kinase inhibitor 5 sulfate hydrate, a potent TRK-A inhibitor, exhibits an IC50 of 1.8 nM and impairs cell viability [1].
Fórmula:C29H35F2N7O6SPureza:98%Forma y color:SolidPeso molecular:647.69Adimanebart
CAS:Amdokitug is a human-derived IgG1λ monoclonal antibody that acts as an inhibitor of MUSK.Forma y color:LiquidPF-06737007
CAS:PF-06737007 is an effective inhibitor of pan-Trk in cell-based assays (IC50s: 7.7 nM, 15 nM, and 3.9 nM for TrkA, TrkB, and TrkC, respectively).Fórmula:C25H28F4N2O6Pureza:98%Forma y color:SolidPeso molecular:528.49GNF-5837
CAS:GNF-5837 is a specific, and orally bioavailable pan-TRK inhibitor for TrkA/TrkB (IC50: 8/12 nM).Fórmula:C28H21F4N5O2Pureza:97.26% - 98.08%Forma y color:SolidPeso molecular:535.49Ref: TM-T6097
5mg48,00€10mg80,00€25mg117,00€50mg178,00€100mg295,00€200mg384,00€500mg622,00€1mL*10mM (DMSO)52,00€Cyclotraxin B acetate(1203586-72-4 free base)
Cyclotraxin B acetate is an antagonist of TrkB receptors; inhibits BDNF-induced TrkB activity (IC50 = 0.30 nM).Fórmula:C50H77N13O19S3Pureza:99.42%Forma y color:SolidPeso molecular:1260.42LM22A-4
CAS:LM22A-4: BDNF mimetic, TrkB agonist, IC50=47 nM (fluorescence anisotropy).
Fórmula:C15H21N3O6Pureza:99.56%Forma y color:SolidPeso molecular:339.34Larotrectinib
CAS:Larotrectinib (LOXO-101) is an orally administered inhibitor of the TRK kinase and is highly selective only for the TRK family of receptors(IC50s = 2-20 nM).Fórmula:C21H22F2N6O2Pureza:99.15% - >99.99%Forma y color:SolidPeso molecular:428.44Ref: TM-T5995
1mg37,00€5mg74,00€10mg90,00€25mg157,00€50mg236,00€100mg356,00€500mg820,00€1mL*10mM (DMSO)81,00€Altiratinib
CAS:Altiratinib (DCC-2701)(DCC-2701) is a novel c-MET/TIE-2/VEGFR inhibitor; effectively reduce tumor burden in vivo and block c-MET pTyr(1349)-mediated signaling,Fórmula:C26H21F3N4O4Pureza:99.67% - 99.75%Forma y color:SolidPeso molecular:510.46Selitrectinib
CAS:Selitrectinib (LOXO-195) is a potent and selective inhibitor of the receptor tyrosine kinases(TRK).Cost-effective and quality-assured.Fórmula:C20H21FN6OPureza:99.55% - ≥95%Forma y color:SolidPeso molecular:380.42Entrectinib
CAS:Entrectinib (RXDX-101) is an orally Trk, ROS1, and ALK inhibitor. Entrectinib exhibits antitumor activity. Cost-effective and quality-assured.Fórmula:C31H34F2N6O2Pureza:98.03% - 99.61%Forma y color:SolidPeso molecular:560.64Ref: TM-T3678
2mg42,00€5mg59,00€10mg88,00€25mg111,00€50mg168,00€100mg283,00€500mg692,00€1mL*10mM (DMSO)69,00€CH7057288
CAS:CH7057288 is an effective and selective TRK inhibitor with an IC50 value of 1.1 nM, 7.8 nM and 5.1 nM for TRKA, TRKB and TRKC, respectively.Fórmula:C32H31N3O5SPureza:99.92%Forma y color:SolidPeso molecular:569.67Ensartinib hydrochloride
CAS:Ensartinib hydrochloride (X-396 dihydrochloride) is a potent new-generation ALK inhibitor with high activity against CNS metastases and a broad range of knownFórmula:C26H29Cl4FN6O3Pureza:98.73%Forma y color:SolidPeso molecular:634.36Ref: TM-T22324
1mg59,00€5mg127,00€10mg188,00€25mg404,00€50mg645,00€100mg938,00€200mg1.264,00€1mL*10mM (DMSO)170,00€Belizatinib
CAS:Belizatinib (TSR-011) is an effective, oral and dual inhibitor of ALK (IC50: 0.7 nM, wild-type recombinant ALK) and TRKA, TRKB, and TRKC.Fórmula:C33H44FN5O3Pureza:99.33% - 99.44%Forma y color:SolidPeso molecular:577.73Ref: TM-T4257
1mg40,00€2mg54,00€5mg93,00€10mg133,00€25mg259,00€50mg358,00€100mg500,00€1mL*10mM (DMSO)105,00€
