Receptor de Trk
Los inhibidores de los receptores Trk se dirigen a las quinasa de receptor de tropomiosina (Trk), una familia de tirosina quinasas receptoras que desempeñan un papel significativo en el desarrollo y la función del sistema nervioso. Los receptores Trk están involucrados en la señalización de neurotrofinas, esencial para la supervivencia, diferenciación y crecimiento de las neuronas. La desregulación de la señalización de Trk está asociada con trastornos neurológicos y ciertos tipos de cáncer. En CymitQuimica, ofrecemos inhibidores de receptores Trk para apoyar su investigación en neurobiología, oncología y enfermedades neurodegenerativas.
Se han encontrado 58 productos de "Receptor de Trk"
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Amitriptyline hydrochloride
CAS:Amitriptyline hydrochloride (Annoyltin) is the hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and antinociceptiveFórmula:C20H24ClNPureza:97% - 99.94%Forma y color:Crystals White To Off-White PowderPeso molecular:313.86N-Acetyl-5-hydroxytryptamine
CAS:<p>N-Acetyl-5-hydroxytryptamine, or Normelatonin, is melatonin's precursor, made from serotonin, and activates TrkB receptor.</p>Fórmula:C12H14N2O2Pureza:98.31% - 99.91%Forma y color:SolidPeso molecular:218.25CE-245677
CAS:<p>CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases. With a cellular IC50s of 4.7 and 1 nM.</p>Fórmula:C24H22Cl2N6O3Pureza:98.99% - 99.23%Forma y color:SolidPeso molecular:513.38Adimanebart
CAS:<p>Amdokitug is a human-derived IgG1λ monoclonal antibody that acts as an inhibitor of MUSK.</p>Forma y color:LiquidTrkA-IN-6
<p>TrkA-IN-6 (compound R48) is a hydrazone-based, selective inhibitor of the tropomyosin receptor kinase A (TrkA). It exhibits greater cytotoxicity towards U87 GBM cells compared to Temozolomide, with an IC50 of 68.99 μM.</p>Fórmula:C16H13N3O5Peso molecular:327.08552Anti-NGF/bNGF Antibody (AS2886401-00)
Anti-NGF/bNGF Antibody (AS2886401-00) is a human monoclonal antibody (mAb) targeting NGF/bNGF. It inhibits intracellular calcium (Ca2+) influx and provides sustained analgesic effects during movement in an osteoarthritis (OA) rat model. This antibody is applicable for research in osteoarthritis.Forma y color:Odour LiquidGNF-8625 monopyridin-N-piperazine hydrochloride
CAS:GNF-8625 monopyridin-N-piperazine hydrochloride is a protomyosin receptor kinase (TRK) inhibitor.Fórmula:C25H27ClFN7Pureza:98.97%Forma y color:SolidPeso molecular:479.98Protein kinase inhibitor 5 sulfate hydrate
<p>Protein kinase inhibitor 5 sulfate hydrate, a potent TRK-A inhibitor, exhibits an IC50 of 1.8 nM and impairs cell viability [1].</p>Fórmula:C29H35F2N7O6SPureza:98%Forma y color:SolidPeso molecular:647.69CRB-0089
CRB-0089 is a human monoclonal antibody targeting NGF/bNGF. It is used in the study of analgesia.Forma y color:Odour LiquidAnti-TrkB/NTRK2 Antibody
<p>Anti-TrkB/NTRK2 Antibody is a human-derived antibody produced in CHO cells, targeting TrkB. For the isotype control of Anti-TrkB/NTRK2 Antibody, refer to HumanIgG2kappa, Isotype Control.</p>Forma y color:Odour LiquidPF-06737007
CAS:PF-06737007 is an effective inhibitor of pan-Trk in cell-based assays (IC50s: 7.7 nM, 15 nM, and 3.9 nM for TrkA, TrkB, and TrkC, respectively).Fórmula:C25H28F4N2O6Pureza:98%Forma y color:SolidPeso molecular:528.49Altiratinib
CAS:Altiratinib (DCC-2701)(DCC-2701) is a novel c-MET/TIE-2/VEGFR inhibitor; effectively reduce tumor burden in vivo and block c-MET pTyr(1349)-mediated signaling,Fórmula:C26H21F3N4O4Pureza:99.67% - 99.75%Forma y color:SolidPeso molecular:510.46Selitrectinib
CAS:Selitrectinib (LOXO-195) is a potent and selective inhibitor of the receptor tyrosine kinases(TRK).Cost-effective and quality-assured.Fórmula:C20H21FN6OPureza:99.55% - ≥95%Forma y color:SolidPeso molecular:380.42GNF-5837
CAS:<p>GNF-5837 is a specific, and orally bioavailable pan-TRK inhibitor for TrkA/TrkB (IC50: 8/12 nM).</p>Fórmula:C28H21F4N5O2Pureza:97.26% - 98.08%Forma y color:SolidPeso molecular:535.49CH7057288
CAS:CH7057288 is an effective and selective TRK inhibitor with an IC50 value of 1.1 nM, 7.8 nM and 5.1 nM for TRKA, TRKB and TRKC, respectively.Fórmula:C32H31N3O5SPureza:99.92%Forma y color:SolidPeso molecular:569.67LM22A-4
CAS:<p>LM22A-4: BDNF mimetic, TrkB agonist, IC50=47 nM (fluorescence anisotropy).</p>Fórmula:C15H21N3O6Pureza:99.56%Forma y color:SolidPeso molecular:339.34Larotrectinib
CAS:<p>Larotrectinib (LOXO-101) is an orally administered inhibitor of the TRK kinase and is highly selective only for the TRK family of receptors(IC50s = 2-20 nM).</p>Fórmula:C21H22F2N6O2Pureza:99.15% - >99.99%Forma y color:SolidPeso molecular:428.44Milciclib
CAS:Milciclib (PHA-848125) is a potent CDK2 inhibitor with a 45 nM IC50, selective over CDK1/2/4/5/7. In Phase 2 trials.Fórmula:C25H32N8OPureza:99.28%Forma y color:SolidPeso molecular:460.57Ensartinib hydrochloride
CAS:Ensartinib hydrochloride (X-396 dihydrochloride) is a potent new-generation ALK inhibitor with high activity against CNS metastases and a broad range of knownFórmula:C26H29Cl4FN6O3Pureza:98.73%Forma y color:SolidPeso molecular:634.36Entrectinib
CAS:Entrectinib (RXDX-101) is an orally Trk, ROS1, and ALK inhibitor. Entrectinib exhibits antitumor activity. Cost-effective and quality-assured.Fórmula:C31H34F2N6O2Pureza:98.03% - 99.61%Forma y color:SolidPeso molecular:560.64
