Receptor de Trk
Los inhibidores de los receptores Trk se dirigen a las quinasa de receptor de tropomiosina (Trk), una familia de tirosina quinasas receptoras que desempeñan un papel significativo en el desarrollo y la función del sistema nervioso. Los receptores Trk están involucrados en la señalización de neurotrofinas, esencial para la supervivencia, diferenciación y crecimiento de las neuronas. La desregulación de la señalización de Trk está asociada con trastornos neurológicos y ciertos tipos de cáncer. En CymitQuimica, ofrecemos inhibidores de receptores Trk para apoyar su investigación en neurobiología, oncología y enfermedades neurodegenerativas.
Se han encontrado 56 productos de "Receptor de Trk"
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Cyclotraxin B acetate(1203586-72-4 free base)
Cyclotraxin B acetate is an antagonist of TrkB receptors; inhibits BDNF-induced TrkB activity (IC50 = 0.30 nM).Fórmula:C50H77N13O19S3Pureza:99.42%Forma y color:SolidPeso molecular:1260.42DS-1205
CAS:DS-1205: AXL kinase inhibitor (IC50=1.3 nM), also targets MER, MET, TRKA (IC50s: 63, 104, 407 nM), hinders cell migration and tumor growth.Fórmula:C41H42FN5O7Pureza:99.75%Forma y color:SolidPeso molecular:735.8GW 441756
CAS:GW 441756 is a specific Tropomyosin-related kinase A (TrkA) inhibitor with an IC50 value of 2 nM.Fórmula:C17H13N3OPureza:97.73% - 99.8%Forma y color:SolidPeso molecular:275.3Tyrphostin AG 879
CAS:Tyrphostin AG 879 (AG 879) effectively inhibits HER2/ErbB2 (IC50: 1 μM), 100- and 500-fold higher selective to ErbB2 than EGFR and PDGFR.Fórmula:C18H24N2OSPureza:99.05%Forma y color:SolidPeso molecular:316.46ONO-7475
CAS:ONO-7475 is an inhibitor with high specificity for anexelekto and MER tyrosine kinaseFórmula:C32H26N4O6Pureza:98.74%Forma y color:SolidPeso molecular:562.57ANA-12
CAS:ANA-12 is a potent and selective TrkB antagonist with anxiolytic and antidepressant activity in mice.
Fórmula:C22H21N3O3SPureza:99.28% - 99.87%Forma y color:SolidPeso molecular:407.497,8-Dihydroxyflavone
CAS:7,8-Dihydroxyflavone (7,8-DHF) is a naturally-occurring flavone and exist in Tridax procumbens, Godmania aesculifolia, and primula tree leaves.Fórmula:C15H10O4Pureza:98.48% - 99.81%Forma y color:SolidPeso molecular:254.24Repotrectinib
CAS:Repotrectinib (TPX-0005) is a potent ALK/ROS1/TRK inhibitor, with IC50 of 1.01/5.3/1.08/1.26 nM for WT ALK, SRC, ALK L1196M and ALK G1202R, respectively.Fórmula:C18H18FN5O2Pureza:99.92% - >99.99%Forma y color:SolidPeso molecular:355.37Ref: TM-T4071
1mg44,00€1mL*10mM (DMSO)92,00€5mg93,00€10mg133,00€25mg260,00€50mg394,00€100mg592,00€200mg827,00€Larotrectinib sulfate
CAS:Larotrectinib sulfate (LOXO-101 sulfate) is an oral active and specific ATP-competitive inhibitor of tropomyosin receptor kinases (TRK).Fórmula:C21H22F2N6O2·H2O4SPureza:98.62% - 99.76%Forma y color:SolidPeso molecular:526.51Ref: TM-T6880
2mg37,00€5mg54,00€1mL*10mM (DMSO)63,00€10mg88,00€25mg124,00€50mg155,00€100mg259,00€500mg623,00€LM22B-10
CAS:LM22B-10 is an activator of TrkB/TrkC neurotrophin receptor and can induce TrkB, TrkC, ERK and AKT activation in vitro and in vivo.Fórmula:C27H33ClN2O4Pureza:98.18%Forma y color:SolidPeso molecular:485.01Sitravatinib
CAS:Sitravatinib (MGCD516) (MGCD516) is an inhibitor targeting multiple RTKs involved in driving sarcoma cell growth, including c-Met, c-Kit, PDGFRα/β, PDGFR, andFórmula:C33H29F2N5O4SPureza:98.9% - 99.85%Forma y color:SolidPeso molecular:629.68Ref: TM-T4349
5mg49,00€1mL*10mM (DMSO)69,00€10mg74,00€25mg130,00€50mg200,00€100mg319,00€200mg507,00€500mg800,00€Frunevetmab
CAS:Frunevetmab (NV-02) is a feline-adapted monoclonal antibody targeting NGF (nerve growth factor), with a Kd value of 20 pM. Feline osteoarthritis (OA).Pureza:95% - 95.3% (SDS-PAGE); 98.7% (SEC-HPLC)Forma y color:LiquidPeso molecular:147.99 kDaTanezumab
CAS:Tanezumab (RN-624) is a humanised monoclonal antibody targeting NGF，pain conditions, including osteoarthritis, knee arthritis, and neuropathic pain.Pureza:95%Forma y color:LiquidPeso molecular:145.43 kDaFulranumab
CAS:Fulranumab (AMG-403) is a humanised monoclonal antibody targeting NGF, analgesic effects, and can be used for the study of chronic pain.Pureza:95%Forma y color:LiquidPeso molecular:145.37 kDaFasinumab
CAS:Fasinumab (anti-NGF mAb) is in Phase III trials for acute sciatica & knee OA. It significantly improves pain & function vs. placebo.Pureza:95%Forma y color:LiquidPeso molecular:144.89 kDaTrkA-IN-1
CAS:TrkA-IN-1 is a potent and selective inhibitor of Tropomyosin-related kinase A (TrkA) (IC50: 99 nM in a cell-based assay) with analgesic activity.Fórmula:C25H20N4OPureza:98%Forma y color:SolidPeso molecular:392.45Protein kinase inhibitor 5
CAS:Protein kinase inhibitor 5 is a potent inhibitor of TRK-A, demonstrating an IC50 of 1.8 nM, and effectively suppresses cell viability [1].Fórmula:C29H31F2N7OPureza:98%Forma y color:SolidPeso molecular:531.6Tavilermide
CAS:Tavilermide (MIM-D3) is a selective TrkA agonist, a cyclic mimetic, which can be used to study dry keratoconjunctivitis and dry eye syndrome.Fórmula:C24H32N6O11Pureza:98.98%Forma y color:SolidPeso molecular:580.54ENT-C225
CAS:ENT-C225 is a potent TrkB neurotrophin receptor (TrkBR) activator with neuroprotective activity for the study of Alzheimer's disease and Parkinson's disease.Fórmula:C26H40N4O5Pureza:99.36% - 99.36%Forma y color:SolidPeso molecular:488.62PF-06733804
CAS:PF-06733804 is a potent inhibitor of pan-Trk in cell-based assays (IC50s: 8.4 nM, 6.2 nM, and 2.2 nM for TrkA, TrkB, and TrkC) with anti-hyperalgesic effect.Fórmula:C20H19F5N4O4Pureza:98%Forma y color:SolidPeso molecular:474.38
