Receptor de Trk
Los inhibidores de los receptores Trk se dirigen a las quinasa de receptor de tropomiosina (Trk), una familia de tirosina quinasas receptoras que desempeñan un papel significativo en el desarrollo y la función del sistema nervioso. Los receptores Trk están involucrados en la señalización de neurotrofinas, esencial para la supervivencia, diferenciación y crecimiento de las neuronas. La desregulación de la señalización de Trk está asociada con trastornos neurológicos y ciertos tipos de cáncer. En CymitQuimica, ofrecemos inhibidores de receptores Trk para apoyar su investigación en neurobiología, oncología y enfermedades neurodegenerativas.
Se han encontrado 70 productos para "Receptor de Trk".
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N-Acetyl-5-hydroxytryptamine
CAS:N-Acetyl-5-hydroxytryptamine, or Normelatonin, is melatonin's precursor, made from serotonin, and activates TrkB receptor.Fórmula:C12H14N2O2Pureza:98.31% - 99.91%Forma y color:Yellow SolidPeso molecular:218.2518CE-245677
CAS:CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases. With a cellular IC50s of 4.7 and 1 nM.Fórmula:C24H22Cl2N6O3Pureza:98.99% - 99.23%Forma y color:SolidPeso molecular:513.376Amitriptyline hydrochloride
CAS:Amitriptyline hydrochloride (Annoyltin) is the hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and antinociceptiveFórmula:C20H24ClNPureza:99.39% - 99.94%Forma y color:SolidPeso molecular:313.864TrkA-IN-6
TrkA-IN-6 (compound R48) is a hydrazone-based, selective inhibitor of the tropomyosin receptor kinase A (TrkA). It exhibits greater cytotoxicity towards U87 GBM cells compared to Temozolomide, with an IC50 of 68.99 μM.Fórmula:C16H13N3O5Forma y color:SolidPeso molecular:327.08552Protein kinase inhibitor 5 sulfate hydrate
Protein kinase inhibitor 5 sulfate hydrate, a potent TRK-A inhibitor, exhibits an IC50 of 1.8 nM and impairs cell viability [1].Fórmula:C29H35F2N7O6SPureza:98%Forma y color:SolidPeso molecular:647.69Luvagrobart
CAS:Luvagrobart is a human monoclonal antibody targeting NGF that inhibits NGF binding to its receptor and is used in pain therapy research.Pureza:95%Peso molecular:~150 kDaGNF-8625 monopyridin-N-piperazine hydrochloride
CAS:GNF-8625 monopyridin-N-piperazine hydrochloride is a protomyosin receptor kinase (TRK) inhibitor.Fórmula:C25H27ClFN7Pureza:99.16%Forma y color:SolidPeso molecular:479.98TRK-IN-31 hydrochloride
TRK-IN-31 hydrochloride is an orally active TRK inhibitor with an IC50 of 1.8 nM. It demonstrates excellent antiproliferative activity in Ba/F3-MPRIP-TRKAG667C cells and selectively inhibits TRK kinase activity. Additionally, TRK-IN-31 hydrochloride significantly suppresses tumor growth in a Ba/F3-MPRIP-TRKAG667C subcutaneous mouse model.Anti-Human NGF Antibody (5D767)
Anti-NGF Antibody (5D767) is a Rabbit IgG monoclonal antibody targeting Human NGF.Forma y color:Odour LiquidAnti-Human NGF Antibody (8W871)
Anti-NGF Antibody (8W871) is a Rabbit IgG monoclonal antibody targeting Human NGF.PF-06737007
CAS:PF-06737007 is an effective inhibitor of pan-Trk in cell-based assays (IC50s: 7.7 nM, 15 nM, and 3.9 nM for TrkA, TrkB, and TrkC, respectively).Fórmula:C25H28F4N2O6Pureza:98%Forma y color:SolidPeso molecular:528.49Anti-Human NGF/bNGF Antibody
Anti-NGF/bNGF Antibody is a neutralizing mAb targeting β-NGF used to study chronic pain and inflammatory mechanisms by blocking NGF signaling.GBR-900
GBR-900 is an anti-TrkA mAb that inhibits pain signaling by blocking NGF binding, used for chronic pain with a better safety profile than anti-NGF antibodies.Pureza:95%Peso molecular:145.90 kDa (Predicted)Anti-Human TrkB/NTRK2 Antibody
Anti-TrkB/NTRK2 Antibody is a potent monoclonal antibody targeting the TrkB/NTRK2 receptor. Anti-TrkB/NTRK2 Antibody demonstrates significant receptor engagement activity in vitro and facilitates the measurable protection of neuronal integrity while improving cognitive performance in various preclinical models of neurodegeneration.Forma y color:Odour LiquidAnti-Human MUSK Antibody
Anti-MUSK Antibody serves as a functional therapeutic tool specifically designed to enable the precise detection and neutralization of the muscle-specific kinase which plays a pivotal role in the maintenance of the neuromuscular junction structural integrity during strictly monitored laboratory observation periods and molecular investigations to evaluate the pathological consequences of receptor tyrosine kinase inhibition in advanced neuroscience and immunology research models to facilitate the study of neuromuscular disorders.Pureza:95%Peso molecular:143.84 kDa (Predicted)CH7057288
CAS:CH7057288 is an effective and selective TRK inhibitor with an IC50 value of 1.1 nM, 7.8 nM and 5.1 nM for TRKA, TRKB and TRKC, respectively.Fórmula:C32H31N3O5SPureza:99.92%Forma y color:SolidPeso molecular:569.671Entrectinib
CAS:Entrectinib (RXDX-101) is an orally Trk, ROS1, and ALK inhibitor. Entrectinib exhibits antitumor activity. Cost-effective and quality-assured.Fórmula:C31H34F2N6O2Pureza:98.03% - 99.67%Forma y color:SolidPeso molecular:560.64LOXO-195
CAS:(6RS)-LOXO-195 (BAY 2731954) is a potent and selective Trk tyrosine kinase inhibitor.Fórmula:C20H21FN6OPureza:99.54%Forma y color:SolidPeso molecular:380.4187Cyclotraxin B acetate
Cyclotraxin B acetate is an antagonist of TrkB receptors; inhibits BDNF-induced TrkB activity (IC50 = 0.30 nM).Fórmula:C50H77N13O19S3Pureza:99.73%Forma y color:SolidPeso molecular:1260.42Altiratinib
CAS:Altiratinib (DCC-2701)(DCC-2701) is a novel c-MET/TIE-2/VEGFR inhibitor; effectively reduce tumor burden in vivo and block c-MET pTyr(1349)-mediated signaling,Fórmula:C26H21F3N4O4Pureza:99.67% - 99.75%Forma y color:SolidPeso molecular:510.4645
