Receptor de Trk
Los inhibidores de los receptores Trk se dirigen a las quinasa de receptor de tropomiosina (Trk), una familia de tirosina quinasas receptoras que desempeñan un papel significativo en el desarrollo y la función del sistema nervioso. Los receptores Trk están involucrados en la señalización de neurotrofinas, esencial para la supervivencia, diferenciación y crecimiento de las neuronas. La desregulación de la señalización de Trk está asociada con trastornos neurológicos y ciertos tipos de cáncer. En CymitQuimica, ofrecemos inhibidores de receptores Trk para apoyar su investigación en neurobiología, oncología y enfermedades neurodegenerativas.
Se han encontrado 57 productos para "Receptor de Trk".
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Amitriptyline hydrochloride
CAS:Amitriptyline hydrochloride (Annoyltin) is the hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and antinociceptiveFórmula:C20H24ClNPureza:99.39% - 99.94%Forma y color:SolidPeso molecular:313.86CE-245677
CAS:CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases. With a cellular IC50s of 4.7 and 1 nM.Fórmula:C24H22Cl2N6O3Pureza:98.99% - 99.23%Forma y color:SolidPeso molecular:513.38Ref: TM-T14921
1mg58,00€2mg82,00€5mg113,00€1mL*10mM (DMSO)129,00€10mg177,00€25mg296,00€50mg409,00€100mg605,00€N-Acetyl-5-hydroxytryptamine
CAS:N-Acetyl-5-hydroxytryptamine, or Normelatonin, is melatonin's precursor, made from serotonin, and activates TrkB receptor.Fórmula:C12H14N2O2Pureza:98.31% - 99.91%Forma y color:Yellow SolidPeso molecular:218.25Anti-NGF/bNGF Antibody (AS2886401-00)
Anti-NGF/bNGF Antibody (AS2886401-00) is a human monoclonal antibody (mAb) targeting NGF/bNGF. It inhibits intracellular calcium (Ca2+) influx and provides sustained analgesic effects during movement in an osteoarthritis (OA) rat model. This antibody is applicable for research in osteoarthritis.Forma y color:Odour LiquidGNF-8625 monopyridin-N-piperazine hydrochloride
CAS:GNF-8625 monopyridin-N-piperazine hydrochloride is a protomyosin receptor kinase (TRK) inhibitor.Fórmula:C25H27ClFN7Pureza:98.97%Forma y color:SolidPeso molecular:479.98CRB-0089
CRB-0089 is a human monoclonal antibody targeting NGF/bNGF. It is used in the study of analgesia.Forma y color:Odour LiquidProtein kinase inhibitor 5 sulfate hydrate
Protein kinase inhibitor 5 sulfate hydrate, a potent TRK-A inhibitor, exhibits an IC50 of 1.8 nM and impairs cell viability [1].Fórmula:C29H35F2N7O6SPureza:98%Forma y color:SolidPeso molecular:647.69TRK-IN-31 hydrochloride
TRK-IN-31 hydrochloride is an orally active TRK inhibitor with an IC50 of 1.8 nM. It demonstrates excellent antiproliferative activity in Ba/F3-MPRIP-TRKAG667C cells and selectively inhibits TRK kinase activity. Additionally, TRK-IN-31 hydrochloride significantly suppresses tumor growth in a Ba/F3-MPRIP-TRKAG667C subcutaneous mouse model.Anti-TrkB/NTRK2 Antibody
Anti-TrkB/NTRK2 Antibody is a potent monoclonal antibody targeting the TrkB/NTRK2 receptor. Anti-TrkB/NTRK2 Antibody demonstrates significant receptor engagement activity in vitro and facilitates the measurable protection of neuronal integrity while improving cognitive performance in various preclinical models of neurodegeneration.Forma y color:Odour LiquidTrkA-IN-6
TrkA-IN-6 (compound R48) is a hydrazone-based, selective inhibitor of the tropomyosin receptor kinase A (TrkA). It exhibits greater cytotoxicity towards U87 GBM cells compared to Temozolomide, with an IC50 of 68.99 μM.Fórmula:C16H13N3O5Forma y color:SolidPeso molecular:327.08552Adimanebart
CAS:Amdokitug is a human-derived IgG1λ monoclonal antibody that acts as an inhibitor of MUSK.Forma y color:LiquidAnti-NGF Antibody (5D767)
Anti-NGF Antibody (5D767) is a Rabbit IgG monoclonal antibody targeting Human NGF.Forma y color:Odour LiquidPF-06737007
CAS:PF-06737007 is an effective inhibitor of pan-Trk in cell-based assays (IC50s: 7.7 nM, 15 nM, and 3.9 nM for TrkA, TrkB, and TrkC, respectively).Fórmula:C25H28F4N2O6Pureza:98%Forma y color:SolidPeso molecular:528.49Altiratinib
CAS:Altiratinib (DCC-2701)(DCC-2701) is a novel c-MET/TIE-2/VEGFR inhibitor; effectively reduce tumor burden in vivo and block c-MET pTyr(1349)-mediated signaling,Fórmula:C26H21F3N4O4Pureza:99.67% - 99.75%Forma y color:SolidPeso molecular:510.46Selitrectinib
CAS:Selitrectinib (LOXO-195) is a potent and selective inhibitor of the receptor tyrosine kinases(TRK).Cost-effective and quality-assured.Fórmula:C20H21FN6OPureza:99.57% - ≥95%Forma y color:SolidPeso molecular:380.42LM22A-4
CAS:LM22A-4: BDNF mimetic, TrkB agonist, IC50=47 nM (fluorescence anisotropy).Fórmula:C15H21N3O6Pureza:99.56%Forma y color:SolidPeso molecular:339.34CH7057288
CAS:CH7057288 is an effective and selective TRK inhibitor with an IC50 value of 1.1 nM, 7.8 nM and 5.1 nM for TRKA, TRKB and TRKC, respectively.Fórmula:C32H31N3O5SPureza:99.92%Forma y color:SolidPeso molecular:569.67Larotrectinib
CAS:Larotrectinib (LOXO-101) is an orally administered inhibitor of the TRK kinase and is highly selective only for the TRK family of receptors(IC50s = 2-20 nM).Fórmula:C21H22F2N6O2Pureza:99.15% - >99.99%Forma y color:SolidPeso molecular:428.44Ref: TM-T5995
1mg37,00€5mg74,00€1mL*10mM (DMSO)81,00€10mg90,00€25mg157,00€50mg236,00€100mg356,00€500mg820,00€Entrectinib
CAS:Entrectinib (RXDX-101) is an orally Trk, ROS1, and ALK inhibitor. Entrectinib exhibits antitumor activity. Cost-effective and quality-assured.Fórmula:C31H34F2N6O2Pureza:98.03% - 99.61%Forma y color:SolidPeso molecular:560.64Ref: TM-T3678
2mg39,00€5mg56,00€1mL*10mM (DMSO)65,00€10mg84,00€25mg105,00€50mg159,00€100mg268,00€500mg655,00€Belizatinib
CAS:Belizatinib (TSR-011) is an effective, oral and dual inhibitor of ALK (IC50: 0.7 nM, wild-type recombinant ALK) and TRKA, TRKB, and TRKC.Fórmula:C33H44FN5O3Pureza:99.33% - 99.44%Forma y color:SolidPeso molecular:577.73Ref: TM-T4257
1mg40,00€2mg54,00€5mg93,00€1mL*10mM (DMSO)105,00€10mg133,00€25mg259,00€50mg358,00€100mg500,00€
