PDGFR
Los inhibidores del receptor del factor de crecimiento derivado de plaquetas (PDGFR) son compuestos que bloquean la señalización del PDGFR, un receptor involucrado en el crecimiento celular, la proliferación y la angiogénesis. El PDGFR desempeña un papel significativo en el desarrollo de los vasos sanguíneos que abastecen a los tumores. Inhibir el PDGFR puede, por lo tanto, prevenir la angiogénesis, lo que convierte a estos inhibidores en herramientas valiosas en la terapia contra el cáncer. En CymitQuimica, ofrecemos una selección de inhibidores de PDGFR de alta calidad para apoyar su investigación en oncología, biología vascular y angiogénesis.
Se han encontrado 129 productos de "PDGFR"
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Crenolanib
CAS:Crenolanib (ARO 002) is an orally bioavailable type III tyrosine kinases inhibitor of PDGFRα/β and FLT3 (IC50s: 11, 3.2, and 4 nM).Fórmula:C26H29N5O2Pureza:98.40% - 99.73%Forma y color:SolidPeso molecular:443.54Vorolanib
CAS:Vorolanib (X-82) is an orally active VEGFR/PDGFR dual inhibitor.Fórmula:C23H26FN5O3Pureza:97.35%Forma y color:SolidPeso molecular:439.48Ref: TM-T8491
1mg101,00€2mg142,00€5mg215,00€10mg340,00€25mg583,00€50mg842,00€100mg1.144,00€200mg1.521,00€1mL*10mM (DMSO)236,00€Masitinib
CAS:Masitinib (AB1010) is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in animals, specifically dogs.Fórmula:C28H30N6OSPureza:97.56% - >99.99%Forma y color:SolidPeso molecular:498.64CP-673451
CAS:CP-673451 is a specific inhibitor of PDGFRα/β (IC50: 10/1 nM) with antiangiogenic and antitumor activity and the selectivity is higher 450-fold than otherFórmula:C24H27N5O2Pureza:99.62% - 99.88%Forma y color:SolidPeso molecular:417.5Ref: TM-T6091
1mg49,00€2mg63,00€5mg90,00€10mg170,00€25mg334,00€50mg512,00€100mg737,00€500mg1.521,00€1mL*10mM (DMSO)108,00€Ripretinib
CAS:Ripretinib (DCC-2618) is an orally bioavailable inhibitor of KIT and PDGFRA.Fórmula:C24H21BrFN5O2Pureza:99.07% - 99.62%Forma y color:SolidPeso molecular:510.36Ref: TM-T8482
1mg74,00€2mg97,00€5mg165,00€10mg274,00€25mg432,00€50mg692,00€100mg1.121,00€200mg1.539,00€1mL*10mM (DMSO)202,00€Regorafenib
CAS:Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor that inhibits RET, C-RAF, VEGFR2, c-Kit, VEGFR1, and PDGFRβ and is orallyFórmula:C21H15ClF4N4O3Pureza:98% - 99.95%Forma y color:SolidPeso molecular:482.82Ref: TM-T1792
5mg34,00€10mg49,00€25mg75,00€50mg90,00€100mg137,00€200mg175,00€500mg294,00€1mL*10mM (DMSO)54,00€PD168393
CAS:PD168393 is an irreversible EGFR inhibitor (IC50: 0.70 nM), irreversibly alkylate Cys-773; inactive against PKC, FGFR, PDGFR, and insulin.Fórmula:C17H13BrN4OPureza:99.13% - 99.83%Forma y color:SolidPeso molecular:369.22Ref: TM-T6932
1mg37,00€2mg50,00€5mg63,00€10mg94,00€25mg146,00€50mg210,00€100mg294,00€1mL*10mM (DMSO)52,00€Lenvatinib mesylate
CAS:Lenvatinib mesylate (E7080 (mesylate)) is an oral and multi-targeted inhibitor of VEGFR1-3, FGFR1-4, PDGFR, KIT, and RET, with potent antitumor activities.Fórmula:C22H23ClN4O7SPureza:99.03% - 99.79%Forma y color:SolidPeso molecular:522.96Regorafenib monohydrate
CAS:Regorafenib Monohydrate is a novel oral multikinase inhibitor with IC50 values of 13, 4.2, 46, 22, 7, 1.5, 2.5, 28, 19 nM for VEGFR1, murine VEGFR2, murineFórmula:C21H17ClF4N4O4Pureza:99.69%Forma y color:SolidPeso molecular:500.83Ref: TM-T1792L
5mg34,00€10mg46,00€25mg65,00€50mg94,00€100mg133,00€200mg197,00€500mg329,00€1mL*10mM (DMSO)55,00€Methylnissolin
CAS:Methylnissolin (3-Hydroxy-9,10-dimethoxyptercarpan) is derived from Astragalus and has antibacterial and anti-cancer effects.Fórmula:C17H16O5Pureza:99.68% - 99.98%Forma y color:SolidPeso molecular:300.31Tyrphostin AG1296
CAS:Tyrphostin AG1296 (Tyrphostin AG 1296) is an inhibitor of PDGFR with IC50 of 0.3-0.5 μM, no activity to EGFR.Fórmula:C16H14N2O2Pureza:99.94% - >99.99%Forma y color:SolidPeso molecular:266.29Ref: TM-T6711
2mg40,00€5mg58,00€10mg90,00€25mg180,00€50mg279,00€100mg411,00€200mg585,00€1mL*10mM (DMSO)81,00€Cediranib
CAS:Cediranib (AZD2171) is a potent KDR tyrosine kinase inhibitor (IC50 < 1nM), also targets Flt1/4, PDGFRβ, c-Kit, and more selective for VEGFR.Fórmula:C25H27FN4O3Pureza:97.21% - 99.94%Forma y color:SolidPeso molecular:450.51Ref: TM-T2500
2mg39,00€5mg59,00€10mg87,00€25mg129,00€50mg168,00€100mg240,00€200mg439,00€500mg703,00€1mL*10mM (DMSO)65,00€Dovitinib lactate hydrate
CAS:Dovitinib lactate hydrate (TKI258) is the Lactate of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit).Fórmula:C24H27FN6O4Pureza:99.82%Forma y color:SolidPeso molecular:482.51Amuvatinib
CAS:Amuvatinib (MP470) is an orally bioavailable synthetic carbothioamide with potential antineoplastic activity.Fórmula:C23H21N5O3SPureza:99.38% - >99.99%Forma y color:SolidPeso molecular:447.51TAK-593
CAS:TAK-593 is an effective VEGFR and PDGFR family inhibitor (IC50s: 3.2, 0.95, 1.1, 4.3, and 13 nM for VEGFR1, VEGFR2, VEGFR3, PDFGRα, and PDFGRβ, respectively).Fórmula:C23H23N7O3Pureza:99.37%Forma y color:SolidPeso molecular:445.47Ref: TM-T16975
2mg42,00€5mg62,00€10mg96,00€25mg182,00€50mg284,00€100mg409,00€200mg575,00€1mL*10mM (DMSO)73,00€Masitinib mesylate
CAS:Masitinib mesylate (AB-1010 mesylate) is a selective and orally bioavailable c-Kit inhibitor (IC50 of 200 nM,540/800 nM,510 nM for human recombinant c-Kit;Fórmula:C29H34N6O4S2Pureza:97.67% - 98.44%Forma y color:SolidPeso molecular:594.75PP121
CAS:PP-121 inhibits PDGFR, Hck, mTOR, VEGFR2, Src, Abl, and DNA-PK with IC50 values ranging from 2 to 60 nM.Fórmula:C17H17N7Pureza:98.45% - 99.93%Forma y color:SolidPeso molecular:319.36SU4312
CAS:SU-4312 (DMBI) inhibits VEGFR & PDGFR (IC50: 0.8, 19.4 μM) and shields neurons from MPP(+)-induced damage by blocking nNOS.Fórmula:C17H16N2OPureza:>99.99%Forma y color:SolidPeso molecular:264.32N-(p-Coumaroyl) serotonin
CAS:N-(p-Coumaroyl) Serotonin, from safflower seeds, has antioxidant, antitumor properties and improves vascular health.Fórmula:C19H18N2O3Pureza:98.10% - 98.89%Forma y color:SolidPeso molecular:322.36Toceranib Phosphate
CAS:Toceranib Phosphate (SU11654 phosphate), is a selective inhibitor of the tyrosine kinase activity of several members of the split kinase RTK family.Fórmula:C22H28FN4O6PPureza:98.56%Forma y color:SolidPeso molecular:494.45
