c-RET
Los inhibidores de c-RET se dirigen al protooncogén RET (Rearranged during Transfection), que codifica una tirosina quinasa receptora involucrada en el crecimiento, diferenciación y supervivencia celular. La activación anormal de la señalización de RET puede llevar a una proliferación celular descontrolada y resistencia a la apoptosis, contribuyendo al desarrollo de cánceres como el carcinoma medular de tiroides y el cáncer de pulmón de células no pequeñas. Inhibir c-RET puede inducir apoptosis en células cancerosas y es un enfoque prometedor en la terapia contra el cáncer dirigida. En CymitQuimica, ofrecemos una variedad de inhibidores de c-RET de alta calidad para apoyar su investigación en oncología, transducción de señales y apoptosis.
Se han encontrado 51 productos de "c-RET"
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RET-IN-5
CAS:<p>RET-IN-5 is a potent inhibitor of RET (IC50: 4.57 nM).</p>Fórmula:C29H26FN9OForma y color:SolidPeso molecular:535.57FHND5071
CAS:<p>FHND5071, a potent and selective RET kinase inhibitor, exerts antitumor effects through the inhibition of RET autophosphorylation and may be utilized for tumor</p>Fórmula:C30H30D3N9OForma y color:SolidPeso molecular:538.66NSC194598
CAS:<p>NSC194598 is a p53 DNA-binding inhibitor, demonstrating an in vitro IC50 of 180 nM and an in vivo range of 2-40 μM.</p>Fórmula:C20H19N3OForma y color:SolidPeso molecular:317.38FLT3/ITD-IN-4
CAS:<p>FLT3/ITD-IN-4 inhibits FLT3-ITD mutations in acute myeloid leukemia (IC50: 2.3 nM).</p>Fórmula:C25H22N4O5Forma y color:SolidPeso molecular:458.47RET-IN-13
CAS:<p>RET-IN-13: potent quinoline RET inhibitor; IC50 = 0.5 nM (WT), 0.9 nM (V804M); potential for RET-related tumor/intestinal disease research.</p>Fórmula:C32H33F4N5O3Forma y color:SolidPeso molecular:611.63RET-IN-10
CAS:<p>RET-IN-10: Potent RET inhibitor, may treat congenital megacolon and tumors (Patent WO2021135938A1, compound 18).</p>Fórmula:C29H28N8OSForma y color:SolidPeso molecular:536.65RET-IN-7
CAS:<p>RET-IN-7 exhibits strong inhibitory effects against RET kinase in vitro and shows significant efficacy in treating RET-driven tumor xenografts in mice through</p>Fórmula:C22H24ClFN6O2Forma y color:SolidPeso molecular:458.92RET-IN-1
CAS:<p>RET-IN-1 is a RET kinase inhibitor (IC50s: 1 nM, 7 nM, and 101 nM for RET (WT), RET (V804M) , and RET (G810R), respectively).</p>Fórmula:C29H31N9O3Pureza:98%Forma y color:SolidPeso molecular:553.61WF-47-JS03
<p>WF-47-JS03: RET kinase inhibitor, crosses blood-brain barrier, 500x more selective for KDR, IC50: 1.7 nM in Ba/F3 cells, 5.3 nM in LC-2/ad lung cancer cells.</p>Fórmula:C30H38N6O2Forma y color:SolidPeso molecular:514.66RET-IN-9
CAS:<p>RET-IN-9 is a potent RET kinase inhibitor, potentially useful for studying RET-related diseases, including lung and thyroid cancer.</p>Fórmula:C26H27N9OForma y color:SolidPeso molecular:481.55Enbezotinib
CAS:<p>Enbezotinib is an inhibitor of RET autophosphorylation and can be used in cancer research.</p>Fórmula:C21H21FN6O3Pureza:99.84%Forma y color:SolidPeso molecular:424.43
